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chlorambucil and Pregnancy

chlorambucil has been researched along with Pregnancy in 88 studies

Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

ExcerptRelevanceReference
"The widely accepted standard therapy for cutaneous sarcoidosis includes corticosteroids, antimalarials, and methotrexate."4.84Cutaneous sarcoidosis therapy updated. ( Badgwell, C; Rosen, T, 2007)
" Methotrexate, azathioprine, mycophenolate mofetil, cyclosporin cyclophosphamide, chlorambucil, and other related drugs have potential benefits in the treatment of severe and/or recalcitrant rheumatic skin diseases."4.81Immunosuppressive and cytotoxic drugs in the treatment of rheumatic skin disorders. ( Callen, JP, 2001)
"This report describes a 53-year-old white woman with metastatic gestational trophoblastic neoplasia that recurred after evacuation of an accidental pregnancy and did not respond sufficiently to treatment with a combination of methotrexate, actinomycin D, and chlorambucil."3.67Chemotherapy-resistant gestational trophoblastic neoplasia treated successfully with cisplatin, etoposide, and bleomycin. ( Aalders, JG; Bouma, J; Sleijfer, DT; Willemse, PH, 1988)
"The clinical features of patients with brain metastases are reviewed in detail."1.29Brain metastases of gestational trophoblastic tumor. ( Bakri, Y; Berkowitz, RS; Goldstein, DP; Jabbar, FA; Senoussi, M; Subhi, J; von Sinner, W, 1994)
"Surgery combined with chemotherapy was applied in 34 out of 178 patients (19."1.29Chemotherapy combined with surgery in the treatment of gestational trophoblastic disease (GTD). ( Kietlińska, Z; Sablińska, B; Zieliński, J, 1993)
"Of 19 patients with gestational trophoblastic tumor and liver metastases, 6 received MAC chemotherapy, and 8 received PEA."1.29Liver metastases of gestational trophoblastic tumor. ( Amer, M; Bakri, YN; Ezzat, A; Jabbar, FA; Sinner, W; Subhi, J; Tweijry, A, 1993)
"Chlorambucil (CHL) was administered ip on d 11 of gestation at doses of 0, 3, and 6 mg/kg; nitrofen (2,4-dichlorophenyl p-nitrophenyl ether) (NIT) was given po on d 8-16 of gestation at 0, 4."1.27Morphometric, biochemical, and physiological assessment of perinatally induced renal dysfunction. ( Gray, JA; Kavlock, RJ, 1983)
"Chlorambucil was three times more potent than cyclophosphamide on an mg/kg basis."1.26Aspects of the teratology of cyclophosphamide (NSC-26271). ( Ashby, R; Davis, L; Dewhurst, BB; Espinal, R; Penn, RN; Upshall, DG, 1976)
" They type and frequency of malformations differed according to the dosage and day of treatment."1.25Teratogenic effects of chlorambucil on in vivo and in vitro organogenesis in mice. ( Kochhar, DM; Salder, TW, 1975)

Research

Studies (88)

