Compounds > chlorambucil
Page last updated: 2024-10-24

chlorambucil and Lymphoma, Large B-Cell, Diffuse

chlorambucil has been researched along with Lymphoma, Large B-Cell, Diffuse in 41 studies

Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.

Lymphoma, Large B-Cell, Diffuse: Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.

Research Excerpts

ExcerptRelevanceReference
"Histopathological subtypes consist of Burkitt's lymphoma (BL) in 32 (43."1.48Demographics and Outome in Paediatric Non-Hodgkin Lymphoma: Single Centre Experience at The Children Hospital Lahore, Pakistan. ( Anwar, S; Faizan, M; Khan, S, 2018)
"One response, however, did relate that diffuse histiocytic lymphoma developed in three of 141 patients receiving prolonged chlorambucil therapy for polycythemia vera."1.26Lymphoma in primary chronic cold hemagglutinin disease treated with chlorambucil. ( Chaplin, H, 1982)
"Low-grade malignant lymphomas are treated best with conventional doses of an alkylating agent."1.26[Chemotherapy in non-Hodgkin's lymphomas (author's transl)]. ( Schmidt, CG, 1977)

Research

Studies (41)

TimeframeStudies, this research(%)All Research%
pre-199034 (82.93)18.7374
1990's1 (2.44)18.2507
2000's1 (2.44)29.6817
2010's4 (9.76)24.3611
2020's1 (2.44)2.80

Authors

AuthorsStudies
Matsuyama, A1
Bienzle, D1
Richardson, D1
Deravi, N1
Hwang, MH1
Darzentas, N1
Keller, SM1
Maddox, JM1
Horan, M1
Tafesh, L1
Shrubsole, C1
Osborne, W1
Faizan, M1
Anwar, S1
Khan, S1
Bhagat, P1
Sachdeva, MU1
Sharma, P1
Naseem, S1
Ahluwalia, J1
Das, R1
Varma, N1
Law, A1
Malhotra, P1
Tadmor, T1
Bejar, J1
Attias, D1
Polliack, A1
PITNEY, WR1
MOLANDER, DW1
WILLIAMS, HM1
FEIWEL, M1
MUNRO, DD1
DIAMANDOPOULOS, GT1
SMITH, EB1
TANIDA, T1
PAPAC, RJ1
WOOD, DA2
KARNOFSKY, DA1
HUTCHISON, JL1
EZDINLI, EZ1
STUTZMAN, L1
WANEBO, HJ1
CLARKSON, BD1
RABENKO, J1
Froehner, M1
Haase, M1
Hakenberg, OW1
Wirth, MP1
Chaplin, H1
Murphy, A1
O'Keane, JC1
Blayney, A1
Powell, FC1
Bennett, JM1
Bakemeier, RF1
Carbone, PP1
Ezdinli, E1
Lenhard, RE2
Schmidt, CG1
Mattsson, W1
von Eyben, F1
Turesson, I1
Wählby, S1
Burrow, JN1
Wright, J1
Juttner, CA1
Crowley, KS1
Kimber, RJ1
Hoerni, B1
Brunet, R1
Hoerni-Simon, G1
Zittoun, R1
Lebon, P1
Diebold, J1
Armstrong, JG1
Morgenfeld, MC3
Helft, F2
Bomchil, G2
Jones, SE1
Rosenberg, SA2
Kaplan, HS1
Kadin, ME1
Dorfman, RF1
Aungst, CW2
Sokal, JE1
Han, T1
Stojcevski, T1
Jacobs, EM1
Peters, FC1
Luce, JK1
Zippin, C1
Kaung, DT1
Wittington, RM1
Spencer, H1
Patno, ME1
Richter, P1
Calamera, JC1
Kierszenbaum, AL1
Lavieri, JC1
Mancini, RE1
Elalouf, C1
Grupper, C1
Miller, DG1
Hartwich, G1
Butzler, W1
Owens, AH1

Reviews

2 reviews available for chlorambucil and Lymphoma, Large B-Cell, Diffuse

ArticleYear
Primary bone marrow lymphoma is a rare neoplasm with poor outcome: case series from single tertiary care centre and review of literature.
    Hematological oncology, 2016, Volume: 34, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; B-Lymphocytes; Biopsy; Bone Marrow; Bone Marrow Exam

