chlorambucil has been researched along with Lymphoma, Mantle-Cell in 15 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Lymphoma, Mantle-Cell: A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. It accounts for about 5% of adult non-Hodgkin lymphomas in the United States and Europe. The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Progressive severe pancytopenia due to the diffuse bone marrow infiltration led to life-threatening infections following oral chlorambucil treatment." | 3.72 | Remarkable response to rituximab in a patient with atypical CD20(++) mantle cell lymphoma of the bone marrow leading to severe pancytopenia. ( Ho, AD; Kraemer, A; Seggewiss, R, 2004) |
| "We conducted an integrated safety analysis to characterize the frequency, severity, natural history, and outcomes of adverse events (AEs) with ibrutinib versus comparators." | 2.87 | Safety Analysis of Four Randomized Controlled Studies of Ibrutinib in Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma or Mantle Cell Lymphoma. ( Barr, PM; Burger, JA; Chang, S; Coutre, S; Cramer, P; Dilhuydy, MS; Fraser, G; Graef, T; Hess, G; Hillmen, P; Howes, A; James, DF; Liu, E; Moreno, C; O'Brien, S; Patel, K; Styles, L; Tedeschi, A; Valentino, R; Vermeulen, J, 2018) |
| "Of 79 evaluable patients, 58 (73%) had follicular lymphoma, 13 (16%) mantle cell lymphoma and 8 (10%) lymphoplasmacytic lymphoma." | 2.73 | Initial chemotherapy with mitoxantrone, chlorambucil, prednisone impairs the collection of stem cells in patients with indolent lymphomas--results of a randomized comparison by the German Low-Grade Lymphoma Study Group. ( Dörken, B; Dreyling, M; Forstpointner, R; Freund, M; Ganser, A; Hiddemann, W; Hoster, E; Huber, C; Ludwig, WD; Nickenig, C; Trümper, L; Unterhalt, M, 2007) |
| "In patients with advanced-stage follicular lymphoma (FL) and mantle cell lymphoma (MCL), conventional chemotherapy remains a noncurative approach, and no major improvement in overall survival has been achieved in recent decades." | 2.72 | Combined cyclophosphamide, vincristine, doxorubicin, and prednisone (CHOP) improves response rates but not survival and has lower hematologic toxicity compared with combined mitoxantrone, chlorambucil, and prednisone (MCP) in follicular and mantle cell ly ( Dreyling, M; Hiddemann, W; Hoster, E; Lengfelder, E; Nickenig, C; Pfreundschuh, M; Reiser, M; Trumper, L; Unterhalt, M; Wandt, H, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (46.67) | 29.6817 |
| 2010's | 8 (53.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| O'Brien, S | 1 |
| Hillmen, P | 1 |
| Coutre, S | 1 |
| Barr, PM | 1 |
| Fraser, G | 1 |
| Tedeschi, A | 1 |
| Burger, JA | 1 |
| Dilhuydy, MS | 1 |
| Hess, G | 1 |
| Moreno, C | 1 |
| Cramer, P | 1 |
| Liu, E | 1 |
| Chang, S | 1 |
| Vermeulen, J | 1 |
| Styles, L | 1 |
| Howes, A | 1 |
| James, DF | 1 |
| Patel, K | 1 |
| Graef, T | 1 |
| Valentino, R | 1 |
| Palmisano, F | 1 |
| Lorusso, V | 1 |
| Spinelli, MG | 1 |
| Dell'Orto, PG | 1 |
| Montanari, E | 1 |
| Guo, JX | 1 |
| Zhou, YH | 1 |
| Pan, JX | 1 |
| Guo, XZ | 1 |
| Wu, SX | 1 |
| Huang, YQ | 1 |
| Gressin, R | 2 |
| Caulet-Maugendre, S | 2 |
| Deconinck, E | 1 |
| Tournilhac, O | 2 |
| Gyan, E | 1 |
| Moles, MP | 2 |
| El Yamani, A | 2 |
| Cornillon, J | 1 |
| Rossi, JF | 1 |
| Le Gouill, S | 2 |
| Lepeu, G | 1 |
| Damaj, G | 1 |
| Celigny, PS | 1 |
| Maisonneuve, H | 2 |
| Corront, B | 1 |
| Vilque, JP | 1 |
| Casassus, P | 1 |
| Lamy, T | 1 |
| Colonna, M | 1 |
| Colombat, P | 1 |
| Geisler, CH | 1 |
| Sachanas, S | 1 |
| Pangalis, GA | 1 |
| Vassilakopoulos, TP | 1 |
| Korkolopoulou, P | 1 |
| Kontopidou, FN | 1 |
| Athanasoulia, M | 1 |
| Yiakoumis, X | 1 |
| Kalpadakis, C | 1 |
| Georgiou, G | 1 |
| Masouridis, S | 1 |
| Moschogiannis, M | 1 |
| Tsirkinidis, P | 1 |
| Pappis, V | 1 |
| Kokoris, SI | 1 |
| Siakantaris, MP | 1 |
| Panayiotidis, P | 1 |
| Angelopoulou, MK | 1 |
| Dreyling, M | 3 |
| Polliack, A | 1 |
| Tadmor, T | 1 |
| Houot, R | 1 |
| Ojeda Uribe, M | 1 |
| Mounier, C | 1 |
| Courby, S | 1 |
| Dartigeas, C | 1 |
| Bouabdallah, K | 1 |
| Alexis Vigier, M | 1 |
| Arakelyan, N | 1 |
| Rodon, P | 1 |
| Sutton, L | 1 |
| Fornecker, L | 1 |
| Assouline, D | 1 |
| Harousseau, JL | 1 |
| Herold, M | 1 |
| Dölken, G | 1 |
| Fiedler, F | 1 |
| Franke, A | 1 |
| Freund, M | 2 |
| Helbig, W | 1 |
| Pasold, R | 1 |
| Seggewiss, R | 1 |
| Ho, AD | 1 |
| Kraemer, A | 1 |
| Robinson, H | 1 |
| Rymes, N | 1 |
| Bauwens, D | 1 |
| Maerevoet, M | 1 |
| Michaux, L | 1 |
| Théate, I | 1 |
| Hagemeijer, A | 1 |
| Stul, M | 1 |
| Danse, E | 1 |
| Costantini, S | 1 |
| Vannuffel, P | 1 |
| Straetmans, N | 1 |
| Vekemans, MC | 1 |
| Deneys, V | 1 |
| Ferrant, A | 1 |
| Van Den Neste, E | 1 |
| Nickenig, C | 2 |
| Hoster, E | 2 |
| Pfreundschuh, M | 1 |
