chlorambucil has been researched along with Nausea in 17 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Nausea: An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this study, the usefulness of granisetron rescue therapy for nausea and vomiting induced by cancer chemotherapies, including CDDP, was examined." | 9.08 | [Efficacy of granisetron rescue therapy for nausea and vomiting induced by cancer chemotherapies in urogenital malignant tumor]. ( Akazawa, S; Inai, T; Kagawa, S; Kanayama, H; Naruo, S; Ogawa, I; Sakurai, N; Sumitani, H; Takigawa, H; Yokoseki, H, 1996) |
| "The therapeutic effect of prednimustine was studied in 35 patients with advanced breast cancer resistant to previous cytotoxic and/or endocrine therapy." | 7.66 | Phase II trial of prednimustine, L-1031, (NSC-134087) in advanced breast cancer. ( Dombernowsky, P; Kristensen, D; Mouridsen, HT; Nielsen, JH, 1980) |
| "Forty patients with lymphocytic lymphoma were treated with escalating doses of chlorambucil biweekly starting at a dose of 0." | 7.66 | Biweekly chlorambucil treatment of lymphocytic lymphoma. ( Knospe, WH; Loeb, V, 1980) |
| "Prednimustine is an ester of chlorambucil and prednisolone." | 6.65 | A phase III trial comparing prednimustine (LEO 1031) to chlorambucil plus prednisolone in advanced breast cancer. ( Christiansen, IE; Dombernowsky, P; Løber, J; Mattsson, W; Mouridsen, HT; Rørth, M, 1983) |
| "In this study, the usefulness of granisetron rescue therapy for nausea and vomiting induced by cancer chemotherapies, including CDDP, was examined." | 5.08 | [Efficacy of granisetron rescue therapy for nausea and vomiting induced by cancer chemotherapies in urogenital malignant tumor]. ( Akazawa, S; Inai, T; Kagawa, S; Kanayama, H; Naruo, S; Ogawa, I; Sakurai, N; Sumitani, H; Takigawa, H; Yokoseki, H, 1996) |
| "A group of 47 patients with advanced breast cancer were treated with a combination of prednimustine, methotrexate, 5-FU, and tamoxifen." | 3.66 | Prednimustine in combination with methotrexate and 5-FU (PMF): a pilot study. ( Boesen, E; Mouridsen, HT, 1982) |
| "The therapeutic effect of prednimustine was studied in 35 patients with advanced breast cancer resistant to previous cytotoxic and/or endocrine therapy." | 3.66 | Phase II trial of prednimustine, L-1031, (NSC-134087) in advanced breast cancer. ( Dombernowsky, P; Kristensen, D; Mouridsen, HT; Nielsen, JH, 1980) |
| "Forty patients with lymphocytic lymphoma were treated with escalating doses of chlorambucil biweekly starting at a dose of 0." | 3.66 | Biweekly chlorambucil treatment of lymphocytic lymphoma. ( Knospe, WH; Loeb, V, 1980) |
| "Patients with biopsy-proven membranous nephropathy and with a nephrotic syndrome were randomized to be given methylprednisolone (1 g intravenously for 3 consecutive days followed by oral methylprednisolone, 0." | 2.69 | A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy. ( Altieri, P; Antonucci, F; Bellazzi, R; Cesana, B; Dugo, M; Farina, M; Grassi, C; Lupo, A; Melis, P; Minari, M; Pasquali, S; Passerini, P; Pedrini, L; Piccoli, G; Pisano, G; Ponticelli, C; Pozzi, C; Roccatello, D; Sasdelli, M; Scalia, A; Scolari, F; Segagni, S; Valzorio, B, 1998) |
