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chlorambucil and Melanoma

chlorambucil has been researched along with Melanoma in 36 studies

Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.

Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)

Research Excerpts

ExcerptRelevanceReference
"Previous NMR studies demonstrated that lonidamine (LND) selectively diminishes the intracellular pH (pHi) of DB-1 melanoma and mouse xenografts of a variety of other prevalent human cancers while decreasing their bioenergetic status (tumor βNTP/Pi ratio) and enhancing the activities of melphalan and doxorubicin in these cancer models."7.83Comparison of the Lonidamine Potentiated Effect of Nitrogen Mustard Alkylating Agents on the Systemic Treatment of DB-1 Human Melanoma Xenografts in Mice. ( Garman, B; Glickson, JD; Leeper, DB; Nath, K; Nathanson, KL; Nelson, DS; Putt, ME, 2016)
" Hence, prophalan-L: , a stable prodrug of melphalan, exhibits potential for efficiently targeting melanoma with reduced systemic toxicity."7.74Proline prodrug of melphalan targeted to prolidase, a prodrug activating enzyme overexpressed in melanoma. ( Amidon, GL; Mittal, S; Song, X; Vig, BS, 2007)
"To enhance affinity for malignant cartilaginous tumors (chondrosarcomas), quaternary ammonium (QA) conjugates of chlorambucil and melphalan were prepared by linking the QA moiety to nitrogen mustards via an amide bond."7.71Synthesis and in vitro evaluation of quaternary ammonium derivatives of chlorambucil and melphalan, anticancer drugs designed for the chemotherapy of chondrosarcoma. ( Giraud, I; Madelmont, JC; Maurizis, JC; Rapp, M, 2002)
"In the human melanoma cell line MM127 , the melphalan survival curve was linear and exhibited reciprocity with respect to concentration and treatment time."7.67Dependence on treatment time of melphalan resistance and DNA cross-linking in human melanoma cell lines. ( Parsons, PG, 1984)
"A set of 23 aniline mustards [X-C6H4N(CH2CH2Cl)2] have been tested for their activity against B-16 melanoma in mice."7.66Structure-activity relationship of aniline mustards acting against B-16 melanoma in mice. ( Hansch, C; Leo, A; Panthananickal, A, 1979)
"Thirteen consecutive patients with inoperable recurrent malignant melanoma were treated by immunochemotherapy with the use of chlorambucil noncovalently bound to goat or rabbit antihuman melanoma globulins."7.65Immunochemotherapy of malignant melanoma with chlorambucil-bound antimelanoma globulins: preliminary results in patients with disseminated disease. ( Bodurtha, A; Ghose, T; Guclu, A; MacDonald, AS; Norvell, ST; Tai, J, 1977)
"Previous NMR studies demonstrated that lonidamine (LND) selectively diminishes the intracellular pH (pHi) of DB-1 melanoma and mouse xenografts of a variety of other prevalent human cancers while decreasing their bioenergetic status (tumor βNTP/Pi ratio) and enhancing the activities of melphalan and doxorubicin in these cancer models."3.83Comparison of the Lonidamine Potentiated Effect of Nitrogen Mustard Alkylating Agents on the Systemic Treatment of DB-1 Human Melanoma Xenografts in Mice. ( Garman, B; Glickson, JD; Leeper, DB; Nath, K; Nathanson, KL; Nelson, DS; Putt, ME, 2016)
" Hence, prophalan-L: , a stable prodrug of melphalan, exhibits potential for efficiently targeting melanoma with reduced systemic toxicity."3.74Proline prodrug of melphalan targeted to prolidase, a prodrug activating enzyme overexpressed in melanoma. ( Amidon, GL; Mittal, S; Song, X; Vig, BS, 2007)
"To enhance affinity for malignant cartilaginous tumors (chondrosarcomas), quaternary ammonium (QA) conjugates of chlorambucil and melphalan were prepared by linking the QA moiety to nitrogen mustards via an amide bond."3.71Synthesis and in vitro evaluation of quaternary ammonium derivatives of chlorambucil and melphalan, anticancer drugs designed for the chemotherapy of chondrosarcoma. ( Giraud, I; Madelmont, JC; Maurizis, JC; Rapp, M, 2002)
"In the human melanoma cell line MM127 , the melphalan survival curve was linear and exhibited reciprocity with respect to concentration and treatment time."3.67Dependence on treatment time of melphalan resistance and DNA cross-linking in human melanoma cell lines. ( Parsons, PG, 1984)
"A set of 23 aniline mustards [X-C6H4N(CH2CH2Cl)2] have been tested for their activity against B-16 melanoma in mice."3.66Structure-activity relationship of aniline mustards acting against B-16 melanoma in mice. ( Hansch, C; Leo, A; Panthananickal, A, 1979)
"Thirteen consecutive patients with inoperable recurrent malignant melanoma were treated by immunochemotherapy with the use of chlorambucil noncovalently bound to goat or rabbit antihuman melanoma globulins."3.65Immunochemotherapy of malignant melanoma with chlorambucil-bound antimelanoma globulins: preliminary results in patients with disseminated disease. ( Bodurtha, A; Ghose, T; Guclu, A; MacDonald, AS; Norvell, ST; Tai, J, 1977)
"Cell-surface localizing heterologous antibodies against the mouse EL4 lymphoma and a human malignant melanoma could be bound to chlorambucil without causing the loss of the alkylating activity of chlorambucil or interfering with the reactivity of the antibodies with their respective tumour cells."3.65Immunochemotherapy of cancer with chlorambucil-carrying antibody. ( Bodurtha, A; Cameron, D; Ghose, T; Guclu, A; MacDonald, AS; Norvell, ST, 1972)
"A median of two cycles were given until disease progression or grade 3/4 toxicity."2.71Low-dose continuous chemotherapy for metastatic melanoma: a phase II trial. ( Neville, F; Nystrom, ML; Oliver, RT; Shamash, J; Steele, JP, 2003)
" The toxicity of these compounds against hepatoma cells (MH3924A) and, to a lesser extent, against mouse fibroblast (NIH 3T3) and cervix carcinoma (HeLa) cells was also enhanced, but they were not as toxic as dacarbazine (HeLa)."1.32Alkylating benzamides with melanoma cytotoxicity. ( Bauder-Wüst, U; Eisenhut, M; Haberkorn, U; Mier, W; Mohammed, A; Schönsiegel, F; Wolf, M, 2004)
"Generally, metastases responded better than the advanced primaries from which they were derived, except for those from breast tumours."1.25The influence of site of metastasis on tumour growth and response to chemotherapy. ( Bross, ID; Slack, NH, 1975)

