chlorambucil has been researched along with Neoplasms in 185 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The results of a five-year study of chlorambucil in patients suffering from rheumatoid arthritis are presented." | 7.65 | Rheumatoid arthritis treated with chlorambucil: a five-year follow-up. ( Thorpe, P, 1976) |
| "There were more deaths from neoplasia and ischaemic heart disease in the younger age group." | 5.26 | Cause of death in patients with rheumatoid arthritis with particular reference to azathioprine. ( Hanka, R; Hazleman, BL; Lewis, P; Roberts, S, 1980) |
| "Bestrabucil, the benzoate of an estradiol-chlorambucil conjugate, was initially developed as a target-oriented anticancer agent for breast cancers with positive estrogen receptors, by conjugating a tumoricidal agent, chlorambucil, to a vehicle, estradiol." | 3.67 | [Bestrabacil: a possible target-oriented anticancer agent]. ( Isurugi, K; Ohsawa, N; Wagatsuma, T; Yamazaki, Z, 1984) |
| "The results of a five-year study of chlorambucil in patients suffering from rheumatoid arthritis are presented." | 3.65 | Rheumatoid arthritis treated with chlorambucil: a five-year follow-up. ( Thorpe, P, 1976) |
| "The purpose of this study was to assess the toxicoses and antitumor activity of metronomic chlorambucil at a dosage of 4 mg m(-2) daily in dogs with naturally occurring cancer." | 2.77 | Prospective trial of metronomic chlorambucil chemotherapy in dogs with naturally occurring cancer. ( Childress, MO; Greene, SN; Knapp, DW; Lahrman, SR; Leach, TN; Mohamed, AS; Moore, GE; Schrempp, DR, 2012) |
| "Chlorambucil and PAM were assayed by a gas chromatographic/mass spectrometry method and prednisolone, by radioimmunoassay." | 2.67 | A pharmacokinetic study of prednimustine as compared with prednisolone plus chlorambucil in cancer patients. ( Bastholt, L; Gunnarsson, PO; Johansson, CJ; Johansson, SA; Mouridsen, H; Pfeiffer, P; Svensson, L, 1991) |
| "Cancer is considered as one of the most serious health problems today." | 2.58 | Therapeutic journery of nitrogen mustard as alkylating anticancer agents: Historic to future perspectives. ( Bhardwaj, TR; Kumar, S; Prasad, DN; Singh, RK, 2018) |
| "Chlorambucil treatment was continued every other day and a single, variably timed sample collection was obtained on day 14." | 1.72 | Population pharmacokinetics identifies rapid gastrointestinal absorption and plasma clearance of oral chlorambucil administered to cats with indolent lymphoproliferative malignancies. ( Al-Nadaf, S; Burton, JH; Skorupski, KA; Wittenburg, LA, 2022) |
| "Improving the tumor targeting of anticancer drugs to minimize systemic exposure remains challenging." | 1.72 | Tumor Targeting by Conjugation of Chlorambucil with Zwitterionic Near-Infrared Fluorophore for Cancer Phototherapy. ( Hyun, H; Jo, G; Kim, EJ, 2022) |
| "Self-assembly of anticancer small molecules into nanostructures may represent an attractive approach to improve the treatment of experimental solid tumors." | 1.42 | Chlorambucil gemcitabine conjugate nanomedicine for cancer therapy. ( Fan, M; Li, Z; Liang, X; Shi, B; Wang, H; Yang, D, 2015) |
| "The excess risk of cancer after chlorambucil appears to persist for 5 years after stopping this treatment." | 1.29 | The very-long-term course of polycythaemia: a complement to the previously published data of the Polycythaemia Vera Study Group. ( Dresch, C; Najean, Y; Rain, JD, 1994) |
| "Thirty patients with advanced cancer were entered in six dose levels: 36, 48, 60, 84, 108, and 144 mg/m2." | 1.27 | A phase I trial of chlorambucil administered in short pulses in patients with advanced malignancies. ( Allegra, JC; Blumenreich, MS; Epremian, BE; Gentile, PS; Kubota, TT; Richman, SP; Sherrill, EJ; Woodcock, TM, 1988) |
| " With long-term administration (the longest term, 20 weeks, 36 patients), the dose-limiting factor was concluded to be a decrease in the peripheral leukocyte count when the total amount administered reached about 10 g." | 1.27 | [Phase I study of bestrabucil (KM 2210)]. ( Agatsuma, T; Fugiwara, A; Fujita, K; Goto, T; Isurugi, K; Kamei, H; Kubota, T; Nakao, I; Suga, S; Takenaka, K, 1986) |
| "Data on the possible increased risk of malignancy in rheumatoid arthritis are still being collected, and until further information is available, the use of immunosuppressive drugs, particularly alkylating agents, in the treatment of rheumatoid arthritis should be reserved for patients with severe progressive disease or life-threatening complications." | 1.27 | Incidence of neoplasms in patients with rheumatoid arthritis exposed to different treatment regimens. ( Hazleman, B, 1985) |
| "Head and neck carcinomas and breast cancer had the highest incidence (5 and 3 cases, respectively)." | 1.26 | Primary malignant neoplasms associated with chronic lymphocytic leukemia. ( Franchi, F; Monfardini, S; Rilke, F; Santoro, A, 1980) |
| "There were more deaths from neoplasia and ischaemic heart disease in the younger age group." | 1.26 | Cause of death in patients with rheumatoid arthritis with particular reference to azathioprine. ( Hanka, R; Hazleman, BL; Lewis, P; Roberts, S, 1980) |
| "Generally, metastases responded better than the advanced primaries from which they were derived, except for those from breast tumours." | 1.25 | The influence of site of metastasis on tumour growth and response to chemotherapy. ( Bross, ID; Slack, NH, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 146 (78.92) | 18.7374 |
| 1990's | 8 (4.32) | 18.2507 |
| 2000's | 6 (3.24) | 29.6817 |
| 2010's | 19 (10.27) | 24.3611 |
| 2020's | 6 (3.24) | 2.80 |
| Authors | Studies |
|---|---|
| Diamandis, P | 1 |
| Wildenhain, J | 1 |
| Clarke, ID | 1 |
| Sacher, AG | 1 |
| Graham, J | 1 |
| Bellows, DS | 1 |
| Ling, EK | 1 |