| "Prednimustine is an ester of chlorambucil and prednisolone." | 2.65 | A phase III trial comparing prednimustine (LEO 1031) to chlorambucil plus prednisolone in advanced breast cancer. ( Christiansen, IE; Dombernowsky, P; Løber, J; Mattsson, W; Mouridsen, HT; Rørth, M, 1983) |
| "46 ambulatory patients with chronic lymphocytic leukemia were treated with Prednimustine either continuously (daily or each other day 20 mg) or intermittently (daily 20 mg for 14 days, followed by a pause of 4 weeks)." | 2.64 | [Effect of Prednimustine (Leo 1031) in chronic lymphatic leukemia]. ( Böhnel, J; Lutz, D, 1977) |
| "Disseminated germ cell testicular cancer proved to be highly sensitive to platinum-containing chemotherapy regimens." | 1.27 | Vinblastine, actinomycin D, bleomycin, cyclophosphamide and cis-platinum for advanced germ cell testis tumors: Brazilian experience. ( de Góes, GM; Simon, SD; Srougi, M, 1985) |
| "Estramustine has been shown previously to be an effective drug in the treatment of metastatic prostatic cancer, demonstrating significant objective and subjective responses in long-term non-randomized trials and in other randomized trials." | 1.26 | The use of estramustine and prednimustine versus prednimustine alone in advanced metastatic prostatic cancer patients who have received prior irradiation. ( Chu, TM; Gaeta, JF; Gibbons, RP; Johnson, DE; Loening, SA; Murphy, GP; Prout, GR; Saroff, J; Schmidt, JD; Scott, WW; Slack, N; Soloway, MS; Wajsman, Z, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (70.59) | 18.7374 |
| 1990's | 2 (11.76) | 18.2507 |
| 2000's | 1 (5.88) | 29.6817 |
| 2010's | 2 (11.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ghoneim, AM | 1 |
| Tadros, MI | 1 |
| Alaa-Eldin, AA | 1 |
| Knauf, WU | 1 |
| Lissichkov, T | 1 |
| Aldaoud, A | 1 |
| Liberati, A | 1 |
| Loscertales, J | 1 |
| Herbrecht, R | 1 |
| Juliusson, G | 1 |
| Postner, G | 1 |
| Gercheva, L | 1 |
| Goranov, S | 1 |
| Becker, M | 1 |
| Fricke, HJ | 1 |
| Huguet, F | 1 |
| Del Giudice, I | 1 |
| Klein, P | 1 |
| Tremmel, L | 1 |
| Merkle, K | 1 |
| Montillo, M | 1 |
| Else, M | 1 |
| Cocks, K | 1 |
| Crofts, S | 1 |
| Wade, R | 1 |
| Richards, SM | 1 |
| Catovsky, D | 1 |
| Smith, AG | 1 |
| Vugrin, D | 1 |
| Whitmore, WF | 1 |
| Løber, J | 1 |
| Mouridsen, HT | 3 |
| Christiansen, IE | 1 |
| Dombernowsky, P | 2 |
| Mattsson, W | 1 |
| Rørth, M | 1 |
| Boesen, E | 1 |
| Kristensen, D | 1 |
| Nielsen, JH | 1 |
| Knospe, WH | 1 |
| Loeb, V | 1 |
| Takigawa, H | 1 |
| Naruo, S | 1 |
| Kanayama, H | 1 |
| Kagawa, S | 1 |
| Yokoseki, H | 1 |
| Inai, T | 1 |
| Sumitani, H | 1 |
| Sakurai, N | 1 |
| Ogawa, I | 1 |
| Akazawa, S | 1 |
| Ponticelli, C | 1 |
| Altieri, P | 1 |
| Scolari, F | 1 |
| Passerini, P | 1 |
| Roccatello, D | 1 |
| Cesana, B | 1 |
| Melis, P | 1 |
| Valzorio, B | 1 |
| Sasdelli, M | 1 |
| Pasquali, S | 1 |
| Pozzi, C | 1 |
| Piccoli, G | 1 |
| Lupo, A | 1 |
| Segagni, S | 1 |
| Antonucci, F | 1 |
| Dugo, M | 1 |
| Minari, M | 1 |
| Scalia, A | 1 |
| Pedrini, L | 1 |
| Pisano, G | 1 |
| Grassi, C | 1 |
| Farina, M | 1 |
| Bellazzi, R | 1 |
| Lutz, D | 1 |
| Böhnel, J | 1 |
| Murphy, GP | 2 |
| Gibbons, RP | 1 |
| Johnson, DE | 1 |
| Prout, GR | 1 |
| Schmidt, JD | 1 |
| Soloway, MS | 1 |
