chlorambucil has been researched along with Lymphocytosis in 16 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Lymphocytosis: Excess of normal lymphocytes in the blood or in any effusion.
| Excerpt | Relevance | Reference |
|---|---|---|
| "B-cell chronic lymphocytic leukemia (CLL) was diagnosed on the basis of severe lymphocytosis and positive expression of the B-cell marker CD20 by lymphocytes in the bone marrow and peripheral blood." | 1.51 | Rapid clinical progression of B-cell chronic lymphocytic leukemia in a horse. ( Felippe, MJB; Frimberger, AE; Javsicas, LH; Long, AE; Stokol, T, 2019) |
| "A patient developed an interstitial pneumonitis while receiving chlorambucil for a chronic lymphocytic leukemia (cumulative dose, 8,340 mg)." | 1.29 | Chlorambucil-associated pneumonitis. ( Clauvel, JP; Couderc, LJ; Crestani, B; Frija, J; Israël-Biet, D; Jaccard, A, 1994) |
| "A method of clinical staging of chronic lymphocytic leukemia (CLL) has been proposed which is based on the concept that CLL is a disease of progressive accumulation of nonfunctioning lymphocytes: stage O, bone marrow and blood lymphocytosis only; stage 1, lymphocytosis with enlarged nodes; stage II, lymphocytosis with enlarged spleen or liver or both; stage III, lymphocytosis with anemia; and stage IV:lymphocytosis with thrombocytopenia." | 1.25 | Clinical staging of chronic lymphocytic leukemia. ( Chanana, AD; Cronkite, EP; Levy, RN; Pasternack, BS; Rai, KR; Sawitsky, A, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (68.75) | 18.7374 |
| 1990's | 1 (6.25) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 2 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Long, AE | 1 |
| Javsicas, LH | 1 |
| Stokol, T | 1 |
| Felippe, MJB | 1 |
| Frimberger, AE | 1 |
| Wynsberghe, MV | 1 |
| Lenain, P | 1 |
| Drieux, F | 1 |
| Guerrot, D | 1 |
| Bertrand, D | 1 |
| Cavard, A | 1 |
| Lidove, O | 1 |
| Aflak, F | 1 |
| Drupt, F | 1 |
| Goldenberg, P | 1 |
| Baglin, AC | 1 |
| Taksin, AL | 1 |
| Malek-Chehire, N | 1 |
| Wasserman, MR | 1 |
| Terré, C | 1 |
| Blétry, O | 1 |
| Ferrer, A | 1 |
| Bosch, F | 1 |
| Villamor, N | 1 |
| Rozman, M | 1 |
| Graus, F | 1 |
| Gutiérrez, G | 1 |
| Mercadal, S | 1 |
| Campo, E | 1 |
| Rozman, C | 1 |
| López-Guillermo, A | 1 |
| Montserrat, E | 1 |
| Silber, R | 1 |
| Wirthmüller, R | 1 |
| Gerhartz, H | 1 |
| Crestani, B | 1 |
| Jaccard, A | 1 |
| Israël-Biet, D | 1 |
| Couderc, LJ | 1 |
| Frija, J | 1 |
| Clauvel, JP | 1 |
| Icli, F | 1 |
| Ezdinli, EZ | 1 |
| Costello, W | 1 |
| Berard, CW | 1 |
| Bennett, JM | 1 |
| Carbone, PP | 1 |
| Rai, KR | 1 |
| Sawitsky, A | 1 |
| Cronkite, EP | 1 |
| Chanana, AD | 1 |
| Levy, RN | 1 |
| Pasternack, BS | 1 |
| Streuli, RA | 1 |
| Pegourie, B | 1 |
| Sotto, JJ | 1 |
| Hollard, D | 1 |
| Michallet, M | 1 |
| Sotto, MF | 1 |
| Spiers, AS | 1 |
| André, R | 1 |
| Duhamel, G | 1 |
| Salmon, C | 1 |
| Najman, A | 1 |
| Homberg, JC | 1 |
| Bessot, M | 1 |
| Brouant, JF | 1 |
| Laurent, J | 1 |
| Macinot, C | 1 |
| Faĭnshteĭn, FE | 1 |
| Aschkenasy, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Treatment of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL): DNA Microarray Gene Expression Analysis[NCT00001586] | Phase 2 | 105 participants (Actual) | Interventional | 1997-09-30 | Completed | ||
| Phase II Clinical Protocol for the Treatment of Patients With Previously Untreated CLL With Four or Six Cycles of Fludarabine and Cyclophosphamide With Rituximab (FCR) Plus Lenalidomide Followed by Lenalidomide Consolidation/ Maintenance[NCT01723839] | Phase 2 | 21 participants (Actual) | Interventional | 2012-02-22 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Here is the number of participants with adverse events. For the detailed list of adverse events see the adverse event module. (NCT00001586)
Timeframe: 13 years, 10.5 months
| Intervention | Participants (Number) |
|---|---|
| Intermediate-high Risk B-Cell Pts | 18 |
Changes in lymphocyte gene expression was measured by deoxyribonucleic acid (DNA) microarray analysis of circulating leukemic cells after completion of study treatment. A change in expression is defined as a >50% increase in circulating leukemic cells or a 30% decrease in circulating leukemic cells. (NCT00001586)
Timeframe: 6 hours post treatment, and 24 hours post treatment
| Intervention | Percent change in cells (Number) | |
|---|---|---|
| 6 hours post treatment (e.g. ># cells) | 24 hours post treatment (e.g. > # cells) | |
| Intermediate-high Risk B-Cell Pts | 30 | 50 |
Analysis of the Primary Endpoint: The complete responses will be estimated by the number of patients with CR divided by the total number of evaluable patients. (NCT01723839)
Timeframe: 28 day cycle, up to 4 cycles
| Intervention | Percentage of Participants (Number) |
|---|---|
| FCR With Lenalidomide | 45 |
Analysis of the other Secondary Endpoints: The overall response rate will be estimated by the number of patients with complete and partial responses divided by the total number of evaluable patients. (NCT01723839)
Timeframe: 28 day cycle, up to 6 cycles
| Intervention | Percentage of Participants (Number) |
|---|---|
| FCR With Lenalidomide | 95 |
1 review available for chlorambucil and Lymphocytosis
| Article | Year |
|---|---|
[Clinical aspects of the problem of treating leukemias].
