chlorambucil has been researched along with Reticulum Cell-Like Sarcoma, Yoshida in 26 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chlorambucil, in contrast, was rapidly absorbed, peak levels (40 microM) occurring within 2 h, after which chlorambucil and phenyl acetic mustard plasma levels decreased with half-lives of 2." | 1.26 | The pharmacokinetics of prednimustine and chlorambucil in the rat. ( Harrap, KR; Newell, DR; Shepherd, CR, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| van der Steen, J | 1 |
| van Wichen, BH | 1 |
| Benckhuysen, C | 1 |
| Newell, DR | 1 |
| Shepherd, CR | 1 |
| Harrap, KR | 17 |
| Riches, PG | 10 |
| Sellwood, SM | 3 |
| Gilby, ED | 1 |
| Wilkinson, R | 1 |
| Konyves, I | 1 |
| Gascoigne, EW | 2 |
| Leese, CL | 1 |
| Hill, BT | 14 |
| Birbeck, MS | 1 |
| Robertson, D | 1 |
| Furness, ME | 2 |
| Douglas, ID | 1 |
| Grover, PL | 1 |
| Tattersall, MH | 1 |
| Jackson, RC | 2 |
| Smith, CA | 1 |
| Jarman, M | 1 |
26 other studies available for chlorambucil and Reticulum Cell-Like Sarcoma, Yoshida
| Article | Year |
|---|---|
Effects of alkylating agents on the DNA replication of cultured Yoshida sarcoma cells.
Topics: Alkylating Agents; Animals; Carmustine; Cell Division; Cell Survival; Chlorambucil; Cyclophosphamide | 1982 |
The pharmacokinetics of prednimustine and chlorambucil in the rat.
Topics: Animals; Chlorambucil; Female; Kinetics; Prednimustine; Rats; Rats, Inbred Strains; Sarcoma, Yoshida | 1981 |
Some effects of chlorambucil on nuclear protein phosphorylation in the Yoshida ascites sarcoma.
Topics: Animals; Cell Nucleus; Chlorambucil; Drug Resistance; Histones; Molecular Weight; Neoplasm Proteins; | 1977 |
Studies on the toxicity and antitumour activity of prednimustine, a prednisolone ester of chlorambucil.
Topics: Animals; Body Weight; Cell Line; Chlorambucil; DNA, Neoplasm; Dose-Response Relationship, Drug; Fema | 1977 |
The effects of chlorambucil on the utilization of exogenous thymidine by tumour cells.
Topics: Alkylating Agents; Animals; Ascites; Cells, Cultured; Chlorambucil; DNA, Neoplasm; Neoplasm Transpla | 1975 |
Differential effects of cytotoxic concentrations of chlorambucil on drug-resistant and drug-sensitive cell lines of the Yoshida ascites sarcoma in culture.
Topics: Animals; Ascitic Fluid; Cell Division; Cell Line; Cell Survival; Cells, Cultured; Chlorambucil; DNA, | 1975 |
An autoradiographic study of the binding of 3-H-chlorambucil to cells of a drug-sensitive and drug-resistant strain of the Yoshida ascites sarcoma.
Topics: Animals; Autoradiography; Cell Line; Cell Nucleus; Chlorambucil; Cytoplasm; Dose-Response Relationsh | 1975 |
The binding of [3H]chlorambucil to nuclear proteins of the Yoshida ascites sarcoma.
Topics: Animals; Cell Nucleus; Chlorambucil; Chromatin; Drug Resistance; Female; Nucleoproteins; Protein Bin | 1975 |
The binding of (3H)chlorambucil to isolated nuclear proteins of the Yoshida ascites sarcoma.
Topics: Alkylating Agents; Animals; Binding Sites; Cell Nucleus; Chlorambucil; Drug Resistance; Neoplasm Pro | 1975 |
The interaction of bifunctional alkylating agents with the DNA of tumour cells.
Topics: Alkylating Agents; Animals; Chlorambucil; DNA Repair; DNA, Neoplasm; In Vitro Techniques; Mechloreth | 1976 |
The cytotoxicity of chlorambucil and its associated effects on NAD metabolism.
Topics: Animals; Cells, Cultured; Chlorambucil; Drug Resistance; Humans; In Vitro Techniques; N-Glycosyl Hyd | 1973 |
The increased anti-tumour activity of chlorambucil after pretreatment with phenobarbitone.
