chlorambucil has been researched along with Lymph Node Metastasis in 36 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare two adjuvant combination chemotherapies, cyclophosphamide, methotrexate, and fluorouracil (CMF) and chlorambucil, methotrexate, and fluorouracil (LMF), for patients who had undergone potentially curative surgery for unilateral breast cancer, in terms of relapse, survival, and toxicity." | 9.08 | Adjuvant chemotherapy in operable breast cancer: cyclophosphamide, methotrexate, and fluorouracil versus chlorambucil, methotrexate, and fluorouracil--11-year results of Swiss Group for Clinical Cancer Research trial SAKK 27/82. ( Castiglione, M; Cavalli, F; Jungi, WF; Leyvraz, S; Maibach, R; Obrecht, JP; Schildknecht, O; Senn, HJ; Siegenthaler, P, 1997) |
| "Between 1974 and 1977, a total of 254 patients with stages T1-3a, N0-1, and M0 operable breast cancer (node negative and node positive, stratified) were randomized to either modified radical mastectomy alone or the same surgery and adjuvant chlorambucil, methotrexate, 5-fluorouracil (LMF) plus BCG." | 9.06 | Swiss adjuvant trial (OSAKO 06/74) with chlorambucil, methotrexate, and 5-fluorouracil plus BCG in node-negative breast cancer patients: nine-year results. ( Amgwerd, R; Ammann, J; Creux, G; Enderlin, F; Engelhart, G; Heinz, C; Hochuli, E; Jungi, WF; Senn, HJ; Wick, A, 1986) |
| "To compare two adjuvant combination chemotherapies, cyclophosphamide, methotrexate, and fluorouracil (CMF) and chlorambucil, methotrexate, and fluorouracil (LMF), for patients who had undergone potentially curative surgery for unilateral breast cancer, in terms of relapse, survival, and toxicity." | 5.08 | Adjuvant chemotherapy in operable breast cancer: cyclophosphamide, methotrexate, and fluorouracil versus chlorambucil, methotrexate, and fluorouracil--11-year results of Swiss Group for Clinical Cancer Research trial SAKK 27/82. ( Castiglione, M; Cavalli, F; Jungi, WF; Leyvraz, S; Maibach, R; Obrecht, JP; Schildknecht, O; Senn, HJ; Siegenthaler, P, 1997) |
| "Between 1976 and 1984, 574 patients with operable breast cancer and histologically negative axillary lymph nodes were randomly assigned after mastectomy to receive either no further treatment or chemotherapy with oral LMF (fluorouracil, 500 mg, methotrexate, 25 mg, and chlorambucil, 10 mg, on day 1; fluorouracil, 500 mg, and chlorambucil, 10 mg, on day 2)." | 5.07 | West Midlands Oncology Association trial of adjuvant chemotherapy in node-negative breast cancer. ( Grieve, RJ; Howell, A; Kelly, KA; Monypenny, IJ; Morrison, JM; Walker, RA; Waterhouse, JA, 1992) |
| "Between 1974 and 1977, a total of 254 patients with stages T1-3a, N0-1, and M0 operable breast cancer (node negative and node positive, stratified) were randomized to either modified radical mastectomy alone or the same surgery and adjuvant chlorambucil, methotrexate, 5-fluorouracil (LMF) plus BCG." | 5.06 | Swiss adjuvant trial (OSAKO 06/74) with chlorambucil, methotrexate, and 5-fluorouracil plus BCG in node-negative breast cancer patients: nine-year results. ( Amgwerd, R; Ammann, J; Creux, G; Enderlin, F; Engelhart, G; Heinz, C; Hochuli, E; Jungi, WF; Senn, HJ; Wick, A, 1986) |
| "Women with node-negative breast cancer have a 30% chance of relapse 5 years after mastectomy." | 2.67 | Swiss adjuvant trials in women with node-negative breast cancer. OSAKO. ( Jungi, WF; Senn, HJ, 1992) |
