chlorambucil has been researched along with Liver Neoplasms in 25 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Liver Neoplasms: Tumors or cancer of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Expression of hepatocellular carcinoma mRNA in oocytes resulted in mainly Na(+)-dependent uptake of chlorambucil-taurocholate." | 7.69 | Chlorambucil-taurocholate is transported by bile acid carriers expressed in human hepatocellular carcinomas. ( Beuers, U; Böker, C; Glasa, J; Grützner, U; Hagenbuch, B; Kramer, W; Kullak-Ublick, GA; Meier, PJ; Oswald, M; Paumgartner, G; Stieger, B; Wess, G, 1997) |
| "In this case report the clinical course of a female patient with metastatic breast cancer receiving a mild cytostatic regimen with chlorambucil, methotrexate and prednisone is described." | 7.67 | [Bone marrow necrosis in a patient with metastatic breast cancer in chemotherapy with chlorambucil, methotrexate and prednisone]. ( Voigtmann, R, 1989) |
| "Expression of hepatocellular carcinoma mRNA in oocytes resulted in mainly Na(+)-dependent uptake of chlorambucil-taurocholate." | 3.69 | Chlorambucil-taurocholate is transported by bile acid carriers expressed in human hepatocellular carcinomas. ( Beuers, U; Böker, C; Glasa, J; Grützner, U; Hagenbuch, B; Kramer, W; Kullak-Ublick, GA; Meier, PJ; Oswald, M; Paumgartner, G; Stieger, B; Wess, G, 1997) |
| "In this case report the clinical course of a female patient with metastatic breast cancer receiving a mild cytostatic regimen with chlorambucil, methotrexate and prednisone is described." | 3.67 | [Bone marrow necrosis in a patient with metastatic breast cancer in chemotherapy with chlorambucil, methotrexate and prednisone]. ( Voigtmann, R, 1989) |
| "We report the case of an 85-year-old chronic lymphocytic leukemia patient with a local metastatic MCVPyV-negative Merkel cell carcinoma at initial diagnosis." | 1.56 | [Merkel cell carcinoma in chronic lymphocytic leukemia : Successful treatment with PD-L 1 inhibition, avelumab and chlorambucil]. ( Dücker, P; Hüning, S; Lorenzen, J; Nashan, D; Rohde, S, 2020) |
| "Self-assembly of anticancer small molecules into nanostructures may represent an attractive approach to improve the treatment of experimental solid tumors." | 1.42 | Chlorambucil gemcitabine conjugate nanomedicine for cancer therapy. ( Fan, M; Li, Z; Liang, X; Shi, B; Wang, H; Yang, D, 2015) |
| "Of 19 patients with gestational trophoblastic tumor and liver metastases, 6 received MAC chemotherapy, and 8 received PEA." | 1.29 | Liver metastases of gestational trophoblastic tumor. ( Amer, M; Bakri, YN; Ezzat, A; Jabbar, FA; Sinner, W; Subhi, J; Tweijry, A, 1993) |
| "A chlorambucil conjugate was prepared and found to have similar qualities in vitro." | 1.25 | Immunochemotherapy of hepatoma in rats. ( Grogan, JB; Lockard, J; Smith, GV; Stribling, J, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (64.00) | 18.7374 |
| 1990's | 6 (24.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (4.00) | 24.3611 |
| 2020's | 2 (8.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sang, L | 1 |
| Li, J | 1 |
| Zhang, F | 1 |
| Jia, J | 1 |
| Zhang, J | 1 |
| Ding, P | 1 |
| Sun, T | 1 |
