chlorambucil has been researched along with Nephrosis, Lipoid in 33 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Nephrosis, Lipoid: A kidney disease with no or minimal histological glomerular changes on light microscopy and with no immune deposits. It is characterized by lipid accumulation in the epithelial cells of KIDNEY TUBULES and in the URINE. Patients usually show NEPHROTIC SYNDROME indicating the presence of PROTEINURIA with accompanying EDEMA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mechlorethamine has been assessed in 28 patients with idiopathic nephrotic syndrome previously treated with prednisone only." | 7.67 | [Effect of mechlorethamine in idiopathic nephrotic syndrome in childhood]. ( Canals, MJ; Cervera, A; Gómez Campderá, FJ; Gómez Campderá, J; López Gómez, JM; Luque, A; Morales, JL, 1984) |
| " For instance, in patients with idiopathic membranous glomerulonephritis a six months treatment with chlorambucil (0." | 5.05 | [Drug treatment of chronic glomerulonephritis: pro]. ( Brodehl, J; Helmchen, U; Koch, KM; Kühn, K, 1985) |
| "Mechlorethamine has been assessed in 28 patients with idiopathic nephrotic syndrome previously treated with prednisone only." | 3.67 | [Effect of mechlorethamine in idiopathic nephrotic syndrome in childhood]. ( Canals, MJ; Cervera, A; Gómez Campderá, FJ; Gómez Campderá, J; López Gómez, JM; Luque, A; Morales, JL, 1984) |
| "Patients with nephrotic syndrome are in a constant state of flux with respect to fluid status, organ function, and critical protein balance." | 2.38 | Pharmacologic management of adult idiopathic nephrotic syndrome. ( Alaniz, C; Brosius, FC; Palmieri, J, 1993) |
| "There is no definite treatment for focal glomerulosclerosis." | 2.38 | Treatment of the nephrotic syndrome with cyclosporin A. ( Ponticelli, C, 1992) |
| " Therefore, intravenous high-dose steroid pulses, alternate-day prednisone, short courses with cytotoxic agents and long-term administration of azathioprine have been suggested as alternatives to the classical prolonged corticotherapy." | 2.38 | Conventional treatment of idiopathic nephrotic syndrome and membranous nephropathy in adults. ( Passerini, P; Ponticelli, C, 1991) |
| "Although nondiabetic nephropathies are common among type 2 diabetic patients, very few cases of minimal change nephrotic syndrome have been reported in diabetic patients." | 1.32 | [Relapsing nephrotic syndrome in a diabetic patient with minimal change]. ( Espejo, B; García Donaire, JA; Gutiérrez Martínez, E; Manzanera, MI; Praga, M; Valentín, MO, 2004) |
| " When the glucocorticoid dosage was reduced or the drug discontinued, the nephrotic syndrome recurred." | 1.29 | [T-cell lymphoma under immunosuppressive treatment in minimal change glomerulopathy with nephrotic syndrome]. ( Schollmeyer, P; Späth, M, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (57.58) | 18.7374 |
| 1990's | 12 (36.36) | 18.2507 |
| 2000's | 1 (3.03) | 29.6817 |
| 2010's | 1 (3.03) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wynsberghe, MV | 1 |
| Lenain, P | 1 |
| Drieux, F | 1 |
| Guerrot, D | 1 |
| Bertrand, D | 1 |
| García Donaire, JA | 1 |
| Manzanera, MI | 1 |
| Valentín, MO | 1 |