2016
Cutaneous presentation of nasal lymphoma: a report of two cases.
    Journal of the American Academy of Dermatology, 1998, Volume: 38, Issue:2 Pt 2

    Topics: Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Chlorambuci

1998

Trials

3 trials available for chlorambucil and Lymphoma, Large B-Cell, Diffuse

ArticleYear
Clinical trials with BCNU (NSC-409962) in malignant lymphomas by the Eastern Cooperative Oncology Group.
    Cancer treatment reports, 1976, Volume: 60, Issue:6

    Topics: Bleomycin; Carmustine; Chlorambucil; Clinical Trials as Topic; Cyclophosphamide; Doxorubicin; Drug T

1976
Mechlorethamine HCl and cyclophosphamide in the treatment of Hodgkin's disease and the lymphomas.
    JAMA, 1968, Feb-05, Volume: 203, Issue:6

    Topics: Chlorambucil; Clinical Trials as Topic; Cyclophosphamide; Dosage Forms; Follow-Up Studies; Hodgkin D

1968
Comparison of chlorambucil and streptonigrin (NSC-45383) in the treatment of malignant lymphomas.
    Cancer, 1969, Volume: 23, Issue:6

    Topics: Antibiotics, Antineoplastic; Bone Marrow; Chlorambucil; Clinical Trials as Topic; Digestive System;

1969

Other Studies

36 other studies available for chlorambucil and Lymphoma, Large B-Cell, Diffuse

ArticleYear
Composite lymphoma of concurrent T zone lymphoma and large cell B cell lymphoma in a dog.
    BMC veterinary research, 2019, Nov-16, Volume: 15, Issue:1

    Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Chlorambucil; Dog Disea

2019
DECC (dexamethasone, etoposide, chlorambucil, lomustine) as an oral chemotherapy regimen in relapsed and refractory diffuse large B-cell lymphoma.
    British journal of haematology, 2021, Volume: 192, Issue:3

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols

2021
Demographics and Outome in Paediatric Non-Hodgkin Lymphoma: Single Centre Experience at The Children Hospital Lahore, Pakistan.
    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2018, Volume: 28, Issue:1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Child; Child, Preschoo

2018
Richter syndrome in chronic lymphocytic leukaemia manifesting only as tumorous hepatomegaly.
    British journal of haematology, 2011, Volume: 155, Issue:2

    Topics: Adrenal Cortex Hormones; Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemo

2011
Chemotherapy of malignant disease. II. Diseases of lymphoid tissue and bone marrow.
    The Medical journal of Australia, 1962, Dec-01, Volume: 49(2)

    Topics: Adrenal Cortex Hormones; Aged; Bone Marrow; Busulfan; Chlorambucil; Cyclophosphamide; Hodgkin Diseas

1962
THE MALIGNANT LYMPHOMAS.
    The American journal of nursing, 1963, Volume: 63

    Topics: Adrenal Cortex Hormones; Chlorambucil; Cyclophosphamide; Hodgkin Disease; Humans; Lymphoma; Lymphoma

1963
CLINICAL EVALUATION OF URACIL MUSTARD.
    Cancer chemotherapy reports, 1963, Volume: 32

    Topics: Anemia; Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Female; Hodgkin Disease; Humans; Kidn

1963
THE RETICULOSES.
    The British journal of clinical practice, 1964, Volume: 18

    Topics: Adrenal Cortex Hormones; Chlorambucil; Cyclophosphamide; Dermatitis, Exfoliative; Genetic Diseases,

1964
PHAGOCYTOSIS IN RETICULUM CELL SARCOMA.
    Cancer, 1964, Volume: 17

    Topics: Adolescent; Black People; Child; Chlorambucil; Cyclophosphamide; Dactinomycin; Geriatrics; Leukemia;

1964
[HISTOPATHOLOGICAL EFFECTS OF ANTINEOPLASTIC AGENTS ON MALIGNANT LYMPHOMA].
    Nagasaki Igakkai zasshi = Nagasaki medical journal, 1964, Volume: 39

