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chlorambucil and Opportunistic Infections

chlorambucil has been researched along with Opportunistic Infections in 9 studies

Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.

Opportunistic Infections: An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression.

Research Excerpts

ExcerptRelevanceReference
" A 52 year old woman is reported who was on long term treatment with chlorambucil and taking a short course of prednisone for familial CLL before she developed progressive dyspnoea, and P carinii pneumonia was diagnosed in bronchoalveolar lavage fluid."3.72Pneumocystis carinii pneumonia in chronic lymphocytic leukaemia. ( Halter, J; Hechelhammer, L; Himmelmann, A; Vavricka, SR, 2004)
"A 4-year-old female with nephrotic syndrome secondary to focal segmental glomerulosclerosis (FSGS) was treated with pulse methylprednisolone and chlorambucil therapy."3.68Fatal Pneumocystis pneumonia in a child treated for focal segmental glomerulosclerosis. ( Chenaille, PJ; Kano, HL; Makker, SP; Murphy, JL, 1993)
"A 62-year-old woman developed paresis in her right arm within several weeks."1.30[Progressive multifocal leukoencephalopathy as a result of immunosuppressive therapy]. ( Arbusow, V; Brandt, T; Brückmann, H; Hatz, H; Samtleben, W; Strupp, M, 1999)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (33.33)18.2507
2000's5 (55.56)29.6817
2010's1 (11.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Eketorp Sylvan, S1
Lundin, J1
Ipek, M1
Palma, M1
Karlsson, C1
Hansson, L1
Bauduer, F1
Schreiter, NF1
Grieser, C1
Schröder, RJ1
Vavricka, SR1
Halter, J1
Hechelhammer, L1
Himmelmann, A1
Del Poeta, G1
Ilaria Del Principe, M1
Buccisano, F1
Maurillo, L1
Niscola, P1
Venditti, A1
Amadori, S1
Hasselbach, HC1
Fickenscher, H1
Nölle, B1
Roider, J1
Murphy, JL1
Kano, HL1
Chenaille, PJ1
Makker, SP1
Arbusow, V1
Strupp, M1
Samtleben, W1
Hatz, H1
Brückmann, H1
Brandt, T1
Cullis, JO1
Hyde, RD1

Reviews

1 review available for chlorambucil and Opportunistic Infections

ArticleYear
Role of immunochemotherapy in the treatment of chronic lymphocytic leukemia.
    Expert review of anticancer therapy, 2006, Volume: 6, Issue:12

    Topics: Aged; Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols;

2006

Other Studies

8 other studies available for chlorambucil and Opportunistic Infections

ArticleYear
Alemtuzumab (anti-CD52 monoclonal antibody) as single-agent therapy in patients with relapsed/refractory chronic lymphocytic leukaemia (CLL)-a single region experience on consecutive patients.
    Annals of hematology, 2014, Volume: 93, Issue:10

    Topics: Aged; Aged, 80 and over; Alemtuzumab; Antibodies, Monoclonal, Humanized; Antimetabolites, Antineopla

2014
[First-line therapy of chronic lymphocytic leukemia in the elderly: be careful with overtreatment].
    Presse medicale (Paris, France : 1983), 2009, Volume: 38, Issue:1

    Topics: Age Factors; Aged; Alemtuzumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodie

2009
[An unusual presentation of progressive multifocal leukoencephalopathy as contrast enhanced lesion].
    RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 2009, Volume: 181, Issue:10

    Topics: Aged; Antineoplastic Agents, Alkylating; Biopsy; Brain; Chlorambucil; Contrast Media; Diagnosis, Dif

2009
Pneumocystis carinii pneumonia in chronic lymphocytic leukaemia.
    Postgraduate medical journal, 2004, Volume: 80, Issue:942

    Topics: Anti-Infective Agents; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Dyspnea; Fatal

2004
[Atypical ocular toxoplasmosis with concomitant ocular reactivation of varicella-zoster virus and cytomegalovirus in an immunocompromised host].
    Klinische Monatsblatter fur Augenheilkunde, 2008, Volume: 225, Issue:3

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Blindness; Chlorambucil; Chorioretinitis; Como

2008
Fatal Pneumocystis pneumonia in a child treated for focal segmental glomerulosclerosis.
    Pediatric nephrology (Berlin, Germany), 1993, Volume: 7, Issue:4

    Topics: Child, Preschool; Chlorambucil; Fatal Outcome; Female; Glomerulosclerosis, Focal Segmental; Humans;

1993
[Progressive multifocal leukoencephalopathy as a result of immunosuppressive therapy].
    Deutsche medizinische Wochenschrift (1946), 1999, May-28, Volume: 124, Issue:21

    Topics: Brain; Chlorambucil; Diagnosis, Differential; Female; Humans; Immunocompromised Host; Immunosuppress

1999
Acute epiglottitis in immunocompromised patients--a report of two cases.
    Clinical and laboratory haematology, 1991, Volume: 13, Issue:4

    Topics: Acute Disease; Chlorambucil; Cyclophosphamide; Epiglottitis; Humans; Immunocompromised Host; Leukemi

1991