chlorambucil has been researched along with Paraproteinemias in 19 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Paraproteinemias: A group of related diseases characterized by an unbalanced or disproportionate proliferation of immunoglobulin-producing cells, usually from a single clone. These cells frequently secrete a structurally homogeneous immunoglobulin (M-component) and/or an abnormal immunoglobulin.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Necrobiotic xanthogranuloma is a rare disease that is part of the non-Langerhans cell histiocytoses." | 3.01 | Therapy of necrobiotic xanthogranuloma - case series and review of the literature. ( Abeck, F; Booken, N; Ghandili, S; Hansen, I; Schneider, SW, 2023) |
| "At the same time, she developed xanthomatous patches on the face, neck, and shoulders (Fig." | 1.33 | Necrobiotic xanthogranuloma associated with paraproteinemia and non-Hodgkin's lymphoma developing into chronic lymphocytic leukemia: the first case reported in the literature and review of the literature. ( Oumeish, I; Oumeish, OY; Salman, T; Sharaiha, A; Tarawneh, M, 2006) |
| "There is a spectrum of types of MPGN seen in patients with CLL and there appears to be an association with the presence of monoclonal gammopathy." | 1.31 | Membranoproliferative glomerulonephritis in association with chronic lymphocytic leukaemia: a report of three cases. ( Dwyer, KM; Firkin, F; Hill, PA; Lee, P; Murphy, BF, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (63.16) | 18.7374 |
| 1990's | 4 (21.05) | 18.2507 |
| 2000's | 2 (10.53) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Hansen, I | 1 |
| Ghandili, S | 1 |
| Abeck, F | 1 |
| Booken, N | 1 |
| Schneider, SW | 1 |
| Oumeish, OY | 1 |
| Oumeish, I | 1 |
| Tarawneh, M | 1 |
| Salman, T | 1 |
| Sharaiha, A | 1 |
| Geltner, D | 1 |
| Kohn, RW | 1 |
| Gorevic, P | 1 |
| Franklin, EC | 1 |
| Kay, LA | 1 |
| Saunders, PW | 1 |
| Horler, AR | 1 |
| Proctor, SJ | 1 |
| Stacher, A | 1 |
| Heinz, R | 1 |
| Waldner, R | 1 |
| Böhnel, J | 1 |
| Seewann, HL | 1 |
| Tilz, GP | 1 |
| Becker, H | 1 |
| Lehnert, M | 1 |
| Oksenhendler, E | 1 |
| Chevret, S | 1 |
| Léger, JM | 1 |
| Louboutin, JP | 1 |
| Bussel, A | 1 |
| Brouet, JC | 1 |
| Vigushin, DM | 1 |
| Hawkins, PN | 1 |
| Hsuan, JJ | 1 |
| Totty, NF | 1 |
| Pepys, MB | 1 |
| Drake, WM | 1 |
| Monson, JP | 1 |
| Trainer, PJ | 1 |
| Sharief, M | 1 |
| Dick, JP | 1 |
| Kelsey, SM | 1 |
| Enzenauer, RW | 1 |
| Brozetti, JJ | 1 |
| Dragoo, RA | 1 |
| Hill, PA | 1 |
| Firkin, F | 1 |
| Dwyer, KM | 1 |
| Lee, P | 1 |
| Murphy, BF | 1 |
| Hopper, JE | 1 |
| Haren, JM | 1 |
| Kmiecik, TE | 1 |
| Kuenn, JW | 1 |
| Weber, R | 1 |
| Teague, PO | 1 |
| Keitt, AS | 1 |
| Shulman, G | 1 |
| Lynch, SR | 1 |
| Bezwoda, WR | 1 |
| Gilich, GC | 1 |
| Hurvitz, AI | 1 |
| MacEwen, EG | 1 |
| Middaugh, CR | 1 |
| Litman, GW | 1 |
| Campbell, AE | 1 |
| De Vine, J | 1 |
| Azam, L | 1 |
| Hamid, J | 1 |
| Delamore, IW | 1 |
| McFarlane, H | 1 |
| Shpilberg, O | 1 |
| Ehrenfeld, M | 1 |
| Berkovitz, M | 1 |
| Maier, MK | 1 |
| Samra, Y | 1 |
| Seitzer, B | 1 |
| Spieker, C | 1 |
| Zidek, W | 1 |
| Vetter, H | 1 |
2 reviews available for chlorambucil and Paraproteinemias
| Article | Year |
|---|---|
Therapy of necrobiotic xanthogranuloma - case series and review of the literature.
Topics: Chlorambucil; Histiocytosis, Non-Langerhans-Cell; Humans; Necrobiotic Xanthogranuloma; Paraproteinem | 2023 |
[Clinical relevance of the Kiel classification of non-Hodgkin's lymphomas (author's transl)].
