chlorambucil has been researched along with Melanoma in 36 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Previous NMR studies demonstrated that lonidamine (LND) selectively diminishes the intracellular pH (pHi) of DB-1 melanoma and mouse xenografts of a variety of other prevalent human cancers while decreasing their bioenergetic status (tumor βNTP/Pi ratio) and enhancing the activities of melphalan and doxorubicin in these cancer models." | 7.83 | Comparison of the Lonidamine Potentiated Effect of Nitrogen Mustard Alkylating Agents on the Systemic Treatment of DB-1 Human Melanoma Xenografts in Mice. ( Garman, B; Glickson, JD; Leeper, DB; Nath, K; Nathanson, KL; Nelson, DS; Putt, ME, 2016) |
| " Hence, prophalan-L: , a stable prodrug of melphalan, exhibits potential for efficiently targeting melanoma with reduced systemic toxicity." | 7.74 | Proline prodrug of melphalan targeted to prolidase, a prodrug activating enzyme overexpressed in melanoma. ( Amidon, GL; Mittal, S; Song, X; Vig, BS, 2007) |
| "To enhance affinity for malignant cartilaginous tumors (chondrosarcomas), quaternary ammonium (QA) conjugates of chlorambucil and melphalan were prepared by linking the QA moiety to nitrogen mustards via an amide bond." | 7.71 | Synthesis and in vitro evaluation of quaternary ammonium derivatives of chlorambucil and melphalan, anticancer drugs designed for the chemotherapy of chondrosarcoma. ( Giraud, I; Madelmont, JC; Maurizis, JC; Rapp, M, 2002) |
| "In the human melanoma cell line MM127 , the melphalan survival curve was linear and exhibited reciprocity with respect to concentration and treatment time." | 7.67 | Dependence on treatment time of melphalan resistance and DNA cross-linking in human melanoma cell lines. ( Parsons, PG, 1984) |
| "A set of 23 aniline mustards [X-C6H4N(CH2CH2Cl)2] have been tested for their activity against B-16 melanoma in mice." | 7.66 | Structure-activity relationship of aniline mustards acting against B-16 melanoma in mice. ( Hansch, C; Leo, A; Panthananickal, A, 1979) |
| "Thirteen consecutive patients with inoperable recurrent malignant melanoma were treated by immunochemotherapy with the use of chlorambucil noncovalently bound to goat or rabbit antihuman melanoma globulins." | 7.65 | Immunochemotherapy of malignant melanoma with chlorambucil-bound antimelanoma globulins: preliminary results in patients with disseminated disease. ( Bodurtha, A; Ghose, T; Guclu, A; MacDonald, AS; Norvell, ST; Tai, J, 1977) |
| "Previous NMR studies demonstrated that lonidamine (LND) selectively diminishes the intracellular pH (pHi) of DB-1 melanoma and mouse xenografts of a variety of other prevalent human cancers while decreasing their bioenergetic status (tumor βNTP/Pi ratio) and enhancing the activities of melphalan and doxorubicin in these cancer models." | 3.83 | Comparison of the Lonidamine Potentiated Effect of Nitrogen Mustard Alkylating Agents on the Systemic Treatment of DB-1 Human Melanoma Xenografts in Mice. ( Garman, B; Glickson, JD; Leeper, DB; Nath, K; Nathanson, KL; Nelson, DS; Putt, ME, 2016) |
