chlorambucil has been researched along with Prostatic Neoplasms in 25 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Prostatic Neoplasms: Tumors or cancer of the PROSTATE.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We examined the effect of bestrabucil, a benzoate of an estradiol-chlorambucil conjugate, on the production of growth factor(s) by Shionogi carcinoma 115 (SC-115) cells, an androgen-responsive cultured cancer cell line." | 7.69 | Inhibitory effects of bestrabucil, a conjugate of chlorambucil and estradiol, on the production of androgen-induced growth factor(s) by Shionogi carcinoma 115 cells. ( Akaza, H; Imada, S; Koiso, K; Tsukamoto, S, 1994) |
| " We examined the effect of bestrabucil, a benzoate of an estradiol-chlorambucil conjugate, on the production of growth factor(s) by Shionogi carcinoma 115 (SC-115) cells, an androgen-responsive cultured cancer cell line." | 3.69 | Inhibitory effects of bestrabucil, a conjugate of chlorambucil and estradiol, on the production of androgen-induced growth factor(s) by Shionogi carcinoma 115 cells. ( Akaza, H; Imada, S; Koiso, K; Tsukamoto, S, 1994) |
| "Bestrabucil, the benzoate of an estradiol-chlorambucil conjugate, was initially developed as a target-oriented anticancer agent for breast cancers with positive estrogen receptors, by conjugating a tumoricidal agent, chlorambucil, to a vehicle, estradiol." | 3.67 | [Bestrabacil: a possible target-oriented anticancer agent]. ( Isurugi, K; Ohsawa, N; Wagatsuma, T; Yamazaki, Z, 1984) |
| "The management of androgen independent prostate cancer is increasingly disputed." | 2.71 | Chlorambucil and lomustine (CL56) in absolute hormone refractory prostate cancer: re-induction of endocrine sensitivity an unexpected finding. ( Ansell, W; Barlow, C; Dancey, G; Oliver, RT; Shamash, J; Wilson, P, 2005) |
| "Patients with biopsy-proven membranous nephropathy and with a nephrotic syndrome were randomized to be given methylprednisolone (1 g intravenously for 3 consecutive days followed by oral methylprednisolone, 0." | 2.69 | A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy. ( Altieri, P; Antonucci, F; Bellazzi, R; Cesana, B; Dugo, M; Farina, M; Grassi, C; Lupo, A; Melis, P; Minari, M; Pasquali, S; Passerini, P; Pedrini, L; Piccoli, G; Pisano, G; Ponticelli, C; Pozzi, C; Roccatello, D; Sasdelli, M; Scalia, A; Scolari, F; Segagni, S; Valzorio, B, 1998) |
| "Ninety-two patients with D2 prostatic cancer were studied." | 2.66 | Sequential hormonal therapy and sequential hormonal and chemotherapy for advanced prostatic cancer. ( Bezwoda, WR; Derman, DP; Ruff, P; Weaving, A, 1989) |
| "We report a case of Lymphocytic Lymphoma presenting with primary manifestation in the prostate." | 1.42 | [Primary manifestation of small Lymphocytic Lymphoma in the Prostate: A case report]. ( Bellaaj, H; Boudawara, T; Elloumi, M; Gouiaa, N; Kassar, O; Mdhaffar, M; Mhiri, N; Mseddi, S, 2015) |
| "Treatment of penile cancer involves chemotherapy with bleomycin and irradiation, which result in considerable improvement." | 1.27 | [Selection of treatment from a pathophysiological point of view. II: Studies on male urogenital tumors]. ( Ishikawa, H; Ishikawa, S; Kanoh, S; Koiso, K; Nemoto, R; Ohtani, M, 1986) |
| "Estramustine has been shown previously to be an effective drug in the treatment of metastatic prostatic cancer, demonstrating significant objective and subjective responses in long-term non-randomized trials and in other randomized trials." | 1.26 | The use of estramustine and prednimustine versus prednimustine alone in advanced metastatic prostatic cancer patients who have received prior irradiation. ( Chu, TM; Gaeta, JF; Gibbons, RP; Johnson, DE; Loening, SA; Murphy, GP; Prout, GR; Saroff, J; Schmidt, JD; Scott, WW; Slack, N; Soloway, MS; Wajsman, Z, 1979) |
| "Estramustine is a combination of estradiol and nitrogen mustard, and alone has shown objective responses in advanced prostatic cancer." | 1.26 | Combined therapy of advanced prostatic carcinoma with estramustine and prednimustine. ( Catane, R; Kaufman, J; Mittelman, A; Murphy, GP, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (76.00) | 18.7374 |