    Topics: Antineoplastic Agents; Child; Chlorambucil; Cyclophosphamide; Dactinomycin; Geriatrics; Hodgkin Dise

1964
LONG TERM RESULTS ACHIEVED WITH THE USE OF ALKYLATING AGENTS IN MALIGNANT LYMPHOMA AND HODGKIN'S DISEASE.
    Acta - Unio Internationalis Contra Cancrum, 1964, Volume: 20

    Topics: Alkylating Agents; Chlorambucil; Cyclophosphamide; Hodgkin Disease; Humans; Lymphoma; Lymphoma, Larg

1964
NONSURGICAL TREATMENT OF PULMONARY CANCER.
    Modern treatment, 1964, Volume: 1

    Topics: Adenocarcinoma, Bronchiolo-Alveolar; Adrenal Cortex Hormones; Alkylating Agents; Antineoplastic Agen

1964
THE MANAGEMENT OF LEUKEMIA AND LYMPHOMA.
    Applied therapeutics, 1964, Volume: 6

    Topics: Adrenal Cortex Hormones; Busulfan; Chlorambucil; Cortisone; Cyclophosphamide; Hodgkin Disease; Human

1964
CHLORAMBUCIL THERAPY FOR LYMPHOMAS AND CHRONIC LYMPHOCYTIC LEUKEMIA.
    JAMA, 1965, Feb-08, Volume: 191

    Topics: Adrenal Cortex Hormones; Chlorambucil; Drug Synergism; Hodgkin Disease; Leukemia; Leukemia, Lymphocy

1965
ESSENTIAL MACROGLOBULINEMIA. REPORT OF A CASE INCLUDING IMMUNOFLUORESCENT AND ELECTRON MICROSCOPIC STUDIES.
    Annals of internal medicine, 1965, Volume: 62

    Topics: Blood Protein Electrophoresis; Bone Marrow Cells; Chlorambucil; Electrons; Fluorescent Antibody Tech

1965
[Results obtained with the use of chlorambucil in the treatment of malignant lymphopathies].
    La Semana medica, 1961, Jul-31, Volume: 119

    Topics: Chlorambucil; Hodgkin Disease; Humans; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodg

1961
Urinary immunocytology for primary bladder B cell lymphoma.
    Urology, 2004, Volume: 63, Issue:2

    Topics: Aged; Antigens, CD20; Antigens, Neoplasm; Antineoplastic Combined Chemotherapy Protocols; B-Lymphocy

2004
Lymphoma in primary chronic cold hemagglutinin disease treated with chlorambucil.
    Archives of internal medicine, 1982, Volume: 142, Issue:12

    Topics: Anemia, Hemolytic, Autoimmune; Chlorambucil; Chronic Disease; Cold Temperature; Humans; Lymphoma, La

1982
[Chemotherapy in non-Hodgkin's lymphomas (author's transl)].
    Strahlentherapie, 1977, Volume: 153, Issue:5

    Topics: Antineoplastic Agents; Bleomycin; Burkitt Lymphoma; Chlorambucil; Cyclophosphamide; Doxorubicin; Dru

1977
Prednimustine (NSC-134087, Leo 1031) treatment of lymphocytic and lymphocytic-histiocytic lymphomas.
    Cancer, 1978, Volume: 41, Issue:1

    Topics: Bone Marrow; Chlorambucil; Female; Humans; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; M

1978
Diffuse histiocytic lymphoma: the 20-year experience of an Australian teaching hospital.
    Australian and New Zealand journal of medicine, 1988, Volume: 18, Issue:6

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Australia; Chlorambucil; Cyclophosphami

1988
[Richter's syndrome. 4 cases and an attempt at analysis].
    Acta haematologica, 1973, Volume: 50, Issue:4

    Topics: Aged; Carcinoma, Squamous Cell; Chlorambucil; Cyclophosphamide; Deglutition Disorders; Drug Therapy,

1973
[Sjögren's syndrome with pseudolymphoma].
    Annales de medecine interne, 1974, Volume: 125, Issue:11

