chlorambucil has been researched along with Pulmonary Fibrosis in 18 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Pulmonary Fibrosis: A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 73-year-old female developed pulmonary disease during treatment with chlorambucil for polycythemia vera." | 3.66 | Pulmonary disease with chlorambucil therapy. ( Cole, SR; Klatsky, AU; Myers, TJ, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (88.89) | 18.7374 |
| 1990's | 2 (11.11) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hagmann, SG | 1 |
| McCune, WJ | 1 |
| Vallance, DK | 1 |
| Lynch, JP | 1 |
| Spanedda, R | 1 |
| Romanini, D | 1 |
| Cinotti, A | 1 |
| Godard, P | 1 |
| Marty, JP | 1 |
| Michel, FB | 1 |
| Cole, SR | 1 |
| Myers, TJ | 1 |
| Klatsky, AU | 1 |
| Rose, MS | 1 |
| Giles, FJ | 1 |
| Smith, MP | 1 |
| Goldstone, AH | 1 |
| Kodo, H | 1 |
| Clements, PJ | 1 |
| Davis, J | 1 |
| Carr, ME | 1 |
| Baumgartner, G | 1 |
| Winterbauer, RH | 1 |
| Riggins, RC | 1 |
| Griesman, FA | 1 |
| Bauermeister, DE | 1 |
| Spiers, AS | 1 |
| Marie, J | 1 |
| Hennequet, A | 1 |
| Lévêque, B | 1 |
| Debauchez, C | 1 |
| Desbois, C | 1 |
| Watchi, JM | 1 |
| Rubio, FA | 1 |
| Brown, CH | 1 |
| Turner-Warwick, M | 1 |
5 reviews available for chlorambucil and Pulmonary Fibrosis
| Article | Year |
|---|---|
Immunosuppressive drug therapy.
Topics: Adrenal Cortex Hormones; Azathioprine; Chlorambucil; Clinical Trials as Topic; Cyclophosphamide; Cyc | 1994 |
Chlorambucil lung toxicity.
Topics: Aged; Chlorambucil; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Pulmonary Fibrosis | 1990 |
Graft-versus-host disease.
Topics: Bone Marrow Transplantation; Cardiac Surgical Procedures; Chlorambucil; Cytomegalovirus Infections; | 1987 |
Cytotoxic drugs: their clinical application to the rheumatic diseases.
Topics: Arthritis; Arthritis, Rheumatoid; Azathioprine; Behcet Syndrome; Bone Marrow; Cell Division; Chemica | 1986 |
Chlorambucil induced pulmonary fibrosis: report of a case and review.
Topics: Chlorambucil; Humans; Leukemia, Lymphoid; Lung; Male; Middle Aged; Pulmonary Fibrosis | 1986 |
13 other studies available for chlorambucil and Pulmonary Fibrosis
| Article | Year |
|---|---|
[Alveolitis and lung fibrosis following therapy with chlorambucil].
Topics: Chlorambucil; Female; Humans; Leukemia, Lymphoid; Lung; Middle Aged; Pneumonia; Pulmonary Alveoli; P | 1984 |
Clinicopathological conference. Two cases of drug-induced disease. Demonstration at the Royal College of Physicians of London.
Topics: Adult; Aged; Bronchiectasis; Chlorambucil; Cyclophosphamide; Demeclocycline; Diabetes Insipidus; Fem | 1978 |
[Evolutionary aspects of the picture of pulmonary pathology in the course of chronic blood diseases (a correlation with cytostatic treatment)].
Topics: Adult; Aged; Antineoplastic Agents; Busulfan; Chlorambucil; Female; Humans; Leukemia, Lymphoid; Leuk | 1979 |
Interstitial pneumonia and chlorambucil.
Topics: Aged; Chlorambucil; Humans; Leukemia, Lymphoid; Male; Pulmonary Fibrosis | 1979 |
Pulmonary disease with chlorambucil therapy.
Topics: Aged; Chlorambucil; Female; Humans; Polycythemia Vera; Pulmonary Alveoli; Pulmonary Fibrosis | 1978 |
Busulphan toxicity syndrome caused by chlorambucil.
Topics: Aged; Busulfan; Chlorambucil; Female; Humans; Leukemia, Lymphoid; Male; Middle Aged; Pigmentation Di | 1975 |
The Hamman-Rich syndrome following treatment of lymphoma with chlorambucil.
Topics: Aged; Chlorambucil; Humans; Lymphoma; Male; Pulmonary Fibrosis | 1975 |
[Results with the cytostatic agent bleomycin in tumour therapy (author's transl)].
Topics: Adult; Aged; Bleomycin; Bronchial Neoplasms; Carcinoma, Squamous Cell; Chlorambucil; Doxorubicin; Dr | 1973 |
Pleuropulmonary manifestations of Waldenstrom's macroglobulinemia.
Topics: Aged; Chlorambucil; Female; Humans; Lung; Lung Diseases; Lymphocytes; Male; Middle Aged; Pleura; Ple | 1974 |
Chronic granulocytic leukaemia and chronic lymphocytic leukaemia.
Topics: Allopurinol; Amenorrhea; Busulfan; Chlorambucil; Chronic Disease; Drug Eruptions; Female; Hemolysis; | 1974 |
[Histiocytic reticulosis in infants or Letterer-Siwe disease. (Clinical and therapeutical study)].
Topics: Acrodermatitis; Betamethasone; Biopsy; Blood Cell Count; Bone Diseases; Child, Preschool; Chlorambuc | 1968 |
Possible pulmonary effects of alkylating agents.
Topics: Alkylating Agents; Chlorambucil; Humans; Leukemia, Lymphoid; Lung; Pulmonary Fibrosis | 1972 |
The treatment of cryptogenic fibrosing alveolitis with immunosuppressant drugs.
Topics: Adult; Agglutination Tests; Antibodies, Antinuclear; Azathioprine; Chlorambucil; Complement Fixation | 1971 |