chlorambucil has been researched along with Lymphoma, Follicular in 36 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Lymphoma, Follicular: Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. The nodules resemble to some extent the GERMINAL CENTER of lymph node follicles and most likely represent neoplastic proliferation of lymph node-derived follicular center B-LYMPHOCYTES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the effect of epirubicin on therapeutic response and survival in patients with indolent nonfollicular B-cell lymphomas (INFL) treated with pulsed high-dose chlorambucil." | 5.10 | Treatment of indolent B-Cell nonfollicular lymphomas: final results of the LL01 randomized trial of the Gruppo Italiano per lo Studio dei Linfomi. ( Baldini, L; Brugiatelli, M; Cavanna, L; Colombi, M; Federico, M; Gobbi, P; Goldaniga, M; Liberati, M; Lombardo, M; Luminari, S; Merli, F; Morabito, F; Sacchi, S; Silingardi, V; Stelitano, C, 2003) |
| "No cases of progression occurred in minimal residual disease (MRD) negative patients after six years of follow-up." | 2.94 | The UK NCRI study of chlorambucil, mitoxantrone and dexamethasone (CMD) versus fludarabine, mitoxantrone and dexamethasone (FMD) for untreated advanced stage follicular lymphoma: molecular response strongly predicts prolonged overall survival. ( Bishton, MJ; Clifton-Hadley, L; Haynes, A; Lush, R; McMillan, A; Patmore, R; Rule, S; Turner, D; Wilson, W, 2020) |
| "Of 79 evaluable patients, 58 (73%) had follicular lymphoma, 13 (16%) mantle cell lymphoma and 8 (10%) lymphoplasmacytic lymphoma." | 2.73 | Initial chemotherapy with mitoxantrone, chlorambucil, prednisone impairs the collection of stem cells in patients with indolent lymphomas--results of a randomized comparison by the German Low-Grade Lymphoma Study Group. ( Dörken, B; Dreyling, M; Forstpointner, R; Freund, M; Ganser, A; Hiddemann, W; Hoster, E; Huber, C; Ludwig, WD; Nickenig, C; Trümper, L; Unterhalt, M, 2007) |
| "In patients with advanced-stage follicular lymphoma (FL) and mantle cell lymphoma (MCL), conventional chemotherapy remains a noncurative approach, and no major improvement in overall survival has been achieved in recent decades." | 2.72 | Combined cyclophosphamide, vincristine, doxorubicin, and prednisone (CHOP) improves response rates but not survival and has lower hematologic toxicity compared with combined mitoxantrone, chlorambucil, and prednisone (MCP) in follicular and mantle cell ly ( Dreyling, M; Hiddemann, W; Hoster, E; Lengfelder, E; Nickenig, C; Pfreundschuh, M; Reiser, M; Trumper, L; Unterhalt, M; Wandt, H, 2006) |
| "The biology of follicular lymphoma evidently includes the potential for tumor dormancy after therapies with varied mechanisms of action, resulting in clinical inactivity for many years." | 2.69 | Anti-idiotype antibodies can induce long-term complete remissions in non-Hodgkin's lymphoma without eradicating the malignant clone. ( Czerwinski, DK; Davis, TA; Levy, R; Liles, TM; Maloney, DG, 1998) |
| "Fewest relapses have been seen in patients who received IFN-alpha 2b throughout." | 2.67 | Interferon-alpha 2b in the treatment of follicular lymphoma: preliminary results of a trial in progress. ( Bailey, N; Blackledge, G; Crowther, D; Deakin, D; Lister, TA; Norton, A; Price, CG; Rohatiner, AZ; Steward, W, 1991) |
