chlorambucil has been researched along with Lymphatic Diseases in 36 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Lymphatic Diseases: Diseases of LYMPH; LYMPH NODES; or LYMPHATIC VESSELS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our clinical experience in 28 patients receiving chlorambucil for rheumatoid arthritis (RA) and the reports on chlorambucil therapy are reviewed." | 7.67 | Chlorambucil therapy in rheumatoid arthritis: clinical experience in 28 patients and literature review. ( Cannon, GW; Clegg, DO; Jackson, CG; Samuelson, CO; Ward, JR; Williams, HJ, 1985) |
| "Our clinical experience in 28 patients receiving chlorambucil for rheumatoid arthritis (RA) and the reports on chlorambucil therapy are reviewed." | 3.67 | Chlorambucil therapy in rheumatoid arthritis: clinical experience in 28 patients and literature review. ( Cannon, GW; Clegg, DO; Jackson, CG; Samuelson, CO; Ward, JR; Williams, HJ, 1985) |
| "Lymphadenopathy, splenomegaly and hepatomegaly were seen in 52 (55%), 63 (66%) and 60 (63%) patients, respectively." | 1.34 | Chronic lymphocytic leukemia in India--a clinico-hematological profile. ( Agrawal, N; Choudhary, VP; Kumar, R; Mahapatra, M; Naithani, R; Panigrahi, I; Pati, HP; Saxena, R, 2007) |
| "Treatment with clarithromycin, ethambutol and rifabutin resulted in improvement of anaemia and general health as well as in regression of lymphadenopathy and splenomegaly." | 1.31 | Mycobacterium genavense infection in a patient with long-standing chronic lymphocytic leukaemia. ( Bodmer, T; Krebs, T; Lämmle, B; Zimmerli, S, 2000) |
| "Bleeding tendency was seen in 17%, infections in 17%, hyperviscosity syndrome in 12%, and cardiac failure in 25% of the patients." | 1.31 | Waldenström's macroglobulinemia: clinical course and prognostic factors in 60 patients. Experience from a single hematology unit. ( Angelopoulou, MK; Boussiotis, V; Dimopoulou, MN; Fessas, P; Gribabis, A; Kittas, C; Konstantopoulos, K; Kontopidou, FN; Kyrtsonis, MC; Pangalis, GA; Siakantaris, P; Vaiopoulos, GA; Vassilakopoulos, TP, 2001) |
| "Low-grade malignant lymphomas are treated best with conventional doses of an alkylating agent." | 1.26 | [Chemotherapy in non-Hodgkin's lymphomas (author's transl)]. ( Schmidt, CG, 1977) |
| "The Sézary syndrome is a lymphoproliferative disorder of the skin, the lymph nodes, and to a smaller extent the bone marrow, which begins with erythrodermia." | 1.26 | [The Sézary syndrome]. ( Fierz, W; Goor, W; Maier, C; Ott, F; Pedio, G; Rüttner, JR; Schmid, W, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 32 (88.89) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| THIERS, H | 1 |
| COLOMB, D | 1 |
| FAYOLLE, J | 1 |
| ARCADIO, F | 1 |
| WITTE, S | 1 |
| KANDLER, T | 1 |
| FEIWEL, M | 1 |
| MUNRO, DD | 1 |
| BOOTSMA, BK | 1 |
| LOPESCARDOZO, E | 1 |
| MOESCHLIN, S | 1 |
| Levin, M | 1 |
| Libster, D | 1 |