| Loening, SA | 1 |
| Chu, TM | 1 |
| Gaeta, JF | 1 |
| Saroff, J | 1 |
| Wajsman, Z | 1 |
| Slack, N | 1 |
| Scott, WW | 1 |
| Slack, NH | 1 |
| Srougi, M | 1 |
| Simon, SD | 1 |
| de Góes, GM | 1 |
| Leonard, RC | 2 |
| Lucraft, HH | 2 |
| Proctor, SJ | 1 |
| Allan, NC | 1 |
| Dawson, AA | 1 |
| McGillivray, JB | 1 |
| Parker, AC | 1 |
| Prescott, RJ | 1 |
| Mead, GM | 1 |
| Williams, CJ | 1 |
| Whitehouse, JM | 1 |
| Senyszyn, JJ | 1 |
| Johnson, RE | 1 |
| Curran, RE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Retrospective Multicenter Trial on Efficacy and Toxicity of Bendamustine Alone or Associated With Rituximab, As Salvage Therapy in Patients With Chronic Lymphoproliferative Disorders[NCT01832597] | 109 participants (Actual) | Observational | 2010-11-30 | Completed | |||
| A Phase I/II Study of Bendamustine, Lenalidomide and Low-dose Dexamethasone, (BdL) for the Treatment of Patients With Relapsed Myeloma.[NCT01686386] | Phase 1/Phase 2 | 60 participants (Anticipated) | Interventional | 2010-02-28 | Recruiting | ||
| Chronic Lymphocytic Leukemia Trial 4: A Randomized Comparison of Chlorambucil, Fludarabine and Fludarabine Plus Cyclophosphamide[NCT00004218] | Phase 3 | 0 participants | Interventional | 1999-10-31 | Completed | ||
| Clinical Study of Rituximab or Cyclophosphamide Combined With Steroids in the Treatment of Idiopathic Membranous Nephropathy[NCT05514015] | Phase 4 | 72 participants (Anticipated) | Interventional | 2022-08-25 | Not yet recruiting | ||
| Random, Open, Control and Monocentric Clinical Research on Tacrolimus Monotherapy for Idiopathic Membranous Nephropathy (IMN)[NCT03549663] | 108 participants (Anticipated) | Interventional | 2018-07-04 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 trials available for chlorambucil and Nausea
| Article | Year |
|---|---|
Phase III randomized study of bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukemia.
Topics: Adult; Aged; Antineoplastic Agents; Bendamustine Hydrochloride; Chlorambucil; Disease-Free Survival; | 2009 |
Phase III randomized study of bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukemia.
Topics: Adult; Aged; Antineoplastic Agents; Bendamustine Hydrochloride; Chlorambucil; Disease-Free Survival; | 2009 |
Phase III randomized study of bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukemia.
Topics: Adult; Aged; Antineoplastic Agents; Bendamustine Hydrochloride; Chlorambucil; Disease-Free Survival; | 2009 |
Phase III randomized study of bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukemia.
Topics: Adult; Aged; Antineoplastic Agents; Bendamustine Hydrochloride; Chlorambucil; Disease-Free Survival; | 2009 |
Quality of life in chronic lymphocytic leukemia: 5-year results from the multicenter randomized LRF CLL4 trial.
Topics: Adult; Aged; Aged, 80 and over; Alopecia; Antineoplastic Combined Chemotherapy Protocols; Chlorambuc | 2012 |
A phase III trial comparing prednimustine (LEO 1031) to chlorambucil plus prednisolone in advanced breast cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chlorambucil; Clinica | 1983 |
[Efficacy of granisetron rescue therapy for nausea and vomiting induced by cancer chemotherapies in urogenital malignant tumor].