TimeframeStudies, this research(%)All Research%
pre-199074 (84.09)18.7374
1990's11 (12.50)18.2507
2000's3 (3.41)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ali, R1
Ozkalemkas, F1
Kimya, Y1
Koksal, N1
Ozkocaman, V1
Yorulmaz, H1
Eroglu, A1
Ozcelik, T1
Tunali, A1
SHOTTON, D1
MONIE, IW1
SULLI, G1
HRESCHCHYSHYN, MM1
BREWER, JI1
GERBIE, AB1
DOLKART, RE1
SKOM, JH1
NAGLE, RG1
TOROK, EE1
EDMONDS, LC1
CARRERA, GM1
RUGH, R2
SKAREDOFF, L1
Badgwell, C1
Rosen, T1
Soukup, S1
Takacs, E1
Warkany, J1
Giavini, E1
Bonanomi, L1
Ornaghi, F1
Harder, M1
Limacher, F1
Kavlock, RJ3
Gray, JA1
Lurain, JR1
Piver, MS1
Sablińska, B2
Cześnin, K1
Ploch, E1
Jones, WB2
Fujii, T1
Nakatsuka, T1
Mirkes, PE1
Greenaway, JC1
Steege, JF1
Caldwell, DS1
Bakri, Y1
Berkowitz, RS1
Goldstein, DP1
Subhi, J2
Senoussi, M1
von Sinner, W1
Jabbar, FA2
Hammond, CB4
Olt, GJ1
Kietlińska, Z1
Zieliński, J1
Bakri, YN1
Amer, M1
Ezzat, A1
Sinner, W1
Tweijry, A1
Powell, JL1
Johnson, NA1
Bailey, CL1
Otis, CN1
Generoso, WM1
Witt, KL1
Cain, KT1
Hughes, L1
Cacheiro, NL1
Lockhart, AM1
Shelby, MD1
Bermas, BL1
Hill, JA1
Ramsey-Goldman, R1
Schilling, E1
Callen, JP2
Lewis, JL1
Lehr, M1
Galbraith, RM1
Eddleston, AL1
Williams, R1
Zuckerman, AJ1
Ross, GT2
Becker, RL1
Avioli, LV1
Tscherne, G1
Einhorn, LH1
Hoffman, R1
Wasserman, LR1
Schaison, G1
Jacquillat, C1
Auclerc, G1
Weil, M1
Brummett, ES1
Johnson, EM1
Pratt, RA1
Di Chiro, G1
Weed, JC1
Schiffman, FJ1
Fisher, JM1
Rabinovitz, M1
O'Neill, E1
Pelegrina, I1
Vicens, R1
Almodóvar, AR1
Sadler, TW1
Kochhar, DM2
Baumgartner, G1
Stutzman, L2
Zipori, D1
Trainin, N1
Brandt, L1
Kónyves, I1
Móller, TR1
Salder, TW1
Ashby, R1
Davis, L1
Dewhurst, BB1
Espinal, R1
Penn, RN1
Upshall, DG1
Ba-Thike, K1
Oo, N1
Mortakis, AE1
Braga, CA1
Willemse, PH1
Aalders, JG1
Bouma, J1
Sleijfer, DT1
du Toit, JP1
Curry, SL1
Blessing, JA1
DiSaia, PJ1
Soper, JT1
Twiggs, LB1
Gerulath, AH1
Dembo, AJ1
Aitken, S1
Quirt, IC1
Osborne, R1
Blackstein, M1
Rider, WD1
Takamizawa, H1
Sekiya, S1
Kobayashi, O1
Matsui, H1
Tanaka, O1
Rehnberg, BF2
Rogers, EH2
Lajos, L1
Székely, J1
Major, A1
Balogh, S1
Bücs, G1
Semenovskiĭ, AV1
Bret, AJ1
Grépinet, J1
Woodruff, JD2
Protos, P1
Peterson, WF1
Clavert, A1
Gabriel-Robez, O1
Armstrong, JG1
Parker, RT2
Li, MC1
Bloomfield, RD1
Ober, WB1
Edgcomb, JH1
Price, EB1
Borchert, LG1
Tyrey, L1
Creasman, WT1
Klener, P1
Hervet, E1
Barrat, J1
Darbois, Y1
Faguer, C1
Shepard, TH1
Skinner, MD1
Schwartz, RS1
Forbes, IJ1
Zittoun, R1
Drox, JP1
de Carbonniére, C1
Bernadou, A1
Bilski-Pasquier, G1
Bousser, J1
Sandström, B1
Sokal, JE1
Baum, J1
Vaughan, J1
Julian, CG1
Mayr, E1
Jacobs, EM1
Johnson, FD1
Froud, PJ1
Henderson, AH1
Kernis, MM1
Marcus, SL1
Wider, JA1
Marshall, JR1
Bardin, CW1
Lipsett, MB1

Reviews

19 reviews available for chlorambucil and Pregnancy

ArticleYear
[MEDICAL THERAPY OF MALIGNANT NEOPLASMS].
    La Clinica terapeutica, 1964, Feb-29, Volume: 28

    Topics: Antimetabolites; Antineoplastic Agents; Antiviral Agents; Blood Transfusion; Busulfan; Chlorambucil;