| Ward, RJ | 1 |
| Jamieson, LG | 1 |
| Tyers, M | 1 |
| Dirks, PB | 1 |
| Perjési, P | 1 |
| Das, U | 1 |
| De Clercq, E | 1 |
| Balzarini, J | 1 |
| Kawase, M | 1 |
| Sakagami, H | 1 |
| Stables, JP | 1 |
| Lorand, T | 1 |
| Rozmer, Z | 1 |
| Dimmock, JR | 1 |
| Shervington, LA | 1 |
| Smith, N | 1 |
| Norman, E | 1 |
| Ward, T | 1 |
| Phillips, R | 1 |
| Shervington, A | 1 |
| Lin, R | 1 |
| Elf, S | 1 |
| Shan, C | 1 |
| Kang, HB | 1 |
| Ji, Q | 1 |
| Zhou, L | 1 |
| Hitosugi, T | 1 |
| Zhang, L | 2 |
| Zhang, S | 1 |
| Seo, JH | 1 |
| Xie, J | 1 |
| Tucker, M | 1 |
| Gu, TL | 1 |
| Sudderth, J | 1 |
| Jiang, L | 1 |
| Mitsche, M | 1 |
| DeBerardinis, RJ | 1 |
| Wu, S | 1 |
| Li, Y | 1 |
| Mao, H | 1 |
| Chen, PR | 1 |
| Wang, D | 2 |
| Chen, GZ | 1 |
| Hurwitz, SJ | 1 |
| Lonial, S | 1 |
| Arellano, ML | 1 |
| Khoury, HJ | 1 |
| Khuri, FR | 1 |
| Lee, BH | 1 |
| Lei, Q | 1 |
| Brat, DJ | 1 |
| Ye, K | 1 |
| Boggon, TJ | 1 |
| He, C | 1 |
| Kang, S | 1 |
| Fan, J | 1 |
| Chen, J | 1 |
| Idowu, T | 1 |
| Samadder, P | 1 |
| Arthur, G | 1 |
| Schweizer, F | 1 |
| Cascioferro, S | 1 |
| Parrino, B | 1 |
| Spanò, V | 1 |
| Carbone, A | 1 |
| Montalbano, A | 1 |
| Barraja, P | 1 |
| Diana, P | 1 |
| Cirrincione, G | 1 |
| Singh, RK | 1 |
| Kumar, S | 1 |
| Prasad, DN | 1 |
| Bhardwaj, TR | 1 |
| Han, T | 1 |
| Wang, Y | 1 |
| Wang, M | 1 |
| Li, X | 2 |
| Cheng, K | 1 |
| Gao, X | 2 |
| Li, Z | 3 |
| Bai, J | 1 |
| Hua, H | 1 |
| Li, D | 1 |
| Zhang, M | 1 |
| Jin, X | 1 |
| Gao, M | 1 |
| Zhang, Y | 3 |
| Tang, BZ | 1 |
| Al-Nadaf, S | 1 |
| Wittenburg, LA | 1 |
| Skorupski, KA | 1 |
| Burton, JH | 1 |
| Jo, G | 3 |
| Kim, EJ | 3 |
| Hyun, H | 3 |
| Yin, H | 1 |
| Fu, XY | 1 |
| Gao, HY | 1 |
| Ma, YN | 1 |
| Yao, JF | 1 |
| Du, SS | 1 |
| Qi, YK | 1 |
| Wang, KW | 1 |
| Liang, W | 1 |
| Fan, Y | 1 |
| Liu, Y | 1 |
| Fang, T | 1 |
| Zhang, J | 1 |
| Xu, Y | 1 |
| Li, J | 1 |
| Tabrizi, L | 1 |
| Abyar, F | 1 |
| Zhang, Q | 1 |
| Xie, X | 1 |
| Xu, X | 1 |
| Klimpel, A | 1 |
| Neundorf, I | 1 |
| MARTINEZDIAZ, J | 1 |
| Yu, G | 1 |
| Yu, W | 1 |
| Mao, Z | 1 |
| Gao, C | 1 |
| Huang, F | 1 |
| Fang, S | 1 |
| Niu, Y | 1 |
| Zhang, W | 1 |
| Yu, L | 1 |
| Fan, M | 1 |
| Liang, X | 1 |
| Wang, H | 1 |
| Yang, D | 1 |
| Shi, B | 1 |
| Custead, MR | 1 |
| Weng, HY | 1 |
| Childress, MO | 2 |
| Lin, J | 1 |
| Qiu, L | 1 |
| Lv, G | 1 |
| Li, K | 1 |
| Wang, W | 1 |
| Liu, G | 1 |
| Zhao, X | 1 |
| Wang, S | 1 |
| Singleton, RS | 1 |
| Guise, CP | 1 |
| Ferry, DM | 1 |
| Pullen, SM | 1 |
| Dorie, MJ | 1 |
| Brown, JM | 1 |
| Patterson, AV | 1 |
| Wilson, WR | 1 |
| Minoshima, M | 1 |
| Bando, T | 1 |
| Shinohara, K | 1 |
| Kashiwazaki, G | 1 |
| Nishijima, S | 1 |
| Sugiyama, H | 1 |
| Hofstra, JM | 1 |
| Wetzels, JF | 1 |
| Birnbaum, AD | 1 |
| Oh, F | 1 |
| Sahin, O | 1 |
| Little, DM | 1 |
| Tessler, HH | 1 |
| Goldstein, DA | 1 |
| Fonseca, SB | 1 |
| Pereira, MP | 1 |
| Mourtada, R | 1 |
| Gronda, M | 1 |
| Horton, KL | 1 |
| Hurren, R | 1 |
| Minden, MD | 1 |
| Schimmer, AD | 1 |
| Kelley, SO | 1 |
| Leach, TN | 1 |
| Greene, SN | 1 |
| Mohamed, AS | 1 |
| Moore, GE | 2 |
| Schrempp, DR | 1 |
| Lahrman, SR | 1 |
| Knapp, DW | 1 |
| Jana, A | 1 |
| Devi, KS | 1 |
| Maiti, TK | 1 |
| Singh, ND | 1 |
| KRAKOFF, IH | 1 |
| KARNOFSKY, DA | 3 |
| BURCHENAL, JH | 1 |
| ULTMANN, JE | 1 |
| HYMAN, GA | 1 |
| GELLHORN, A | 1 |
| OLSON, KB | 1 |
| PERRONE, V | 1 |
| FAIELLA, A | 1 |
| ZARRILLI, D | 1 |
| PIACENTINI, G | 2 |
| PERSICO, L | 1 |
| BRAMBILLA, G | 1 |
| BALDINI, L | 1 |
| PITNEY, WR | 1 |
| HOTCHIN, J | 1 |
| BIERMAN, HR | 1 |
| MOLANDER, DW | 2 |
| ELSON, LA | 1 |
| EVANS, AM | 1 |
| RIEKHOF, P | 1 |
| GOLDENBERG, DM | 1 |
| MILLER, DG | 1 |
| PHILLIPS, RF | 1 |
| WILLIAMS, HM | 1 |
| AISENBERG, AC | 1 |
| WILTSHAW, E | 2 |
| OTTOMAN, RE | 1 |
| LANGDON, EA | 1 |
| ROCHLIN, DB | 1 |
| SMART, CR | 1 |
| NIZET, A | 1 |
| GENTIL, F | 1 |
| ARROYONOMBELA, JJ | 1 |
| RODRIGUEZMURCIA, C | 1 |
| FEIWEL, M | 1 |
| MUNRO, DD | 1 |
| VIGI, F | 1 |
| KREMENTZ, ET | 1 |
| KOKAME, GM | 1 |
| IGLESIAS, F | 1 |
| BOWDEN, L | 1 |
| DIAMANDOPOULOS, GT | 1 |
| SMITH, EB | 1 |
| IRVINE, RA | 1 |
| ROBERTSON, WB | 1 |
| BOOTSMA, BK | 1 |
| SULLI, G | 1 |
| DARGENT, M | 1 |
| POMMATAU, E | 1 |
| LESBROS, F | 1 |
| MOORE, JG | 1 |
| VANCAMPENHOUT, JL | 1 |
| BRANDKAMP, WW | 1 |
| PHELAN, JT | 1 |
| CABRERA, A | 1 |
| EISMAN, SG | 1 |
| RICHARDSON, FM | 1 |
| TANIDA, T | 1 |
| STEEL, SJ | 1 |
| COBB, JP | 1 |
| WALKER, DG | 2 |
| PAPAC, RJ | 1 |
| WOOD, DA | 1 |
| HUNEYCUTT, HC | 1 |
| ANDERSON, WR | 1 |
| HENDRY, WS | 1 |
| LADUE, JS | 1 |
| HARMAN, JB | 1 |
| COWLING, DC | 1 |
| QUAGLINO, D | 1 |
| HAYHOE, FG | 1 |
| PAPAVASILIOU, C | 1 |
| KOSTOUROS, D | 1 |
| SANDBERG, AA | 1 |
| ISHIHARA, T | 1 |
| KIKUCHI, Y | 1 |
| CROSSWHITE, LH | 1 |
| HUTCHISON, JL | 1 |
| DONALDSON, SS | 1 |
| FLETCHER, WS | 1 |
| INNES, J | 1 |
| ZELENIK, JS | 1 |
| HALPERN, AJ | 1 |
| WILLIAMS, DW | 1 |
| MIALE, A | 1 |
| KESLER, K | 1 |
| WRIGHT, JC | 1 |
| LYONS, MM | 1 |
| GOLOMB, FM | 1 |
| GUMPORT, SL | 1 |
| MEDREK, TJ | 1 |
| HRESCHCHYSHYN, MM | 1 |
| DUMA, RJ | 1 |
| BOYETT, JD | 1 |
| BEETHAM, WP | 1 |
| EZDINLI, EZ | 1 |
| STUTZMAN, L | 2 |
| NAVASHIN, SM | 1 |
| FOMINA, IP | 1 |
| TERENTEVA, TG | 1 |
| SMITH, JC | 1 |
| BOLANDE, RP | 1 |
| GREEN, RA | 1 |
| DIXON, H | 1 |
| HORWITZ, H | 1 |
| WRIGHT, TL | 1 |
| PERRY, H | 1 |
| BARRETT, CM | 1 |
| MOESCHLIN, S | 1 |
| BOYLAND, E | 1 |
| KINDER, CH | 1 |
| WILLIAMS, K | 1 |
| LACHER, MJ | 1 |
| DURANT, JR | 1 |
| LEBHERZ, TB | 2 |
| HUSTON, JW | 1 |
| AUSTIN, JA | 1 |
| BOYCE, CR | 1 |
| WANEBO, HJ | 1 |
| CLARKSON, BD | 1 |
| ENGLE, I | 1 |
| AAKHUS, T | 1 |
| FISHER, BK | 1 |
| ELLIOTT, GB | 1 |
| PARKER, RT | 1 |
| BRODY, JI | 1 |
| BEIZER, LH | 1 |