Topics: Adolescent; Adult; Aged; B-Lymphocytes; Child; Chlorambucil; Drug Therapy, Combination; Humans; Lymp | 1980 |
1 trial available for chlorambucil and Paraproteinemias
| Article | Year |
|---|---|
Plasma exchange and chlorambucil in polyneuropathy associated with monoclonal IgM gammopathy. IgM-associated Polyneuropathy Study Group.
Topics: Aged; Chlorambucil; Female; Humans; Immunoglobulin M; Male; Middle Aged; Neural Conduction; Paraprot | 1995 |
16 other studies available for chlorambucil and Paraproteinemias
| Article | Year |
|---|---|
Necrobiotic xanthogranuloma associated with paraproteinemia and non-Hodgkin's lymphoma developing into chronic lymphocytic leukemia: the first case reported in the literature and review of the literature.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Cyc | 2006 |
The effect of combination therapy (steroids, immunosuppressives, and plasmapheresis) on 5 mixed cryoglobulinemia patients with renal, neurologic, and vascular involvement.
Topics: Aged; Chlorambucil; Cryoglobulinemia; Female; Humans; Kidney Diseases; Male; Middle Aged; Paraprotei | 1981 |
Lymphoplasmacytoid lymphoma, associated paraproteinaemia and haemolytic anaemia: a report of 2 cases and review of the literature.
Topics: Anemia, Hemolytic; Chlorambucil; Female; Humans; Immunoglobulin D; Immunoglobulin G; Immunoglobulin | 1983 |
[IgD-paraproteinemia in lymphoplasmacytoid immunocytoma].
Topics: Chlorambucil; Cyclophosphamide; Diagnosis, Differential; Humans; Immunoglobulin D; Lymphoma; Male; M | 1982 |
AL kappa amyloid in a solitary extradural lymphoma.
Topics: Aged; Amino Acid Sequence; Amyloid; Chlorambucil; Combined Modality Therapy; Craniotomy; Dysarthria; | 1994 |
Acute polyneuropathy with chronic lymphocytic leukaemia and paraproteinaemia: response to chlorambucil and prednisolone.
Topics: Acute Disease; Aged; Anti-Inflammatory Agents; Antineoplastic Agents, Alkylating; Chlorambucil; Demy | 1998 |
Central retinal vein occlusion in a patient with IgG lambda monoclonal gammopathy.
Topics: Aged; Bone Marrow; Chlorambucil; Drug Therapy, Combination; Fluorescein Angiography; Humans; Hyperga | 1999 |
Membranoproliferative glomerulonephritis in association with chronic lymphocytic leukaemia: a report of three cases.
Topics: Adult; Aged; Antineoplastic Agents; Chlorambucil; Drug Therapy, Combination; Female; Glomerular Mesa | 2002 |
Evidence for shared idiotypy expressed by the IgM, IgG, and IgA serum proteins of a patient with a complex multiple paraprotein disorder.
Topics: Aged; Animals; Antibody Specificity; Binding Sites; Chlorambucil; Epitopes; Female; Humans; Immunogl | 1979 |
Cryopathic gangrene with an IgM lambda cryoprecipitating cold agglutinin.
Topics: Adult; Agglutinins; Autoantibodies; Breast Neoplasms; Chlorambucil; Cryoglobulins; Female; Gangrene; | 1978 |
Serum beta-lipoprotein and other specific protein concentrations in patients with immunocytoma.
Topics: Aged; Blood Protein Electrophoresis; Blood Proteins; Chlorambucil; Cholesterol; Female; Follow-Up St | 1976 |
Monoclonal cryoglobulinemia with macroglobulinemia in a dog.
Topics: Animals; Blood Proteins; Chlorambucil; Cryoglobulins; Dog Diseases; Dogs; Female; Immunoglobulin M; | 1977 |
Clinical conference: Mixed cryoimmunoglobulinemia.
Topics: Chlorambucil; Cryoglobulins; Female; Humans; Immunoglobulin G; Immunoglobulin M; Leukopenia; Lung; L | 1976 |
Lymphocyte transformation in patients with paraproteinaemia.
Topics: Chlorambucil; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Lymphocyte Activation; M | 1975 |
Hairy cell leukemia with an autoimmune syndrome, paraproteinemia, and cryoglobulinemia.
Topics: Aged; Aged, 80 and over; Autoimmune Diseases; Chlorambucil; Cryoglobulinemia; Humans; Immunoglobulin | 1989 |
[Muscle weakness, polyneuropathy].
Topics: Autoimmune Diseases; Chlorambucil; Humans; Immunoglobulin M; Male; Middle Aged; Muscle Hypotonia; Pa | 1987 |