chlorambucil has been researched along with Menopause in 14 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Menopause: The last menstrual period. Permanent cessation of menses (MENSTRUATION) is usually defined after 6 to 12 months of AMENORRHEA in a woman over 45 years of age. In the United States, menopause generally occurs in women between 48 and 55 years of age.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare two adjuvant combination chemotherapies, cyclophosphamide, methotrexate, and fluorouracil (CMF) and chlorambucil, methotrexate, and fluorouracil (LMF), for patients who had undergone potentially curative surgery for unilateral breast cancer, in terms of relapse, survival, and toxicity." | 9.08 | Adjuvant chemotherapy in operable breast cancer: cyclophosphamide, methotrexate, and fluorouracil versus chlorambucil, methotrexate, and fluorouracil--11-year results of Swiss Group for Clinical Cancer Research trial SAKK 27/82. ( Castiglione, M; Cavalli, F; Jungi, WF; Leyvraz, S; Maibach, R; Obrecht, JP; Schildknecht, O; Senn, HJ; Siegenthaler, P, 1997) |
| "Thirty-four women with first recurrence of breast cancer were randomized into two groups, and received either Diethylstilbestrol (DES) 5 mg orally (PO) t." | 9.04 | Comparison of DES vs DES + chlorambucil in women with first recurrence of breast cancer. ( Harvey, HA; Holzer, D; Lipton, A, 1979) |
| "Forty-seven patients with advanced breast cancer were treated with a combination of prednimustine (P), methotrexate (M), 5-fluorouracil (F), and tamoxifen (TAM)." | 7.66 | Prednimustine in combination with methotrexate and 5-fluorouracil in advanced breast cancer: a phase I-II study. ( Boesen, E; Mouridsen, HT, 1983) |
| "To compare two adjuvant combination chemotherapies, cyclophosphamide, methotrexate, and fluorouracil (CMF) and chlorambucil, methotrexate, and fluorouracil (LMF), for patients who had undergone potentially curative surgery for unilateral breast cancer, in terms of relapse, survival, and toxicity." | 5.08 | Adjuvant chemotherapy in operable breast cancer: cyclophosphamide, methotrexate, and fluorouracil versus chlorambucil, methotrexate, and fluorouracil--11-year results of Swiss Group for Clinical Cancer Research trial SAKK 27/82. ( Castiglione, M; Cavalli, F; Jungi, WF; Leyvraz, S; Maibach, R; Obrecht, JP; Schildknecht, O; Senn, HJ; Siegenthaler, P, 1997) |
| "We report the results of a randomized trial carried out by the Swiss Group for Clinical Cancer Research (SAKK) and in which 230 patients with advanced breast cancer receiving concurrently a hormonal treatment (oophorectomy for pre- and tamoxifen for postmenopausal women) were randomly allocated to three different regimens of combination chemotherapy." | 5.05 | Randomized trial of 3 different regimens of combination chemotherapy in patients receiving simultaneously a hormonal treatment for advanced breast cancer. ( Alberto, P; Brunner, KW; Cavalli, F; Goldhirsch, A; Jungi, WF; Martz, G; Mermillod, B; Pedrazzini, A, 1983) |
| "Thirty-four women with first recurrence of breast cancer were randomized into two groups, and received either Diethylstilbestrol (DES) 5 mg orally (PO) t." | 5.04 | Comparison of DES vs DES + chlorambucil in women with first recurrence of breast cancer. ( Harvey, HA; Holzer, D; Lipton, A, 1979) |
| "Forty-seven patients with advanced breast cancer were treated with a combination of prednimustine (P), methotrexate (M), 5-fluorouracil (F), and tamoxifen (TAM)." | 3.66 | Prednimustine in combination with methotrexate and 5-fluorouracil in advanced breast cancer: a phase I-II study. ( Boesen, E; Mouridsen, HT, 1983) |
| "Since in the treatment of advanced breast cancer chemotherapy and the various hormonal manipulations seem recently to have reached a plateau of effectiveness when used alone, it is widely assumed that the combination of both treatment modalities could improve therapeutic results." | 2.65 | [Simultaneous or sequential hormono/chemotherapy and a comparison of various polychemotherapies in the treatment of metastatic breast cancer]. ( Alberto, P; Beer, M; Brunner, KW; Cavalli, F; Jungi, WF; Martz, G; Mermillod, B; Obrecht, JP, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (92.86) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wallgren, A | 1 |
| Baral, E | 1 |
| Beling, U | 1 |
| Carstensen, J | 1 |
| Friberg, S | 1 |
| Glas, U | 1 |
| Kaigas, M | 1 |
| Skoog, L | 1 |