| Trumper, L | 2 |
| Reiser, M | 1 |
| Wandt, H | 1 |
| Lengfelder, E | 1 |
| Unterhalt, M | 2 |
| Hiddemann, W | 2 |
| Ludwig, WD | 1 |
| Dörken, B | 1 |
| Huber, C | 1 |
| Ganser, A | 1 |
| Forstpointner, R | 1 |
| Ferrer, A | 1 |
| Bosch, F | 1 |
| Villamor, N | 1 |
| Rozman, M | 1 |
| Graus, F | 1 |
| Gutiérrez, G | 1 |
| Mercadal, S | 1 |
| Campo, E | 1 |
| Rozman, C | 1 |
| López-Guillermo, A | 1 |
| Montserrat, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Long-term Effect of Chronic Ibrutinib Therapy on Left Atrial Function[NCT03751410] | 40 participants (Actual) | Observational [Patient Registry] | 2018-12-01 | Completed | |||
| Treatment in First Line of Mantle Cell Lymphoma for Patients Under 66 Years by the VAD-CHLORAMBUCIL -Rituximab Regimen Followed by Intensification and Autologous PBSC Transplantation After Marrow Purging With Rituximab[NCT00285389] | Phase 2 | 39 participants (Actual) | Interventional | 2002-02-28 | Completed | ||
| Exploring Patient Engagement Patterns and Participation Trends in Mantle Cell Lymphoma Clinical Trials[NCT06049472] | 500 participants (Anticipated) | Observational | 2024-10-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for chlorambucil and Lymphoma, Mantle-Cell
| Article | Year |
|---|---|
Blastoid variant of mantle cell lymphoma of the female urethra mimicking a caruncle: A rare but highly aggressive subtype case with literature review.
Topics: Aged, 80 and over; Antineoplastic Agents, Alkylating; Chlorambucil; Diagnosis, Differential; Disease | 2019 |
8 trials available for chlorambucil and Lymphoma, Mantle-Cell
| Article | Year |
|---|---|
Safety Analysis of Four Randomized Controlled Studies of Ibrutinib in Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma or Mantle Cell Lymphoma.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; | 2018 |
Evaluation of the (R)VAD+C regimen for the treatment of newly diagnosed mantle cell lymphoma. Combined results of two prospective phase II trials from the French GOELAMS group.
Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherap | 2010 |
Combination of rituximab with chlorambucil as first line treatment in patients with mantle cell lymphoma: a highly effective regimen.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Anti | 2011 |
Combination of rituximab, bortezomib, doxorubicin, dexamethasone and chlorambucil (RiPAD+C) as first-line therapy for elderly mantle cell lymphoma patients: results of a phase II trial from the GOELAMS.
Topics: Aged; Aged, 80 and over; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherap | 2012 |
Randomized phase III study for the treatment of advanced indolent non-Hodgkin's lymphomas (NHL) and mantle cell lymphoma: chemotherapy versus chemotherapy plus rituximab.
Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplas | 2003 |
Activity and safety of combined rituximab with chlorambucil in patients with mantle cell lymphoma.
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined | 2005 |
Combined cyclophosphamide, vincristine, doxorubicin, and prednisone (CHOP) improves response rates but not survival and has lower hematologic toxicity compared with combined mitoxantrone, chlorambucil, and prednisone (MCP) in follicular and mantle cell ly
Topics: Adult; Aged; Agranulocytosis; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Cyclopho | 2006 |
Initial chemotherapy with mitoxantrone, chlorambucil, prednisone impairs the collection of stem cells in patients with indolent lymphomas--results of a randomized comparison by the German Low-Grade Lymphoma Study Group.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Chlorambucil; Cyclophospham | 2007 |
6 other studies available for chlorambucil and Lymphoma, Mantle-Cell
| Article | Year |
|---|---|
[Action Mechanism of Chlorambucil against Mantle Cell Lymphoma Cell Line Jeko-1].
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Chlorambucil; Down-Regulation; Humans; Lymphoma, Ma | 2016 |
Front-line treatment of mantle cell lymphoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Combined Modality Therapy; Cytarabine; | 2010 |
Chlorambucil in indolent mantle cell lymphoma--just another old drug for a new disease?
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Chlorambucil; Disease Progressio | 2011 |
Remarkable response to rituximab in a patient with atypical CD20(++) mantle cell lymphoma of the bone marrow leading to severe pancytopenia.
Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antigens, CD20; Antineoplastic | 2004 |
Extranodal mantle cell lymphoma in a prolapsed ileostomy stump.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Dexamethasone; Humans; Ileal Neo | 2005 |
Central nervous system involvement in mantle cell lymphoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocol | 2008 |