1964
Cutaneous sarcoidosis therapy updated.
    Journal of the American Academy of Dermatology, 2007, Volume: 56, Issue:1

    Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Allopurinol; Animals; Anti-Inflammatory Agents

2007
Management of advanced juvenile granulosa cell tumor of the ovary.
    Gynecologic oncology, 1993, Volume: 48, Issue:1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Combined Modality Therapy;

1993
Effects of immunosuppressive drugs during pregnancy.
    Arthritis and rheumatism, 1995, Volume: 38, Issue:12

    Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Animals; Azathioprine; Chlorambucil; Cyclophos

1995
Immunosuppressive drug use during pregnancy.
    Rheumatic diseases clinics of North America, 1997, Volume: 23, Issue:1

    Topics: Adrenal Cortex Hormones; Animals; Azathioprine; Chlorambucil; Cyclophosphamide; Cyclosporine; Female

1997
Immunosuppressive and cytotoxic drugs in the treatment of rheumatic skin disorders.
    Seminars in cutaneous medicine and surgery, 2001, Volume: 20, Issue:1

    Topics: Adult; Alkylating Agents; Antimetabolites; Azathioprine; Child; Chlorambucil; Cladribine; Cyclophosp

2001
[New aspects of diagnosis, treatment and follow-up of trophoblastic tumours (author's transl)].
    Wiener klinische Wochenschrift. Supplementum, 1979, Volume: 103

    Topics: Adult; Aftercare; Brain Neoplasms; Chlorambucil; Chorionic Gonadotropin; Dactinomycin; Drug Therapy,

1979
Natural history and management of polycythemia vera.
    Advances in internal medicine, 1979, Volume: 24

    Topics: Acute Disease; Adult; Antineoplastic Agents; Bloodletting; Cell Transformation, Neoplastic; Chloramb

1979
Chlorambucil.
    IARC monographs on the evaluation of the carcinogenic risk of chemicals to man, 1975, Volume: 9

    Topics: Animals; Carcinogens; Chlorambucil; Drug Evaluation, Preclinical; Female; Fetus; Humans; Lethal Dose

1975
Current status of treatment of lymphomas.
    Southern medical journal, 1975, Volume: 68, Issue:7

    Topics: Adrenal Cortex Hormones; Antineoplastic Agents; Chlorambucil; Cyclophosphamide; Drug Therapy, Combin

1975
Immunosuppressive and cytotoxic drugs: uses in the dermatologic patient.
    Advances in dermatology, 1990, Volume: 5

    Topics: Azathioprine; Chlorambucil; Cyclophosphamide; Drug Interactions; Female; Humans; Immunosuppressive A

1990
[Chemotherapy of trophoblastic disease].
    Voprosy onkologii, 1974, Volume: 20, Issue:2

    Topics: Chemotherapy, Cancer, Regional Perfusion; Chlorambucil; Choriocarcinoma; Chorionic Gonadotropin; Cyc

1974
Trophoblastic disease: natural history, diagnosis, and treatment.
    Annals of internal medicine, 1971, Volume: 74, Issue:1

    Topics: Alkylating Agents; Aminopterin; Chlorambucil; Choriocarcinoma; Chorionic Gonadotropin; Dactinomycin;

1971
Current cancer chemotherapy in obstetrics and gynecology.
    American journal of obstetrics and gynecology, 1971, Feb-01, Volume: 109, Issue:3

    Topics: Alkaloids; Alkylating Agents; Anti-Bacterial Agents; Antimetabolites; Blood Cell Count; Bone Marrow;

1971
Immunosuppressive therapy. 2.
    The New England journal of medicine, 1972, Aug-10, Volume: 287, Issue:6

    Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Adult; Azathioprine; Child; Chlorambucil; Clin

1972
Use of anticancer drugs during pregnancy.
    Clinical obstetrics and gynecology, 1968, Volume: 11, Issue:2

    Topics: Alkylating Agents; Aminopterin; Animals; Antimetabolites; Antineoplastic Agents; Busulfan; Chlorambu