| Agrawal, N | 1 |
| Naithani, R | 1 |
| Mahapatra, M | 1 |
| Panigrahi, I | 1 |
| Kumar, R | 1 |
| Pati, HP | 1 |
| Saxena, R | 1 |
| Choudhary, VP | 1 |
| Suarez, CR | 1 |
| Zeller, WP | 1 |
| Silberman, S | 1 |
| Rust, G | 1 |
| Messmore, H | 1 |
| Doherty, M | 1 |
| Martin, MF | 1 |
| Dieppe, PA | 1 |
| Krebs, T | 1 |
| Zimmerli, S | 1 |
| Bodmer, T | 1 |
| Lämmle, B | 1 |
| Kyrtsonis, MC | 1 |
| Vassilakopoulos, TP | 1 |
| Angelopoulou, MK | 1 |
| Siakantaris, P | 1 |
| Kontopidou, FN | 1 |
| Dimopoulou, MN | 1 |
| Boussiotis, V | 1 |
| Gribabis, A | 1 |
| Konstantopoulos, K | 1 |
| Vaiopoulos, GA | 1 |
| Fessas, P | 1 |
| Kittas, C | 1 |
| Pangalis, GA | 1 |
| Schmidt, CG | 1 |
| Maier, C | 1 |
| Fierz, W | 1 |
| Goor, W | 1 |
| Ott, F | 1 |
| Pedio, G | 1 |
| Rüttner, JR | 1 |
| Schmid, W | 1 |
| Vance, JC | 1 |
| Cervenka, J | 1 |
| Ullman, S | 1 |
| Kersey, JH | 1 |
| Sabad, A | 1 |
| Green, N | 1 |
| Schmitt, T | 1 |
| Mathiot, C | 1 |
| Benveniste, M | 1 |
| Varet, B | 1 |
| Levy, JP | 1 |
| Bauters, F | 1 |
| Latte, J | 1 |
| Jouet, JP | 1 |
| Goudemand, J | 1 |
| Goudemand, M | 1 |
| Smith, PJ | 1 |
| Ekert, H | 1 |
| Campbell, PE | 1 |
| Gallagher, CJ | 1 |
| Gregory, WM | 1 |
| Jones, AE | 1 |
| Stansfeld, AG | 1 |
| Richards, MA | 1 |
| Dhaliwal, HS | 1 |
| Malpas, JS | 1 |
| Lister, TA | 1 |
| Cannon, GW | 1 |
| Jackson, CG | 1 |
| Samuelson, CO | 1 |
| Ward, JR | 1 |
| Williams, HJ | 1 |
| Clegg, DO | 1 |
| Hermanský, F | 1 |
| Janele, J | 1 |
| Smetana, K | 1 |
| Zittoun, R | 1 |
| Lebon, P | 1 |
| Diebold, J | 1 |
| Durepaire, R | 1 |
| Eisenmann, D | 1 |
| Grupper, C | 1 |
| Winkelmann, RK | 2 |
| Perry, HO | 2 |
| Muller, SA | 2 |
| Schroeter, AL | 2 |
| Jordon, RE | 2 |
| Rogers, RS | 2 |
| Rossier, A | 1 |
| Smith, M | 1 |
| McCormack, LJ | 1 |
| Van Ordstrand, HS | 1 |
| Mercer, RD | 1 |
| Amor, B | 1 |
| Saporta, L | 1 |
| Forest, M | 1 |
| Saltiel, H | 1 |
| Raulo, P | 1 |
| Chouraki, L | 1 |
| Delbarre, F | 1 |
| Haak, HL | 1 |
| de Man, JC | 1 |
| Hijmans, W | 1 |
| Speck, B | 1 |
| Marie, J | 1 |
| Hennequet, A | 1 |
| Lévêque, B | 1 |
| Debauchez, C | 1 |
| Desbois, C | 1 |
| Watchi, JM | 1 |
| Mokeeva, RA | 1 |
| Papush, ND | 1 |
| Novikova, EZ | 1 |
| Hartwich, G | 1 |
| Butzler, W | 1 |
| Davies, SW | 1 |
| Scarrow, GD | 1 |
| Macaulay, MB | 1 |
| Blez, F | 1 |
| Norcross, JW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase II Trial of Combined Weekly Bortezomib and Tositumomab I-131 in Patients With Relapsed or Refractory Follicular Non-Hodg[NCT00479167] | Phase 2 | 1 participants (Actual) | Interventional | 2007-05-31 | Terminated (stopped due to Lack of accrual and interest in study) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
36 other studies available for chlorambucil and Lymphatic Diseases
| Article | Year |
|---|---|
[Profuse lymphodermia; cure by combined cortisone & chloraminophen].
