chlorambucil has been researched along with Multiple Primary Neoplasms in 15 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chlorambucil and melphalan were the most leukemogenic drugs, followed by thiotepa; cyclophosphamide and treosulfan were the weakest leukemogens, and the effect per gram was substantially lower at high doses than at lower doses." | 2.67 | Leukemia following chemotherapy for ovarian cancer. ( Bell, J; Clarke, EA; Day, NE; Høst, H; Kaldor, JM; Karjalainen, S; Mehnert, W; Pedersen, D; Pettersson, F; Prior, P, 1990) |
| "We report a new case of coincidence of chronic lymphocytic leukemia (CLL) and mixed cellularity Hodgkin's disease (HD) in the same lymph node." | 1.29 | [Coexistence of chronic lymphoid leukemia and Hodgkin's disease. Immunohistochemical study]. ( Fresno, MF; González, M; Herrero, A; Pérez del Río, MJ; Ramírez, A; Veiga, M, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (53.33) | 18.7374 |
| 1990's | 3 (20.00) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 1 (6.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schauer, C | 1 |
| Cunliffe, R | 1 |
| Geerts, ML | 1 |
| Hamers, J | 1 |
| Schwarze, EW | 1 |
| Kint, A | 1 |
| Roels, H | 1 |
| Lennert, K | 1 |
| Morales, PH | 1 |
| Fayos, JV | 1 |
| Falk, S | 1 |
| Walther, F | 1 |
| Denk, R | 1 |
| Pérez del Río, MJ | 1 |
| Fresno, MF | 1 |
| Ramírez, A | 1 |
| Veiga, M | 1 |
| González, M | 1 |
| Herrero, A | 1 |
| Lesesve, JF | 1 |
| Feugier, P | 1 |
| Lamy, T | 1 |
| Béné, MC | 1 |
| Grégoire, MJ | 1 |
| Lenormand, B | 1 |
| Loughran, T | 1 |
| Hall, RL | 1 |
| Leahy, MF | 1 |
| Volk, AL | 1 |
| Vannucci, SA | 1 |
| Cook, W | 1 |
| Thompson, KA | 1 |
| Listinsky, CM | 1 |
| Queisser, W | 1 |
| Kalb, M | 1 |
| Morrison, J | 1 |
| Yon, JL | 1 |
| Kaldor, JM | 1 |
| Day, NE | 1 |
| Pettersson, F | 1 |
| Clarke, EA | 1 |
| Pedersen, D | 1 |
| Mehnert, W | 1 |
| Bell, J | 1 |
| Høst, H | 1 |
| Prior, P | 1 |
| Karjalainen, S | 1 |
| Iwasaki, M | 1 |
| Kazama, T | 1 |
| Nakada, T | 1 |
| Katayama, T | 1 |
| Sahakian, GJ | 1 |
| al-Mondhiry, H | 1 |
| Lacher, MJ | 1 |
| Connolly, CE | 1 |
| Gudgeon, DH | 1 |
| Gunz, FW | 1 |
| Levi, JA | 1 |
| Lind, DE | 1 |
| Vincent, PC | 1 |
2 reviews available for chlorambucil and Multiple Primary Neoplasms
| Article | Year |
|---|---|
[Metastatic malignant melanoma in treated non-Hodgkin's lymphoma].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Humans; Lymph Nodes; Lymphatic | 1996 |
[A case report of extragonadal germ cell tumor with special reference to VAB-6 therapy].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Bleomycin; Chlorambucil; C | 1988 |
1 trial available for chlorambucil and Multiple Primary Neoplasms
| Article | Year |
|---|---|
Leukemia following chemotherapy for ovarian cancer.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Case-Control Studie | 1990 |
12 other studies available for chlorambucil and Multiple Primary Neoplasms
| Article | Year |
|---|---|
Marginal Zone Lymphoma of the Entire Gastrointestinal Tract.
Topics: Aged, 80 and over; Antineoplastic Agents, Alkylating; Chlorambucil; Colonic Neoplasms; Duodenal Neop | 2018 |
Mycosis fungoides and lymphoplasmacytoid immunocytoma in the same patient. A case report.
Topics: Chlorambucil; Cytoplasm; Female; Hematologic Tests; Humans; Immunoglobulin lambda-Chains; Immunoglob | 1984 |
Epithelial carcinoma of the ovary.
Topics: Adolescent; Adult; Aged; Biopsy; Carcinoma; Chlorambucil; Female; Follow-Up Studies; Humans; Hystere | 1981 |
[Coexistence of chronic lymphoid leukemia and Hodgkin's disease. Immunohistochemical study].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Hodgkin Disease; Humans; Immunop | 1996 |
Association of B-chronic lymphocytic leukaemia and T-large granular lymphocyte leukaemia.
Topics: Aged; Aged, 80 and over; CD56 Antigen; Chlorambucil; Cytogenetics; Fatal Outcome; Gene Rearrangement | 2000 |
Acquired Factor VIII autoantibody: four cases demonstrating the heterogenous nature of this condition and problems involved in diagnosis and treatment.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Autoantibodies; Autoimmune Diseases; Azathiop | 2001 |
Composite mycosis fungoides and B-cell chronic lymphocytic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carmustine; Chlorambucil; Combined Modality Therapy; | 2002 |
[Secondary carcinoma: a complication of cytostatic therapy?].
Topics: Antineoplastic Agents; Breast Neoplasms; Carcinogens; Chlorambucil; Female; Humans; Immunosuppressio | 1979 |
Acute leukemia following chlorambucil therapy of advanced ovarian and fallopian tube carcinoma.
Topics: Acute Disease; Carcinoma; Chlorambucil; Fallopian Tube Neoplasms; Female; Humans; Leukemia; Middle A | 1978 |
Acute leukemia in Hodgkin's disease.
Topics: Adult; Bleomycin; Carmustine; Chlorambucil; Drug Therapy, Combination; Female; Hodgkin Disease; Huma | 1974 |
Mixed mesodermal tumour of the uterus occurring after radiotherapy.
Topics: Aged; Chlorambucil; Cystadenoma; Female; Humans; Neoplasms, Germ Cell and Embryonal; Neoplasms, Mult | 1968 |
Development of acute leukaemia in a patient with lymphosarcoma.
Topics: Autopsy; Bone Marrow; Bone Marrow Cells; Chlorambucil; Humans; Immunoglobulins; Karyotyping; Leukemi | 1973 |