| MASTERSON, JG | 1 |
| CALAME, RJ | 1 |
| NELSON, J | 1 |
| PERISCO, L | 1 |
| PRADHAN, SN | 1 |
| WEST, WL | 1 |
| Gerweck, LE | 1 |
| Vijayappa, S | 1 |
| Kozin, S | 1 |
| Alvarez, D | 1 |
| Chou, CJ | 1 |
| Latella, L | 1 |
| Zeitlin, SG | 1 |
| Ku, S | 1 |
| Puri, PL | 1 |
| Dervan, PB | 1 |
| Gottesfeld, JM | 1 |
| Ludwig, C | 1 |
| Gaynon, PS | 1 |
| Baum, ES | 1 |
| Krivit, W | 1 |
| Hammond, D | 1 |
| Sikora, K | 1 |
| Smedley, H | 1 |
| Thorpe, P | 2 |
| Palmer, RG | 1 |
| Denman, AM | 1 |
| Krel', AA | 1 |
| Kanevskaia, MZ | 1 |
| Rashchupkina, ZP | 1 |
| Bolotin, EV | 1 |
| Chichasova, NV | 1 |
| Ohsawa, N | 2 |
| Yamazaki, Z | 1 |
| Wagatsuma, T | 1 |
| Isurugi, K | 2 |
| Gaver, RC | 1 |
| Deeb, G | 1 |
| Pittman, KA | 1 |
| Issell, BF | 1 |
| Mittelman, A | 1 |
| Smyth, RD | 1 |
| Pascual Gómez, E | 1 |
| Clare, MG | 1 |
| Jones, WG | 1 |
| Taylor, JH | 1 |
| Amor, B | 1 |
| Balthazar, PA | 1 |
| Schmähl, D | 1 |
| Habs, M | 1 |
| Lorenz, M | 1 |
| Wagner, I | 1 |
| Ahmed, AE | 1 |
| Koenig, M | 1 |
| Farrish, HH | 1 |
| Santoro, A | 1 |
| Rilke, F | 1 |
| Franchi, F | 1 |
| Monfardini, S | 1 |
| Lewis, P | 1 |
| Hazleman, BL | 1 |
| Hanka, R | 1 |
| Roberts, S | 1 |
| Dousset, B | 1 |
| Boudet, MJ | 1 |
| Soubrane, O | 1 |
| Calmus, Y | 1 |
| Bernard, O | 1 |
| Houssin, D | 1 |
| Najean, Y | 1 |
| Dresch, C | 1 |
| Rain, JD | 1 |
| Lind, MJ | 1 |
| Ardiet, C | 1 |
| Ponticelli, C | 1 |
| Passerini, P | 1 |
| Como, G | 1 |
| Melis, P | 1 |
| Viganò, E | 1 |
| Pozzi, C | 1 |
| Altieri, P | 1 |
| Einhorn, LH | 1 |
| Cox, PJ | 1 |
| Farmer, PB | 1 |
| Kinlen, LJ | 1 |
| Sheil, AG | 1 |
| Peto, J | 1 |
| Doll, R | 1 |
| Schaison, G | 1 |
| Jacquillat, C | 1 |
| Auclerc, G | 1 |
| Weil, M | 1 |
| Queisser, W | 1 |
| Kalb, M | 1 |
| Schiffman, FJ | 1 |
| Fisher, JM | 1 |
| Rabinovitz, M | 1 |
| Cazalis, P | 1 |
| Caroit, M | 1 |
| Zittoun, R | 1 |
| Kahn, MF | 1 |
| Sèze, S | 1 |
| Berry, RJ | 1 |
| Laing, AH | 1 |
| Wells, J | 1 |
| Baumgartner, G | 2 |
| Ghose, T | 2 |
| Tai, J | 1 |
| Guclu, A | 1 |
| Norvell, ST | 1 |
| Bodurha, A | 1 |
| Aquino, J | 1 |
| MacDonald, AS | 1 |
| Riches, PG | 1 |
| Gascoigne, EW | 1 |
| Leese, CL | 1 |
| Harrap, KR | 1 |
| Blakeslee, D | 1 |
| Chen, M | 1 |
| Kennedy, JC | 1 |
| Slack, NH | 3 |
| Bross, ID | 5 |
| Weiss, RB | 1 |
| Alley, MC | 1 |
| Pacula-Cox, CM | 1 |
| Hursey, ML | 1 |
| Rubinstein, LR | 1 |
| Boyd, MR | 1 |
| Bastholt, L | 1 |
| Johansson, CJ | 1 |
| Pfeiffer, P | 1 |
| Svensson, L | 1 |
| Johansson, SA | 1 |
| Gunnarsson, PO | 1 |
| Mouridsen, H | 1 |
| Hancock, BW | 1 |
| Vaughan Hudson, G | 1 |
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| Haybittle, JL | 1 |
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| MacLennan, KA | 1 |
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| Cervantes, F | 1 |
| Viñolas, N | 1 |
| Rovira, M | 1 |
| Urbano-Ispizua, A | 1 |
| Montserrat, E | 1 |
| Rozman, C | 1 |
| Clements, PJ | 1 |
| Davis, J | 1 |
| Horikoshi, N | 1 |
| Blumenreich, MS | 1 |
| Woodcock, TM | 1 |
| Sherrill, EJ | 1 |
| Richman, SP | 1 |
| Gentile, PS | 1 |
| Epremian, BE | 1 |
| Kubota, TT | 1 |
| Allegra, JC | 1 |
| Scarffe, JH | 1 |
| Wagstaff, J | 1 |
| Crowther, D | 1 |
| Kamei, H | 1 |
| Takenaka, K | 1 |
| Goto, T | 1 |
| Suga, S | 1 |
| Fugiwara, A | 1 |
| Nakao, I | 1 |
| Agatsuma, T | 1 |
| Fujita, K | 1 |
| Kubota, T | 1 |
| Hamza, MH | 1 |
| Nashel, DJ | 1 |
| Schein, PS | 1 |
| Cavalli, F | 1 |
| Hazleman, B | 1 |
| Adair, CG | 1 |
| Burns, DT | 1 |
| Crockard, AD | 1 |
| Harriott, M | 1 |
| Rubens, RD | 1 |
| Siering, VH | 1 |
| Abendroth, K | 1 |
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| Le Goff, P | 1 |
| Le Menn, G | 1 |
| Skinner, MD | 1 |
| Schwartz, RS | 1 |
| Haddow, A | 1 |
| Thornes, RD | 1 |
| Greenwald, ES | 1 |
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| Robinson, E | 1 |
| Pengelly, CD | 1 |
| Berndt, H | 1 |
| Rieche, K | 1 |
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| Sokal, JE | 1 |
| Ausman, R | 1 |
| Nadler, S | 1 |
| Jones, R | 3 |
| Slack, N | 1 |
| Rimm, AA | 4 |
| Vermel', EM | 1 |
| Klemm, D | 1 |
| Couture, J | 1 |
| Deschênes, L | 1 |
| Hartwich, G | 1 |
| Butzler, W | 1 |
| Schmidt, CG | 1 |
| Lleander, VC | 1 |
| Goldstein, G | 1 |
| Horsley, JS | 1 |
| Kostanecki, W | 1 |
| Mazurkiewicz, W | 1 |
| Górkiewicz, A | 1 |
| Zborzil, J | 1 |
| Ahlstrom, JK | 1 |
| Fazio, M | 1 |
| Bachi, C | 1 |
| Cavallero, P | 1 |
| Sartoris, S | 1 |
| Vergnano, F | 1 |
| Bartelheimer, H | 1 |
| Frenzel, H | 1 |
| Robert, J | 1 |
| Barbier, P | 1 |
| Manaster, J | 1 |
| Jacobs, E | 1 |
| Ausman, RK | 2 |
24 reviews available for chlorambucil and Neoplasms
| Article | Year |
|---|---|
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms; | 2015 |
1,3,5-Triazines: A promising scaffold for anticancer drugs development.
Topics: Animals; Antineoplastic Agents; Chemistry Techniques, Synthetic; Drug Discovery; Humans; Models, Mol | 2017 |
Therapeutic journery of nitrogen mustard as alkylating anticancer agents: Historic to future perspectives.
Topics: Animals; Antineoplastic Agents, Alkylating; Drug Delivery Systems; Humans; Neoplasms; Nitrogen Musta | 2018 |
Alkylating agents in membranous nephropathy: efficacy proven beyond doubt.
Topics: Alkylating Agents; Chlorambucil; Cyclophosphamide; Glomerulonephritis, Membranous; Humans; Immunosup | 2010 |
HODGKIN'S DISEASE--PROGNOSIS, TREATMENT AND ETIOLOGIC AND IMMUNOLOGIC CONSIDERATIONS.
Topics: Antineoplastic Agents; Chlorambucil; Hodgkin Disease; Humans; Neoplasms; Nitrogen Mustard Compounds; | 1964 |
[MEDICAL THERAPY OF MALIGNANT NEOPLASMS].
Topics: Antimetabolites; Antineoplastic Agents; Antiviral Agents; Blood Transfusion; Busulfan; Chlorambucil; | 1964 |
Tumour imaging and drug targeting.