1968
Immunosuppressive drugs in rheumatoid arthritis.
    Annals of internal medicine, 1969, Volume: 71, Issue:1

    Topics: Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Cyclophosphamide; Female; Humans; Immunosuppressi

1969
The role of chemotherapy in the treatment of primary ovarian malignancy.
    Obstetrical & gynecological survey, 1969, Volume: 24, Issue:11

    Topics: Alkylating Agents; Antimetabolites; Antineoplastic Agents; Ascites; Chlorambucil; Chromium; DNA Repl

1969
[Antirheumatics. 40].
    Pharmazeutische Praxis, 1969, Volume: 12

    Topics: Anti-Inflammatory Agents; Antilymphocyte Serum; Azathioprine; Chlorambucil; Female; Humans; Immunosu

1969

Trials

3 trials available for chlorambucil and Pregnancy

ArticleYear
A prospective randomized comparison of methotrexate, dactinomycin, and chlorambucil versus methotrexate, dactinomycin, cyclophosphamide, doxorubicin, melphalan, hydroxyurea, and vincristine in "poor prognosis" metastatic gestational trophoblastic disease:
    Obstetrics and gynecology, 1989, Volume: 73, Issue:3 Pt 1

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Cyclophosphamide; Dactinomycin;

1989
Vinca alkaloids. Experimental and clinical trials.
    Acta Universitatis Carolinae. Medica. Monographia, 1974, Issue:58

    Topics: Animals; Cell Movement; Chlorambucil; Choriocarcinoma; Female; Hematopoiesis; Hematopoietic Stem Cel

1974
Immunosuppressive therapy. 2.
    The New England journal of medicine, 1972, Aug-10, Volume: 287, Issue:6

    Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Adult; Azathioprine; Child; Chlorambucil; Clin

1972

Other Studies

67 other studies available for chlorambucil and Pregnancy

ArticleYear
Pregnancy in chronic lymphocytic leukemia: experience with fetal exposure to chlorambucil.
    Leukemia research, 2009, Volume: 33, Issue:4

    Topics: Adult; Allopurinol; Antimetabolites; Antineoplastic Agents, Alkylating; Chlorambucil; Female; Fetus;

2009
POSSIBLE TERATOGENIC EFFECT OF CHLORAMBUCIL ON A HUMAN FETUS.
    JAMA, 1963, Oct-05, Volume: 186

    Topics: Chlorambucil; Congenital Abnormalities; Female; Fetus; Hodgkin Disease; Humans; Pregnancy; Pregnancy

1963
EXPERIENCES WITH CHEMOTHERAPY IN GYNECOLOGIC CANCER.
    New York state journal of medicine, 1964, Oct-01, Volume: 64

    Topics: Antineoplastic Agents; Biomedical Research; Chlorambucil; Cyclophosphamide; Dactinomycin; Female; Ge

1964
CHEMOTHERAPY IN TROPHOBLASTIC DISEASES.
    American journal of obstetrics and gynecology, 1964, Nov-01, Volume: 90

    Topics: Chlorambucil; Choriocarcinoma; Chorionic Gonadotropin; Dactinomycin; Drug Therapy; Female; Gestation

1964
EXTRAGENITAL CHORIOCARCINOMA.
    The Journal of pediatrics, 1965, Volume: 67

    Topics: Autopsy; Brain Neoplasms; Child; Chlorambucil; Choriocarcinoma; Dactinomycin; Drug Therapy; Epistaxi

1965
RADIATION AND RADIOMIMETRIC CHLORAMBUCIL AND THE FETAL RETINA.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1965, Volume: 74

    Topics: Abnormalities, Drug-Induced; Animals; Biomedical Research; Chlorambucil; Congenital Abnormalities; E

1965
Chromosome changes in embryos treated with various teratogens.
    Journal of embryology and experimental morphology, 1967, Volume: 18, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Chlorambucil; Chromosome Aberrations; Diet; Female; Hydroxyure

1967
Developmental toxicity during the preimplantation period: embryotoxicity and clastogenic effects of chlorambucil in the rat.
    Teratogenesis, carcinogenesis, and mutagenesis, 1984, Volume: 4, Issue:4

    Topics: Animals; Blastocyst; Bone Marrow; Cell Nucleus; Chlorambucil; Embryo Implantation; Embryonic Develop