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-199026 (72.22)18.7374
1990's1 (2.78)18.2507
2000's6 (16.67)29.6817
2010's2 (5.56)24.3611
2020's1 (2.78)2.80

Authors

AuthorsStudies
Panthananickal, A1
Hansch, C1
Leo, A1
MacDiarmid, JE1
Rose, WC1
Biddle, WC1
Perlman, ME1
Breiner, RG1
Ambrus, JL1
Bardos, TJ1
Giraud, I1
Rapp, M1
Maurizis, JC1
Madelmont, JC1
Gilad, Y1
Tuchinsky, H1
Ben-David, G1
Minnes, R1
Gancz, A1
Senderowitz, H1
Luboshits, G1
Firer, MA1
Gellerman, G1
Venkatesh, Y1
Vangala, V1
Mengji, R1
Chaudhuri, A1
Bhattacharya, S1
Datta, PK1
Banerjee, R1
Jana, A1
Singh, NDP1
Nath, K1
Nelson, DS1
Putt, ME1
Leeper, DB1
Garman, B1
Nathanson, KL1
Glickson, JD1
Fontanilla, FA1
Edward, DP1
Wong, M1
Tessler, HH1
Eagle, RC1
Goldstein, DA1
Nystrom, ML1
Steele, JP1
Shamash, J1
Neville, F1
Oliver, RT1
VIGI, F1
MOORE, JG1
VANCAMPENHOUT, JL1
BRANDKAMP, WW1
COBB, JP1
WALKER, DG1
Depeille, P1
Cuq, P1
Mary, S1
Passagne, I1
Evrard, A1
Cupissol, D1
Vian, L1
Wolf, M1
Bauder-Wüst, U1
Mohammed, A1
Schönsiegel, F1
Mier, W1
Haberkorn, U1
Eisenhut, M1
Mittal, S1
Song, X1
Vig, BS1
Amidon, GL1
Stehlin, JS1
Hills, WJ1
Rufino, C1
Lehman, JA1
Berman, JH1
Parsons, PG1
De Weger, RA2
Dullens, HF2
Den Otter, W2
Falk, S1
Walther, F1
Denk, R1
Vennegoor, C2
Van Smeerdijk, D1
Rümke, P1
Everall, KD1
Dowd, P1
Davies, DA1
O'Neill, GJ1
Rowland, GF1
Berry, RJ1
Laing, AH1
Wells, J1
Ghose, T3
Norvell, ST3
Guclu, A3
Bodurtha, A2
Tai, J1
MacDonald, AS3
Hill, BH1
Slack, NH1
Bross, ID1
Pedersen, L1
Løber, J1
Dalmark, M1
Mouridsen, HT1
Grant, RM1
Mackie, R1
Cochran, AJ1
Murray, EL1
Hoyle, D1
Ross, C1
Johnson, FD1
Jacobs, EM1
Dargent, M1
Pommatau, E1
Brunat, M1
Cameron, D1
Couture, J1
Deschênes, L1
Cook, JL1
Badgett, WJ1