| "Treatment of penile cancer involves chemotherapy with bleomycin and irradiation, which result in considerable improvement." | 1.27 | [Selection of treatment from a pathophysiological point of view. II: Studies on male urogenital tumors]. ( Ishikawa, H; Ishikawa, S; Kanoh, S; Koiso, K; Nemoto, R; Ohtani, M, 1986) |
| "Methods of management of testicular cancer in the eighties differ significantly from those employed in the seventies." | 1.27 | [Management and drug therapy of patients with disseminated testicular tumors]. ( Garin, AM; Khlebnov, AV; Lichinitser, MR; Tiuliandin, SA, 1986) |
| "Of 250 testicular tumors treated up to May 1975 233 (93." | 1.26 | The combined surgical and chemotherapeutic approach to non-seminomatous cancer of the testicle. ( Vahlensieck, W; Weissbach, L, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (80.56) | 18.7374 |
| 1990's | 5 (13.89) | 18.2507 |
| 2000's | 2 (5.56) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Taylor, F | 1 |
| Gear, R | 1 |
| Hoather, T | 1 |
| Dobson, J | 1 |
| Bompas, E | 1 |
| Fléchon, A | 1 |
| Biron, P | 1 |
| Droz, JP | 1 |
| Stehlin, JS | 1 |
| Hills, WJ | 1 |
| Rufino, C | 1 |
| Lehman, JA | 1 |
| Berman, JH | 1 |
| Vugrin, D | 2 |
| Whitmore, WF | 2 |
| Cvitkovic, E | 2 |
| Grabstald, H | 1 |
| Sogani, P | 1 |
| Barzell, W | 1 |
| Golbey, RB | 2 |
| Williams, SD | 1 |
| Loehrer, PJ | 1 |
| Einhorn, LH | 1 |
| Jungi, WF | 9 |
| Alberto, P | 1 |
| Brunner, KW | 1 |
| Mermillod, B | 1 |
| Barrelet, L | 1 |
| Cavalli, F | 2 |
| Wallgren, A | 1 |
| Baral, E | 1 |
| Beling, U | 1 |
| Carstensen, J | 1 |
| Friberg, S | 1 |
| Glas, U | 1 |
| Kaigas, M | 1 |
| Skoog, L | 1 |
| Senn, HJ | 9 |
| Amgwerd, R | 5 |
| Hochuli, E | 3 |
| Ammann, J | 3 |
| Engelhart, G | 4 |
| Heinz, C | 4 |
| Wick, A | 4 |
| Enderlin, F | 4 |
| Creux, G | 4 |
| Hochuli, R | 1 |
| Simon, B | 1 |
| Lanz, R | 2 |
| Bigler, R | 2 |
| Seiler, S | 1 |
| Fennelly, JJ | 1 |
| Cantwell, B | 1 |
| Jones, M | 1 |
| Falk, S | 1 |
| Walther, F | 1 |
| Denk, R | 1 |
| Maibach, R | 1 |
| Castiglione, M | 1 |
| Leyvraz, S | 1 |
| Obrecht, JP | 1 |
| Schildknecht, O | 1 |
| Siegenthaler, P | 1 |
| Sprenger, F | 1 |
| Hochueli, R | 1 |
| Simeon, B | 1 |
| Vahlensieck, W | 2 |
| Weissbach, L | 1 |
| Morrison, JM | 1 |
| Kelly, KA | 1 |
| Howell, A | 1 |
| Grieve, RJ | 1 |
| Monypenny, IJ | 1 |
| Walker, RA | 1 |
| Waterhouse, JA | 1 |
| Honda, N | 1 |
| Uchida, T | 1 |
| Mukai, N | 1 |
| Go, M | 1 |
| Yokoyama, E | 1 |
| Mashimo, S | 1 |
| Endo, T | 1 |
| Ishibashi, A | 1 |
| Koshiba, K | 1 |
| Shibuya, M | 1 |
| Koiso, K | 1 |
| Kanoh, S | 1 |
| Nemoto, R | 1 |
| Ishikawa, H | 1 |
| Ishikawa, S | 1 |
| Ohtani, M | 1 |
| Bassoulet, J | 1 |
| Raoul, Y | 1 |
| Garetta, L | 1 |
| Garin, AM | 2 |
| Lichinitser, MR | 1 |
| Khlebnov, AV | 2 |
| Tiuliandin, SA | 3 |
| Iwasaki, M | 1 |
| Kazama, T | 1 |
| Nakada, T | 1 |
| Katayama, T | 1 |
| Abdyldaev, TA | 1 |
| Kupchan, DZ | 1 |
| Le Duc, A | 1 |
| Gisselbrecht, C | 1 |
| Le Doze, H | 1 |
| Mignot, L | 1 |
| Barett-Mahler, AR | 1 |
| Gödde, S | 1 |
| Grant, RM | 1 |
| Mackie, R | 1 |
| Cochran, AJ | 1 |
| Murray, EL | 1 |
| Hoyle, D | 1 |
| Ross, C | 1 |
| Morgenfeld, MC | 1 |
| Helft, F | 1 |
| Bomchil, G | 1 |
| Moncada, R | 1 |
| Cooper, RA | 1 |
| Garces, M | 1 |
| Badrinath, K | 1 |
| Skinner, DG | 1 |
| Leadbetter, WF | 1 |
| Henefer, EP | 1 |
| Nelson, JF | 1 |
| Beaupre, EM | 1 |
5 reviews available for chlorambucil and Lymph Node Metastasis
| Article | Year |
|---|---|
[Adjuvant chemotherapy in breast cancer].