| Wang, D | 1 |
| Dücker, P | 1 |
| Hüning, S | 1 |
| Rohde, S | 1 |
| Lorenzen, J | 1 |
| Nashan, D | 1 |
| Fan, M | 1 |
| Liang, X | 1 |
| Li, Z | 1 |
| Wang, H | 1 |
| Yang, D | 1 |
| Shi, B | 1 |
| BOWDEN, L | 1 |
| SMITH, JC | 1 |
| BOLANDE, RP | 1 |
| Harder, M | 1 |
| Limacher, F | 1 |
| Gaynon, PS | 1 |
| Baum, ES | 1 |
| Krivit, W | 2 |
| Hammond, D | 1 |
| Parlier, H | 1 |
| Poupon, R | 1 |
| Darnis, F | 1 |
| Bakri, YN | 1 |
| Subhi, J | 1 |
| Amer, M | 1 |
| Ezzat, A | 1 |
| Sinner, W | 1 |
| Tweijry, A | 1 |
| Jabbar, FA | 1 |
| Kullak-Ublick, GA | 1 |
| Glasa, J | 1 |
| Böker, C | 1 |
| Oswald, M | 1 |
| Grützner, U | 1 |
| Hagenbuch, B | 1 |
| Stieger, B | 1 |
| Meier, PJ | 1 |
| Beuers, U | 1 |
| Kramer, W | 1 |
| Wess, G | 1 |
| Paumgartner, G | 1 |
| Smith, GV | 2 |
| Grogan, JB | 2 |
| Stribling, J | 2 |
| Lockard, J | 2 |
| Smith, PJ | 1 |
| Ekert, H | 1 |
| Campbell, PE | 1 |
| Brock, PR | 1 |
| Yeomans, EC | 1 |
| Bellman, SC | 1 |
| Pritchard, J | 1 |
| O'Brien, P | 1 |
| Crow, J | 1 |
| Brada, M | 2 |
| Ashley, S | 1 |
| Horwich, A | 1 |
| Mortakis, AE | 1 |
| Braga, CA | 1 |
| Selby, P | 1 |
| Patel, P | 1 |
| Milan, S | 1 |
| Meldrum, M | 1 |
| Mansi, J | 1 |
| Mbidde, E | 1 |
| Perren, T | 1 |
| Forgeson, G | 1 |
| Gore, M | 1 |
| Masuda, F | 1 |
| Nakada, J | 1 |
| Kondo, N | 1 |
| Takahashi, T | 1 |
| Mochizuki, A | 1 |
| Iizuka, N | 1 |
| Voigtmann, R | 1 |
| Tsukamoto, N | 1 |
| Imachi, M | 1 |
| Uchino, H | 1 |
| Ono, M | 1 |
| Kamura, T | 1 |
| Saito, T | 1 |
| Matsukuma, K | 1 |
| Gerulath, AH | 1 |
| Dembo, AJ | 1 |
| Aitken, S | 1 |
| Quirt, IC | 1 |
| Osborne, R | 1 |
| Blackstein, M | 1 |
| Rider, WD | 1 |
| Wedemeyer, PP | 1 |
| White, JG | 1 |
| Nesbit, ME | 1 |
| Aust, JB | 1 |
| Leonard, AS | 1 |
| D'Angio, GJ | 1 |
| Hammond, CB | 1 |
| Borchert, LG | 1 |
| Tyrey, L | 1 |
| Creasman, WT | 1 |
| Parker, RT | 1 |
| Calne, RY | 1 |
| Williams, R | 1 |
| Dawson, JL | 1 |
| Ansell, ID | 1 |
| Evans, DB | 1 |
| Flute, PT | 1 |
| Herbertson, PM | 1 |
| Joysey, V | 1 |
| Keates, GH | 1 |
| Knill-Jones, RP | 1 |
| Mason, SA | 1 |
| Millard, PR | 1 |
| Pena, JR | 1 |
| Pentlow, BD | 1 |
| Salaman, JR | 1 |
| Sells, RA | 1 |
| Cullum, PA | 1 |
| Hartwich, G | 1 |
| Butzler, W | 1 |
25 other studies available for chlorambucil and Liver Neoplasms
| Article | Year |
|---|---|
Glycyrrhetinic acid modified chlorambucil prodrug for hepatocellular carcinoma treatment based on DNA replication and tumor microenvironment.
Topics: Carcinoma, Hepatocellular; Chlorambucil; DNA Replication; Glycyrrhetinic Acid; Humans; Liver Neoplas | 2022 |
[Merkel cell carcinoma in chronic lymphocytic leukemia : Successful treatment with PD-L 1 inhibition, avelumab and chlorambucil].
Topics: Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Carcinoma, Merkel Cell | 2020 |
Chlorambucil gemcitabine conjugate nanomedicine for cancer therapy.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Apoptosis; Carcinoma, H | 2015 |
CLINICAL MANAGEMENT OF SOFT PART SARCOMAS.
Topics: Chlorambucil; Dactinomycin; Geriatrics; Humans; Leiomyosarcoma; Liposarcoma; Liver Neoplasms; Methot | 1964 |
RADIATION AND DRUG INDUCED HYALINIZATION OF THE STOMACH.