| Espejo, B | 1 |
| Gutiérrez Martínez, E | 1 |
| Praga, M | 1 |
| Bodaghi, E | 1 |
| Chamsa, AM | 1 |
| Ponticelli, C | 4 |
| Banfi, G | 1 |
| Imbasciati, E | 1 |
| Tarantino, A | 1 |
| Gómez Campderá, FJ | 1 |
| López Gómez, JM | 1 |
| Cervera, A | 1 |
| Gómez Campderá, J | 1 |
| Canals, MJ | 1 |
| Morales, JL | 1 |
| Luque, A | 1 |
| McEnery, PT | 1 |
| Strife, CF | 1 |
| Donadio, JV | 1 |
| Späth, M | 1 |
| Schollmeyer, P | 1 |
| Passerini, P | 2 |
| Como, G | 1 |
| Melis, P | 1 |
| Viganò, E | 1 |
| Pozzi, C | 1 |
| Altieri, P | 1 |
| Almeida, AF | 1 |
| Chafekar, DS | 1 |
| Alaniz, C | 1 |
| Brosius, FC | 1 |
| Palmieri, J | 1 |
| Abu-Farsakh, H | 1 |
| Berry, PL | 1 |
| Hill, LL | 1 |
| Powell, D | 1 |
| Hawkins, EP | 1 |
| Di Toro, R | 1 |
| Parlier, G | 1 |
| Bensman, A | 1 |
| Leverger, G | 1 |
| Boccon-Gibod, L | 1 |
| Gruner, M | 1 |
| Sten'shinskaia, EV | 1 |
| Ilamanov, M | 1 |
| Naumova, VI | 1 |
| Brodehl, J | 3 |
| Tejani, A | 1 |
| Jones, DP | 1 |
| Stapleton, FB | 1 |
| Roy, S | 1 |
| Wyatt, RJ | 1 |
| Schulman, SL | 1 |
| Kaiser, BA | 1 |
| Polinsky, MS | 1 |
| Srinivasan, R | 1 |
| Baluarte, HJ | 1 |
| Kalinicheva, EO | 1 |
| Papaian, AV | 1 |
| Kashtan, C | 1 |
| Melvin, T | 1 |
| Kim, Y | 1 |
| Trompeter, RS | 1 |
| Kühn, K | 1 |
| Koch, KM | 1 |
| Helmchen, U | 1 |
| Shapiro, CM | 1 |
| Vander Laan, BF | 1 |
| Jao, W | 1 |
| Sloan, DE | 1 |
| Hooft, C | 1 |
| van Acker, KJ | 1 |
| Méry, JP | 1 |
| Girard, JF | 1 |
| Boda, D | 1 |
| Koltay, M | 1 |
| Virág, I | 1 |
| Oechslen, D | 1 |
| Kluthe, R | 1 |
| Sarre, H | 1 |
| Wyszyńska, T | 1 |
| Wojnarowski, M | 1 |
| Rowecka-Trzebicka, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Ofatumumab in Children With Steroid- and Calcineurin-inhibitor-resistant Nephrotic Syndrome: a Double-blind Randomized, Controlled, Superiority Trial[NCT02394106] | Phase 2 | 13 participants (Actual) | Interventional | 2015-07-31 | Terminated | ||
| Ofatumumab Versus Rituximab in Children With Steroid and Calcineurin Inhibitor-dependent Idiopathic Nephrotic Syndrome: an Open-label, Randomized, Controlled, Superiority Trial.[NCT02394119] | Phase 2 | 140 participants (Actual) | Interventional | 2015-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
10 reviews available for chlorambucil and Nephrosis, Lipoid
| Article | Year |
|---|---|
Immunosuppressive therapy in primary glomerulonephritis (pros).
Topics: Adrenocorticotropic Hormone; Azathioprine; Chlorambucil; Cyclophosphamide; Dipyridamole; Glomerulone | 1982 |
Nephrotic syndrome in childhood. Management and treatment in patients with minimal change disease, mesangial proliferation, or focal glomerulosclerosis.
Topics: Adolescent; Child; Child, Preschool; Chlorambucil; Cyclophosphamide; Diuretics; Female; Glomerulonep | 1982 |
Nephrotic syndrome in childhood. Management and treatment in patients with minimal change disease, mesangial proliferation, or focal glomerulosclerosis.
Topics: Adolescent; Child; Child, Preschool; Chlorambucil; Cyclophosphamide; Diuretics; Female; Glomerulonep | 1982 |
Nephrotic syndrome in childhood. Management and treatment in patients with minimal change disease, mesangial proliferation, or focal glomerulosclerosis.