Topics: Adolescent; Alpha Particles; Animals; Antibodies, Monoclonal; Antibodies, Neoplasm; Antibody Specifi | 1984 |
Malignancies induced by chlorambucil.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Chlorambucil; Female; Humans; Leukemia; Male; Midd | 1984 |
Pharmacokinetics of alkylating agents.
Topics: Alkylating Agents; Carmustine; Chlorambucil; Cyclophosphamide; Humans; Ifosfamide; Lomustine; Melpha | 1993 |
Primary nephrotic syndrome in the elderly.
Topics: Actuarial Analysis; Acute Kidney Injury; Adrenal Cortex Hormones; Adult; Aged; Chlorambucil; Female; | 1993 |
Towards selectivity? Approaches to the design of new anti-tumour agents--I.
Topics: Aerosols; Animals; Antibodies, Neoplasm; Antimetabolites, Antineoplastic; Antineoplastic Agents; Che | 1977 |
Chlorambucil.
Topics: Animals; Carcinogens; Chlorambucil; Drug Evaluation, Preclinical; Female; Fetus; Humans; Lethal Dose | 1975 |
Hypersensitivity reactions.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Asparaginase; Aziridines; Benzoquinones; Bleomyc | 1992 |
The design of cytotoxic-agent-antibody conjugates.
Topics: Antibiotics, Antineoplastic; Antibodies, Monoclonal; Antibody Specificity; Antigens, Neoplasm; Bleom | 1987 |
Cytotoxic drugs: their clinical application to the rheumatic diseases.
Topics: Arthritis; Arthritis, Rheumatoid; Azathioprine; Behcet Syndrome; Bone Marrow; Cell Division; Chemica | 1986 |
Mechanisms of action and clinical applications of cytotoxic drugs in rheumatic disorders.
Topics: Arthritis, Reactive; Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Collagen Diseases; Cyclophos | 1985 |
[Principles of the effect of cytostatics].
Topics: Antineoplastic Agents; Asparaginase; Cell Division; Chlorambucil; Cyclophosphamide; Cytarabine; Drug | 1974 |
Immunosuppressive therapy. 2.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Adult; Azathioprine; Child; Chlorambucil; Clin | 1972 |
On the biological alkylating agents.
Topics: Alkylating Agents; Busulfan; Carcinogens; Chlorambucil; Melphalan; Mustard Compounds; Mutation; Neop | 1973 |
Cancer chemotherapy. I.
Topics: Animals; Busulfan; Chlorambucil; Cyclophosphamide; Female; Humans; Male; Mechlorethamine; Melphalan; | 1972 |
[Combination chemotherapy in the treatment of cancer].
Topics: Administration, Oral; Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Cyclophosphamide; Dacti | 1972 |
Use of anticancer drugs during pregnancy.
Topics: Alkylating Agents; Aminopterin; Animals; Antimetabolites; Antineoplastic Agents; Busulfan; Chlorambu | 1968 |
[Current views on drug therapy of tumors].
Topics: Animals; Antineoplastic Agents; Carcinoma, Brown-Pearce; Carcinoma, Ehrlich Tumor; Chlorambucil; Cyc | 1970 |
[Alkylating cytostatic agents].
Topics: Alkylating Agents; Alkylation; Animals; Busulfan; Cell Division; Chemical Phenomena; Chemistry; Chlo | 1971 |
8 trials available for chlorambucil and Neoplasms
| Article | Year |
|---|---|
Prospective trial of metronomic chlorambucil chemotherapy in dogs with naturally occurring cancer.
Topics: Administration, Metronomic; Animals; Antineoplastic Agents, Alkylating; Chlorambucil; Dog Diseases; | 2012 |
A phase II clinical trial of prednimustine. Clinical screening cooperative group of E.O.R.T.C.
Topics: Adolescent; Adult; Aged; Chlorambucil; Clinical Trials as Topic; Female; Humans; Leukemia, Lymphoid; | 1977 |
A pharmacokinetic study of prednimustine as compared with prednisolone plus chlorambucil in cancer patients.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biological Availability; Chlorambucil; | 1991 |
British National Lymphoma Investigation randomised study of MOPP (mustine, Oncovin, procarbazine, prednisolone) against LOPP (Leukeran substituted for mustine) in advanced Hodgkin's disease--long term results.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Female; Follow-Up S | 1991 |
Immunosuppressive therapy. 2.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Adult; Azathioprine; Child; Chlorambucil; Clin | 1972 |
Oral anticoagulant therapy of human cancer.
Topics: Administration, Oral; Anticoagulants; Antineoplastic Agents; Breast Neoplasms; Busulfan; Chlorambuci | 1974 |
Effects of chlorambucil (NSC-3088) in 374 patients with advanced cancer. Eastern Clinical Drug Evualuation Program.
Topics: Carcinoma; Chlorambucil; Clinical Trials as Topic; Female; Humans; Neoplasms; Ovarian Neoplasms; Pan | 1968 |
What is objective tumor response?
Topics: Antineoplastic Agents; Azirines; Body Weight; Chlorambucil; Clinical Trials as Topic; Electronic Dat | 1967 |
154 other studies available for chlorambucil and Neoplasms
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic | 2007 |
Design, synthesis and antiproliferative activity of some 3-benzylidene-2,3-dihydro-1-benzopyran-4-ones which display selective toxicity for malignant cells.
Topics: Animals; Antineoplastic Agents; Benzopyrans; Cell Survival; Drug Design; Drug Screening Assays, Anti | 2008 |
To determine the cytotoxicity of chlorambucil and one of its nitro-derivatives, conjugated to prasterone and pregnenolone, towards eight human cancer cell-lines.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Chlorambucil; Chromatography, High Pressure Liquid | 2009 |
Amphiphilic Modulation of Glycosylated Antitumor Ether Lipids Results in a Potent Triamino Scaffold against Epithelial Cancer Cell Lines and BT474 Cancer Stem Cells.
Topics: Amination; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Epithelial Cells; Glycosylation; | 2017 |
Synthesis of scutellarein derivatives with antiproliferative activity and selectivity through the intrinsic pathway.
Topics: Antineoplastic Agents; Apigenin; Apoptosis; Apoptosis Regulatory Proteins; Benzoic Acid; Cell Line, | 2018 |
A Self-Reporting Fluorescent Salicylaldehyde-Chlorambucil Conjugate as a Type-II ICD Inducer for Cancer Vaccines.
Topics: Aldehydes; Antineoplastic Agents; Cancer Vaccines; Chlorambucil; Humans; Immunogenic Cell Death; Neo | 2022 |
Population pharmacokinetics identifies rapid gastrointestinal absorption and plasma clearance of oral chlorambucil administered to cats with indolent lymphoproliferative malignancies.
Topics: Administration, Oral; Animals; Area Under Curve; Cat Diseases; Cats; Chlorambucil; Gastrointestinal | 2022 |
Tumor Targeting by Conjugation of Chlorambucil with Zwitterionic Near-Infrared Fluorophore for Cancer Phototherapy.
Topics: Animals; Antineoplastic Agents; Chlorambucil; Fluorescent Dyes; Humans; Ionophores; Mice; Neoplasms; | 2022 |
Tumor Targeting by Conjugation of Chlorambucil with Zwitterionic Near-Infrared Fluorophore for Cancer Phototherapy.
Topics: Animals; Antineoplastic Agents; Chlorambucil; Fluorescent Dyes; Humans; Ionophores; Mice; Neoplasms; | 2022 |
Tumor Targeting by Conjugation of Chlorambucil with Zwitterionic Near-Infrared Fluorophore for Cancer Phototherapy.
Topics: Animals; Antineoplastic Agents; Chlorambucil; Fluorescent Dyes; Humans; Ionophores; Mice; Neoplasms; | 2022 |
Tumor Targeting by Conjugation of Chlorambucil with Zwitterionic Near-Infrared Fluorophore for Cancer Phototherapy.
Topics: Animals; Antineoplastic Agents; Chlorambucil; Fluorescent Dyes; Humans; Ionophores; Mice; Neoplasms; | 2022 |
Tumor Targeting by Conjugation of Chlorambucil with Zwitterionic Near-Infrared Fluorophore for Cancer Phototherapy.
Topics: Animals; Antineoplastic Agents; Chlorambucil; Fluorescent Dyes; Humans; Ionophores; Mice; Neoplasms; | 2022 |
Tumor Targeting by Conjugation of Chlorambucil with Zwitterionic Near-Infrared Fluorophore for Cancer Phototherapy.
Topics: Animals; Antineoplastic Agents; Chlorambucil; Fluorescent Dyes; Humans; Ionophores; Mice; Neoplasms; | 2022 |
Tumor Targeting by Conjugation of Chlorambucil with Zwitterionic Near-Infrared Fluorophore for Cancer Phototherapy.
Topics: Animals; Antineoplastic Agents; Chlorambucil; Fluorescent Dyes; Humans; Ionophores; Mice; Neoplasms; | 2022 |
Tumor Targeting by Conjugation of Chlorambucil with Zwitterionic Near-Infrared Fluorophore for Cancer Phototherapy.