| " Hence, prophalan-L: , a stable prodrug of melphalan, exhibits potential for efficiently targeting melanoma with reduced systemic toxicity." | 3.74 | Proline prodrug of melphalan targeted to prolidase, a prodrug activating enzyme overexpressed in melanoma. ( Amidon, GL; Mittal, S; Song, X; Vig, BS, 2007) |
| "To enhance affinity for malignant cartilaginous tumors (chondrosarcomas), quaternary ammonium (QA) conjugates of chlorambucil and melphalan were prepared by linking the QA moiety to nitrogen mustards via an amide bond." | 3.71 | Synthesis and in vitro evaluation of quaternary ammonium derivatives of chlorambucil and melphalan, anticancer drugs designed for the chemotherapy of chondrosarcoma. ( Giraud, I; Madelmont, JC; Maurizis, JC; Rapp, M, 2002) |
| "In the human melanoma cell line MM127 , the melphalan survival curve was linear and exhibited reciprocity with respect to concentration and treatment time." | 3.67 | Dependence on treatment time of melphalan resistance and DNA cross-linking in human melanoma cell lines. ( Parsons, PG, 1984) |
| "A set of 23 aniline mustards [X-C6H4N(CH2CH2Cl)2] have been tested for their activity against B-16 melanoma in mice." | 3.66 | Structure-activity relationship of aniline mustards acting against B-16 melanoma in mice. ( Hansch, C; Leo, A; Panthananickal, A, 1979) |
| "Thirteen consecutive patients with inoperable recurrent malignant melanoma were treated by immunochemotherapy with the use of chlorambucil noncovalently bound to goat or rabbit antihuman melanoma globulins." | 3.65 | Immunochemotherapy of malignant melanoma with chlorambucil-bound antimelanoma globulins: preliminary results in patients with disseminated disease. ( Bodurtha, A; Ghose, T; Guclu, A; MacDonald, AS; Norvell, ST; Tai, J, 1977) |
| "Cell-surface localizing heterologous antibodies against the mouse EL4 lymphoma and a human malignant melanoma could be bound to chlorambucil without causing the loss of the alkylating activity of chlorambucil or interfering with the reactivity of the antibodies with their respective tumour cells." | 3.65 | Immunochemotherapy of cancer with chlorambucil-carrying antibody. ( Bodurtha, A; Cameron, D; Ghose, T; Guclu, A; MacDonald, AS; Norvell, ST, 1972) |
| "A median of two cycles were given until disease progression or grade 3/4 toxicity." | 2.71 | Low-dose continuous chemotherapy for metastatic melanoma: a phase II trial. ( Neville, F; Nystrom, ML; Oliver, RT; Shamash, J; Steele, JP, 2003) |
| " The toxicity of these compounds against hepatoma cells (MH3924A) and, to a lesser extent, against mouse fibroblast (NIH 3T3) and cervix carcinoma (HeLa) cells was also enhanced, but they were not as toxic as dacarbazine (HeLa)." | 1.32 | Alkylating benzamides with melanoma cytotoxicity. ( Bauder-Wüst, U; Eisenhut, M; Haberkorn, U; Mier, W; Mohammed, A; Schönsiegel, F; Wolf, M, 2004) |
| "Generally, metastases responded better than the advanced primaries from which they were derived, except for those from breast tumours." | 1.25 | The influence of site of metastasis on tumour growth and response to chemotherapy. ( Bross, ID; Slack, NH, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (72.22) | 18.7374 |