| 1990's | 2 (8.00) | 18.2507 |
| 2000's | 2 (8.00) | 29.6817 |
| 2010's | 2 (8.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bastien, D | 1 |
| Hanna, R | 1 |
| Leblanc, V | 1 |
| Asselin, É | 1 |
| Bérubé, G | 1 |
| Kassar, O | 1 |
| Gouiaa, N | 1 |
| Mdhaffar, M | 1 |
| Bellaaj, H | 1 |
| Mseddi, S | 1 |
| Boudawara, T | 1 |
| Mhiri, N | 1 |
| Elloumi, M | 1 |
| HARMAN, JB | 1 |
| Shamash, J | 1 |
| Dancey, G | 1 |
| Barlow, C | 1 |
| Wilson, P | 1 |
| Ansell, W | 1 |
| Oliver, RT | 1 |
| Berry, WR | 1 |
| Isurugi, K | 2 |
| Ohsawa, N | 2 |
| Yamazaki, Z | 2 |
| Wagatsuma, T | 1 |
| Beckley, S | 1 |
| Wajsman, LZ | 1 |
| Slack, NH | 2 |
| Murphy, GP | 6 |
| Akaza, H | 1 |
| Imada, S | 1 |
| Tsukamoto, S | 1 |
| Koiso, K | 2 |
| Ponticelli, C | 1 |
| Altieri, P | 1 |
| Scolari, F | 1 |
| Passerini, P | 1 |
| Roccatello, D | 1 |
| Cesana, B | 1 |
| Melis, P | 1 |
| Valzorio, B | 1 |
| Sasdelli, M | 1 |
| Pasquali, S | 1 |
| Pozzi, C | 1 |
| Piccoli, G | 1 |
| Lupo, A | 1 |
| Segagni, S | 1 |
| Antonucci, F | 1 |
| Dugo, M | 1 |
| Minari, M | 1 |
| Scalia, A | 1 |
| Pedrini, L | 1 |
| Pisano, G | 1 |
| Grassi, C | 1 |
| Farina, M | 1 |
| Bellazzi, R | 1 |
| Gibbons, RP | 1 |
| Johnson, DE | 1 |
| Prout, GR | 1 |
| Schmidt, JD | 1 |
| Soloway, MS | 1 |
| Loening, SA | 1 |
| Chu, TM | 1 |
| Gaeta, JF | 1 |
| Saroff, J | 1 |
| Wajsman, Z | 1 |
| Slack, N | 1 |
| Scott, WW | 1 |
| Catane, R | 3 |
| Kaufman, JH | 1 |
| Madajewicz, S | 1 |
| Mittelman, A | 2 |
| Kaufman, J | 1 |
| Belman, AB | 1 |
| Baum, ES | 1 |
| Kanoh, S | 1 |
| Nemoto, R | 1 |
| Ishikawa, H | 1 |
| Ishikawa, S | 1 |
| Ohtani, M | 1 |
| Ruff, P | 1 |
| Derman, DP | 1 |
| Weaving, A | 1 |
| Bezwoda, WR | 1 |
| Bajusz, S | 1 |
| Janaky, T | 1 |
| Csernus, VJ | 1 |
| Bokser, L | 1 |
| Fekete, M | 1 |
| Srkalovic, G | 1 |
| Redding, TW | 1 |
| Schally, AV | 1 |
| Nasu, Y | 1 |
| Saegusa, M | 1 |
| Hara, M | 1 |
| Ochi, J | 1 |
| Akagi, T | 1 |
| Obama, T | 1 |
| Tsushima, T | 1 |
| Yoshimoto, J | 1 |
| Ozaki, Y | 1 |
| Matsumura, Y | 1 |
| Feustel, A | 1 |
| Armstrong, JG | 1 |
| Furnari, S | 1 |
| Pavone-Macaluso, M | 1 |
| Veroux, G | 1 |
| Mattea, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical Study of Rituximab or Cyclophosphamide Combined With Steroids in the Treatment of Idiopathic Membranous Nephropathy[NCT05514015] | Phase 4 | 72 participants (Anticipated) | Interventional | 2022-08-25 | Not yet recruiting | ||
| Random, Open, Control and Monocentric Clinical Research on Tacrolimus Monotherapy for Idiopathic Membranous Nephropathy (IMN)[NCT03549663] | 108 participants (Anticipated) | Interventional | 2018-07-04 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for chlorambucil and Prostatic Neoplasms
| Article | Year |
|---|---|
[Tumor-oriented anti-cancer agent with estrogen as a carrier].
Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Chlorambucil; Drug Carriers; Estradiol; Estra | 1988 |
5 trials available for chlorambucil and Prostatic Neoplasms
| Article | Year |
|---|---|
Chlorambucil and lomustine (CL56) in absolute hormone refractory prostate cancer: re-induction of endocrine sensitivity an unexpected finding.
Topics: Aged; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; | 2005 |
Chemotherapy in metastatic, hormone refractory prostatic cancer using chlorambucil in combination with prednisolone versus conjugate, prednimustine (Leo 1031).
Topics: Aged; Antineoplastic Agents; Chlorambucil; Clinical Trials as Topic; Drug Therapy, Combination; Huma | 1981 |
A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy.
Topics: Adolescent; Adult; Aged; Amenorrhea; Anemia; Antineoplastic Agents, Alkylating; Carcinoma; Chlorambu | 1998 |
A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy.
Topics: Adolescent; Adult; Aged; Amenorrhea; Anemia; Antineoplastic Agents, Alkylating; Carcinoma; Chlorambu | 1998 |
A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy.