Topics: Animals; Antineoplastic Agents; Chlorambucil; Fluorescent Dyes; Humans; Ionophores; Mice; Neoplasms; | 2022 |
Tumor Targeting by Conjugation of Chlorambucil with Zwitterionic Near-Infrared Fluorophore for Cancer Phototherapy.
Topics: Animals; Antineoplastic Agents; Chlorambucil; Fluorescent Dyes; Humans; Ionophores; Mice; Neoplasms; | 2022 |
Design, synthesis and anticancer evaluation of novel oncolytic peptide-chlorambucil conjugates.
Topics: Animals; Chlorambucil; DNA; Mice; Neoplasms; Nitrogen; Nitrogen Mustard Compounds; Peptides | 2023 |
ROS/pH dual-sensitive emodin-chlorambucil co-loaded micelles enhance anti-tumor effect through combining oxidative damage and chemotherapy.
Topics: Chlorambucil; Emodin; Glutathione; Humans; Hydrogen-Ion Concentration; Micelles; Neoplasms; Oxidativ | 2023 |
Conjugation of a gold(iii) complex with vitamin B1 and chlorambucil derivatives: anticancer evaluation and mechanistic insights.
Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Apoptosis; Chlorambucil; Cisplatin; Coordi | 2020 |
Inducing Controlled Release and Increased Tumor-Targeted Delivery of Chlorambucil via Albumin/Liposome Hybrid Nanoparticles.
Topics: Animals; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Chlorambucil; Delayed-Action Preparati | 2017 |
Bifunctional peptide hybrids targeting the matrix of mitochondria.
Topics: Amino Acid Sequence; Antineoplastic Agents, Alkylating; Cell Survival; Cell-Penetrating Peptides; Ch | 2018 |
[ON HODGKIN'S DISEASE. PERSONAL EXPERIENCE].
Topics: Anti-Bacterial Agents; Antineoplastic Agents; Aziridines; Biopsy; Chlorambucil; Classification; Hodg | 1964 |
A pillararene-based ternary drug-delivery system with photocontrolled anticancer drug release.
Topics: Antineoplastic Agents; Cell Line, Tumor; Chlorambucil; Drug Carriers; Drug Delivery Systems; Humans; | 2015 |
Liposome-like nanocapsules of dual drug-tailed betaine for cancer therapy.
Topics: Animals; Antineoplastic Agents, Alkylating; Betaine; Cell Survival; Chlorambucil; Drug Stability; Fe | 2015 |
Chlorambucil gemcitabine conjugate nanomedicine for cancer therapy.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Apoptosis; Carcinoma, H | 2015 |
Retrospective comparison of three doses of metronomic chlorambucil for tolerability and efficacy in dogs with spontaneous cancer.
Topics: Administration, Metronomic; Animals; Antineoplastic Agents, Alkylating; Bone Marrow; Chlorambucil; D | 2017 |
Synthesis and preliminary biological evaluation of a
Topics: Amines; Animals; Chlorambucil; Female; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms; Picolinic A | 2017 |
DNA cross-links in human tumor cells exposed to the prodrug PR-104A: relationships to hypoxia, bioreductive metabolism, and cytotoxicity.
Topics: Animals; Cell Death; Cell Hypoxia; Cell Line, Tumor; Chlorambucil; Chromatography, Liquid; DNA Damag | 2009 |
Comparative analysis of DNA alkylation by conjugates between pyrrole-imidazole hairpin polyamides and chlorambucil or seco-CBI.
Topics: Antineoplastic Agents, Alkylating; Cell Line, Tumor; Cell Survival; Chlorambucil; DNA; Humans; Imida | 2010 |
Chlorambucil and malignancy.
Topics: Antineoplastic Agents, Alkylating; Chlorambucil; Databases, Factual; Follow-Up Studies; Humans; Neop | 2010 |
Rerouting chlorambucil to mitochondria combats drug deactivation and resistance in cancer cells.
Topics: Alkylation; Antineoplastic Agents; Biological Transport; Cell Line, Tumor; Chlorambucil; DNA Damage; | 2011 |
Chlorambucil.
Topics: Animals; Antineoplastic Agents, Alkylating; Carcinogens; Chlorambucil; Humans; Neoplasms | 2011 |
Perylene-3-ylmethanol: fluorescent organic nanoparticles as a single-component photoresponsive nanocarrier with real-time monitoring of anticancer drug release.
Topics: Antineoplastic Agents; Biocompatible Materials; Chlorambucil; Delayed-Action Preparations; Fluoresce | 2012 |
Remissions induced by chlorambucil in chronic granulocytic leukemia.
Topics: Chlorambucil; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mechlorethamine; Neoplasms | 1958 |
Chlorambucil and triethylene thiophosphoramide in the treatment of neoplastic disease.
Topics: Antineoplastic Agents; Chlorambucil; Humans; Mechlorethamine; Neoplasms; Nitrogen Mustard Compounds; | 1958 |
P-(Di-2-chloroethyl) aminophenylbutyric acid (CB 1348) in the treatment of cancer.
Topics: Chlorambucil; Mechlorethamine; Neoplasms; Nitrogen Mustard Compounds | 1958 |
[Observations & results in patients with malignant hemolymphatic diseases treated with p-(N,N-di-2-chloroethyl) aminophenylbutyric acid (CB 1348)].
Topics: Chlorambucil; Lymphoma; Mechlorethamine; Neoplasms; Nitrogen Mustard Compounds | 1959 |
[p-(N, N-Di-2-chloroethyl)-aminophenylbutyric acid (CB-1348) in oncological therapy].
Topics: Chlorambucil; Internal Medicine; Mechlorethamine; Neoplasms; Nitrogen Mustard Compounds | 1960 |
[Effect of the association of 6-mercaptopurine-chlorambucil and 6-mercaptopurine-myleran on the growth of Galliera sarcoma in the rat].
Topics: Animals; Antineoplastic Agents; Busulfan; Chlorambucil; Mercaptopurine; Neoplasms; Rats; Sarcoma | 1960 |
Chemotherapy of malignant disease. II. Diseases of lymphoid tissue and bone marrow.
Topics: Adrenal Cortex Hormones; Aged; Bone Marrow; Busulfan; Chlorambucil; Cyclophosphamide; Hodgkin Diseas | 1962 |
The biology of lymphocytic choriomeningitis infection: virus-induced immune disease.
Topics: Autoimmune Diseases; Biology; Chlorambucil; Endotoxins; Immune System Diseases; Lymphocytic Choriome | 1962 |
The chemotherapy of intrathoracic tumors.
Topics: Busulfan; Chlorambucil; Cyclophosphamide; Dactinomycin; Humans; Mechlorethamine; Methotrexate; Neopl | 1962 |
THE MALIGNANT LYMPHOMAS.
Topics: Adrenal Cortex Hormones; Chlorambucil; Cyclophosphamide; Hodgkin Disease; Humans; Lymphoma; Lymphoma | 1963 |
EXPERIMENTAL APPROACHES TO THE CHEMOTHERAPY OF LEUKAEMIA.
Topics: Busulfan; Chlorambucil; Leukemia; Leukemia, Experimental; Neoplasms; Rats; Research | 1963 |
LEUKEMIA. AN ANALYSIS OF 209 CASES FROM THE ELLIS FISCHEL STATE CANCER HOSPITAL.
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Antineoplastic Agents; Busulfan; Cancer Care Facilit | 1963 |
DRUGS OF CURRENT USE FOR THE TREATMENT OF CANCER AND ALLIED DISEASES. (1ST REPORT).
Topics: Antineoplastic Agents; Chlorambucil; Cyclophosphamide; France; Germany; Germany, West; Humans; Neopl | 1963 |
ROLE OF CHEMOTHERAPY IN THE MANAGEMENT OF EARLY HODGKIN'S DISEASE.
Topics: Bone Marrow Examination; Chlorambucil; Disease Management; Histological Techniques; Histology; Hodgk | 1963 |
CLINICAL EVALUATION OF URACIL MUSTARD.
Topics: Anemia; Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Female; Hodgkin Disease; Humans; Kidn | 1963 |
THE TREATMENT OF LEUKEMIA.
Topics: Antineoplastic Agents; Busulfan; Chlorambucil; Cyclophosphamide; Leukemia; Mercaptopurine; Methotrex | 1964 |
SIDE-EFFECTS OF COMBINED RADIATION AND CHEMOTHERAPY IN THE TREATMENT OF MALIGNANT TUMORS.
Topics: Chlorambucil; Dactinomycin; Fluorouracil; Mitomycin; Mitomycins; Neoplasms; Toxicology | 1963 |
[HOW TO TREAT LEUKEMIA IN 1963].
Topics: Busulfan; Child; Chlorambucil; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Mercaptopuri | 1963 |
[CHEMOTHERAPY OF CANCER OF THE OVARY].