Reviews

2 reviews available for chlorambucil and Melanoma

ArticleYear
Eradication of murine lymphoma and melanoma cells by chlorambucil-antibody complexes.
    Immunological reviews, 1982, Volume: 62

    Topics: Animals; Antibodies, Neoplasm; Chlorambucil; Cytotoxicity Tests, Immunologic; Drug Combinations; Dru

1982
[Metastatic malignant melanoma in treated non-Hodgkin's lymphoma].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1996, Volume: 47, Issue:9

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Humans; Lymph Nodes; Lymphatic

1996

Trials

3 trials available for chlorambucil and Melanoma

ArticleYear
Low-dose continuous chemotherapy for metastatic melanoma: a phase II trial.
    Melanoma research, 2003, Volume: 13, Issue:2

    Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylatin

2003
A phase II clinical trial of prednimustine. Clinical screening cooperative group of E.O.R.T.C.
    Biomedicine / [publiee pour l'A.A.I.C.I.G.], 1977, Volume: 27, Issue:4

    Topics: Adolescent; Adult; Aged; Chlorambucil; Clinical Trials as Topic; Female; Humans; Leukemia, Lymphoid;

1977
Results of administering B.C.G. to patients with melanoma.
    Lancet (London, England), 1974, Nov-09, Volume: 2, Issue:7889

    Topics: Adult; Aged; Antibodies, Neoplasm; BCG Vaccine; Blood Cell Count; Cell Migration Inhibition; Chloram

1974

Other Studies

31 other studies available for chlorambucil and Melanoma

ArticleYear
Structure-activity relationship of aniline mustards acting against B-16 melanoma in mice.
    Journal of medicinal chemistry, 1979, Volume: 22, Issue:10

    Topics: Aniline Mustard; Animals; Antineoplastic Agents; Melanoma; Mice; Neoplasms, Experimental; Nitrogen M

1979
Synthesis and properties of bis(2,2-dimethylaziridinyl)phosphinic amides: a series of new antineoplastic agents.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:11

    Topics: Animals; Aziridines; Azirines; Chemical Phenomena; Chemistry; Chlorambucil; Cholinesterase Inhibitor

1985
Synthesis and in vitro evaluation of quaternary ammonium derivatives of chlorambucil and melphalan, anticancer drugs designed for the chemotherapy of chondrosarcoma.
    Journal of medicinal chemistry, 2002, May-09, Volume: 45, Issue:10

    Topics: Animals; Antineoplastic Agents; Chlorambucil; Chondrosarcoma; Drug Screening Assays, Antitumor; Huma

2002
Discovery of potent molecular chimera (CM358) to treat human metastatic melanoma.
    European journal of medicinal chemistry, 2017, Sep-29, Volume: 138

    Topics: Animals; Antineoplastic Agents; Cell Proliferation; DNA Topoisomerases, Type II; Dose-Response Relat

