chlorambucil has been researched along with Nervous System Diseases in 7 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Nervous System Diseases: Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Prednisone dosage was successfully tapered to 10 to 20 mg/d without worsening symptoms in 10 (38%) of the 26 patients studied." | 2.68 | Therapeutic considerations in patients with refractory neurosarcoidosis. ( Agbogu, BN; Sewell, C; Stern, BJ; Yang, G, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (57.14) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pentsova, E | 1 |
| Rosenblum, M | 1 |
| Holodny, A | 1 |
| Palomba, ML | 1 |
| Omuro, A | 1 |
| Agbogu, BN | 1 |
| Stern, BJ | 1 |
| Sewell, C | 1 |
| Yang, G | 1 |
| Newton, LK | 1 |
| Ciobanu, N | 1 |
| Runowicz, C | 1 |
| Gucalp, R | 1 |
| Frank, M | 1 |
| Charuvanki, V | 1 |
| Kaufman, D | 1 |
| Wiernik, PH | 1 |
| Ranselaar, CG | 1 |
| Boone, RM | 1 |
| Kluin-Nelemans, HC | 1 |
| Desser, RK | 1 |
| Ultmann, JE | 1 |
| Delespesse, G | 1 |
| Kennes, B | 1 |
| Duchateau, J | 1 |
3 reviews available for chlorambucil and Nervous System Diseases
| Article | Year |
|---|---|
Neurologic complications of polycythemia and their impact on therapy.
Topics: Bloodletting; Chlorambucil; Clinical Protocols; Combined Modality Therapy; Humans; Nervous System Di | 1990 |
The sensitivity of Hodgkin's disease to chemotherapeutic agents administered singly.
Topics: Adrenal Cortex Hormones; Alopecia; Antineoplastic Agents; Bleomycin; Blood Platelet Disorders; Carmu | 1973 |
[Auto-immune diseases and immunodepressive therapy. II. Current clinical indications].
Topics: Adrenal Cortex Hormones; Anemia, Hemolytic, Autoimmune; Antineoplastic Agents; Arteritis; Autoimmune | 1974 |
1 trial available for chlorambucil and Nervous System Diseases
| Article | Year |
|---|---|
Therapeutic considerations in patients with refractory neurosarcoidosis.
Topics: Adult; Azathioprine; Chlorambucil; Cyclophosphamide; Cyclosporine; Female; Humans; Immunosuppressive | 1995 |
3 other studies available for chlorambucil and Nervous System Diseases
| Article | Year |
|---|---|
Chemotherapy-related magnetic resonance imaging abnormalities mimicking disease progression following intraventricular liposomal cytarabine and high dose methotrexate for neurolymphomatosis.
Topics: Aged; Antineoplastic Agents; Autopsy; Brain; Brain Injuries; Chlorambucil; Cytarabine; Disease Progr | 2012 |
Reversible central nervous system toxicity associated with high-dose chlorambucil in autologous bone marrow transplantation for ovarian carcinoma.
Topics: Adult; Bone Marrow Transplantation; Carcinoma; Chlorambucil; Dose-Response Relationship, Drug; Femal | 1987 |
Thalidomide in the treatment of neuro-Behçet's syndrome.
Topics: Adult; Behcet Syndrome; Chlorambucil; Drug Therapy, Combination; Humans; Male; Nervous System Diseas | 1986 |