1984
[Generalized metastasizing chorion carcinoma with complete remission after cytostatic therapy].
    Gynakologische Rundschau, 1983, Volume: 22 Suppl 3

    Topics: Adult; Breast Neoplasms; Chlorambucil; Choriocarcinoma; Chorionic Gonadotropin; Cyclophosphamide; Da

1983
Morphometric, biochemical, and physiological assessment of perinatally induced renal dysfunction.
    Journal of toxicology and environmental health, 1983, Volume: 11, Issue:1

    Topics: Age Factors; Animals; Animals, Newborn; Chlorambucil; Deamino Arginine Vasopressin; Diuresis; Dogs;

1983
Metastatic gestational trophoblastic disease: secondary chemotherapy.
    New York state journal of medicine, 1980, Volume: 80, Issue:2

    Topics: Antineoplastic Agents; Chlorambucil; Dactinomycin; Drug Therapy, Combination; Female; Humans; Methot

1980
[Management of trophoblastic disease].
    Ginekologia polska, 1980, Volume: 51, Issue:10

    Topics: Adolescent; Adult; Antineoplastic Agents; Chlorambucil; Drug Therapy, Combination; Female; Follow-Up

1980
Management of low-risk metastatic gestational trophoblastic disease.
    The Journal of reproductive medicine, 1981, Volume: 26, Issue:4

    Topics: Antineoplastic Agents; Chlorambucil; Dactinomycin; Drug Therapy, Combination; Female; Humans; Hyster

1981
Potentiating effects of caffeine on teratogenicity of alkylating agents in mice.
    Teratology, 1983, Volume: 28, Issue:1

    Topics: Abnormalities, Drug-Induced; Abnormalities, Radiation-Induced; Alkylating Agents; Animals; Antibioti

1983
Chlorambucil.
    IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, 1981, Volume: 26

    Topics: Animals; Carcinogens; Chemical Phenomena; Chemistry; Chlorambucil; Drug Interactions; Female; Fetal

1981
Teratogenicity of chlorambucil in rat embryos in vitro.
    Teratology, 1982, Volume: 26, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Biotransformation; Chlorambucil; Cyclophosphamide; Dose-Respon

1982
Renal agenesis after first trimester exposure to chlorambucil.
    Southern medical journal, 1980, Volume: 73, Issue:10

    Topics: Abnormalities, Drug-Induced; Abortion, Therapeutic; Adult; Chlorambucil; Female; Humans; Kidney; Mal

1980
Brain metastases of gestational trophoblastic tumor.
    The Journal of reproductive medicine, 1994, Volume: 39, Issue:3

    Topics: Adult; Antineoplastic Agents; Biomarkers, Tumor; Brain Neoplasms; Chlorambucil; Chorionic Gonadotrop

1994
Gestational trophoblastic disease.
    Current therapy in endocrinology and metabolism, 1994, Volume: 5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Cyclophosphamide; Dactinomycin; Drug A

1994
Chemotherapy combined with surgery in the treatment of gestational trophoblastic disease (GTD).
    European journal of gynaecological oncology, 1993, Volume: 14 Suppl

    Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Chorioca

1993
Liver metastases of gestational trophoblastic tumor.
    Gynecologic oncology, 1993, Volume: 48, Issue:1

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Cisplatin; Dactinomycin; Etopos

1993
Dominant lethal and heritable translocation tests with chlorambucil and melphalan in male mice.
    Mutation research, 1995, Volume: 345, Issue:3-4

    Topics: Animals; Antineoplastic Agents, Alkylating; Chlorambucil; Female; Genes, Dominant; Genes, Lethal; Ge

1995
Monitor of chemotherapy in gestational trophoblastic neoplasm by radioimmunoassay of the beta-subunit of human chorionic gonadotropin.
    American journal of obstetrics and gynecology, 1975, Mar-01, Volume: 121, Issue:5

    Topics: Adult; Antineoplastic Agents; Biological Assay; Bleomycin; Chlorambucil; Choriocarcinoma; Chorionic

