chlorambucil has been researched along with Pancytopenia in 5 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Pancytopenia: Deficiency of all three cell elements of the blood, erythrocytes, leukocytes and platelets.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chlorambucil is useful in patients with rheumatoid arthritis (RA) refractory to other agents but there is concern about the risk of haematological malignancy with this agent." | 7.67 | The oncogenicity of chlorambucil in rheumatoid arthritis. ( Browne, CD; Champion, GD; Cohen, ML; Day, RO; Graham, S; Patapanian, H; Sambrook, PN, 1988) |
| "Four postsplenectomy patients with progressive hairy cell leukemia were treated with daily low doses of an alkylating agent (chlorambucil, 4 mg)." | 7.66 | Treatment of hairy cell leukemia (leukemic reticuloendotheliosis) II. Chlorambucil therapy in postsplenectomy patients with progressive disease. ( Golomb, HM; Mintz, U, 1979) |
| " Progressive severe pancytopenia due to the diffuse bone marrow infiltration led to life-threatening infections following oral chlorambucil treatment." | 3.72 | Remarkable response to rituximab in a patient with atypical CD20(++) mantle cell lymphoma of the bone marrow leading to severe pancytopenia. ( Ho, AD; Kraemer, A; Seggewiss, R, 2004) |
| "Chlorambucil is useful in patients with rheumatoid arthritis (RA) refractory to other agents but there is concern about the risk of haematological malignancy with this agent." | 3.67 | The oncogenicity of chlorambucil in rheumatoid arthritis. ( Browne, CD; Champion, GD; Cohen, ML; Day, RO; Graham, S; Patapanian, H; Sambrook, PN, 1988) |
| "Four postsplenectomy patients with progressive hairy cell leukemia were treated with daily low doses of an alkylating agent (chlorambucil, 4 mg)." | 3.66 | Treatment of hairy cell leukemia (leukemic reticuloendotheliosis) II. Chlorambucil therapy in postsplenectomy patients with progressive disease. ( Golomb, HM; Mintz, U, 1979) |
| "Proteinuria was reduced in all eight, from a mean (SD) of 15." | 1.27 | Prednisolone and chlorambucil treatment in idiopathic membranous nephropathy with deteriorating renal function. ( Evans, DJ; Maidment, CG; Mathieson, PW; Rees, AJ; Turner, AN, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (80.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Seggewiss, R | 1 |
| Ho, AD | 1 |
| Kraemer, A | 1 |
| Golomb, HM | 2 |
| Mintz, U | 1 |
| Mathieson, PW | 1 |
| Turner, AN | 1 |
| Maidment, CG | 1 |
| Evans, DJ | 1 |
| Rees, AJ | 1 |
| Patapanian, H | 1 |
| Graham, S | 1 |
| Sambrook, PN | 1 |
| Browne, CD | 1 |
| Champion, GD | 1 |
| Cohen, ML | 1 |
| Day, RO | 1 |
1 review available for chlorambucil and Pancytopenia
| Article | Year |
|---|---|
Hairy cell leukemia: the importance of accurate diagnosis and sequential management.
Topics: Adult; Aged; Blood Cell Count; Bone Marrow Transplantation; Chlorambucil; Combined Modality Therapy; | 1984 |
4 other studies available for chlorambucil and Pancytopenia
| Article | Year |
|---|---|
Remarkable response to rituximab in a patient with atypical CD20(++) mantle cell lymphoma of the bone marrow leading to severe pancytopenia.
Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antigens, CD20; Antineoplastic | 2004 |
Treatment of hairy cell leukemia (leukemic reticuloendotheliosis) II. Chlorambucil therapy in postsplenectomy patients with progressive disease.
Topics: Chlorambucil; Humans; Leukemia, Hairy Cell; Pancytopenia; Splenectomy | 1979 |
Prednisolone and chlorambucil treatment in idiopathic membranous nephropathy with deteriorating renal function.
Topics: Adult; Chlorambucil; Drug Administration Schedule; Drug Evaluation; Female; Follow-Up Studies; Glome | 1988 |
The oncogenicity of chlorambucil in rheumatoid arthritis.
Topics: Acute Disease; Arthritis, Rheumatoid; Azathioprine; Carcinogens; Chlorambucil; Humans; Leukemia, Mye | 1988 |