| 1990's | 1 (2.78) | 18.2507 |
| 2000's | 6 (16.67) | 29.6817 |
| 2010's | 2 (5.56) | 24.3611 |
| 2020's | 1 (2.78) | 2.80 |
| Authors | Studies |
|---|---|
| Panthananickal, A | 1 |
| Hansch, C | 1 |
| Leo, A | 1 |
| MacDiarmid, JE | 1 |
| Rose, WC | 1 |
| Biddle, WC | 1 |
| Perlman, ME | 1 |
| Breiner, RG | 1 |
| Ambrus, JL | 1 |
| Bardos, TJ | 1 |
| Giraud, I | 1 |
| Rapp, M | 1 |
| Maurizis, JC | 1 |
| Madelmont, JC | 1 |
| Gilad, Y | 1 |
| Tuchinsky, H | 1 |
| Ben-David, G | 1 |
| Minnes, R | 1 |
| Gancz, A | 1 |
| Senderowitz, H | 1 |
| Luboshits, G | 1 |
| Firer, MA | 1 |
| Gellerman, G | 1 |
| Venkatesh, Y | 1 |
| Vangala, V | 1 |
| Mengji, R | 1 |
| Chaudhuri, A | 1 |
| Bhattacharya, S | 1 |
| Datta, PK | 1 |
| Banerjee, R | 1 |
| Jana, A | 1 |
| Singh, NDP | 1 |
| Nath, K | 1 |
| Nelson, DS | 1 |
| Putt, ME | 1 |
| Leeper, DB | 1 |
| Garman, B | 1 |
| Nathanson, KL | 1 |
| Glickson, JD | 1 |
| Fontanilla, FA | 1 |
| Edward, DP | 1 |
| Wong, M | 1 |
| Tessler, HH | 1 |
| Eagle, RC | 1 |
| Goldstein, DA | 1 |
| Nystrom, ML | 1 |
| Steele, JP | 1 |
| Shamash, J | 1 |
| Neville, F | 1 |
| Oliver, RT | 1 |
| VIGI, F | 1 |
| MOORE, JG | 1 |
| VANCAMPENHOUT, JL | 1 |
| BRANDKAMP, WW | 1 |
| COBB, JP | 1 |
| WALKER, DG | 1 |
| Depeille, P | 1 |
| Cuq, P | 1 |
| Mary, S | 1 |
| Passagne, I | 1 |
| Evrard, A | 1 |
| Cupissol, D | 1 |
| Vian, L | 1 |
| Wolf, M | 1 |
| Bauder-Wüst, U | 1 |
| Mohammed, A | 1 |
| Schönsiegel, F | 1 |
| Mier, W | 1 |
| Haberkorn, U | 1 |
| Eisenhut, M | 1 |
| Mittal, S | 1 |
| Song, X | 1 |
| Vig, BS | 1 |
| Amidon, GL | 1 |
| Stehlin, JS | 1 |
| Hills, WJ | 1 |
| Rufino, C | 1 |
| Lehman, JA | 1 |
| Berman, JH | 1 |
| Parsons, PG | 1 |
| De Weger, RA | 2 |
| Dullens, HF | 2 |
| Den Otter, W | 2 |
| Falk, S | 1 |
| Walther, F | 1 |
| Denk, R | 1 |
| Vennegoor, C | 2 |
| Van Smeerdijk, D | 1 |
| Rümke, P | 1 |
| Everall, KD | 1 |
| Dowd, P | 1 |
| Davies, DA | 1 |
| O'Neill, GJ | 1 |
| Rowland, GF | 1 |
| Berry, RJ | 1 |
| Laing, AH | 1 |
| Wells, J | 1 |
| Ghose, T | 3 |
| Norvell, ST | 3 |
| Guclu, A | 3 |
| Bodurtha, A | 2 |
| Tai, J | 1 |
| MacDonald, AS | 3 |
| Hill, BH | 1 |
| Slack, NH | 1 |
| Bross, ID | 1 |
| Pedersen, L | 1 |
| Løber, J | 1 |
| Dalmark, M | 1 |
| Mouridsen, HT | 1 |
| Grant, RM | 1 |
| Mackie, R | 1 |
| Cochran, AJ | 1 |
| Murray, EL | 1 |
| Hoyle, D | 1 |
| Ross, C | 1 |
| Johnson, FD | 1 |
| Jacobs, EM | 1 |
| Dargent, M | 1 |
| Pommatau, E | 1 |
| Brunat, M | 1 |
| Cameron, D | 1 |
| Couture, J | 1 |
| Deschênes, L | 1 |
| Cook, JL | 1 |
| Badgett, WJ | 1 |
2 reviews available for chlorambucil and Melanoma
| Article | Year |
|---|---|
Eradication of murine lymphoma and melanoma cells by chlorambucil-antibody complexes.
Topics: Animals; Antibodies, Neoplasm; Chlorambucil; Cytotoxicity Tests, Immunologic; Drug Combinations; Dru | 1982 |
[Metastatic malignant melanoma in treated non-Hodgkin's lymphoma].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Humans; Lymph Nodes; Lymphatic | 1996 |
3 trials available for chlorambucil and Melanoma
| Article | Year |
|---|---|
Low-dose continuous chemotherapy for metastatic melanoma: a phase II trial.
Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylatin | 2003 |
A phase II clinical trial of prednimustine. Clinical screening cooperative group of E.O.R.T.C.
Topics: Adolescent; Adult; Aged; Chlorambucil; Clinical Trials as Topic; Female; Humans; Leukemia, Lymphoid; | 1977 |
Results of administering B.C.G. to patients with melanoma.
Topics: Adult; Aged; Antibodies, Neoplasm; BCG Vaccine; Blood Cell Count; Cell Migration Inhibition; Chloram | 1974 |
31 other studies available for chlorambucil and Melanoma
| Article | Year |
|---|---|
Structure-activity relationship of aniline mustards acting against B-16 melanoma in mice.
Topics: Aniline Mustard; Animals; Antineoplastic Agents; Melanoma; Mice; Neoplasms, Experimental; Nitrogen M | 1979 |
Synthesis and properties of bis(2,2-dimethylaziridinyl)phosphinic amides: a series of new antineoplastic agents.
Topics: Animals; Aziridines; Azirines; Chemical Phenomena; Chemistry; Chlorambucil; Cholinesterase Inhibitor | 1985 |
Synthesis and in vitro evaluation of quaternary ammonium derivatives of chlorambucil and melphalan, anticancer drugs designed for the chemotherapy of chondrosarcoma.
Topics: Animals; Antineoplastic Agents; Chlorambucil; Chondrosarcoma; Drug Screening Assays, Antitumor; Huma | 2002 |
Discovery of potent molecular chimera (CM358) to treat human metastatic melanoma.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; DNA Topoisomerases, Type II; Dose-Response Relat | 2017 |
One- and Two-Photon Uncaging of Carbon Monoxide (CO) with Real-Time Monitoring: On-Demand Carbazole-Based Dual CO-Releasing Platform to Test over Single and Combinatorial Approaches for the Efficient Regression of Orthotopic Murine Melanoma
Topics: Animals; Antineoplastic Agents; Apoptosis; Carbazoles; Carbon Monoxide; Cell Line, Tumor; Dioxoles; | 2022 |
Comparison of the Lonidamine Potentiated Effect of Nitrogen Mustard Alkylating Agents on the Systemic Treatment of DB-1 Human Melanoma Xenografts in Mice.
Topics: Alkylating Agents; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell S | 2016 |
Juvenile xanthogranuloma masquerading as melanoma.
Topics: Anti-Inflammatory Agents; Antineoplastic Agents, Alkylating; Child; Chlorambucil; Cyclosporine; Diag | 2009 |
[CURRENT PRACTICE IN THE TREATMENT OF TUMORS WITH INTRA-ARTERIAL INJECTIONS OF ANTINEOPLASTIC SUBSTANCES].
Topics: Aminopterin; Antineoplastic Agents; Carcinoma; Chemotherapy, Cancer, Regional Perfusion; Chlorambuci | 1963 |
EFFECTS OF IONIZING IRRADIATION AND CHEMOTHERAPEUTIC AGENTS ON HUMAN CHROMOSOMES.
Topics: Antineoplastic Agents; Biomedical Research; Chlorambucil; Choriocarcinoma; Chromosome Aberrations; C | 1964 |
STUDIES ON HUMAN MELANOMA CELLS IN TISSUE CULTURE. II. EFFECTS OF SEVERAL CANCER CHEMOTHERAPEUTIC AGENTS ON CYTOLOGY AND GROWTH.
Topics: Anti-Bacterial Agents; Antineoplastic Agents; Chlorambucil; Dactinomycin; Fluorouracil; Melanoma; Me | 1964 |
Glutathione S-transferase M1 and multidrug resistance protein 1 act in synergy to protect melanoma cells from vincristine effects.
Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Div | 2004 |
Alkylating benzamides with melanoma cytotoxicity.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Benzamides; Cell Line, Tumor; Cel | 2004 |
Proline prodrug of melphalan targeted to prolidase, a prodrug activating enzyme overexpressed in melanoma.
Topics: Antineoplastic Agents, Alkylating; Biological Transport; Biotransformation; Cell Line, Tumor; Cell P | 2007 |
Disseminated melanoma. Biologic behavior and treatment.
