chlorambucil has been researched along with Multiple Sclerosis in 18 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Immunological and clinical functions were studied over a 2 year period in conjunction with a placebo controlled trial of isoprinosine and chlorambucil in 21 patients with exacerbating remitting multiple sclerosis." | 9.06 | Immunosuppressive effects of isoprinosine in man: a comparison to chlorambucil effects in multiple sclerosis. ( Buge, A; Cour, V; Delsaux, MC; Meunier, C; Pompidou, A; Rancurel, G; Telvi, L, 1987) |
| "Thirty-three patients with chronic progressive multiple sclerosis (MS) were assigned to intervention groups receiving monthly pulses of chlorambucil (CB) for about one year." | 7.68 | Preferential reductions in lymphocyte sub-populations induced by monthly pulses of chlorambucil: studies in patients with chronic progressive multiple sclerosis. ( Chiappelli, F; Ellison, GW; Fahey, JL; Liao, D; Myers, LW, 1991) |
| "A new case is reported here of acute myeloid leukemia after chlorambucil therapy for multiple sclerosis." | 7.67 | [Acute leukemia secondary to the treatment of multiple sclerosis with chlorambucil]. ( Aymard, JP; Barroche, G; Conroy, T; Humbert, JC; Lederlin, P; Streiff, F; Witz, F, 1985) |
| "Immunological and clinical functions were studied over a 2 year period in conjunction with a placebo controlled trial of isoprinosine and chlorambucil in 21 patients with exacerbating remitting multiple sclerosis." | 5.06 | Immunosuppressive effects of isoprinosine in man: a comparison to chlorambucil effects in multiple sclerosis. ( Buge, A; Cour, V; Delsaux, MC; Meunier, C; Pompidou, A; Rancurel, G; Telvi, L, 1987) |
| "Thirty-three patients with chronic progressive multiple sclerosis (MS) were assigned to intervention groups receiving monthly pulses of chlorambucil (CB) for about one year." | 3.68 | Preferential reductions in lymphocyte sub-populations induced by monthly pulses of chlorambucil: studies in patients with chronic progressive multiple sclerosis. ( Chiappelli, F; Ellison, GW; Fahey, JL; Liao, D; Myers, LW, 1991) |
| "A new case is reported here of acute myeloid leukemia after chlorambucil therapy for multiple sclerosis." | 3.67 | [Acute leukemia secondary to the treatment of multiple sclerosis with chlorambucil]. ( Aymard, JP; Barroche, G; Conroy, T; Humbert, JC; Lederlin, P; Streiff, F; Witz, F, 1985) |
| "A case of acute myeloblastic leukaemia is reported in a patient treated with chlorambucil during 72 months for multiple sclerosis." | 3.66 | Acute leukaemia after prolonged chlorambucil treatment for non-malignant disease: report of a new case and literature survey. ( Aymard, JP; Colomb, JN; Frustin, J; Herbeuval, R; Lederlin, P; Witz, F, 1980) |
| "The mean mutant frequency before treatment for six multiple sclerosis patients treated with high-dose CP was 2." | 1.31 | Induction of mutant lymphocytes in cyclophosphamide- and chlorambucil-treated patients. ( Henner, WD; Johnson, KJ; Sanderson, BJ, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (88.89) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 1 (5.56) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ellison, GW | 2 |
| Myers, LW | 2 |
| Aymard, JP | 3 |
| Lederlin, P | 3 |
| Witz, F | 3 |
| Rumilly, F | 1 |
| Eisemann, JC | 1 |
| Buisine, J | 1 |
| Gregoire, MJ | 1 |
| Guerci, O | 1 |
| Streiff, F | 2 |
| Frustin, J | 1 |
| Colomb, JN | 1 |
| Herbeuval, R | 1 |
| Olszewska, Z | 1 |
| Arkuszewska, C | 1 |
| Najman, A | 1 |
| Gorin, NC | 1 |
| Duhamel, G | 1 |
| Roger, M | 1 |
| Dry, J | 1 |
| Sanderson, BJ | 1 |
| Johnson, KJ | 1 |
| Henner, WD | 1 |
| Tchernia, G | 1 |
| Mielot, F | 1 |
| Subtil, E | 1 |
| Parmentier, C | 1 |
| Chiappelli, F | 1 |
| Liao, D | 1 |
| Fahey, JL | 1 |
| Pompidou, A | 1 |
| Rancurel, G | 1 |
| Delsaux, MC | 1 |
| Meunier, C | 1 |
| Telvi, L | 1 |
| Cour, V | 1 |
| Buge, A | 1 |
| Conroy, T | 1 |
| Humbert, JC | 1 |
| Barroche, G | 1 |
| Cendrowski, WS | 1 |
| Cendrowski, W | 1 |
| Moskalewska, K | 1 |
| Plonka, T | 1 |
| Niedzielska, K | 1 |
| Bonnet, M | 1 |
| Sigwald, J | 1 |
| Mazalton, A | 1 |
| Raymondeaud, C | 1 |
| Piot, C | 1 |
| Jacquillat, C | 1 |
| Hervet, E | 1 |
| Barrat, J | 1 |
| Darbois, Y | 1 |
| Faguer, C | 1 |
| Skinner, MD | 1 |
| Schwartz, RS | 1 |
| Steinberg, AD | 1 |
| Perkins, ES | 1 |
6 reviews available for chlorambucil and Multiple Sclerosis
| Article | Year |
|---|---|
Immunosuppressive drugs in multiple sclerosis: pro and con.