Topics: Antineoplastic Agents; Axilla; Breast Neoplasms; Chlorambucil; Cyclophosphamide; Doxorubicin; Drug T | 1981 |
[Metastatic malignant melanoma in treated non-Hodgkin's lymphoma].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Humans; Lymph Nodes; Lymphatic | 1996 |
[Chemotherapy of disseminated germ cell tumors of the testis].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Cisplatin; Cyclophosphamide | 1987 |
[A case report of extragonadal germ cell tumor with special reference to VAB-6 therapy].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Bleomycin; Chlorambucil; C | 1988 |
Calcified metastases from malignant ovarian neoplasm. Review of the literature.
Topics: Abdominal Neoplasms; Adult; Aged; Axilla; Biopsy; Breast Neoplasms; Calcinosis; Chlorambucil; Cystad | 1974 |
11 trials available for chlorambucil and Lymph Node Metastasis
| Article | Year |
|---|---|
Short- or long-term chemotherapy for node-positive breast cancer: LMF 6 versus 18 cycles. SAKK study 27/76.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chlorambucil; Clinical Trials as T | 1984 |
Tamoxifen and combination chemotherapy as adjuvant treatment in postmenopausal women with breast cancer.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chlorambucil; Clinical Trial | 1984 |
Divergent effect of adjuvant chemo-immunotherapy on recurrence rates in node-negative and node-positive breast cancer patients.
Topics: BCG Vaccine; Breast Neoplasms; Chlorambucil; Clinical Trials as Topic; Drug Therapy, Combination; Fe | 1980 |
Adjuvant chemoimmunotherapy with LMF plus BCG in node-negative and node-positive breast cancer - intermediate report at 4 years.
Topics: Breast Neoplasms; Chlorambucil; Clinical Trials as Topic; Drug Therapy, Combination; Female; Fluorou | 1982 |
Adjuvant chemotherapy in operable breast cancer: cyclophosphamide, methotrexate, and fluorouracil versus chlorambucil, methotrexate, and fluorouracil--11-year results of Swiss Group for Clinical Cancer Research trial SAKK 27/82.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvan | 1997 |
Adjuvant chemoimmunotherapy with LMF + BCG in node-negative and node-positive breast cancer patients. Intermediate report of a randomized trial in 242 patients.
Topics: Administration, Oral; Aged; BCG Vaccine; Breast Neoplasms; Chlorambucil; Clinical Trials as Topic; F | 1978 |
Swiss adjuvant trials in women with node-negative breast cancer. OSAKO.
Topics: Antineoplastic Combined Chemotherapy Protocols; BCG Vaccine; Breast Neoplasms; Chemotherapy, Adjuvan | 1992 |
West Midlands Oncology Association trial of adjuvant chemotherapy in node-negative breast cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Chlorambuc | 1992 |
Adjuvant chemoimmunotherapy with LMF + BCG in node-negative and node-positive breast cancer patients: 10 year results.
Topics: Antineoplastic Combined Chemotherapy Protocols; BCG Vaccine; Breast Neoplasms; Chlorambucil; Combine | 1989 |
Swiss adjuvant trial (OSAKO 06/74) with chlorambucil, methotrexate, and 5-fluorouracil plus BCG in node-negative breast cancer patients: nine-year results.
Topics: Antineoplastic Combined Chemotherapy Protocols; BCG Vaccine; Breast Neoplasms; Chlorambucil; Clinica | 1986 |
Results of administering B.C.G. to patients with melanoma.