1975
Fulminant hepatic failure in leukaemia and choriocarcinoma related to withdrawal of cytotoxic drug therapy.
    Lancet (London, England), 1975, Sep-20, Volume: 2, Issue:7934

    Topics: Adult; Antineoplastic Agents; Chlorambucil; Choriocarcinoma; Cyclophosphamide; Dactinomycin; Female;

1975
Congenital anomalies among children born of mothers receiving chemotherapy for gestational trophoblastic neoplasms.
    Cancer, 1976, Volume: 37, Issue:2 Suppl

    Topics: Abnormalities, Drug-Induced; Antineoplastic Agents; Chlorambucil; Drug Therapy, Combination; Female;

1976
Gestational trophoblastic disease.
    Archives of internal medicine, 1977, Volume: 137, Issue:2

    Topics: Adult; Brain Neoplasms; Cerebral Hemorrhage; Chlorambucil; Choriocarcinoma; Dactinomycin; Female; He

1977
Cancer chemotherapy.
    American family physician, 1977, Volume: 15, Issue:3

    Topics: Chlorambucil; Choriocarcinoma; Cyclophosphamide; Dactinomycin; Female; Hodgkin Disease; Humans; Leuk

1977
[Fetal risk of cancer chemotherapy (author's transl)].
    Bulletin du cancer, 1979, Volume: 66, Issue:2

    Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Alkaloids; Animals; Antibiotics, Antineop

1979
Morphological alterations in the developing fetal rat limb due to maternal injection of chlorambucil.
    Teratology, 1979, Volume: 20, Issue:2

    Topics: Animals; Bone and Bones; Bone Development; Chlorambucil; Extremities; Female; Gestational Age; Mater

1979
Cerebral necrosis following irradiation and chemotherapy for metastatic choriocarcinoma.
    Surgical neurology, 1977, Volume: 7, Issue:3

    Topics: Adult; Antineoplastic Agents; Brain; Brain Diseases; Brain Neoplasms; Chlorambucil; Choriocarcinoma;

1977
Serum displacing agents in cancer chemotherapy.
    Cancer treatment reports, 1977, Volume: 61, Issue:7

    Topics: Animals; Cattle; Cells, Cultured; Chemical Phenomena; Chemistry; Chlorambucil; Clofibrate; Culture M

1977
Normal pregnancy and delivery after cerebral metastases of choriocarcinoma: Case report.
    Cancer, 1976, Volume: 38, Issue:2

    Topics: Adolescent; Brain Neoplasms; Chlorambucil; Choriocarcinoma; Dactinomycin; Drug Therapy, Combination;

1976
Chlorambucil-induced cell death in embryonic mouse limb buds.
    Toxicology and applied pharmacology, 1976, Volume: 37, Issue:2

    Topics: Acid Phosphatase; Animals; Cells, Cultured; Chlorambucil; Cytoplasm; Embryo, Mammalian; Extremities;

1976
[Cytostatic therapy of inoperable carcinomas].
    Wiener medizinische Wochenschrift (1946), 1976, Jan-30, Volume: 126, Issue:5

    Topics: Breast Neoplasms; Bronchial Neoplasms; Chlorambucil; Choriocarcinoma; Cyclophosphamide; Dactinomycin

1976
The role of a thymus humoral factor in the proliferation of bone marrow CFU-S from thymectomized mice.
    Experimental hematology, 1975, Volume: 3, Issue:6

    Topics: Animals; Bone Marrow; Bone Marrow Cells; Bone Marrow Transplantation; Cell Division; Chlorambucil; C

1975
Therapeutic effect of Leo 1031, an alkylating corticosteroid ester, in lymphoproliferative disorders. I. chronic lymphocytic leukaemia.
    Acta medica Scandinavica, 1975, Volume: 197, Issue:4

    Topics: Adult; Aged; Chlorambucil; Drug Evaluation; Esters; Female; Humans; Leukemia, Lymphoid; Male; Middle

1975
Teratogenic effects of chlorambucil on in vivo and in vitro organogenesis in mice.
    Teratology, 1975, Volume: 12, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Cells, Cultured; Chlorambucil; Female; Fetus; Gestational Age;