| "Two cases of CLL and one each of follicular lymphoma and pseudolymphoma achieved partial remission." | 1.27 | [Phase II study of chlorambucil in patients with hematological malignancies]. ( Horikoshi, N; Imajoh, K; Inoue, K; Itoh, Y; Mukaiyama, T; Nagamine, D; Ogawa, M; Ozeki, H; Shinagawa, K, 1987) |
| " We conclude that PMN is effective for FL and CLL, and that in addition, it has an advantage in that its mild side effects allow long-term administration through outpatient clinics, so that the quality of life for patients is not impaired." | 1.27 | [Phase II study of prednimustine in follicular lymphoma and chronic lymphocytic leukemia]. ( Horikoshi, N; Imajou, K; Inoue, K; Ito, Y; Miyaoka, K; Mukaiyama, T; Nakamura, T; Ogawa, M; Ozeki, H; Ueno, K, 1987) |
| "Low-grade malignant lymphomas are treated best with conventional doses of an alkylating agent." | 1.26 | [Chemotherapy in non-Hodgkin's lymphomas (author's transl)]. ( Schmidt, CG, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (30.56) | 18.7374 |
| 1990's | 7 (19.44) | 18.2507 |
| 2000's | 12 (33.33) | 29.6817 |
| 2010's | 5 (13.89) | 24.3611 |
| 2020's | 1 (2.78) | 2.80 |
| Authors | Studies |
|---|---|
| Bishton, MJ | 1 |
| Rule, S | 1 |
| Wilson, W | 1 |
| Turner, D | 1 |
| Patmore, R | 1 |
| Clifton-Hadley, L | 1 |
| McMillan, A | 1 |
| Lush, R | 1 |
| Haynes, A | 1 |
| Budau, L | 1 |
| Wilhelm, C | 1 |
| Moll, R | 1 |
| Jäkel, J | 1 |
| Hirt, C | 3 |
| Dölken, G | 3 |
| Maschmeyer, G | 1 |
| Neubauer, E | 1 |
| Strauch, K | 1 |
| Burchert, A | 1 |
| Herold, M | 4 |
| Neubauer, A | 2 |
| Martinelli, G | 2 |
| Montoro, J | 1 |
| Vanazzi, A | 1 |
| Andreola, G | 2 |
| Liptrott, S | 1 |
| Radice, D | 2 |
| Negri, M | 1 |
| Preda, L | 1 |
| Pruneri, G | 2 |
| Laszlo, D | 2 |
| Scholz, CW | 1 |
| Rothmann, F | 1 |
| Lakner, V | 1 |
| Naumann, R | 2 |
| Barzenje, DA | 1 |
| Cvancarova Småstuen, M | 1 |
| Liestøl, K | 1 |
| Fosså, A | 1 |
| Delabie, J | 1 |
| Kolstad, A | 1 |
| Holte, H | 1 |
| Papaioannou, D | 1 |
| Rafia, R | 1 |
| Rathbone, J | 1 |
| Stevenson, M | 1 |
| Buckley Woods, H | 1 |
| Stevens, J | 1 |
| Baxter, NP | 1 |
| Lane, G | 1 |
| Swift, S | 1 |
| Baldini, L | 1 |
| Brugiatelli, M | 1 |
| Luminari, S | 1 |
| Lombardo, M | 1 |
| Merli, F | 1 |
| Sacchi, S | 1 |
| Gobbi, P | 1 |
| Liberati, M | 1 |
| Cavanna, L | 1 |
| Colombi, M | 1 |
| Stelitano, C | 1 |
| Goldaniga, M | 1 |
| Morabito, F | 1 |
| Federico, M | 1 |
| Silingardi, V | 1 |
| Haas, RL | 1 |
| Girinsky, T | 1 |
| MOLANDER, DW | 1 |
| PERRONE, V | 1 |
| FAIELLA, A | 1 |
| ZARRILLI, D | 1 |
| CAJANO, A | 1 |
| Manoharan, A | 1 |
| Nickenig, C | 2 |
| Dreyling, M | 2 |
| Hoster, E | 2 |
| Pfreundschuh, M | 1 |
| Trumper, L | 2 |
| Reiser, M | 1 |
| Wandt, H | 1 |
| Lengfelder, E | 1 |
| Unterhalt, M | 2 |
| Hiddemann, W | 2 |
| Ludwig, WD | 1 |
| Dörken, B | 1 |
| Freund, M | 2 |
| Huber, C | 1 |
| Ganser, A | 1 |
| Forstpointner, R | 1 |
| Marcus, R | 1 |
| Rabascio, C | 1 |
| Raia, V | 1 |
| Calabrese, L | 1 |
| Saronni, L | 1 |
| Haas, A | 2 |
| Srock, S | 2 |
| Neser, S | 2 |
| Al-Ali, KH | 1 |
| Knauf, W | 1 |
| Rohrberg, R | 2 |
| Höffken, K | 1 |
| Franke, A | 1 |
| Ittel, T | 1 |
| Kettner, E | 1 |
| Haak, U | 1 |
| Mey, U | 1 |
| Klinkenstein, C | 1 |
| Assmann, M | 2 |
| von Grünhagen, U | 1 |
| Rigacci, L | 1 |
| Nassi, L | 1 |