Topics: Animals; Cell Line; Chlorambucil; Drug Synergism; Enzyme Induction; Phenobarbital; Rats; Sarcoma, Yo | 1972 |
Some effects of chlorambucil on the chromatin of Yoshida ascites sarcoma cells.
Topics: Animals; Carbon Isotopes; Cell Fractionation; Cell Nucleus; Chlorambucil; Chromatin; DNA, Neoplasm; | 1973 |
Increased antitumour activity of chlorambucil following pretreatment with inducers of drug-metabolizing enzymes.
Topics: Animals; Benz(a)Anthracenes; Chlorambucil; DNA, Neoplasm; Drug Resistance; Drug Synergism; Enzyme In | 1973 |
Brief communication: Effect of chlorambucil on thymidine utilization by Yoshida ascites tumor cells.
Topics: Animals; Carbon Radioisotopes; Chlorambucil; Deoxyribonucleosides; DNA, Neoplasm; Rats; Sarcoma, Yos | 1973 |
Some effects of chlorambucil on the uptake and utilization of sulphydryl-containing compounds by tumour cells.
Topics: Animals; Cell Line; Chlorambucil; Cysteine; Cystine; Disulfides; Drug Resistance; Drug Stability; Fe | 1973 |
Studies on the transport and cellular distribution of chlorambucil in the Yoshida ascites sarcoma.
Topics: Animals; Biological Transport; Carbon Isotopes; Chlorambucil; Cyanides; Diffusion; Dinitrophenols; D | 1972 |
The effect of chlorambucil on nuclear protein synthesis in Yoshida ascites-sarcoma cells.
Topics: Animals; Carbon Isotopes; Cell Nucleus; Chlorambucil; Chromatin; DNA, Neoplasm; Histones; Leucine; N | 1971 |
The absorption, distribution and excretion of 3 H-chlorambucil in rats bearing the Yoshida ascites sarcoma.
Topics: Animals; Ascitic Fluid; Chlorambucil; DNA, Neoplasm; Injections, Subcutaneous; Neoplasm Proteins; Ra | 1971 |
Selectivity of action of alkylating agents and drug resistance. 4. Synthesis of tritium-labeled chlorambucil and a study of its cellular uptake by drug-sensitive and drug-resistant strains of the Yoshida ascites sarcoma in vitro.
Topics: Animals; Biopharmaceutics; Chlorambucil; Drug Resistance; Histocytochemistry; Isotope Labeling; Kine | 1971 |
The effect of chlorambucil on the incorporation of tritiated precursors into the nucleic acids and proteins of Yoshida ascites sarcoma cells.
Topics: Animals; Chlorambucil; DNA, Neoplasm; Lysine; Neoplasm Proteins; Rats; RNA, Neoplasm; Sarcoma, Yoshi | 1970 |
The selectivity of action of alkylating agents and drug resistance. 3. The uptake and degradation of alkylating drugs by Yoshida ascites sarcoma cells in vitro.
Topics: Animals; Busulfan; Cell Membrane Permeability; Chemical Phenomena; Chemistry; Chlorambucil; Culture | 1970 |
Effects of chlorambucil treatment on the rates of respiration and glycolysis in drug-sensitive and -resistant strains of the Yoshida ascites sarcoma.
Topics: Aerobiosis; Anaerobiosis; Animals; Ascitic Fluid; Carbon Dioxide; Chlorambucil; Glycolysis; In Vitro | 1970 |
The selectivity of action of alkylating agents and drug resistance. I. Biochemical changes occurring in sensitive and resistant strains of the Yoshida ascites sarcoma following chemotherapy.
Topics: Animals; Busulfan; Chlorambucil; DNA; Female; Glutamates; Glutathione; Glycine; Melphalan; Neoplasm | 1969 |
The selectivity of action of alkylating agents and drug resistance. II. A comparison of the effects of alkylating drugs on growth inhibition and cell size in sensitive and resistant strains of the Yoshida ascites sarcoma.
Topics: Animals; Busulfan; Cell Division; Chlorambucil; Female; Growth; Lymphocytes; Macrophages; Melphalan; | 1969 |
Some effects of chlorambucil on enzymes of glutathione metabolism in drug-sensitive and -resistant strains of the Yoshida ascites sarcoma.
Topics: Acyltransferases; Animals; Chlorambucil; Female; Glucosephosphate Dehydrogenase; Glutathione; Glutat | 1969 |