Topics: Androgens; Castration; Chlorambucil; Cobalt Isotopes; Corpus Luteum Hormones; Female; Humans; Neopla | 1963 |
[CYTOSTATICS OF VEGETABLE ORIGIN AND OF SYNTHETIC ORIGIN].
Topics: Animals; Antineoplastic Agents; Biological Assay; Carcinoma, Ehrlich Tumor; Chlorambucil; Cytostatic | 1963 |
THE RETICULOSES.
Topics: Adrenal Cortex Hormones; Chlorambucil; Cyclophosphamide; Dermatitis, Exfoliative; Genetic Diseases, | 1964 |
[CURRENT PRACTICE IN THE TREATMENT OF TUMORS WITH INTRA-ARTERIAL INJECTIONS OF ANTINEOPLASTIC SUBSTANCES].
Topics: Aminopterin; Antineoplastic Agents; Carcinoma; Chemotherapy, Cancer, Regional Perfusion; Chlorambuci | 1963 |
CURRENT STATUS OF CHEMOTHERAPY OF CANCER.
Topics: Alkylating Agents; Anti-Bacterial Agents; Antineoplastic Agents; Black People; Chemotherapy, Cancer, | 1964 |
CLINICAL MANAGEMENT OF SOFT PART SARCOMAS.
Topics: Chlorambucil; Dactinomycin; Geriatrics; Humans; Leiomyosarcoma; Liposarcoma; Liver Neoplasms; Methot | 1964 |
PHAGOCYTOSIS IN RETICULUM CELL SARCOMA.
Topics: Adolescent; Black People; Child; Chlorambucil; Cyclophosphamide; Dactinomycin; Geriatrics; Leukemia; | 1964 |
SPINAL-CORD COMPRESSION IN THE MALIGNANT LYMPHOMAS.
Topics: Chlorambucil; Hematopoiesis; Hodgkin Disease; Humans; Lymphoma; Lymphoma, Non-Hodgkin; Mercaptopurin | 1964 |
[EXPERIENCE IN THE TREATMENT OF MALIGNANT DISEASES OF THE RETICULOENDOTHELIAL SYSTEM AND LEUKEMIAS. II].
Topics: Betamethasone; Busulfan; Chlorambucil; Copper; Cyclophosphamide; Dexamethasone; Genetic Diseases, X- | 1964 |
[ACTION OF COMBINED TRIPLE ANTICANCER CHEMOTHERAPY. STUDY ON 32 PATIENTS].
Topics: Adolescent; Anti-Bacterial Agents; Child; Chlorambucil; Cyclophosphamide; Dactinomycin; Drug Therapy | 1964 |
EFFECTS OF IONIZING IRRADIATION AND CHEMOTHERAPEUTIC AGENTS ON HUMAN CHROMOSOMES.
Topics: Antineoplastic Agents; Biomedical Research; Chlorambucil; Choriocarcinoma; Chromosome Aberrations; C | 1964 |
EWING'S SARCOMA.
Topics: Adolescent; Amputation, Surgical; Antineoplastic Agents; Child; Chlorambucil; Femoral Neoplasms; Fib | 1964 |
CANCER CHEMOTHERAPY.
Topics: Adrenal Cortex Hormones; Aminopterin; Androgens; Antimetabolites; Antineoplastic Agents; Blood Plate | 1964 |
[HISTOPATHOLOGICAL EFFECTS OF ANTINEOPLASTIC AGENTS ON MALIGNANT LYMPHOMA].
Topics: Antineoplastic Agents; Child; Chlorambucil; Cyclophosphamide; Dactinomycin; Geriatrics; Hodgkin Dise | 1964 |
HODGKIN'S DISEASE OF THE LUNG WITH CAVITATION.
Topics: Antineoplastic Agents; Chlorambucil; Diagnosis, Differential; Hodgkin Disease; Lung Neoplasms; Mechl | 1964 |
STUDIES ON HUMAN MELANOMA CELLS IN TISSUE CULTURE. II. EFFECTS OF SEVERAL CANCER CHEMOTHERAPEUTIC AGENTS ON CYTOLOGY AND GROWTH.
Topics: Anti-Bacterial Agents; Antineoplastic Agents; Chlorambucil; Dactinomycin; Fluorouracil; Melanoma; Me | 1964 |
LONG TERM RESULTS ACHIEVED WITH THE USE OF ALKYLATING AGENTS IN MALIGNANT LYMPHOMA AND HODGKIN'S DISEASE.
Topics: Alkylating Agents; Chlorambucil; Cyclophosphamide; Hodgkin Disease; Humans; Lymphoma; Lymphoma, Larg | 1964 |
PNEUMOCYSTIS CARINII PNEUMONIA. CASE STUDIES WITH ELECTRON MICROSCOPY.
Topics: Chlorambucil; Chloramphenicol; Cytomegalovirus Infections; Diagnosis, Differential; Digoxin; Electro | 1964 |
NONSURGICAL TREATMENT OF PULMONARY CANCER.
Topics: Adenocarcinoma, Bronchiolo-Alveolar; Adrenal Cortex Hormones; Alkylating Agents; Antineoplastic Agen | 1964 |
CHRONIC LEUKEMIA.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Alkylating Agents; Anemia; Anemia, Hemolytic, | 1964 |
THE TREATMENT OF INCURABLE MALIGNANT DISEASE.
Topics: Adrenalectomy; Androgens; Breast Neoplasms; Busulfan; Chlorambucil; Estrogens; Heroin; Hormones; Hum | 1964 |
PLASMA FACTORS IN LEUKAEMIA. IMMUNOLOGICAL AND "IN VITRO" CULTURAL STUDIES.
Topics: Blood Group Antigens; Busulfan; Chlorambucil; Complement Fixation Tests; Coombs Test; Humans; In Vit | 1964 |
COMBINED TREATMENT OF DISSEMINATED OVARIAN CARCINOMA WITH COBALT TELETHERAPY AND CYTOSTATICS (CHLORAMBUCIL).
Topics: Carcinoma; Chlorambucil; Cobalt; Cobalt Isotopes; Combined Modality Therapy; Cytostatic Agents; Fema | 1964 |
CHROMOSOMES OF LYMPHOSARCOMA AND CANCER CELLS IN BONE MARROW.
Topics: Alkaloids; Antineoplastic Agents; Bone Marrow; Bone Marrow Examination; Chlorambucil; Chromosome Abe | 1964 |
THE MANAGEMENT OF LEUKEMIA AND LYMPHOMA.
Topics: Adrenal Cortex Hormones; Busulfan; Chlorambucil; Cortisone; Cyclophosphamide; Hodgkin Disease; Human | 1964 |
THE TREATMENT OF CANCER BY ISOLATION PERFUSION.
Topics: Alkylating Agents; Anti-Bacterial Agents; Antimetabolites; Antineoplastic Agents; Chemotherapy, Canc | 1964 |
ANTI-LEUKAEMIC DRUGS.
Topics: Busulfan; Chlorambucil; Cyclophosphamide; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; M | 1964 |
TREATMENT OF NEOPLASTIC EFFUSIONS WITH CHLORAMBUCIL.
Topics: Ascites; Chlorambucil; Female; Humans; Neoplasms; Ovarian Neoplasms; Pharmacology; Pleural Effusion; | 1964 |
OVARIAN DISGERMINOMA. REPORT OF A CASE TREATED WITH ACTINOMYCIN D, CHLORAMBUCIL, AND METHOTREXATE AFTER MASSIVE IRRADIATION.
Topics: Chlorambucil; Dactinomycin; Drug Therapy; Dysgerminoma; Female; Humans; Methotrexate; Neoplasms; Neo | 1964 |
OBSERVATIONS ON THE USE OF CANCER CHEMOTHERAPEUTIC AGENTS IN PATIENTS WITH MYCOSIS FUNGOIDES.
Topics: Alkylating Agents; Anti-Bacterial Agents; Antineoplastic Agents; Carbamates; Chlorambucil; Dactinomy | 1964 |
EXPERIENCES WITH CHEMOTHERAPY IN GYNECOLOGIC CANCER.
Topics: Antineoplastic Agents; Biomedical Research; Chlorambucil; Cyclophosphamide; Dactinomycin; Female; Ge | 1964 |
MEDICAL GRAND ROUNDS FROM THE UNIVERSITY OF ALABAMA MEDICAL CENTER.
Topics: Beta-Globulins; Blood Protein Disorders; Bone Marrow Examination; Bone Resorption; Chlorambucil; Dia | 1964 |
CHLORAMBUCIL THERAPY FOR LYMPHOMAS AND CHRONIC LYMPHOCYTIC LEUKEMIA.
Topics: Adrenal Cortex Hormones; Chlorambucil; Drug Synergism; Hodgkin Disease; Leukemia; Leukemia, Lymphocy | 1965 |
[STUDIES ON THE ANTINEOPLASTIC EFFECT OF CHLORBUTINPENICILLIN].