Topics: Antineoplastic Agents; Child; Chlorambucil; Cyclophosphamide; Drug Therapy; Ganglioneuroma; Gastroin | 1965 |
[Generalized metastasizing chorion carcinoma with complete remission after cytostatic therapy].
Topics: Adult; Breast Neoplasms; Chlorambucil; Choriocarcinoma; Chorionic Gonadotropin; Cyclophosphamide; Da | 1983 |
Phase II trial of prednimustine in children with recurrent cancer: a Children's Cancer Study Group report.
Topics: Adolescent; Adult; Carcinoma, Hepatocellular; Child; Child, Preschool; Chlorambucil; Drug Administra | 1982 |
[Relation between monoclonal gammopathy and hepatobiliary disease].
Topics: Adult; Aged; Carcinoma, Hepatocellular; Chlorambucil; Cholestasis; Chronic Disease; Female; Hepatiti | 1982 |
Liver metastases of gestational trophoblastic tumor.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Cisplatin; Dactinomycin; Etopos | 1993 |
Chlorambucil-taurocholate is transported by bile acid carriers expressed in human hepatocellular carcinomas.
Topics: Animals; Antineoplastic Agents; Biological Transport; Carcinoma, Hepatocellular; Carrier Proteins; C | 1997 |
Immunochemotherapy of hepatoma in rats.
Topics: Animals; Antigen-Antibody Complex; Carcinoma, Hepatocellular; Cell Nucleus; Chlorambucil; Chromatin; | 1975 |
Improved prognosis in disseminated histiocytosis.
Topics: Adolescent; Bone Neoplasms; Child; Child, Preschool; Chlorambucil; Female; Humans; Infant; Liver Neo | 1976 |
Cisplatin therapy in infants: short and long-term morbidity.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Chlorambucil; Cisplatin; | 1992 |
Hodgkin's disease of the liver; prognosis and possible indications for radiotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Clinical Protocols; Hodgkin Disease; H | 1991 |
"Poor prognosis" metastatic gestational trophoblastic disease: the prognostic significance of the scoring system in predicting chemotherapy failures.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chlorambucil; Choriocarcinom | 1990 |
ChlVPP combination chemotherapy for Hodgkin's disease: long-term results.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bone Mar | 1990 |
[Treatment of nonseminomatous testicular tumor with liver metastases].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Choriocarcinoma; Cis | 1988 |
[Bone marrow necrosis in a patient with metastatic breast cancer in chemotherapy with chlorambucil, methotrexate and prednisone].
Topics: Adenocarcinoma, Scirrhous; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Breast Neopl | 1989 |
Modified VAB-3 combination chemotherapy of advanced and recurrent endodermal sinus tumors of the ovary.
Topics: Adolescent; Adult; alpha-Fetoproteins; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Ca | 1985 |
Poor prognosis metastatic gestational trophoblastic disease: experience with moderate dose methotrexate plus folinic acid rescue as initial therapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chlorambucil; Chorionic Gonadotropi | 1986 |
Resection of metastases in Wilms' tumor: a report of three cases cured of pulmonary and hepatic metastases.
Topics: Child, Preschool; Chlorambucil; Cobalt Isotopes; Dactinomycin; Female; Humans; Infant; Liver Neoplas | 1968 |
Treatment of metastatic trophoblastic disease: good and poor prognosis.
Topics: Brain Neoplasms; Chlorambucil; Choriocarcinoma; Chorionic Gonadotropin; Dactinomycin; Female; Follow | 1973 |
Immunochemotherapy of hepatoma in rats.
Topics: Animals; Carcinoma, Hepatocellular; Chlorambucil; Immunoglobulin G; Immunotherapy; Liver Neoplasms; | 1974 |
Liver transplantation in man. II. A report of two orthotopic liver transplants in adult recipients.
Topics: Adult; Blood Coagulation Tests; Chlorambucil; Female; Hepatectomy; Hepatic Artery; Hepatitis A; Hist | 1968 |
[Secondary tumors in hemoblastoses during cytostatic treatment].
Topics: Adrenal Gland Neoplasms; Aged; Antineoplastic Agents; Bronchial Neoplasms; Busulfan; Carcinoma; Chlo | 1971 |