1975
Aspects of the teratology of cyclophosphamide (NSC-26271).
    Cancer treatment reports, 1976, Volume: 60, Issue:4

    Topics: Abnormalities, Drug-Induced; Alkylation; Animals; Chemical Phenomena; Chemistry; Chlorambucil; Cyclo

1976
Non-Hodgkin's lymphoma in pregnancy.
    Asia-Oceania journal of obstetrics and gynaecology, 1990, Volume: 16, Issue:3

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Cyclophosphamide; Female; Fetus

1990
"Poor prognosis" metastatic gestational trophoblastic disease: the prognostic significance of the scoring system in predicting chemotherapy failures.
    Obstetrics and gynecology, 1990, Volume: 76, Issue:2

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chlorambucil; Choriocarcinom

1990
Chemotherapy-resistant gestational trophoblastic neoplasia treated successfully with cisplatin, etoposide, and bleomycin.
    Obstetrics and gynecology, 1988, Volume: 71, Issue:3 Pt 2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Cisplatin; Dactinomycin; Et

1988
High risk malignant gestational trophoblastic disease: experience with triple chemotherapy (MAC) in Third World circumstances.
    Gynecologic oncology, 1989, Volume: 32, Issue:3

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Dactinomycin; Female; Humans; L

1989
Poor prognosis metastatic gestational trophoblastic disease: experience with moderate dose methotrexate plus folinic acid rescue as initial therapy.
    Gynecologic oncology, 1986, Volume: 25, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chlorambucil; Chorionic Gonadotropi

1986
Chemotherapy for gestational trophoblastic tumors.
    Seminars in surgical oncology, 1987, Volume: 3, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Choriocarcinoma; Chorionic Gonadotropi

1987
[Abnormalities of brain differentiation induced by chemical agents].
    No to hattatsu = Brain and development, 1988, Volume: 20, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Brain; Chlorambucil; Female; Mice; Neural Tube Defects; Oncoge

1988
Chlorambucil induced congenital renal hypoplasia: effects on basal renal function in the developing rat.
    Toxicology, 1986, Volume: 40, Issue:3

    Topics: Animals; Blood Urea Nitrogen; Body Weight; Chlorambucil; Dose-Response Relationship, Drug; Female; K

1986
Critical prenatal periods for chlorambucil-induced functional alterations of the rat kidney.
    Toxicology, 1987, Volume: 43, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Chlorambucil; Female; Gestational Age; Kidney; Li

1987
[Importance of chemotherapeutic agents in the treatment of malignant trophoblast tumors].
    Zeitschrift fur Geburtshilfe und Gynakologie, 1969, Volume: 171, Issue:3

    Topics: Adnexa Uteri; Adult; Chlorambucil; Choriocarcinoma; Chorionic Gonadotropin; Dactinomycin; Female; Hu

1969
[Uterine chorioepithelioma].
    Munchener medizinische Wochenschrift (1950), 1966, Sep-23, Volume: 108, Issue:38

    Topics: Abortion, Spontaneous; Adult; Antineoplastic Agents; Chlorambucil; Chloramines; Choriocarcinoma; Dac

1966
Ovarian teratomas. Relationship of histologic and ontogenic factors to prognosis.
    American journal of obstetrics and gynecology, 1968, Nov-01, Volume: 102, Issue:5

    Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Chlorambucil; Choriocarcinoma; Dactinomycin

1968
[Ocular abnormalities induced by chloraminophene in the mouse].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1974, Volume: 168, Issue:8-9

    Topics: Animals; Atrophy; Chlorambucil; Eye; Female; Lens, Crystalline; Mice; Morphogenesis; Optic Nerve; Pr

1974
Current problems in the use of the oncolytic drugs.
    Acta geneticae medicae et gemellologiae, 1968, Volume: 17, Issue:1

    Topics: Antineoplastic Agents; Busulfan; Carcinoma, Squamous Cell; Child; Chlorambucil; Choriocarcinoma; Dac

1968
Diagnosis and treatment of trophoblastic disease. A report from the Southeastern Regional Center.
    Obstetrics and gynecology, 1970, Volume: 35, Issue:1