Topics: Animals; Antineoplastic Agents; Chlorambucil; Neoplasms; Penicillins; Pharmacology; Rats; Research; | 1964 |
RADIATION AND DRUG INDUCED HYALINIZATION OF THE STOMACH.
Topics: Antineoplastic Agents; Child; Chlorambucil; Cyclophosphamide; Drug Therapy; Ganglioneuroma; Gastroin | 1965 |
EXPECTANCY FOR LIFE IN CHRONIC LYMPHATIC LEUKEMIA.
Topics: Adrenal Cortex Hormones; Alkylating Agents; Antineoplastic Agents; Child; Chlorambucil; Cyclophospha | 1965 |
"SUPPRESSIVE" CHEMOTHERAPY IN BRONCHOGENIC CARCINOMA: A RANDOMIZED PROSPECTIVE CLINICAL TRIAL.
Topics: Adenocarcinoma; Biomedical Research; Carcinoma; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; C | 1965 |
[MODERN TREATMENT OF LEUKEMIA].
Topics: Agranulocytosis; Busulfan; Chlorambucil; Cyclophosphamide; Drug Therapy; Genetic Diseases, X-Linked; | 1965 |
THE TREATMENT OF CARCINOMA IN DOGS' BLADDERS WITH CYTOTOXIC DRUGS.
Topics: Alkylating Agents; Antineoplastic Agents; Carcinogens; Carcinoma; Chlorambucil; Cyclophosphamide; Do | 1965 |
COMBINED VINBLASTINE AND CHLORAMBUCIL THERAPY OF HODGKIN'S DISEASE.
Topics: Chlorambucil; Drug Synergism; Hodgkin Disease; Humans; Neoplasms; Toxicology; Vinblastine | 1965 |
SUSTAINED PALLIATION IN OVARIAN CARCINOMA.
Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Ascites; Carcinoma; Chlorambucil; Dysgerminoma; Female; Gr | 1965 |
ESSENTIAL MACROGLOBULINEMIA. REPORT OF A CASE INCLUDING IMMUNOFLUORESCENT AND ELECTRON MICROSCOPIC STUDIES.
Topics: Blood Protein Electrophoresis; Bone Marrow Cells; Chlorambucil; Electrons; Fluorescent Antibody Tech | 1965 |
INTESTINAL OBSTRUCTION IN MYCOSIS FUNGOIDES.
Topics: Chlorambucil; Drug Therapy; Humans; Intestinal Neoplasms; Intestinal Obstruction; Mycosis Fungoides; | 1965 |
TRIPLE DRUG THERAPY WITH ACTINOMYCIN D (NSC-3053), CHLORAMBUCIL (NSC-3088), AND METHOTREXATE (NSC-740) IN METASTATIC SOLID TUMORS IN CHILDREN.
Topics: Child; Chlorambucil; Dactinomycin; Humans; Infant; Methotrexate; Neoplasms | 1965 |
CARCINOMA OF THE OVARY.
Topics: Adenocarcinoma; Chlorambucil; Dactinomycin; Drug Therapy; Female; Humans; Lung Neoplasms; Methotrexa | 1965 |
ALTERATION OF BLOOD GROUP ANTIGENS IN LEUKEMIC LYMPHOCYTES.
Topics: ABO Blood-Group System; Anemia; Anemia, Aplastic; Antigens; Blood Group Antigens; Child; Chlorambuci | 1965 |
A RETROSPECTIVE COMPARISON OF CHLORAMBUCIL AND RADIOTHERAPY IN THE TREATMENT OF OVARIAN ADENOCARCINOMA.
Topics: Adenocarcinoma; Carcinoma, Ovarian Epithelial; Chlorambucil; Drug Therapy; Female; Humans; Neoplasms | 1965 |
A clinical study on the use of chlorambucil in the treatment of cancer of the ovary.
Topics: Antineoplastic Agents; Biomedical Research; Chlorambucil; Female; Humans; Neoplasms; Ovarian Neoplas | 1960 |
[p-(Bis-2-chloroethylamino)-phenylbutyric acid (CB 1348) in oncological therapy].
Topics: Chlorambucil; Mechlorethamine; Neoplasms; Nitrogen Mustard Compounds; Phenylbutyrates | 1960 |
Effect of chlorambucil on synthesis of protein and nucleic acids in tumor-bearing mice.
Topics: Animals; Chlorambucil; Lymphoma, Non-Hodgkin; Mechlorethamine; Mice; Neoplasms; Nitrogen Mustard Com | 1960 |
Tumor pH controls the in vivo efficacy of weak acid and base chemotherapeutics.
Topics: Animals; Antineoplastic Agents; Chlorambucil; Doxorubicin; Extracellular Space; Glucose; Humans; Hyd | 2006 |
A two-hit mechanism for pre-mitotic arrest of cancer cell proliferation by a polyamide-alkylator conjugate.
Topics: Cell Division; Cell Line, Tumor; Cell Proliferation; Chlorambucil; G2 Phase; Gene Expression Regulat | 2006 |
[The meaning of maintenance therapy in oncology].
Topics: Breast Neoplasms; Chlorambucil; Hodgkin Disease; Leukemia, Myeloid, Acute; Lymphoma; Methotrexate; N | 1980 |
Phase II trial of prednimustine in children with recurrent cancer: a Children's Cancer Study Group report.
Topics: Adolescent; Adult; Carcinoma, Hepatocellular; Child; Child, Preschool; Chlorambucil; Drug Administra | 1982 |
[Chlorbutin, azathioprine, D-penicillamine, and levamisole (Decaris) in the treatment of rheumatoid arthritis patients. I. Comparative analysis of side effects].
Topics: Arthritis, Rheumatoid; Azathioprine; Bronchial Spasm; Chlorambucil; Drug Eruptions; Dyspepsia; Human | 1981 |
[Bestrabacil: a possible target-oriented anticancer agent].
Topics: Administration, Oral; Aged; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Division; Chloram | 1984 |
Disposition of orally administered 14C-prednimustine in cancer patients.
Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Carbon Radioisotopes; Chlorambucil; Colonic Neopl | 1983 |
[The use of immunosuppressive drugs in the treatment of rheumatoid arthritis].
Topics: Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Cyclophosphamide; Humans; Immunosuppressive Agent | 1983 |
Sister chromatid exchanges in human lymphocytes exposed to single cytotoxic drugs in vivo or in vitro.
Topics: Adult; Aged; Antineoplastic Agents; Busulfan; Cells, Cultured; Chlorambucil; Crossing Over, Genetic; | 1982 |
Cytotoxic drugs in rheumatoid arthritis.
Topics: Alopecia; Antibiotics, Antineoplastic; Arthritis, Rheumatoid; Chlorambucil; Cyclophosphamide; Cystit | 1980 |
[Leukemia and other neoplasms possibly induced by immunosuppressors in non-malignant diseases (author's transl)].
Topics: Animals; Azathioprine; Chlorambucil; Cyclophosphamide; Humans; Immunosuppressive Agents; Leukemia; N | 1980 |
Occurrence of second tumors in man after anticancer drug treatment.
Topics: Adolescent; Adult; Aged; Alkylating Agents; Antineoplastic Agents; Arthritis, Rheumatoid; Azathiopri | 1982 |
Studies on the quantitation of chlorambucil in plasma by reversed-phase high-performance liquid chromatography.
Topics: Animals; Chlorambucil; Chromatography, High Pressure Liquid; Hydrogen-Ion Concentration; Male; Neopl | 1982 |
Primary malignant neoplasms associated with chronic lymphocytic leukemia.
Topics: Breast Neoplasms; Chlorambucil; Colonic Neoplasms; Cyclophosphamide; Female; Head and Neck Neoplasms | 1980 |
Cause of death in patients with rheumatoid arthritis with particular reference to azathioprine.
Topics: Adult; Aged; Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Cyclophosphamide; Humans; Middle Age | 1980 |
Liver transplantation in patients with preexisting malignancy.
Topics: Adenocarcinoma; Adolescent; Adult; Carcinoma, Renal Cell; Child; Child, Preschool; Chlorambucil; Col | 1995 |
The very-long-term course of polycythaemia: a complement to the previously published data of the Polycythaemia Vera Study Group.
Topics: Aged; Bloodletting; Chlorambucil; Follow-Up Studies; Humans; Middle Aged; Neoplasms; Phosphorus Radi | 1994 |
Cancer chemotherapy.
Topics: Chlorambucil; Choriocarcinoma; Cyclophosphamide; Dactinomycin; Female; Hodgkin Disease; Humans; Leuk | 1977 |
Collaborative United Kingdom-Australasian study of cancer in patients treated with immunosuppressive drugs.
Topics: Adolescent; Adult; Aged; Australia; Azathioprine; Chlorambucil; Cyclophosphamide; Female; Follow-Up | 1979 |
[Fetal risk of cancer chemotherapy (author's transl)].