Topics: Chlorambucil; Cortisone; Disease; Lymph Nodes; Lymphatic Diseases; Mechlorethamine; Nitrogen Mustard | 1959 |
[Results of therapy with chlorambucil (N,N-bis-(2-chloroethyl)-p-aminophenylbutyric acid) in lymphatic systemic diseases, reticuloses and related diseases].
Topics: Chlorambucil; Disease; Humans; Lymphatic Diseases; Lymphatic System; Lymphatic Vessels; Mechloretham | 1961 |
CHEMOTHERAPY IN RETICULOSES.
Topics: Chlorambucil; Cyclophosphamide; Genetic Diseases, X-Linked; Hodgkin Disease; Humans; Leukemia, Hairy | 1963 |
THE RETICULOSES.
Topics: Adrenal Cortex Hormones; Chlorambucil; Cyclophosphamide; Dermatitis, Exfoliative; Genetic Diseases, | 1964 |
[EXPERIENCE IN THE TREATMENT OF MALIGNANT DISEASES OF THE RETICULOENDOTHELIAL SYSTEM AND LEUKEMIAS. II].
Topics: Betamethasone; Busulfan; Chlorambucil; Copper; Cyclophosphamide; Dexamethasone; Genetic Diseases, X- | 1964 |
[CYTOSTATIC THERAPY].
Topics: Antineoplastic Agents; Breast Neoplasms; Busulfan; Chlorambucil; Colchicine; Cyclophosphamide; Femal | 1964 |
[MODERN TREATMENT OF LEUKEMIA].
Topics: Agranulocytosis; Busulfan; Chlorambucil; Cyclophosphamide; Drug Therapy; Genetic Diseases, X-Linked; | 1965 |
Allergic reaction to chlorambucil in chronic lymphocytic leukemia presenting with fever and lymphadenopathy.
Topics: Aged; Chlorambucil; Disease Progression; Drug Hypersensitivity; Female; Fever; Humans; Leukemia, Lym | 2005 |
Chronic lymphocytic leukemia in India--a clinico-hematological profile.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Anemia; Chlorambucil; Female; Hematologic Tests; Hepato | 2007 |
Sinus histiocytosis with massive lymphadenopathy: remission with chemotherapy.
Topics: Biopsy; Child; Chlorambucil; Female; Humans; Lymph Nodes; Lymphatic Diseases; Prednisone; Syndrome | 1983 |
Multicentric reticulohistiocytosis associated with primary biliary cirrhosis: successful treatment with cytotoxic agents.
Topics: Antineoplastic Agents; Arthritis, Rheumatoid; Chlorambucil; Cyclophosphamide; Diagnosis, Differentia | 1984 |
Mycobacterium genavense infection in a patient with long-standing chronic lymphocytic leukaemia.
Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antibiotics, Antitubercula | 2000 |
Waldenström's macroglobulinemia: clinical course and prognostic factors in 60 patients. Experience from a single hematology unit.
Topics: Adult; Aged; Aged, 80 and over; Blood Viscosity; Cardiac Output, Low; Chlorambucil; Fatigue; Female; | 2001 |
[Chemotherapy in non-Hodgkin's lymphomas (author's transl)].
Topics: Antineoplastic Agents; Bleomycin; Burkitt Lymphoma; Chlorambucil; Cyclophosphamide; Doxorubicin; Dru | 1977 |
[The Sézary syndrome].
Topics: Chlorambucil; Dermatitis, Exfoliative; Histiocytes; Humans; Lymph Nodes; Lymphatic Diseases; Lymphoc | 1976 |
Immunological and chromosomal studies in a patient with Sézary syndrome.
Topics: Chlorambucil; Dermatitis, Exfoliative; Humans; Keratoderma, Palmoplantar; Lymphatic Diseases; Lympho | 1977 |
[Auto-immune hemolytic anemia associated with Kaposi's sarcoma. Report of a new case (author's transl)].
Topics: Aged; Anemia, Hemolytic, Autoimmune; Chlorambucil; Female; Humans; Immune System Diseases; Lymphatic | 1979 |
[Leukemia with tricholeukocytes: clinical, hematological and evolutive study (apropos of 10 cases)].