| Puccioni, M | 1 |
| Mappa, S | 1 |
| Polito, E | 1 |
| Dal Pozzo, S | 1 |
| Alterini, R | 1 |
| Carrai, V | 1 |
| Puccini, B | 1 |
| Bosi, A | 1 |
| Schüler, F | 1 |
| Kiefer, T | 1 |
| Schwenke, C | 1 |
| Niederwieser, D | 1 |
| Dachselt, K | 1 |
| Leithäuser, M | 1 |
| Rabkin, CS | 1 |
| Cadman, E | 1 |
| Drislane, F | 1 |
| Waldron, JA | 1 |
| Farber, L | 1 |
| Prosnitz, L | 1 |
| Bertino, JR | 1 |
| Denham, JW | 1 |
| Denham, E | 1 |
| Dear, KB | 1 |
| Hudson, GV | 1 |
| Davis, TA | 1 |
| Maloney, DG | 1 |
| Czerwinski, DK | 1 |
| Liles, TM | 1 |
| Levy, R | 2 |
| Sternberg, AJ | 1 |
| Matutes, E | 1 |
| Killick, S | 1 |
| Wotherspoon, AC | 1 |
| Catovsky, D | 1 |
| Rohatiner, A | 1 |
| Radford, J | 1 |
| Deakin, D | 3 |
| Earl, H | 1 |
| Love, SB | 1 |
| Price, O | 1 |
| Wilson, A | 1 |
| Lister, TA | 4 |
| Schmidt, CG | 2 |
| Betourne, C | 1 |
| Cassan, P | 1 |
| Franc, B | 1 |
| Bacri, JL | 1 |
| Chisesi, T | 1 |
| Congiu, M | 1 |
| Contu, A | 1 |
| Coser, P | 1 |
| Moretti, L | 1 |
| Porcellini, A | 1 |
| Rancan, L | 1 |
| Salvagno, L | 1 |
| Santini, G | 1 |
| Vinante, O | 1 |
| Price, CG | 2 |
| Rohatiner, AZ | 2 |
| Steward, W | 2 |
| Bailey, N | 2 |
| Norton, A | 2 |
| Blackledge, G | 2 |
| Crowther, D | 2 |
| Cavaliere, A | 1 |
| Pietropaoli, N | 1 |
| Alberti, PF | 1 |
| Vitali, R | 1 |
| Inoue, K | 2 |
| Ogawa, M | 2 |
| Horikoshi, N | 2 |
| Mukaiyama, T | 2 |
| Itoh, Y | 1 |
| Imajoh, K | 1 |
| Ozeki, H | 2 |
| Nagamine, D | 1 |
| Shinagawa, K | 1 |
| Gallagher, CJ | 1 |
| Gregory, WM | 1 |
| Jones, AE | 1 |
| Stansfeld, AG | 1 |
| Richards, MA | 1 |
| Dhaliwal, HS | 1 |
| Malpas, JS | 1 |
| Hirano, M | 1 |
| Shirakawa, S | 1 |
| Ito, Y | 1 |
| Nakamura, T | 1 |
| Ueno, K | 1 |
| Imajou, K | 1 |
| Miyaoka, K | 1 |
| Kaung, DT | 1 |
| Wittington, RM | 1 |
| Spencer, H | 1 |
| Patno, ME | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Chlorambucil Versus 2x2 Gy Involved Field Radiotherapy in Stage III/IV Previously Untreated Follicular Lymphoma Patients. A Prospective, Randomized Phase III Clinical Trial[NCT00028691] | Phase 3 | 0 participants | Interventional | 2002-12-31 | Active, not recruiting | ||
| Exploring Patient Engagement Patterns and Participation Trends in Mantle Cell Lymphoma Clinical Trials[NCT06049472] | 500 participants (Anticipated) | Observational | 2024-10-31 | Not yet recruiting | |||
| A Multicenter Phase II Study Evaluating BeEAM (Bendamustine, Etoposide, Cytarabine, Melphalan) Prior to Autologous Stem Cell Transplant for First and Second Chemosensitive Relapses in Patients With Follicular Lymphoma[NCT02008006] | Phase 2 | 21 participants (Actual) | Interventional | 2014-07-09 | Terminated (stopped due to Insufficient recruitment and unavailability of the treatment) | ||
| A Phase II Trial of Combined Weekly Bortezomib and Tositumomab I-131 in Patients With Relapsed or Refractory Follicular Non-Hodg[NCT00479167] | Phase 2 | 1 participants (Actual) | Interventional | 2007-05-31 | Terminated (stopped due to Lack of accrual and interest in study) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for chlorambucil and Lymphoma, Follicular
| Article | Year |
|---|---|
Rituximab for the first-line treatment of stage III-IV follicular lymphoma (review of Technology Appraisal No. 110): a systematic review and economic evaluation.