| Cavalli, F | 3 |
| Pedrazzini, A | 1 |
| Martz, G | 3 |
| Jungi, WF | 5 |
| Brunner, KW | 3 |
| Goldhirsch, A | 1 |
| Mermillod, B | 2 |
| Alberto, P | 3 |
| Mouridsen, HT | 1 |
| Boesen, E | 1 |
| Senn, HJ | 4 |
| Amgwerd, R | 2 |
| Hochuli, R | 1 |
| Ammann, J | 1 |
| Engelhart, G | 2 |
| Heinz, C | 2 |
| Wick, A | 2 |
| Enderlin, F | 2 |
| Creux, G | 2 |
| Simon, B | 1 |
| Lanz, R | 2 |
| Bigler, R | 2 |
| Seiler, S | 1 |
| Beer, M | 1 |
| Obrecht, JP | 2 |
| Queisser, W | 1 |
| Maibach, R | 1 |
| Castiglione, M | 1 |
| Leyvraz, S | 1 |
| Schildknecht, O | 1 |
| Siegenthaler, P | 1 |
| Canavese, JC | 1 |
| Sonntag, RW | 1 |
| Obrecht, P | 1 |
| Maurice, P | 1 |
| Sprenger, F | 1 |
| Hochueli, R | 1 |
| Simeon, B | 1 |
| Kaufmann, M | 1 |
| Kubli, F | 1 |
| Drings, P | 1 |
| Lammers, G | 1 |
| Holzer, D | 1 |
| Harvey, HA | 1 |
| Lipton, A | 1 |
| Bonadonna, G | 1 |
| Zambetti, M | 1 |
| Valagussa, P | 1 |
| Carter, SK | 1 |
4 reviews available for chlorambucil and Menopause
| Article | Year |
|---|---|
[Lupus erythematosus, modern aspects (author's transl)].
Topics: Antacids; Antibodies, Antinuclear; Antigen-Antibody Complex; Azathioprine; Chlorambucil; Cyclophosph | 1977 |
[Adjuvant (preventive) postoperative chemotherapy in breast carcinoma].
Topics: Breast Neoplasms; Chlorambucil; Cyclophosphamide; Female; Fluorouracil; Humans; Melphalan; Menopause | 1978 |
Adjuvant chemotherapy for node-negative breast cancer patients.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chlorambucil; Combined Modality Th | 1989 |
Single and combination nonhormonal chemotherapy in breast cancer.
Topics: Alkylating Agents; Animals; Antibiotics, Antineoplastic; Antimetabolites; Antineoplastic Agents; Bre | 1972 |
9 trials available for chlorambucil and Menopause
| Article | Year |
|---|---|
Tamoxifen and combination chemotherapy as adjuvant treatment in postmenopausal women with breast cancer.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chlorambucil; Clinical Trial | 1984 |
Randomized trial of 3 different regimens of combination chemotherapy in patients receiving simultaneously a hormonal treatment for advanced breast cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Castration; Chlorambucil; Combined | 1983 |
Adjuvant chemoimmunotherapy with LMF plus BCG in node-negative and node-positive breast cancer - intermediate report at 4 years.
Topics: Breast Neoplasms; Chlorambucil; Clinical Trials as Topic; Drug Therapy, Combination; Female; Fluorou | 1982 |
[Simultaneous or sequential hormono/chemotherapy and a comparison of various polychemotherapies in the treatment of metastatic breast cancer].
Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Castration; Chlorambucil; Clinical Trials as T | 1982 |
Adjuvant chemotherapy in operable breast cancer: cyclophosphamide, methotrexate, and fluorouracil versus chlorambucil, methotrexate, and fluorouracil--11-year results of Swiss Group for Clinical Cancer Research trial SAKK 27/82.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvan | 1997 |
Combined chemo- and hormonal therapy in advanced breast cancer.
Topics: Antineoplastic Agents; Breast Neoplasms; Castration; Chlorambucil; Clinical Trials as Topic; Cycloph | 1977 |
Adjuvant chemoimmunotherapy with LMF + BCG in node-negative and node-positive breast cancer patients. Intermediate report of a randomized trial in 242 patients.
Topics: Administration, Oral; Aged; BCG Vaccine; Breast Neoplasms; Chlorambucil; Clinical Trials as Topic; F | 1978 |
Comparison of DES vs DES + chlorambucil in women with first recurrence of breast cancer.
Topics: Aged; Breast Neoplasms; Chlorambucil; Diethylstilbestrol; Drug Therapy, Combination; Female; Humans; | 1979 |
Adjuvant chemotherapy for node-negative breast cancer patients.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chlorambucil; Combined Modality Th | 1989 |
2 other studies available for chlorambucil and Menopause
| Article | Year |
|---|---|
Prednimustine in combination with methotrexate and 5-fluorouracil in advanced breast cancer: a phase I-II study.
Topics: Aged; Breast Neoplasms; Chlorambucil; Drug Administration Schedule; Drug Evaluation; Drug Therapy, C | 1983 |
[Adjuvant chemotherapy of breast neoplasms. Review of the up-to-date results of various studies including the Heidelberg study].
Topics: Adult; Breast Neoplasms; Chlorambucil; Cyclophosphamide; Evaluation Studies as Topic; Female; Fluoro | 1980 |