2017
One- and Two-Photon Uncaging of Carbon Monoxide (CO) with Real-Time Monitoring: On-Demand Carbazole-Based Dual CO-Releasing Platform to Test over Single and Combinatorial Approaches for the Efficient Regression of Orthotopic Murine Melanoma
    Journal of medicinal chemistry, 2022, 02-10, Volume: 65, Issue:3

    Topics: Animals; Antineoplastic Agents; Apoptosis; Carbazoles; Carbon Monoxide; Cell Line, Tumor; Dioxoles;

2022
Comparison of the Lonidamine Potentiated Effect of Nitrogen Mustard Alkylating Agents on the Systemic Treatment of DB-1 Human Melanoma Xenografts in Mice.
    PloS one, 2016, Volume: 11, Issue:6

    Topics: Alkylating Agents; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell S

2016
Juvenile xanthogranuloma masquerading as melanoma.
    Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 2009, Volume: 13, Issue:5

    Topics: Anti-Inflammatory Agents; Antineoplastic Agents, Alkylating; Child; Chlorambucil; Cyclosporine; Diag

2009
[CURRENT PRACTICE IN THE TREATMENT OF TUMORS WITH INTRA-ARTERIAL INJECTIONS OF ANTINEOPLASTIC SUBSTANCES].
    Minerva medica, 1963, Nov-03, Volume: 54

    Topics: Aminopterin; Antineoplastic Agents; Carcinoma; Chemotherapy, Cancer, Regional Perfusion; Chlorambuci

1963
EFFECTS OF IONIZING IRRADIATION AND CHEMOTHERAPEUTIC AGENTS ON HUMAN CHROMOSOMES.
    American journal of obstetrics and gynecology, 1964, Apr-15, Volume: 88

    Topics: Antineoplastic Agents; Biomedical Research; Chlorambucil; Choriocarcinoma; Chromosome Aberrations; C

1964
STUDIES ON HUMAN MELANOMA CELLS IN TISSUE CULTURE. II. EFFECTS OF SEVERAL CANCER CHEMOTHERAPEUTIC AGENTS ON CYTOLOGY AND GROWTH.
    Acta - Unio Internationalis Contra Cancrum, 1964, Volume: 20

    Topics: Anti-Bacterial Agents; Antineoplastic Agents; Chlorambucil; Dactinomycin; Fluorouracil; Melanoma; Me

1964
Glutathione S-transferase M1 and multidrug resistance protein 1 act in synergy to protect melanoma cells from vincristine effects.
    Molecular pharmacology, 2004, Volume: 65, Issue:4

    Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Div

2004
Alkylating benzamides with melanoma cytotoxicity.
    Melanoma research, 2004, Volume: 14, Issue:5

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Benzamides; Cell Line, Tumor; Cel

2004
Proline prodrug of melphalan targeted to prolidase, a prodrug activating enzyme overexpressed in melanoma.
    Pharmaceutical research, 2007, Volume: 24, Issue:7

    Topics: Antineoplastic Agents, Alkylating; Biological Transport; Biotransformation; Cell Line, Tumor; Cell P

2007
Disseminated melanoma. Biologic behavior and treatment.
    Archives of surgery (Chicago, Ill. : 1960), 1967, Volume: 94, Issue:4

    Topics: Antineoplastic Agents; Chlorambucil; Cyclophosphamide; Dactinomycin; Fluorouracil; Humans; Hydrazine

1967
Chemotherapy in disseminated malignant melanoma.
    The Ohio State medical journal, 1967, Volume: 63, Issue:4

    Topics: Adult; Chlorambucil; Female; Humans; Lymphatic Metastasis; Male; Melanoma; Middle Aged; Vinblastine

1967
Dependence on treatment time of melphalan resistance and DNA cross-linking in human melanoma cell lines.
    Cancer research, 1984, Volume: 44, Issue:7

    Topics: Caffeine; Cell Line; Cell Survival; Chlorambucil; DNA, Neoplasm; Drug Resistance; Drug Synergism; Ho

1984
Effects of mixtures and complexes of chlorambucil and antibody on a human melanoma cell line.
    European journal of cancer, 1975, Volume: 11, Issue:10

