chlorambucil has been researched along with MS (Multiple Sclerosis) in 18 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Immunological and clinical functions were studied over a 2 year period in conjunction with a placebo controlled trial of isoprinosine and chlorambucil in 21 patients with exacerbating remitting multiple sclerosis." | 9.06 | Immunosuppressive effects of isoprinosine in man: a comparison to chlorambucil effects in multiple sclerosis. ( Buge, A; Cour, V; Delsaux, MC; Meunier, C; Pompidou, A; Rancurel, G; Telvi, L, 1987) |
| "Thirty-three patients with chronic progressive multiple sclerosis (MS) were assigned to intervention groups receiving monthly pulses of chlorambucil (CB) for about one year." | 7.68 | Preferential reductions in lymphocyte sub-populations induced by monthly pulses of chlorambucil: studies in patients with chronic progressive multiple sclerosis. ( Chiappelli, F; Ellison, GW; Fahey, JL; Liao, D; Myers, LW, 1991) |
| "A new case is reported here of acute myeloid leukemia after chlorambucil therapy for multiple sclerosis." | 7.67 | [Acute leukemia secondary to the treatment of multiple sclerosis with chlorambucil]. ( Aymard, JP; Barroche, G; Conroy, T; Humbert, JC; Lederlin, P; Streiff, F; Witz, F, 1985) |
| "Immunological and clinical functions were studied over a 2 year period in conjunction with a placebo controlled trial of isoprinosine and chlorambucil in 21 patients with exacerbating remitting multiple sclerosis." | 5.06 | Immunosuppressive effects of isoprinosine in man: a comparison to chlorambucil effects in multiple sclerosis. ( Buge, A; Cour, V; Delsaux, MC; Meunier, C; Pompidou, A; Rancurel, G; Telvi, L, 1987) |
| "Thirty-three patients with chronic progressive multiple sclerosis (MS) were assigned to intervention groups receiving monthly pulses of chlorambucil (CB) for about one year." | 3.68 | Preferential reductions in lymphocyte sub-populations induced by monthly pulses of chlorambucil: studies in patients with chronic progressive multiple sclerosis. ( Chiappelli, F; Ellison, GW; Fahey, JL; Liao, D; Myers, LW, 1991) |
| "A new case is reported here of acute myeloid leukemia after chlorambucil therapy for multiple sclerosis." | 3.67 | [Acute leukemia secondary to the treatment of multiple sclerosis with chlorambucil]. ( Aymard, JP; Barroche, G; Conroy, T; Humbert, JC; Lederlin, P; Streiff, F; Witz, F, 1985) |
| "A case of acute myeloblastic leukaemia is reported in a patient treated with chlorambucil during 72 months for multiple sclerosis." | 3.66 | Acute leukaemia after prolonged chlorambucil treatment for non-malignant disease: report of a new case and literature survey. ( Aymard, JP; Colomb, JN; Frustin, J; Herbeuval, R; Lederlin, P; Witz, F, 1980) |
| "The mean mutant frequency before treatment for six multiple sclerosis patients treated with high-dose CP was 2." | 1.31 | Induction of mutant lymphocytes in cyclophosphamide- and chlorambucil-treated patients. ( Henner, WD; Johnson, KJ; Sanderson, BJ, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (88.89) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 1 (5.56) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ellison, GW | 2 |
| Myers, LW | 2 |
| Aymard, JP | 3 |
| Lederlin, P | 3 |
| Witz, F | 3 |
| Rumilly, F | 1 |
| Eisemann, JC | 1 |
| Buisine, J | 1 |
| Gregoire, MJ | 1 |
| Guerci, O | 1 |
| Streiff, F | 2 |
| Frustin, J | 1 |
| Colomb, JN | 1 |
| Herbeuval, R | 1 |
| Olszewska, Z | 1 |
| Arkuszewska, C | 1 |
| Najman, A | 1 |
| Gorin, NC | 1 |
| Duhamel, G | 1 |
| Roger, M | 1 |
| Dry, J | 1 |
| Sanderson, BJ | 1 |
| Johnson, KJ | 1 |
| Henner, WD | 1 |
| Tchernia, G | 1 |
| Mielot, F | 1 |
| Subtil, E | 1 |
| Parmentier, C | 1 |
| Chiappelli, F | 1 |
| Liao, D | 1 |
| Fahey, JL | 1 |
| Pompidou, A | 1 |
| Rancurel, G | 1 |
| Delsaux, MC | 1 |
| Meunier, C | 1 |
| Telvi, L | 1 |
| Cour, V | 1 |
| Buge, A | 1 |
| Conroy, T | 1 |
| Humbert, JC | 1 |
| Barroche, G | 1 |
| Cendrowski, WS | 1 |
| Cendrowski, W | 1 |
| Moskalewska, K | 1 |
| Plonka, T | 1 |
| Niedzielska, K | 1 |
| Bonnet, M | 1 |
| Sigwald, J | 1 |
| Mazalton, A | 1 |
| Raymondeaud, C | 1 |
| Piot, C | 1 |
| Jacquillat, C | 1 |
| Hervet, E | 1 |
| Barrat, J | 1 |
| Darbois, Y | 1 |
| Faguer, C | 1 |
| Skinner, MD | 1 |
| Schwartz, RS | 1 |
| Steinberg, AD | 1 |
| Perkins, ES | 1 |
6 reviews available for chlorambucil and MS (Multiple Sclerosis)
| Article | Year |
|---|---|
Immunosuppressive drugs in multiple sclerosis: pro and con.