Topics: Adrenocorticotropic Hormone; Alkylating Agents; Antimetabolites; Azathioprine; Chlorambucil; Cycloph | 1980 |
Acute leukaemia following prolonged chlorambucil treatment for non-neoplastic disease - a study of two cases and literature review.
Topics: Adult; Aged; Chlorambucil; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Leukemia | 1983 |
[Immunodepressors in ophthalmology].
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Antibiotics, Antineoplastic; Antilymphocyte Se | 1971 |
Immunosuppressive therapy. 2.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Adult; Azathioprine; Child; Chlorambucil; Clin | 1972 |
An approach to the use of immunosuppressive drugs in nonmalignant diseases.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Chlorambucil; Cyclophosphamide; G | 1973 |
Recent advances in the study of uveitis.
Topics: Adult; Antibodies; Antigen-Antibody Reactions; Aqueous Humor; Azathioprine; Cell Migration Inhibitio | 1974 |
2 trials available for chlorambucil and Multiple Sclerosis
| Article | Year |
|---|---|
Immunosuppressive effects of isoprinosine in man: a comparison to chlorambucil effects in multiple sclerosis.
Topics: Adult; Chlorambucil; Clinical Trials as Topic; Double-Blind Method; Humans; Hypersensitivity, Delaye | 1987 |
Immunosuppressive therapy. 2.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Adult; Azathioprine; Child; Chlorambucil; Clin | 1972 |
11 other studies available for chlorambucil and Multiple Sclerosis
| Article | Year |
|---|---|
Acute leukaemia after prolonged chlorambucil treatment for non-malignant disease: report of a new case and literature survey.
Topics: Adult; Chlorambucil; Female; Humans; Immunosuppression Therapy; Leukemia, Myeloid, Acute; Multiple S | 1980 |
[Remote results of leukeran treatment of multiple sclerosis based on systematic clinical and paraclinical follow-up].
Topics: Adult; Chlorambucil; Female; Follow-Up Studies; Humans; Middle Aged; Multiple Sclerosis; Time Factor | 1981 |
[Acute myelofibrosis after chlorambucil treatment (author's transl)].
Topics: Acute Disease; Chlorambucil; Humans; Male; Middle Aged; Multiple Sclerosis; Primary Myelofibrosis | 1980 |
Induction of mutant lymphocytes in cyclophosphamide- and chlorambucil-treated patients.
Topics: Adult; Antineoplastic Agents, Alkylating; Chlorambucil; Cyclophosphamide; DNA Mutational Analysis; D | 2001 |
Acute myeloblastic leukemia after immunodepressive therapy for primary nonmalignant disease.
Topics: Arthritis, Rheumatoid; Bone Marrow; Bone Marrow Cells; Chlorambucil; Cyclophosphamide; Diagnosis, Di | 1976 |
Preferential reductions in lymphocyte sub-populations induced by monthly pulses of chlorambucil: studies in patients with chronic progressive multiple sclerosis.
Topics: Antigens, CD; Azathioprine; Chlorambucil; Cyclophosphamide; Dose-Response Relationship, Drug; Drug E | 1991 |
[Acute leukemia secondary to the treatment of multiple sclerosis with chlorambucil].
Topics: Adult; Alkylating Agents; Chlorambucil; Female; Humans; Immunosuppressive Agents; Leukemia, Myeloid, | 1985 |
Multiple sclerosis: pilot therapeutic trial of immunosuppressants.
Topics: Adrenocorticotropic Hormone; Adult; Chlorambucil; Cyclophosphamide; Female; Humans; Immunosuppressiv | 1969 |
[Plant agglutinin- and PPD tuberculin-stimulated lymphocyte transformation in vitro in patients with disseminated sclerosis].
Topics: Adrenocorticotropic Hormone; Adult; Azathioprine; Chlorambucil; Cyclophosphamide; Female; Humans; Le | 1971 |
[Critic study of multiple sclerosis treatment by chlorambucil and intraspinal corticotherapy. Apropos of 100 cases followed up from 2 to 9 years].
Topics: Acetates; Adrenocorticotropic Hormone; Adult; Amenorrhea; Chlorambucil; Female; Follow-Up Studies; H | 1973 |
[Letter: Teratogenic effects of medications].
Topics: Abnormalities, Drug-Induced; Adult; Chlorambucil; Female; Humans; Hydroxyurea; Leukemia, Lymphoid; M | 1974 |