Topics: Acute Disease; Antineoplastic Agents; Chlorambucil; Chlorine; Chronic Disease; Daunorubicin; Dimetho | 1973 |
15 other studies available for chlorambucil and Lymphocytosis
| Article | Year |
|---|---|
Rapid clinical progression of B-cell chronic lymphocytic leukemia in a horse.
Topics: Animals; Bone Marrow; Chlorambucil; Horse Diseases; Horses; Leukemia, Lymphocytic, Chronic, B-Cell; | 2019 |
Monoclonal B lymphocytosis and minimal change disease: a new monoclonal B-cell disorder of renal significance?
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; B-Lymphocytes; Chlorambucil; Female; Humans; L | 2018 |
[IgG-secreting lymphoplasmocytoid leukemia revealed by ophthalmologic hyperviscosity symptoms].
Topics: Aged; Antibodies, Neoplasm; Antineoplastic Combined Chemotherapy Protocols; Blood Viscosity; Chloram | 2002 |
Central nervous system involvement in mantle cell lymphoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocol | 2008 |
Chronic lymphocytic leukemia in the elderly.
Topics: Aged; B-Lymphocytes; Chlorambucil; Diagnosis, Differential; Glucosephosphate Dehydrogenase; Humans; | 1982 |
[Prolymphocytic leukemia: clinical, cytologic and immunologic findings].
Topics: Aged; B-Lymphocytes; Cell Differentiation; Chlorambucil; Female; Humans; Leukemia, Lymphoid; Lymphoc | 1980 |
Chlorambucil-associated pneumonitis.
Topics: Alveolitis, Extrinsic Allergic; Bronchoalveolar Lavage Fluid; Chlorambucil; Humans; Leukemia, Lympho | 1994 |
Diffuse well-differentiated lymphocytic lymphoma (DLWD): response and survival.
Topics: Aged; Antineoplastic Agents; Carmustine; Cell Differentiation; Chlorambucil; Cyclophosphamide; Drug | 1978 |
Clinical staging of chronic lymphocytic leukemia.
Topics: Adrenal Cortex Hormones; Age Factors; Aged; Anemia; Blood Cell Count; Bone Marrow Examination; Chlor | 1975 |
Clinical staging of chronic lymphocytic leukemia.
Topics: Adrenal Cortex Hormones; Age Factors; Aged; Anemia; Blood Cell Count; Bone Marrow Examination; Chlor | 1975 |
Clinical staging of chronic lymphocytic leukemia.
Topics: Adrenal Cortex Hormones; Age Factors; Aged; Anemia; Blood Cell Count; Bone Marrow Examination; Chlor | 1975 |
Clinical staging of chronic lymphocytic leukemia.
Topics: Adrenal Cortex Hormones; Age Factors; Aged; Anemia; Blood Cell Count; Bone Marrow Examination; Chlor | 1975 |
[Chronic lymphatic leukemia].
Topics: Bone Marrow; Chlorambucil; Humans; Leukemia, Lymphoid; Leukocyte Count; Lymphocytosis; Lymphoma; Mal | 1986 |
Splenectomy during chronic lymphocytic leukemia.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Combin | 1987 |
Chronic granulocytic leukaemia and chronic lymphocytic leukaemia.
Topics: Allopurinol; Amenorrhea; Busulfan; Chlorambucil; Chronic Disease; Drug Eruptions; Female; Hemolysis; | 1974 |
[Autoimmune hemolytic anemia with lymphatic nodules in the bone marrow].
Topics: Aged; Anemia, Hemolytic, Autoimmune; Autoantibodies; Bone Marrow; Bone Marrow Examination; Chlorambu | 1968 |
[Lymphoid tumor of the stomach].
Topics: Chlorambucil; Female; Humans; Lymphocytosis; Lymphography; Lymphoma, Non-Hodgkin; Middle Aged; Stoma | 1969 |
[Effects of casein on the regeneration of blood neutrophils and lymphocytes in rats injected with a radiomimetic agent (chlorambucil) and depleted of proteins. A possible immunologic mechanism for the lymphopoietic effect of ingested proteins].
Topics: Animals; Antigen-Antibody Reactions; Caseins; Chlorambucil; Diet; Hematopoiesis; Leukocyte Count; Le | 1968 |