Topics: Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Antineoplastic Combined Chemotherapy | 2012 |
Use of rituximab in patients with follicular lymphoma.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Antineoplasti | 2007 |
17 trials available for chlorambucil and Lymphoma, Follicular
| Article | Year |
|---|---|
The UK NCRI study of chlorambucil, mitoxantrone and dexamethasone (CMD) versus fludarabine, mitoxantrone and dexamethasone (FMD) for untreated advanced stage follicular lymphoma: molecular response strongly predicts prolonged overall survival.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Dexamethasone | 2020 |
Low number of intrafollicular T cells may predict favourable response to rituximab-based immuno-chemotherapy in advanced follicular lymphoma: a secondary analysis of a randomized clinical trial.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Female; Humans; Immunotherapy; Killer | 2019 |
Long-term follow-up of rituximab plus first-line mitoxantrone, chlorambucil, prednisolone and interferon-alpha as maintenance therapy in follicular lymphoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Follow-Up Studies; Humans | 2015 |
Treatment of indolent B-Cell nonfollicular lymphomas: final results of the LL01 randomized trial of the Gruppo Italiano per lo Studio dei Linfomi.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Disease-Free Survival; Dr | 2003 |
HOVON 47/EORTC 20013: chlorambucil vs 2x2 Gy involved field radiotherapy in stage III/IV previously untreated follicular lymphoma patients.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Protocols; Chlorambucil; | 2003 |
Combined cyclophosphamide, vincristine, doxorubicin, and prednisone (CHOP) improves response rates but not survival and has lower hematologic toxicity compared with combined mitoxantrone, chlorambucil, and prednisone (MCP) in follicular and mantle cell ly
Topics: Adult; Aged; Agranulocytosis; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Cyclopho | 2006 |
Initial chemotherapy with mitoxantrone, chlorambucil, prednisone impairs the collection of stem cells in patients with indolent lymphomas--results of a randomized comparison by the German Low-Grade Lymphoma Study Group.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Chlorambucil; Cyclophospham | 2007 |
Rituximab added to first-line mitoxantrone, chlorambucil, and prednisolone chemotherapy followed by interferon maintenance prolongs survival in patients with advanced follicular lymphoma: an East German Study Group Hematology and Oncology Study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-D | 2007 |
Rituximab and chlorambucil as first-line treatment for low-grade ocular adnexal lymphomas.
Topics: Aged; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplas | 2007 |
Rapid and sustained clearance of circulating lymphoma cells after chemotherapy plus rituximab: clinical significance of quantitative t(14;18) PCR monitoring in advanced stage follicular lymphoma patients.
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined | 2008 |
The follicular non-Hodgkin's lymphomas--I. The possibility of cure.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Combined Modality Therapy; Cyclophosph | 1996 |
Anti-idiotype antibodies can induce long-term complete remissions in non-Hodgkin's lymphoma without eradicating the malignant clone.
Topics: Animals; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; Antibodies, Neoplasm; Antineoplastic Ag | 1998 |
A randomized controlled trial to evaluate the role of interferon as initial and maintenance therapy in patients with follicular lymphoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocol | 2001 |
Randomized study of chlorambucil (CB) compared to interferon (alfa-2b) combined with CB in low-grade non-Hodgkin's lymphoma: an interim report of a randomized study. Non-Hodgkin's Lymphoma Cooperative Study Group.
Topics: Adult; Aged; Aged, 80 and over; Chlorambucil; Combined Modality Therapy; Female; Humans; Interferon | 1991 |
Interferon alfa-2b in addition to chlorambucil in the treatment of follicular lymphoma: preliminary results of a randomized trial in progress.
Topics: Adult; Aged; Aged, 80 and over; Chlorambucil; Combined Modality Therapy; Humans; Interferon alpha-2; | 1991 |
Interferon-alpha 2b in the treatment of follicular lymphoma: preliminary results of a trial in progress.