Topics: Adrenal Cortex Hormones; Adult; Aged; Chlorambucil; Female; Humans; Leukemia; Lymphatic Diseases; Ma | 1977 |
Improved prognosis in disseminated histiocytosis.
Topics: Adolescent; Bone Neoplasms; Child; Child, Preschool; Chlorambucil; Female; Humans; Infant; Liver Neo | 1976 |
Follicular lymphoma: prognostic factors for response and survival.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Female; Hepatomegaly; Hum | 1986 |
Chlorambucil therapy in rheumatoid arthritis: clinical experience in 28 patients and literature review.
Topics: Adult; Arthritis, Rheumatoid; Chlorambucil; Drug Evaluation; Female; Humans; Leukemia, Myeloid, Acut | 1985 |
Notes on morphologically less usual forms of chronic lymphadenosis.
Topics: Aged; Blood Cell Count; Bone Marrow Examination; Cell Nucleolus; Cell Nucleus; Cell Transformation, | 1968 |
[Sjögren's syndrome with pseudolymphoma].
Topics: Biopsy; Chlorambucil; Diagnosis, Differential; Female; Hodgkin Disease; Humans; Lymph Nodes; Lymphat | 1974 |
[Malignant reticulosis with Sezary's cells and psoriasis].
Topics: Aged; Chlorambucil; Dermatitis, Exfoliative; Diagnosis, Differential; Edema; Foot Dermatoses; Hand D | 1971 |
The pre-Sezary erythroderma syndrome.
Topics: Adolescent; Adult; Aged; Child; Chlorambucil; Dermatitis, Exfoliative; Female; Humans; Keratoderma, | 1974 |
Treatment of Sezary syndrome.
Topics: Chlorambucil; Cyclophosphamide; Dermatitis, Exfoliative; Humans; Keratoderma, Palmoplantar; Lymphati | 1974 |
[Trial therapy of reticulosis X].
Topics: Adrenocorticotropic Hormone; Aminopterin; Chlorambucil; Cortisone; Eosinophilic Granuloma; Glucocort | 1969 |
"Primary" pulmonary histiocytosis X.
Topics: Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Age Factors; Anti-Bacterial | 1974 |
[Multicentric reticulohistiocytosis: 2 cases].
Topics: Adrenal Cortex Hormones; Adrenal Insufficiency; Adult; Anti-Inflammatory Agents; Arthritis; Arthriti | 1974 |
Further evidence for the lymphocytic nature of leukaemic reticuloendotheliosis (hairy-cell leukaemia).
Topics: Acid Phosphatase; Blood Cell Count; Chlorambucil; Fluorescent Antibody Technique; Histocytochemistry | 1974 |
[Histiocytic reticulosis in infants or Letterer-Siwe disease. (Clinical and therapeutical study)].
Topics: Acrodermatitis; Betamethasone; Biopsy; Blood Cell Count; Bone Diseases; Child, Preschool; Chlorambuc | 1968 |
[Tumor transformations in macroglobulinemic reticulosis].
Topics: Adult; Chlorambucil; Female; Humans; Lymphatic Diseases; Middle Aged; Waldenstrom Macroglobulinemia | 1969 |
[Secondary tumors in hemoblastoses during cytostatic treatment].
Topics: Adrenal Gland Neoplasms; Aged; Antineoplastic Agents; Bronchial Neoplasms; Busulfan; Carcinoma; Chlo | 1971 |
Multiple lymphomatous polyposis of the gastro-intestinal tract.
Topics: Chlorambucil; Colitis, Ulcerative; Colonic Diseases; Diagnosis, Differential; Folic Acid; Hodgkin Di | 1970 |
[Follicular mucinosis with reticuloendotheliosis].
Topics: Adult; Chlorambucil; Folliculitis; Humans; Lymphatic Diseases; Male | 1968 |
Chronic lymphatic leukemia in the older patient.
Topics: Aged; Anemia; Chlorambucil; Diagnosis, Differential; Humans; Infections; Leukemia, Lymphoid; Lymphat | 1968 |