Topics: Adolescent; Child; Child, Preschool; Chlorambucil; Cyclophosphamide; Diuretics; Female; Glomerulonep | 1982 |
Nephrotic syndrome in childhood. Management and treatment in patients with minimal change disease, mesangial proliferation, or focal glomerulosclerosis.
Topics: Adolescent; Child; Child, Preschool; Chlorambucil; Cyclophosphamide; Diuretics; Female; Glomerulonep | 1982 |
Primary nephrotic syndrome in the elderly.
Topics: Actuarial Analysis; Acute Kidney Injury; Adrenal Cortex Hormones; Adult; Aged; Chlorambucil; Female; | 1993 |
Pharmacologic management of adult idiopathic nephrotic syndrome.
Topics: Adrenal Cortex Hormones; Chlorambucil; Cyclosporine; Drug Therapy, Combination; Edema; Glomeruloneph | 1993 |
Treatment of the nephrotic syndrome with cyclosporin A.
Topics: Chlorambucil; Cyclophosphamide; Cyclosporine; Glomerulonephritis, Membranous; Glomerulosclerosis, Fo | 1992 |
Conventional treatment of idiopathic nephrotic syndrome and membranous nephropathy in adults.
Topics: Adult; Chlorambucil; Cyclophosphamide; Glomerulonephritis, Membranous; Glomerulosclerosis, Focal Seg | 1991 |
Conventional therapy for idiopathic nephrotic syndrome in children.
Topics: Child; Chlorambucil; Cyclophosphamide; Humans; Nephrosis, Lipoid; Prednisone; Recurrence | 1991 |
The treatment of minimal change nephrotic syndrome: lessons learned from multicentre co-operative studies.
Topics: Alkylating Agents; Child; Chlorambucil; Cyclophosphamide; Cyclosporins; Humans; Immunosuppressive Ag | 1991 |
[Effect of cytostatic preparations used in the treatment of glomerulonephritis in children on the functional activity of the gonads].
Topics: Amenorrhea; Chlorambucil; Cyclophosphamide; Female; Humans; Male; Nephrosis, Lipoid; Oligospermia | 1987 |
[Prognosis of the idiopathic nephrotic syndrome in children].
Topics: Adrenocorticotropic Hormone; Biopsy; Blood Proteins; Chlorambucil; Cyclophosphamide; Female; Humans; | 1974 |
3 trials available for chlorambucil and Nephrosis, Lipoid
| Article | Year |
|---|---|
[Evaluation of the effectiveness of various programs of active therapy of primary glomerulonephritis with nephrotic syndrome in children].
Topics: Adolescent; Child; Child, Preschool; Chlorambucil; Drug Administration Schedule; Drug Therapy, Combi | 1991 |
The treatment of minimal change nephrotic syndrome: lessons learned from multicentre co-operative studies.
Topics: Alkylating Agents; Child; Chlorambucil; Cyclophosphamide; Cyclosporins; Humans; Immunosuppressive Ag | 1991 |
[Drug treatment of chronic glomerulonephritis: pro].
Topics: Chlorambucil; Chronic Disease; Clinical Trials as Topic; Cyclophosphamide; Cyclosporins; Glomerulone | 1985 |
21 other studies available for chlorambucil and Nephrosis, Lipoid
| Article | Year |
|---|---|
Monoclonal B lymphocytosis and minimal change disease: a new monoclonal B-cell disorder of renal significance?
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; B-Lymphocytes; Chlorambucil; Female; Humans; L | 2018 |
[Relapsing nephrotic syndrome in a diabetic patient with minimal change].
Topics: Chlorambucil; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diagnosis, Differential; Drug Thera | 2004 |
[Primary nephrotic syndromes in children in Iran].
Topics: Adolescent; Anti-Inflammatory Agents; Biopsy; Child; Child, Preschool; Chlorambucil; Cyclophosphamid | 1978 |
[Effect of mechlorethamine in idiopathic nephrotic syndrome in childhood].
Topics: Child; Child, Preschool; Chlorambucil; Cyclophosphamide; Drug Tolerance; Female; Glomerulosclerosis, | 1984 |
Primary glomerular disease: to treat or not to treat.