    Topics: Adult; Antineoplastic Agents; Chlorambucil; Choriocarcinoma; Chorionic Gonadotropin; Dactinomycin; D

1970
The pathology of choriocarcinoma.
    Annals of the New York Academy of Sciences, 1971, Jan-28, Volume: 172, Issue:10

    Topics: Adolescent; Adult; Age Factors; Animals; Autopsy; Child; Chlorambucil; Choriocarcinoma; Chorionic Go

1971
Treatment of metastatic trophoblastic disease: good and poor prognosis.
    American journal of obstetrics and gynecology, 1973, Feb-15, Volume: 115, Issue:4

    Topics: Brain Neoplasms; Chlorambucil; Choriocarcinoma; Chorionic Gonadotropin; Dactinomycin; Female; Follow

1973
[Letter: Teratogenic effects of medications].
    La Nouvelle presse medicale, 1974, Nov-02, Volume: 3, Issue:37

    Topics: Abnormalities, Drug-Induced; Adult; Chlorambucil; Female; Humans; Hydroxyurea; Leukemia, Lymphoid; M

1974
Teratogenicity from drugs--an increasing problem.
    Disease-a-month : DM, 1974

    Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Aminopterin; Amniocentesis; Animals; Anti-Bact

1974
The clinical use of immunosuppressive drugs.
    The Medical journal of Australia, 1973, Apr-14, Volume: 1, Issue:15

    Topics: Adrenal Cortex Hormones; Aged; Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Cyclophosphamide;

1973
[The evolution of idiopathic autoimmune hemolytic anemia].
    Annales de medecine interne, 1973, Volume: 124, Issue:4

    Topics: Age Factors; Anemia, Hemolytic, Autoimmune; Antibodies; Chlorambucil; Cyclophosphamide; Female; Huma

1973
[Malignant mole and choriocarcinoma].
    Lakartidningen, 1973, Oct-10, Volume: 70, Issue:41

    Topics: Chlorambucil; Choriocarcinoma; Female; Humans; Hydatidiform Mole; Methotrexate; Pregnancy; Prognosis

1973
Radiobiology. NYO-2740-4.
    NYO [reports]. U.S. Atomic Energy Commission, 1967, Jan-01

    Topics: Animals; Animals, Newborn; Cataract; Chlorambucil; Embryo, Mammalian; Female; Fetus; Haplorhini; Hum

1967
Cytotoxic agents in the treatment of malignant disease.
    British medical journal, 1968, Nov-16, Volume: 4, Issue:5628

    Topics: Antimetabolites; Antineoplastic Agents; Breast Neoplasms; Carcinoma; Chlorambucil; Choriocarcinoma;

1968
Gestational choriocarcinoma.
    Oncology, 1972, Volume: 26, Issue:2

    Topics: Adult; California; Chlorambucil; Choriocarcinoma; Chorionic Gonadotropin; Dactinomycin; Female; Huma

1972
The treatment of Wegener's granulomatosis with immunosuppressive-cytotoxic drugs.
    The Journal of laryngology and otology, 1971, Volume: 85, Issue:7

    Topics: Adult; Azathioprine; Chlorambucil; Female; Granulomatosis with Polyangiitis; Humans; Male; Methylpre

1971
Abnormal yolk sac function induced by chlorambucil.
    Experientia, 1971, Volume: 27, Issue:11

    Topics: Abnormalities, Drug-Induced; Animals; Carbon Isotopes; Chlorambucil; Embryo, Mammalian; Extraembryon

1971
Effect of induced leukopenia on the contraceptive action of an intrauterine device in the rat.
    Obstetrics and gynecology, 1971, Volume: 38, Issue:1

    Topics: Animals; Chlorambucil; Contraception; Embryo Implantation; Endometrium; Exudates and Transudates; Fe

1971
Sustained remissions after chemotherapy for primary ovarian cancers containing choriocarcinoma.
    The New England journal of medicine, 1969, Jun-26, Volume: 280, Issue:26

    Topics: Adolescent; Adult; Child; Chlorambucil; Choriocarcinoma; Chorionic Gonadotropin; Dactinomycin; Dysge

1969