Topics: Antineoplastic Agents; Chlorambucil; Cyclophosphamide; Dactinomycin; Fluorouracil; Humans; Hydrazine | 1967 |
Chemotherapy in disseminated malignant melanoma.
Topics: Adult; Chlorambucil; Female; Humans; Lymphatic Metastasis; Male; Melanoma; Middle Aged; Vinblastine | 1967 |
Dependence on treatment time of melphalan resistance and DNA cross-linking in human melanoma cell lines.
Topics: Caffeine; Cell Line; Cell Survival; Chlorambucil; DNA, Neoplasm; Drug Resistance; Drug Synergism; Ho | 1984 |
Effects of mixtures and complexes of chlorambucil and antibody on a human melanoma cell line.
Topics: Cell Line; Chlorambucil; gamma-Globulins; Humans; Melanoma; Protein Binding | 1975 |
Treatment of melanoma by passive humoral immunotherapy using antibody drug synergism.
Topics: Animals; Antineoplastic Agents; Chlorambucil; Drug Synergism; Goats; Humans; Immunoglobulins; Immuno | 1977 |
Anti-tumour effect of chlorambucil-antibody complexes in a murine melanoma system.
Topics: Animals; Carrier Proteins; Cell Survival; Cells, Cultured; Chlorambucil; Female; Immune Sera; Immuno | 1979 |
Fresh explant culture of human tumours in vitro and the assessment of sensitivity to cytotoxic chemotherapy.
Topics: Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Culture Techniques; Drug Evaluation, Preclini | 1975 |
Immunochemotherapy of malignant melanoma with chlorambucil-bound antimelanoma globulins: preliminary results in patients with disseminated disease.
Topics: Adolescent; Adult; Aged; Antibodies, Neoplasm; Chlorambucil; Dacarbazine; Female; Humans; Hypersensi | 1977 |
Immunosuppressive drug therapy as a potentiator of skin tumours in five patients with lymphoma.
Topics: Adult; Aged; Antineoplastic Agents; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Chlorambucil; H | 1976 |
Immunochemotherapy of human malignant melanoma with chlorambucil-carrying antibody.
Topics: Aged; Animals; Antibodies, Neoplasm; Antigens, Neoplasm; Cell Membrane; Chlorambucil; Cross Reaction | 1975 |
The influence of site of metastasis on tumour growth and response to chemotherapy.
Topics: Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Female; Fluorouracil; Genital Neoplasms, Fema | 1975 |
Prednimustine in advanced malignant melanoma: a phase II study.
Topics: Adult; Aged; Chlorambucil; Drug Evaluation; Humans; Melanoma; Middle Aged; Prednimustine | 1987 |
Chemotherapy of metastatic malignant melanoma. Experience with 73 patients.
Topics: Adult; Aged; Antineoplastic Agents; Chlorambucil; Colchicine; Cyclophosphamide; Cytarabine; Eye Neop | 1971 |
[Apropos of an experience with the polychemotherapy of cancer].
Topics: Adult; Bone Neoplasms; Child; Chlorambucil; Cyclophosphamide; Dactinomycin; Drug Synergism; Dysgermi | 1968 |
Immunochemotherapy of cancer with chlorambucil-carrying antibody.
Topics: Aged; Animals; Antibodies; Cell Membrane; Chlorambucil; Fluorescent Antibody Technique; Goats; Human | 1972 |
[Chemotherapy of solid tumors].
Topics: Antineoplastic Agents; Child; Chlorambucil; Cyclophosphamide; Dactinomycin; Drug Synergism; Fluorour | 1970 |
Immunochemotherapy of cancer.
Topics: Animals; Antibodies; Antibody Specificity; Antigens, Neoplasm; Antineoplastic Agents; Chlorambucil; | 1972 |
Chlorambucil-carrying antibody.
Topics: Animals; Antibodies, Neoplasm; Chlorambucil; Humans; Lymphoma; Melanoma; Mice; Neoplasms, Experiment | 1972 |