chlorambucil has been researched along with Myasthenia Gravis in 4 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Myasthenia Gravis: A disorder of neuromuscular transmission characterized by fatigable weakness of cranial and skeletal muscles with elevated titers of ACETYLCHOLINE RECEPTORS or muscle-specific receptor tyrosine kinase (MuSK) autoantibodies. Clinical manifestations may include ocular muscle weakness (fluctuating, asymmetric, external ophthalmoplegia; diplopia; ptosis; and weakness of eye closure) and extraocular fatigable weakness of facial, bulbar, respiratory, and proximal limb muscles. The disease may remain limited to the ocular muscles (ocular myasthenia). THYMOMA is commonly associated with this condition.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Radical excision of the tumor, if possible, and the remaining thymus, high dosage alternate day prednisone, and radiation therapy, if indicated, seem the treatments of choice." | 1.25 | Myasthenia gravis and invasive thymoma: a 20-year experience. ( Brown, WJ; Goldman, AJ; Herrmann, C; Keesey, JC; Mulder, DG, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Oosterhuis, HJ | 1 |
| Limburg, PC | 1 |
| Hummel-Tappel, E | 1 |
| The, TH | 1 |
| Dau, PC | 1 |
| Goldman, AJ | 1 |
| Herrmann, C | 1 |
| Keesey, JC | 1 |
| Mulder, DG | 1 |
| Brown, WJ | 1 |
| Skinner, MD | 1 |
| Schwartz, RS | 1 |
1 review available for chlorambucil and Myasthenia Gravis
| Article | Year |
|---|---|
Immunosuppressive therapy. 2.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Adult; Azathioprine; Child; Chlorambucil; Clin | 1972 |
1 trial available for chlorambucil and Myasthenia Gravis
| Article | Year |
|---|---|
Immunosuppressive therapy. 2.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Adult; Azathioprine; Child; Chlorambucil; Clin | 1972 |
3 other studies available for chlorambucil and Myasthenia Gravis
| Article | Year |
|---|---|
Anti-acetylcholine receptor antibodies in myasthenia gravis. Part 2. Clinical and serological follow-up of individual patients.
Topics: Adolescent; Adult; Aged; Autoantibodies; Azathioprine; Child; Chlorambucil; Female; Humans; Male; Mi | 1983 |
Plasmapheresis in myasthenia gravis.
Topics: Adult; Aged; Autoantibodies; Azathioprine; Chlorambucil; Cyclophosphamide; Female; Humans; Immunosup | 1982 |
Myasthenia gravis and invasive thymoma: a 20-year experience.
Topics: Adult; Aged; Chlorambucil; Cyclophosphamide; Female; Humans; Male; Middle Aged; Myasthenia Gravis; N | 1975 |