chlorambucil has been researched along with Monosomy in 2 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Monosomy: The condition in which one chromosome of a pair is missing. In a normally diploid cell it is represented symbolically as 2N-1.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We recently observed a 39-year-old female patient with Behçet's disease developing a myelodysplastic syndrome (MDS) FAB subtype refractory anemia with excess of blasts in transformation [RAEB-t] with a monosomy 7 after being treated with cyclosporin A and chlorambucil for several years." | 3.70 | Myelodysplastic syndrome with monosomy 7 after immunosuppressive therapy in Behçet's disease. ( Bangerter, M; Griesshammer, M; Hafner, M; Heil, G; Heiss, M; Kern, P; Kern, W; Krauter, J; v Tirpitz, C, 1999) |
| "Cytogenetic analysis showed complex chromosomal abnormalities including 5q deletion, 12p deletion and monosomy 18." | 1.33 | Myelodysplastic syndrome with complex karyotypic abnormality in a patient with Waldenström's macroglobulinemia after sequential treatment with chlorambucil and fludarabine. ( Cho, HS; Chun, SH; Hyun, MS; Kim, KO; Kim, MK; Lee, KH; Shin, SJ, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shin, SJ | 1 |
| Chun, SH | 1 |
| Kim, KO | 1 |
| Kim, MK | 1 |
| Lee, KH | 1 |
| Hyun, MS | 1 |
| Cho, HS | 1 |
| Bangerter, M | 1 |
| Griesshammer, M | 1 |
| v Tirpitz, C | 1 |
| Krauter, J | 1 |
| Heil, G | 1 |
| Hafner, M | 1 |
| Kern, W | 1 |
| Heiss, M | 1 |
| Kern, P | 1 |
2 other studies available for chlorambucil and Monosomy
| Article | Year |
|---|---|
Myelodysplastic syndrome with complex karyotypic abnormality in a patient with Waldenström's macroglobulinemia after sequential treatment with chlorambucil and fludarabine.
Topics: Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow | 2005 |
Myelodysplastic syndrome with monosomy 7 after immunosuppressive therapy in Behçet's disease.
Topics: Adult; Antineoplastic Agents, Alkylating; Behcet Syndrome; Bone Marrow Cells; Chlorambucil; Chromoso | 1999 |