Topics: Adult; Aged; Aged, 80 and over; Chlorambucil; Drug Administration Schedule; Female; Follow-Up Studie | 1991 |
Comparison of chlorambucil and streptonigrin (NSC-45383) in the treatment of malignant lymphomas.
Topics: Antibiotics, Antineoplastic; Bone Marrow; Chlorambucil; Clinical Trials as Topic; Digestive System; | 1969 |
17 other studies available for chlorambucil and Lymphoma, Follicular
| Article | Year |
|---|---|
Chlorambucil-rituximab as first-line therapy in patients affected by follicular non-Hodgkin's lymphoma: a retrospective single-centre study.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Chlorambucil; Female; Humans; Lym | 2015 |
Radiotherapy Compared to Other Strategies in the Treatment of Stage I/II Follicular Lymphoma: A Study of 404 Patients with a Median Follow-Up of 15 Years.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cardiova | 2015 |
Primary malignant follicular lymphoma of the cervix: a rare cause of postmenopausal bleeding.
Topics: Aged; Antineoplastic Agents, Alkylating; Chlorambucil; Female; Humans; Immunohistochemistry; Lymphom | 2003 |
THE MALIGNANT LYMPHOMAS.
Topics: Adrenal Cortex Hormones; Chlorambucil; Cyclophosphamide; Hodgkin Disease; Humans; Lymphoma; Lymphoma | 1963 |
Clinical and haematological observations in lymphoma patients (Hodgkin's disease, Brill-Symmer's disease, lymphogenous leukaemia) treated with N N Di-2-chloroethyl gamma-P-aminophenyl butiric acid (amboclorin).
Topics: Antineoplastic Agents; Chlorambucil; Hodgkin Disease; Humans; Leukemia, Lymphoid; Lymphoma; Lymphoma | 1960 |
Long-term maintenance therapy with weekly chlorambucil in patients with symptomatic or progressive follicular lymphoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Chlorambucil; Disease Progression | 2004 |
Chlorambucil - rituximab as first line combination therapy in follicular non-Hodgkin's lymphoma: a clinical and biological analysis.
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antigens, CD20; Antineo | 2007 |
High-dose pulse chlorambucil: effective therapy for rapid remission induction in nodular lymphocytic poorly differentiated lymphoma.
Topics: Adult; Aged; Chlorambucil; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Lymphoma | 1982 |
Prolonged disease-free survival in relapsed/refractory low-grade lymphoma treated with fludarabine: a report of four cases.
Topics: Adult; Anthracyclines; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Comb | 1998 |
[Chemotherapy in non-Hodgkin's lymphomas (author's transl)].
Topics: Antineoplastic Agents; Bleomycin; Burkitt Lymphoma; Chlorambucil; Cyclophosphamide; Doxorubicin; Dru | 1977 |
[Malignant lymphopathy in a patient suffering from acute disseminated lupus erythematosus (author's transl)].
Topics: Chlorambucil; Ganglia, Spinal; Humans; Lupus Erythematosus, Systemic; Lymphoma, Follicular; Male; Mi | 1977 |
[Letter: Giant-follicular lymphoblastoma (Brill-Symmers)].
Topics: Chlorambucil; Cyclophosphamide; Humans; Interferons; Lymphoma, Follicular; Prognosis | 1975 |
Chlorambucil carcinogenesis in BALB/c mice.
Topics: Adenocarcinoma; Administration, Oral; Animals; Chlorambucil; Female; Incidence; Leukemia, Myeloid; L | 1990 |
[Phase II study of chlorambucil in patients with hematological malignancies].
Topics: Administration, Oral; Adult; Aged; Chlorambucil; Drug Administration Schedule; Drug Evaluation; Fema | 1987 |
Follicular lymphoma: prognostic factors for response and survival.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Female; Hepatomegaly; Hum | 1986 |
[Bestrabucil-induced complete remission in a case of follicular lymphoma, medium-sized cell type, stage IV (leukemic)].
Topics: Adult; Chlorambucil; Estradiol; Humans; Lymph Nodes; Lymphoma, Follicular; Male; Neoplasm Staging | 1986 |
[Phase II study of prednimustine in follicular lymphoma and chronic lymphocytic leukemia].
Topics: Administration, Oral; Adult; Aged; Chlorambucil; Drug Administration Schedule; Drug Evaluation; Fema | 1987 |