Topics: Adolescent; Adult; Aged; Amenorrhea; Anemia; Antineoplastic Agents, Alkylating; Carcinoma; Chlorambu | 1998 |
A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy.
Topics: Adolescent; Adult; Aged; Amenorrhea; Anemia; Antineoplastic Agents, Alkylating; Carcinoma; Chlorambu | 1998 |
[Chemotherapy of advanced prostate cancer].
Topics: Chlorambucil; Clinical Trials as Topic; Cyclophosphamide; Dacarbazine; Diethylstilbestrol; Drug Eval | 1977 |
Sequential hormonal therapy and sequential hormonal and chemotherapy for advanced prostatic cancer.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Combined Modality Ther | 1989 |
19 other studies available for chlorambucil and Prostatic Neoplasms
| Article | Year |
|---|---|
Synthesis and preliminary in vitro biological evaluation of 7α-testosterone-chlorambucil hybrid designed for the treatment of prostate cancer.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Chlorambucil; Dose-Response Relationshi | 2013 |
[Primary manifestation of small Lymphocytic Lymphoma in the Prostate: A case report].
Topics: Aged, 80 and over; Antineoplastic Agents, Alkylating; Chlorambucil; Humans; Leukemia, Lymphocytic, C | 2015 |
THE TREATMENT OF INCURABLE MALIGNANT DISEASE.
Topics: Adrenalectomy; Androgens; Breast Neoplasms; Busulfan; Chlorambucil; Estrogens; Heroin; Hormones; Hum | 1964 |
Re-induction of hormonal sensitivity in hormone-refractory prostate cancer--fact or fiction?
Topics: Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Clinical Trials as Topic; Drug Resista | 2005 |
[Clinical application of KM 2210 (estradiol-chlorambucil) in patients with advanced prostatic carcinoma].
Topics: Aged; Animals; Child; Chlorambucil; Estradiol; Humans; Male; Middle Aged; Prostate; Prostatic Neopla | 1984 |
[Bestrabacil: a possible target-oriented anticancer agent].
Topics: Administration, Oral; Aged; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Division; Chloram | 1984 |
Inhibitory effects of bestrabucil, a conjugate of chlorambucil and estradiol, on the production of androgen-induced growth factor(s) by Shionogi carcinoma 115 cells.
Topics: Androgens; Animals; Antineoplastic Agents; Carcinoma; Cell Count; Chlorambucil; Culture Media, Condi | 1994 |
The use of estramustine and prednimustine versus prednimustine alone in advanced metastatic prostatic cancer patients who have received prior irradiation.
Topics: Chlorambucil; Drug Therapy, Combination; Estramustine; Humans; Male; Nausea; Neoplasm Metastasis; Ni | 1979 |
Prednimustine for prostate cancer therapy.
Topics: Chlorambucil; Estramustine; Hematopoiesis; Humans; Male; Nausea; Prednimustine; Prostatic Neoplasms; | 1979 |
Prednimustine therapy for advanced prostatic cancer.
Topics: Adrenal Glands; Aged; Chemical Phenomena; Chemistry; Chlorambucil; Drug Combinations; Humans; Male; | 1978 |
Clinical experience with estramustine phosphate and predinimustine, two steroidal alkylating agents compounds [proceedings].
Topics: Chlorambucil; Estramustine; Humans; Male; Nitrogen Mustard Compounds; Prednisolone; Prostatic Neopla | 1978 |
Combined therapy of advanced prostatic carcinoma with estramustine and prednimustine.
Topics: Aged; Antineoplastic Agents; Chlorambucil; Drug Therapy, Combination; Estramustine; Humans; Male; Mi | 1977 |
Current trends in treatment of childhood rhabdomyosarcoma of lower genitourinary tract.
Topics: Biopsy, Needle; Child; Child, Preschool; Chlorambucil; Dactinomycin; Humans; Infant; Male; Prostatic | 1976 |
[Selection of treatment from a pathophysiological point of view. II: Studies on male urogenital tumors].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Cisplatin; Combined Modalit | 1986 |
Highly potent analogues of luteinizing hormone-releasing hormone containing D-phenylalanine nitrogen mustard in position 6.
Topics: Amino Acid Sequence; Animals; Breast Neoplasms; Cell Membrane; Chlorambucil; Female; Gonadotropin-Re | 1989 |
[A new anti-cancer agent, bestrabucil (KM 2210): I. Concentration in the serum and tissue in urogenital tumors].
Topics: Administration, Oral; Chlorambucil; Estradiol; Humans; Kidney Neoplasms; Male; Prostatic Neoplasms; | 1987 |
[Therapy of the most important male genital carcinomas].
Topics: Chlorambucil; Choriocarcinoma; Cyproterone; Dactinomycin; Estrogens; Humans; Lymph Node Excision; Ma | 1973 |
Current problems in the use of the oncolytic drugs.
Topics: Antineoplastic Agents; Busulfan; Carcinoma, Squamous Cell; Child; Chlorambucil; Choriocarcinoma; Dac | 1968 |
Cancer chemotherapy in urology.
Topics: Adenocarcinoma; Alkylating Agents; Antibiotics, Antineoplastic; Antimetabolites; Chlorambucil; Cobal | 1971 |