Topics: Adult; Aged; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; C | 1996 |
A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy.
Topics: Adolescent; Adult; Aged; Amenorrhea; Anemia; Antineoplastic Agents, Alkylating; Carcinoma; Chlorambu | 1998 |
A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy.
Topics: Adolescent; Adult; Aged; Amenorrhea; Anemia; Antineoplastic Agents, Alkylating; Carcinoma; Chlorambu | 1998 |
A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy.
Topics: Adolescent; Adult; Aged; Amenorrhea; Anemia; Antineoplastic Agents, Alkylating; Carcinoma; Chlorambu | 1998 |
A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy.
Topics: Adolescent; Adult; Aged; Amenorrhea; Anemia; Antineoplastic Agents, Alkylating; Carcinoma; Chlorambu | 1998 |
[Effect of Prednimustine (Leo 1031) in chronic lymphatic leukemia].
Topics: Adult; Aged; Chlorambucil; Clinical Trials as Topic; Drug Combinations; Drug Evaluation; Female; Gin | 1977 |
Treatment of metastatic Ewing's sarcoma with actinomycin D (NSC-3053).
Topics: Adolescent; Adult; Child; Chlorambucil; Clinical Trials as Topic; Cyclophosphamide; Dactinomycin; Hu | 1970 |
10 other studies available for chlorambucil and Nausea
| Article | Year |
|---|---|
Spray-Dried Silica Xerogel Nanoparticles as a Promising Gastroretentive Carrier System for the Management of Chemotherapy-Induced Nausea and Vomiting.
Topics: Animals; Antineoplastic Agents; Chlorambucil; Drug Delivery Systems; Drug Liberation; Gels; Male; Na | 2019 |
The VAB-6 regimen in the treatment of metastatic seminoma.
Topics: Abdominal Neoplasms; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Cispla | 1984 |
Prednimustine in combination with methotrexate and 5-FU (PMF): a pilot study.
Topics: Aged; Alopecia; Breast Neoplasms; Chlorambucil; Drug Therapy, Combination; Female; Fluorouracil; Hum | 1982 |
Phase II trial of prednimustine, L-1031, (NSC-134087) in advanced breast cancer.
Topics: Adult; Aged; Breast Neoplasms; Chlorambucil; Drug Evaluation; Female; Humans; Leukopenia; Middle Age | 1980 |
Biweekly chlorambucil treatment of lymphocytic lymphoma.
Topics: Antineoplastic Agents; Chlorambucil; Drug Evaluation; Drug Therapy, Combination; Follow-Up Studies; | 1980 |
The use of estramustine and prednimustine versus prednimustine alone in advanced metastatic prostatic cancer patients who have received prior irradiation.
Topics: Chlorambucil; Drug Therapy, Combination; Estramustine; Humans; Male; Nausea; Neoplasm Metastasis; Ni | 1979 |
Prednimustine for prostate cancer therapy.
Topics: Chlorambucil; Estramustine; Hematopoiesis; Humans; Male; Nausea; Prednimustine; Prostatic Neoplasms; | 1979 |
Vinblastine, actinomycin D, bleomycin, cyclophosphamide and cis-platinum for advanced germ cell testis tumors: Brazilian experience.
Topics: Adult; Alopecia; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Brazil; Chlorambucil; Ci | 1985 |
Methylprednisolone, etoposide, vindesine, and chlorambucil (PEEC) alone or alternating with CHOP as initial or salvage therapy for non-Hodgkin's lymphoma.
Topics: Adult; Aged; Alopecia; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Cyclophosphamid | 1988 |
Cisplatin, adriamycin and cyclophosphamide (PACe) combination chemotherapy in patients with ovarian carcinoma resistant to chlorambucil.
Topics: Alopecia; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Cisplatin; Cyclophosphamide; | 1985 |