Topics: Adrenocorticotropic Hormone; Alkylating Agents; Antimetabolites; Azathioprine; Chlorambucil; Cycloph | 1980 |
Acute leukaemia following prolonged chlorambucil treatment for non-neoplastic disease - a study of two cases and literature review.
Topics: Adult; Aged; Chlorambucil; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Leukemia | 1983 |
[Immunodepressors in ophthalmology].
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Antibiotics, Antineoplastic; Antilymphocyte Se | 1971 |
Immunosuppressive therapy. 2.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Adult; Azathioprine; Child; Chlorambucil; Clin | 1972 |
An approach to the use of immunosuppressive drugs in nonmalignant diseases.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Chlorambucil; Cyclophosphamide; G | 1973 |
Recent advances in the study of uveitis.
Topics: Adult; Antibodies; Antigen-Antibody Reactions; Aqueous Humor; Azathioprine; Cell Migration Inhibitio | 1974 |
2 trials available for chlorambucil and MS (Multiple Sclerosis)
| Article | Year |
|---|---|
Immunosuppressive effects of isoprinosine in man: a comparison to chlorambucil effects in multiple sclerosis.
Topics: Adult; Chlorambucil; Clinical Trials as Topic; Double-Blind Method; Humans; Hypersensitivity, Delaye | 1987 |
Immunosuppressive therapy. 2.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Adult; Azathioprine; Child; Chlorambucil; Clin | 1972 |
11 other studies available for chlorambucil and MS (Multiple Sclerosis)
| Article | Year |
|---|---|
Acute leukaemia after prolonged chlorambucil treatment for non-malignant disease: report of a new case and literature survey.
Topics: Adult; Chlorambucil; Female; Humans; Immunosuppression Therapy; Leukemia, Myeloid, Acute; Multiple S | 1980 |
[Remote results of leukeran treatment of multiple sclerosis based on systematic clinical and paraclinical follow-up].
Topics: Adult; Chlorambucil; Female; Follow-Up Studies; Humans; Middle Aged; Multiple Sclerosis; Time Factor | 1981 |
[Acute myelofibrosis after chlorambucil treatment (author's transl)].
Topics: Acute Disease; Chlorambucil; Humans; Male; Middle Aged; Multiple Sclerosis; Primary Myelofibrosis | 1980 |
Induction of mutant lymphocytes in cyclophosphamide- and chlorambucil-treated patients.
Topics: Adult; Antineoplastic Agents, Alkylating; Chlorambucil; Cyclophosphamide; DNA Mutational Analysis; D | 2001 |
Acute myeloblastic leukemia after immunodepressive therapy for primary nonmalignant disease.
Topics: Arthritis, Rheumatoid; Bone Marrow; Bone Marrow Cells; Chlorambucil; Cyclophosphamide; Diagnosis, Di | 1976 |
Preferential reductions in lymphocyte sub-populations induced by monthly pulses of chlorambucil: studies in patients with chronic progressive multiple sclerosis.
Topics: Antigens, CD; Azathioprine; Chlorambucil; Cyclophosphamide; Dose-Response Relationship, Drug; Drug E | 1991 |
[Acute leukemia secondary to the treatment of multiple sclerosis with chlorambucil].
Topics: Adult; Alkylating Agents; Chlorambucil; Female; Humans; Immunosuppressive Agents; Leukemia, Myeloid, | 1985 |
Multiple sclerosis: pilot therapeutic trial of immunosuppressants.
Topics: Adrenocorticotropic Hormone; Adult; Chlorambucil; Cyclophosphamide; Female; Humans; Immunosuppressiv | 1969 |
[Plant agglutinin- and PPD tuberculin-stimulated lymphocyte transformation in vitro in patients with disseminated sclerosis].
Topics: Adrenocorticotropic Hormone; Adult; Azathioprine; Chlorambucil; Cyclophosphamide; Female; Humans; Le | 1971 |
[Critic study of multiple sclerosis treatment by chlorambucil and intraspinal corticotherapy. Apropos of 100 cases followed up from 2 to 9 years].
Topics: Acetates; Adrenocorticotropic Hormone; Adult; Amenorrhea; Chlorambucil; Female; Follow-Up Studies; H | 1973 |
[Letter: Teratogenic effects of medications].
Topics: Abnormalities, Drug-Induced; Adult; Chlorambucil; Female; Humans; Hydroxyurea; Leukemia, Lymphoid; M | 1974 |