    Topics: Biopsy; Chlorambucil; Diagnosis, Differential; Female; Hodgkin Disease; Humans; Lymph Nodes; Lymphat

1974
Current problems in the use of the oncolytic drugs.
    Acta geneticae medicae et gemellologiae, 1968, Volume: 17, Issue:1

    Topics: Antineoplastic Agents; Busulfan; Carcinoma, Squamous Cell; Child; Chlorambucil; Choriocarcinoma; Dac

1968
[Different response of the superficial and deep lymph nodes to therapy in malignant lymphoreticulopathies].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1968, Apr-14, Volume: 44, Issue:18

    Topics: Adult; Chlorambucil; Cyclophosphamide; Female; Humans; Leukemia, Lymphoid; Lymphatic Metastasis; Lym

1968
Non-Hodgkin's lymphomas. II. Single agent chemotherapy.
    Cancer, 1972, Volume: 30, Issue:1

    Topics: Alkylating Agents; Chlorambucil; Cyclophosphamide; Humans; Lymphoma; Lymphoma, Large B-Cell, Diffuse

1972
Treatment of Hodgkin's disease and other malignant lymphomas.
    Journal of surgical oncology, 1973, Volume: 5, Issue:6

    Topics: Alkylating Agents; Antineoplastic Agents; Carmustine; Chlorambucil; Cyclohexanes; Cyclophosphamide;

1973
Effect of BCG on delayed hypersensitivity responses of patients with neoplastic disease.
    International journal of cancer, 1973, Jul-15, Volume: 12, Issue:1

    Topics: Animals; Antigen-Antibody Reactions; BCG Vaccine; Cattle; Chlorambucil; Cyclophosphamide; Hodgkin Di

1973
Haemolytic anaemia in malignant lymphoreticuloendothelial diseases.
    Haematologia, 1974, Volume: 8, Issue:1-4

    Topics: Adult; Anemia, Hemolytic; Anemia, Hemolytic, Autoimmune; Autoantibodies; Bone Marrow Examination; Ce

1974
Contribution of lymphangiography to our understanding of lymphoma.
    Cancer chemotherapy reports, 1968, Volume: 52, Issue:1

    Topics: Chlorambucil; Hodgkin Disease; Humans; Lymphography; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymp

1968
Effect of chlorambucil on spermatogenesis in the human with malignant lymphoma.
    Cancer, 1970, Volume: 25, Issue:5

    Topics: Adolescent; Adult; Biopsy; Chlorambucil; Hodgkin Disease; Humans; Infertility, Male; Lymphoma; Lymph

1970
[Localized malignant reticulosis ameliorated by chloraminophene].
    Bulletin de la Societe francaise de dermatologie et de syphiligraphie, 1969, Volume: 76, Issue:6

    Topics: Adult; Chlorambucil; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Skin Neoplasms

1969
Alkylating agents and human spermatogenesis.
    JAMA, 1971, Sep-20, Volume: 217, Issue:12

    Topics: Adolescent; Adult; Alkylating Agents; Chlorambucil; Cyclophosphamide; Hodgkin Disease; Humans; Lymph

1971
[Different response of superficial and deep lymph nodes to drug therapy in malignant lymphoreticulopathy].
    Therapeutique (La Semaine des hopitaux), 1969, Volume: 45, Issue:3

    Topics: Aged; Chlorambucil; Cyclophosphamide; Female; Humans; Leukemia, Lymphoid; Lymph Nodes; Lymphoma, Lar

1969
[Secondary tumors in hemoblastoses during cytostatic treatment].
    Medizinische Klinik, 1971, Oct-22, Volume: 66, Issue:43

    Topics: Adrenal Gland Neoplasms; Aged; Antineoplastic Agents; Bronchial Neoplasms; Busulfan; Carcinoma; Chlo

1971
Recent advances in chemotherapy of lymphoma.
    The Johns Hopkins medical journal, 1967, Volume: 121, Issue:2

    Topics: Alkylating Agents; Chlorambucil; Cyclophosphamide; Hodgkin Disease; Humans; Lymphoma; Lymphoma, Larg

1967