Topics: Adult; Aged; Antibodies, Neoplasm; BCG Vaccine; Blood Cell Count; Cell Migration Inhibition; Chloram | 1974 |
20 other studies available for chlorambucil and Lymph Node Metastasis
| Article | Year |
|---|---|
Chlorambucil and prednisolone chemotherapy for dogs with inoperable mast cell tumours: 21 cases.
Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Antineoplastic Combined | 2009 |
[Management of advanced seminoma: retrospective study of 96 patients].
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Cisplati | 2002 |
Disseminated melanoma. Biologic behavior and treatment.
Topics: Antineoplastic Agents; Chlorambucil; Cyclophosphamide; Dactinomycin; Fluorouracil; Humans; Hydrazine | 1967 |
Chemotherapy in disseminated malignant melanoma.
Topics: Adult; Chlorambucil; Female; Humans; Lymphatic Metastasis; Male; Melanoma; Middle Aged; Vinblastine | 1967 |
Adjuvant chemotherapy combination of vinblastine, actinomycin D, Bleomycin, and Chlorambucil following retroperitoneal lymph node dissection for stage II testis tumor.
Topics: Adult; Antineoplastic Agents; Bleomycin; Chlorambucil; Dactinomycin; Drug Therapy, Combination; Huma | 1981 |
Adjuvant chemotherapy in non-seminomatous testis cancer: "mini-VAB" regimen: long-term followup.
Topics: Antineoplastic Agents; Bleomycin; Chlorambucil; Dactinomycin; Drug Therapy, Combination; Follow-Up S | 1981 |
Chemotherapy of advanced testicular cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Cisplatin; Combined Modalit | 1984 |
Adjuvant chemoimmunotherapy with LMF + BCG in node-negative and node-positive breast cancer: 8 year results.
Topics: Antineoplastic Combined Chemotherapy Protocols; BCG Vaccine; Breast Neoplasms; Chlorambucil; Combine | 1984 |
A study over a 5-year period of adjuvant chemotherapy after mastectomy for breast cancer.
Topics: Breast Neoplasms; Chlorambucil; Drug Therapy, Combination; Female; Fluorouracil; Follow-Up Studies; | 1981 |
The combined surgical and chemotherapeutic approach to non-seminomatous cancer of the testicle.
Topics: Chlorambucil; Dactinomycin; Drug Therapy, Combination; Dysgerminoma; Humans; Ifosfamide; Lymph Node | 1977 |
[A case of retrovesical embryonal cell carcinoma].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Cisplatin; Combined | 1991 |
[Selection of treatment from a pathophysiological point of view. II: Studies on male urogenital tumors].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Cisplatin; Combined Modalit | 1986 |
[Advanced non-seminoma germinal tumors of the testicle. Therapeutic strategy and method of action of chemotherapy].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Cisplatin; Combined Modalit | 1986 |
[Management and drug therapy of patients with disseminated testicular tumors].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Cisplatin; Combined | 1986 |
[The results of the use of bleomycin and its analogs in the VAB-6 protocol in treating testicular tumors].
Topics: alpha-Fetoproteins; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Bleomycin; Ch | 1988 |
[Role of chemotherapy in the treatment of cancer of the testis in adults].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Choriocarcinoma; Cis | 1985 |
[Transperitoneal lymph node excision and cytostatic postoperative treatment of malignant germinal testicular neoplasms].
Topics: Antineoplastic Agents; Chlorambucil; Dactinomycin; Drug Synergism; Dysgerminoma; Humans; Lymph Node | 1968 |
[Different response of the superficial and deep lymph nodes to therapy in malignant lymphoreticulopathies].
Topics: Adult; Chlorambucil; Cyclophosphamide; Female; Humans; Leukemia, Lymphoid; Lymphatic Metastasis; Lym | 1968 |
The surgical management of testis tumors.
Topics: Adolescent; Adult; Castration; Child; Child, Preschool; Chlorambucil; Choriocarcinoma; Dactinomycin; | 1971 |
Palatal enlargement in chronic lymphocytic leukemia: report of case.
Topics: Aged; Chlorambucil; Edema; Humans; Leukemia, Lymphoid; Lymphatic Metastasis; Lymphoma, Non-Hodgkin; | 1970 |