Topics: Azathioprine; Chlorambucil; Cyclophosphamide; Dipyridamole; Glomerulonephritis; Glomerulosclerosis, | 1982 |
[T-cell lymphoma under immunosuppressive treatment in minimal change glomerulopathy with nephrotic syndrome].
Topics: Adult; Chlorambucil; Cyclosporins; Female; Humans; Immunosuppressive Agents; Lymphoma, T-Cell; Nephr | 1995 |
Minimal change nephrotic syndrome.
Topics: Adult; Child; Chlorambucil; Cyclophosphamide; Humans; Nephrosis, Lipoid; Prednisolone; Remission Ind | 1993 |
Mesangial IgG in childhood minimal change disease: clinical relevance.
Topics: Biopsy; Child, Preschool; Chlorambucil; Cyclophosphamide; Cyclosporine; Fluorescent Antibody Techniq | 1993 |
[Therapy of lipoid nephrosis].
Topics: Calcium; Child; Child, Preschool; Chlorambucil; Diuretics; Glucocorticoids; Humans; Immunosuppressiv | 1977 |
[Neurectodermal malignant tumor of the soft tissues after treatment with immunosuppressive agents of lipoid nephrosis].
Topics: Adrenal Cortex Hormones; Antineoplastic Combined Chemotherapy Protocols; Child; Chlorambucil; Cyclop | 1992 |
[Results of the treatment of glomerulonephritis in children with hepatitis B].
Topics: Adolescent; Age Factors; Child; Child, Preschool; Chlorambucil; Cyclophosphamide; Drug Resistance; D | 1991 |
Relapsing nephrotic syndrome.
Topics: Captopril; Chlorambucil; Cyclophosphamide; Cyclosporins; Glomerular Mesangium; Humans; Immune Comple | 1987 |
Beneficial effect of second courses of cytotoxic therapy in children with minimal change nephrotic syndrome.
Topics: Adolescent; Child; Child, Preschool; Chlorambucil; Cyclophosphamide; Drug Resistance; Female; Humans | 1988 |
Predicting the response to cytotoxic therapy for childhood nephrotic syndrome: superiority of response to corticosteroid therapy over histopathologic patterns.
Topics: Adolescent; Biopsy; Child; Child, Preschool; Chlorambucil; Cyclophosphamide; Glomerulonephritis; Glo | 1988 |
Long-term follow-up of patients with steroid-dependent, minimal change nephrotic syndrome.
Topics: Adolescent; Adult; Chlorambucil; Cyclophosphamide; Follow-Up Studies; Growth; Humans; Nephrosis, Lip | 1988 |
Minimal change nephrotic syndrome and cyclophosphamide.
Topics: Child; Chlorambucil; Cyclophosphamide; Humans; Mechlorethamine; Nephrosis, Lipoid | 1986 |
Nephrotic syndrome in two patients with cured Hodgkin's disease.
Topics: Adult; Chlorambucil; Gallium Radioisotopes; Hodgkin Disease; Humans; Male; Nephrosis, Lipoid; Nephro | 1985 |
[Indications for immunosuppressive agents in glomerular nephropathies].
Topics: Adrenal Cortex Hormones; Anti-Glomerular Basement Membrane Disease; Azathioprine; Chlorambucil; Cycl | 1974 |
[Immunosuppressive treatment of corticoid resistant nephrotic syndrome in childhood].
Topics: Azathioprine; Child; Child, Preschool; Chlorambucil; Dexamethasone; Female; Humans; Male; Nephrosis, | 1969 |
[Cytostatic treatment of the steroid-resistant nephrotic syndrome. (Long term study on 24 patients)].
Topics: Adult; Azathioprine; Biopsy; Chlorambucil; Female; Glomerulonephritis; Humans; Kidney Function Tests | 1968 |
[Results of immunosuppressive treatment of diseases of renal glomerulus in children].
Topics: Azathioprine; Child; Child, Preschool; Chlorambucil; Chronic Disease; Female; Glomerulonephritis; Hu | 1969 |