    Topics: Cell Line; Chlorambucil; gamma-Globulins; Humans; Melanoma; Protein Binding

1975
Treatment of melanoma by passive humoral immunotherapy using antibody drug synergism.
    Lancet (London, England), 1977, May-21, Volume: 1, Issue:8021

    Topics: Animals; Antineoplastic Agents; Chlorambucil; Drug Synergism; Goats; Humans; Immunoglobulins; Immuno

1977
Anti-tumour effect of chlorambucil-antibody complexes in a murine melanoma system.
    European journal of cancer, 1979, Volume: 15, Issue:1

    Topics: Animals; Carrier Proteins; Cell Survival; Cells, Cultured; Chlorambucil; Female; Immune Sera; Immuno

1979
Fresh explant culture of human tumours in vitro and the assessment of sensitivity to cytotoxic chemotherapy.
    British journal of cancer, 1975, Volume: 31, Issue:2

    Topics: Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Culture Techniques; Drug Evaluation, Preclini

1975
Immunochemotherapy of malignant melanoma with chlorambucil-bound antimelanoma globulins: preliminary results in patients with disseminated disease.
    Journal of the National Cancer Institute, 1977, Volume: 58, Issue:4

    Topics: Adolescent; Adult; Aged; Antibodies, Neoplasm; Chlorambucil; Dacarbazine; Female; Humans; Hypersensi

1977
Immunosuppressive drug therapy as a potentiator of skin tumours in five patients with lymphoma.
    The Australasian journal of dermatology, 1976, Volume: 17, Issue:2

    Topics: Adult; Aged; Antineoplastic Agents; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Chlorambucil; H

1976
Immunochemotherapy of human malignant melanoma with chlorambucil-carrying antibody.
    European journal of cancer, 1975, Volume: 11, Issue:5

    Topics: Aged; Animals; Antibodies, Neoplasm; Antigens, Neoplasm; Cell Membrane; Chlorambucil; Cross Reaction

1975
The influence of site of metastasis on tumour growth and response to chemotherapy.
    British journal of cancer, 1975, Volume: 32, Issue:1

    Topics: Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Female; Fluorouracil; Genital Neoplasms, Fema

1975
Prednimustine in advanced malignant melanoma: a phase II study.
    Cancer treatment reports, 1987, Volume: 71, Issue:12

    Topics: Adult; Aged; Chlorambucil; Drug Evaluation; Humans; Melanoma; Middle Aged; Prednimustine

1987
Chemotherapy of metastatic malignant melanoma. Experience with 73 patients.
    Cancer, 1971, Volume: 27, Issue:6

    Topics: Adult; Aged; Antineoplastic Agents; Chlorambucil; Colchicine; Cyclophosphamide; Cytarabine; Eye Neop

1971
[Apropos of an experience with the polychemotherapy of cancer].
    Le Poumon et le coeur, 1968, Volume: 24, Issue:1

    Topics: Adult; Bone Neoplasms; Child; Chlorambucil; Cyclophosphamide; Dactinomycin; Drug Synergism; Dysgermi

1968
Immunochemotherapy of cancer with chlorambucil-carrying antibody.
    British medical journal, 1972, Aug-26, Volume: 3, Issue:5825

    Topics: Aged; Animals; Antibodies; Cell Membrane; Chlorambucil; Fluorescent Antibody Technique; Goats; Human

1972
[Chemotherapy of solid tumors].
    L'union medicale du Canada, 1970, Volume: 99, Issue:6

    Topics: Antineoplastic Agents; Child; Chlorambucil; Cyclophosphamide; Dactinomycin; Drug Synergism; Fluorour

1970
Immunochemotherapy of cancer.
    British medical journal, 1972, Aug-26, Volume: 3, Issue:5825

    Topics: Animals; Antibodies; Antibody Specificity; Antigens, Neoplasm; Antineoplastic Agents; Chlorambucil;

1972
Chlorambucil-carrying antibody.
    British medical journal, 1972, Oct-07, Volume: 4, Issue:5831

    Topics: Animals; Antibodies, Neoplasm; Chlorambucil; Humans; Lymphoma; Melanoma; Mice; Neoplasms, Experiment

1972