chlorambucil has been researched along with Osteolysis in 2 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Osteolysis: Dissolution of bone that particularly involves the removal or loss of calcium.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with chlorambucil resulted in normalization of the peripheral blood smear, but the malignant infiltration of the bone marrow continued and manifested itself by appearance of new osteolytic lesions, though some of the old lesions underwent recalcification after treatment." | 1.26 | Macroglobulinemia of Waldenström associated with severe osteolytic lesions. ( Krausz, Y; Zlotnick, A, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Krausz, Y | 1 |
| Zlotnick, A | 1 |
| Lembersky, BC | 1 |
| Ratain, MJ | 1 |
| Golomb, HM | 1 |
2 other studies available for chlorambucil and Osteolysis
| Article | Year |
|---|---|
Macroglobulinemia of Waldenström associated with severe osteolytic lesions.
Topics: Aged; Bone Resorption; Chlorambucil; Female; Humans; Leukemia, Lymphoid; Osteolysis; Waldenstrom Mac | 1977 |
Skeletal complications in hairy cell leukemia: diagnosis and therapy.
Topics: Adult; Bone Marrow; Chlorambucil; Humans; Interferon Type I; Leukemia, Hairy Cell; Male; Medical Rec | 1988 |