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Alkaloids; Animals; Antibiotics, Antineop | 1979 |
[Secondary carcinoma: a complication of cytostatic therapy?].
Topics: Antineoplastic Agents; Breast Neoplasms; Carcinogens; Chlorambucil; Female; Humans; Immunosuppressio | 1979 |
Serum displacing agents in cancer chemotherapy.
Topics: Animals; Cattle; Cells, Cultured; Chemical Phenomena; Chemistry; Chlorambucil; Clofibrate; Culture M | 1977 |
[A particular risk of prolonged immunosuppressive treatment: a case of acute myelomonocytic leukemia after chlorambucil treatment of severe rheumatoid arhtritis].
Topics: Adult; Antineoplastic Agents; Arthritis, Rheumatoid; Autoimmune Diseases; Carcinogens; Chlorambucil; | 1976 |
Fresh explant culture of human tumours in vitro and the assessment of sensitivity to cytotoxic chemotherapy.
Topics: Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Culture Techniques; Drug Evaluation, Preclini | 1975 |
Rheumatoid arthritis treated with chlorambucil: a five-year follow-up.
Topics: Acute Disease; Aged; Arthritis, Rheumatoid; Chlorambucil; Chronic Disease; Female; Follow-Up Studies | 1976 |
[Cytostatic therapy of inoperable carcinomas].
Topics: Breast Neoplasms; Bronchial Neoplasms; Chlorambucil; Choriocarcinoma; Cyclophosphamide; Dactinomycin | 1976 |
Antibodies as carriers of radionuclides and cytotoxic drugs in the treatment and diagnosis of cancer.
Topics: Animals; Antibodies, Neoplasm; Antineoplastic Agents; Chlorambucil; Female; Humans; Immunoelectropho | 1976 |
The effects of chlorambucil on the utilization of exogenous thymidine by tumour cells.
Topics: Alkylating Agents; Animals; Ascites; Cells, Cultured; Chlorambucil; DNA, Neoplasm; Neoplasm Transpla | 1975 |
Aggregation of chlorambucil in vitro may cause misinterpretation of protein binding data.
Topics: Agglutination; Antibodies, Neoplasm; Chlorambucil; Chromatography, Gel; Cytotoxicity Tests, Immunolo | 1975 |
The influence of site of metastasis on tumour growth and response to chemotherapy.
Topics: Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Female; Fluorouracil; Genital Neoplasms, Fema | 1975 |
Morphometric and colorimetric analyses of human tumor cell line growth and drug sensitivity in soft agar culture.
Topics: Bleomycin; Carmustine; Cell Division; Cell Line; Chlorambucil; Cisplatin; Colony-Forming Units Assay | 1991 |
[Neoplasms associated with chronic lymphatic leukemia. Incidence and characteristics in a series of 232 patients].
Topics: Actuarial Analysis; Adult; Aged; Aged, 80 and over; Chlorambucil; Cyclophosphamide; Female; Humans; | 1989 |
[Clinical experiences in tumor-oriented anti-cancer drugs].
Topics: Administration, Oral; Antibodies, Monoclonal; Chlorambucil; Estradiol; Estramustine; Humans; Neoplas | 1988 |
[Second malignancies and cancer chemotherapy].
Topics: Antineoplastic Agents; Chlorambucil; Hodgkin Disease; Humans; Leukemia; Melphalan; Neoplasms; Risk F | 1989 |
A phase I trial of chlorambucil administered in short pulses in patients with advanced malignancies.
Topics: Adult; Aged; Aged, 80 and over; Bone Marrow; Brain; Chlorambucil; Drug Evaluation; Female; Humans; M | 1988 |
Clinical use of interferon alfa-2b (intron-A): the Manchester experience.
Topics: Chlorambucil; Combined Modality Therapy; Drug Evaluation; Humans; Infusions, Intravenous; Injections | 1987 |
[Phase I study of bestrabucil (KM 2210)].
Topics: Adult; Aged; Animals; Anorexia; Chlorambucil; Dose-Response Relationship, Drug; Drug Administration | 1986 |
Cancer complicating Behçet's disease treated with chlorambucil.
Topics: Adult; Behcet Syndrome; Chlorambucil; Humans; Male; Neoplasms | 1986 |
Prednimustine: the rationale for clinical development.
Topics: Chlorambucil; Humans; Neoplasms; Prednimustine | 1986 |
Prednimustine.
Topics: Chlorambucil; Humans; Neoplasms; Prednimustine | 1986 |
Incidence of neoplasms in patients with rheumatoid arthritis exposed to different treatment regimens.
Topics: Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Cyclophosphamide; Cystitis; Humans; Immunosuppres | 1985 |
Determination of chlorambucil in plasma using reversed-phase high-performance liquid chromatography.
Topics: Chlorambucil; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Kinetics; Neopl | 1985 |
[Results with the cytostatic agent bleomycin in tumour therapy (author's transl)].
Topics: Adult; Aged; Bleomycin; Bronchial Neoplasms; Carcinoma, Squamous Cell; Chlorambucil; Doxorubicin; Dr | 1973 |
Antibodies as carriers of anticancer agents.
Topics: Animals; Antibodies, Neoplasm; Antigen-Antibody Reactions; Antigens, Neoplasm; Antineoplastic Agents | 1974 |
Responses of freshly cultured tumour cells to certain selected chemotherapeutic agents.
Topics: Adenocarcinoma; Antineoplastic Agents; Chlorambucil; Colchicine; Culture Techniques; Cyclophosphamid | 1968 |
[Cancer and immunosuppressive treatment. Apropos of 2 cases].
Topics: Arthritis, Rheumatoid; Autoimmune Diseases; Brain Neoplasms; Carcinoma, Squamous Cell; Chlorambucil; | 1974 |
Oxymetholone in the chemotherapy of malignant disease.
Topics: Administration, Oral; Blood Cell Count; Blood Platelets; Bone Marrow; Chlorambucil; Cyclophosphamide | 1973 |
[Chemotherapy of cancer. Hints for continuing medical education].
Topics: Antineoplastic Agents; Busulfan; Chlorambucil; Cyclophosphamide; Cytarabine; Daunorubicin; Education | 1974 |
[Clinical picture of rheumatologic diseases. Current status of cytostatic therapy].
Topics: Antineoplastic Agents; Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Cyclophosphamide; Humans; | 1974 |
[Paraproteinemic diseases].
Topics: Anemia, Hemolytic; Blood Protein Disorders; Chlorambucil; Cryoglobulins; Cyclophosphamide; Diagnosis | 1969 |
[Chemotherapy of solid tumors].
Topics: Antineoplastic Agents; Child; Chlorambucil; Cyclophosphamide; Dactinomycin; Drug Synergism; Fluorour | 1970 |
[Secondary tumors in hemoblastoses during cytostatic treatment].
Topics: Adrenal Gland Neoplasms; Aged; Antineoplastic Agents; Bronchial Neoplasms; Busulfan; Carcinoma; Chlo | 1971 |
Chemotherapy in the management of metastatic cancer of unknown primary site.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Carcinoma; Carcinoma, Squamous Cell; Chlorambucil; Cyclopho | 1972 |
Immunochemotherapy of cancer.
Topics: Animals; Antibodies; Antibody Specificity; Antigens, Neoplasm; Antineoplastic Agents; Chlorambucil; | 1972 |
[Hair changes in immunosuppressive therapy].
Topics: Antineoplastic Agents; Azathioprine; Chlorambucil; Cyclophosphamide; Hair; Humans; Immunosuppression | 1971 |
[Polychemotherapy of the advanced stages of malignant proliferative disorders].
Topics: Adult; Aged; Antineoplastic Agents; Chlorambucil; Cyclophosphamide; Female; Humans; Male; Mercaptopu | 1971 |
[Desired and undesirable effects of cytostatic therapy].
Topics: Androgens; Anti-Bacterial Agents; Antineoplastic Agents; Busulfan; Chlorambucil; Cyclophosphamide; E | 1967 |
[Internal cancer therapy: cooperative clinical studies. Principles, organization and first results of the Swiss chemotherapy group].
Topics: Adenocarcinoma; Androgens; Antibiotics, Antineoplastic; Antineoplastic Agents; Breast Neoplasms; Car | 1967 |
[Hepatotoxicity of antimitotic treatments. Effect of hepatic tests].
Topics: Adolescent; Adult; Animals; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Chlorambu | 1968 |
Is toxicity really necessary? I. The question.
Topics: Alkylating Agents; Carbamates; Chlorambucil; Fluorouracil; Humans; Leukocyte Count; Mercaptopurine; | 1966 |
Is toxicity really necessary? II. Source and analysis of data.
Topics: Alkylating Agents; Carbamates; Chlorambucil; Fluorouracil; Humans; Leukocyte Count; Leukopenia; Merc | 1966 |