Page last updated: 2024-10-24

chlorambucil and Monosomy

chlorambucil has been researched along with Monosomy in 2 studies

Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.

Monosomy: The condition in which one chromosome of a pair is missing. In a normally diploid cell it is represented symbolically as 2N-1.

Research Excerpts

ExcerptRelevanceReference
" We recently observed a 39-year-old female patient with Behçet's disease developing a myelodysplastic syndrome (MDS) FAB subtype refractory anemia with excess of blasts in transformation [RAEB-t] with a monosomy 7 after being treated with cyclosporin A and chlorambucil for several years."3.70Myelodysplastic syndrome with monosomy 7 after immunosuppressive therapy in Behçet's disease. ( Bangerter, M; Griesshammer, M; Hafner, M; Heil, G; Heiss, M; Kern, P; Kern, W; Krauter, J; v Tirpitz, C, 1999)
"Cytogenetic analysis showed complex chromosomal abnormalities including 5q deletion, 12p deletion and monosomy 18."1.33Myelodysplastic syndrome with complex karyotypic abnormality in a patient with Waldenström's macroglobulinemia after sequential treatment with chlorambucil and fludarabine. ( Cho, HS; Chun, SH; Hyun, MS; Kim, KO; Kim, MK; Lee, KH; Shin, SJ, 2005)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (50.00)18.2507
2000's1 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Shin, SJ1
Chun, SH1
Kim, KO1
Kim, MK1
Lee, KH1
Hyun, MS1
Cho, HS1
Bangerter, M1
Griesshammer, M1
v Tirpitz, C1
Krauter, J1
Heil, G1
Hafner, M1
Kern, W1
Heiss, M1
Kern, P1

Other Studies

2 other studies available for chlorambucil and Monosomy

ArticleYear
Myelodysplastic syndrome with complex karyotypic abnormality in a patient with Waldenström's macroglobulinemia after sequential treatment with chlorambucil and fludarabine.
    Japanese journal of clinical oncology, 2005, Volume: 35, Issue:10

    Topics: Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow

2005
Myelodysplastic syndrome with monosomy 7 after immunosuppressive therapy in Behçet's disease.
    Scandinavian journal of rheumatology, 1999, Volume: 28, Issue:2

    Topics: Adult; Antineoplastic Agents, Alkylating; Behcet Syndrome; Bone Marrow Cells; Chlorambucil; Chromoso

1999