chlorambucil has been researched along with Libman-Sacks Disease in 55 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The heavy proteinuria exhibited a striking steroid-dependent course during a three-year period of time, with ten relapses occurring whenever attempts were made to withdraw prednisone therapy." | 7.67 | Steroid-dependent nephrotic syndrome in lupus nephritis. Response to chlorambucil. ( Abuelo, JG; Esparza, AR; Garella, S, 1984) |
| " Chlorambucil may hold advantages over the immunosuppressive drugs normally recommended in this condition, azathioprine and cyclophosphamide, as it appears less liable to cause important marrow suppression and, unlike cyclophosphamide is not associated with alopecia and haemorrhagic cystitis." | 7.65 | Treatment of patients with systemic lupus erythematosus including nephritis with chlorambucil. ( Dunnill, MS; Halley, W; Holt, JM; Oliver, DO; Snaith, ML; Stephenson, AC, 1973) |
| "163 patients with diffuse lupus glomerulonephritis, proven by renal biopsy, were divided into four therapeutic trial groups: 67 were put on corticosteroids alone, 11 on corticosteroids and azathioprine, 32 on corticosteroids and cyclophosphamide, and 53 on corticosteroids and chlorambucil and were followed up for several years." | 5.04 | Comparison of chlorambucil, azathioprine or cyclophosphamide combined with corticosteroids in the treatment of lupus nephritis. ( Osman, LM; Sabbour, MS, 1979) |
| " The heavy proteinuria exhibited a striking steroid-dependent course during a three-year period of time, with ten relapses occurring whenever attempts were made to withdraw prednisone therapy." | 3.67 | Steroid-dependent nephrotic syndrome in lupus nephritis. Response to chlorambucil. ( Abuelo, JG; Esparza, AR; Garella, S, 1984) |
| " Chlorambucil may hold advantages over the immunosuppressive drugs normally recommended in this condition, azathioprine and cyclophosphamide, as it appears less liable to cause important marrow suppression and, unlike cyclophosphamide is not associated with alopecia and haemorrhagic cystitis." | 3.65 | Treatment of patients with systemic lupus erythematosus including nephritis with chlorambucil. ( Dunnill, MS; Halley, W; Holt, JM; Oliver, DO; Snaith, ML; Stephenson, AC, 1973) |
| "Persistent hyperlipidemia increases the risk of cardiovascular diseases." | 2.42 | [Membranous nephropathy]. ( Godin, M; Legallicier, B; Passos, EM, 2003) |
| "Azathioprine is a valuable alternative to slow-acting antirheumatic drugs in older patients with rheumatoid arthritis." | 2.38 | Azathioprine, cyclophosphamide and chlorambucil. ( Bacon, PA; Luqmani, RA; Palmer, RG, 1990) |
| "Children with systemic lupus erythematosus and nephritis may benefit from the addition of cytotoxic agents to their corticosteroid regime, although the indications for this are not clear, and controlled evidence is lacking." | 2.36 | Immunosuppressive agents in the treatment of the nephrotic syndrome and glomerulonephritis in children. ( Cameron, JS, 1979) |
| "A 62-year-old woman developed paresis in her right arm within several weeks." | 1.30 | [Progressive multifocal leukoencephalopathy as a result of immunosuppressive therapy]. ( Arbusow, V; Brandt, T; Brückmann, H; Hatz, H; Samtleben, W; Strupp, M, 1999) |
| " Each case was associated with prior chlorambucil administration, effective in controlling the clinical manifestations (total dosage 398 and 1,764 mg respectively)." | 1.25 | Irreversible bone marrow failure with chlorambucil. ( Epstein, WV; Fries, JF; Rudd, P, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 52 (94.55) | 18.7374 |
| 1990's | 2 (3.64) | 18.2507 |
| 2000's | 1 (1.82) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| RAY, RN | 1 |
| CHATTERJEA, JB | 1 |
| DAMESHEK, W | 1 |
| BRODY, JI | 1 |
| BEIZER, LH | 1 |
| Passos, EM | 1 |
| Legallicier, B | 1 |
| Godin, M | 1 |
| Adams, DA | 1 |
| Gordon, A | 1 |
| Maxwell, MH | 1 |
| Davis, BM | 1 |
| Gilliam, JN | 1 |
| Abuelo, JG | 1 |
| Esparza, AR | 1 |
| Garella, S | 1 |
| Gerster, JC | 1 |
| Métrailler, A | 1 |
| Saudan, Y | 1 |
| Nasonova, VA | 1 |
| Ivanova, MM | 2 |
| Speranskiĭ, AI | 1 |
| Solov'ev, SK | 2 |
| Shumakov, VI | 1 |
| Stepanova, NS | 1 |
| Kaĭnova, AS | 1 |
| Arbusow, V | 1 |
| Strupp, M | 1 |
| Samtleben, W | 1 |
| Hatz, H | 1 |
| Brückmann, H | 1 |
| Brandt, T | 1 |
| Canavese, JC | 1 |
| Sabbour, MS | 1 |
| Osman, LM | 1 |
| Betourne, C | 1 |
| Cassan, P | 1 |
| Franc, B | 1 |
| Bacri, JL | 1 |
| Levy, R | 1 |
| Cameron, JS | 3 |
| Pollak, VE | 1 |
| Epstein, WV | 3 |
| Rudd, P | 1 |
| Fries, JF | 1 |
| Luqmani, RA | 1 |
| Palmer, RG | 2 |
| Bacon, PA | 1 |
| Clements, PJ | 1 |
| Davis, J | 1 |
| Smith-Burchnell, CA | 1 |
| Doré, CJ | 1 |
| Denman, AM | 1 |
| Andrassy, K | 1 |
| Waldherr, R | 1 |
| Ritz, E | 1 |
| Nashel, DJ | 1 |
| Boulton-Jones, M | 1 |
| Robinson, R | 1 |
| Ogg, C | 1 |
| Oken, MM | 1 |
| Griffiths, RW | 1 |
| Williams, RC | 1 |
| Reimann, BE | 1 |
| Kampf, D | 1 |
| Baethke, R | 1 |
| Delespesse, G | 1 |
| Kennes, B | 1 |
| Duchateau, J | 1 |
| Sudre, Y | 1 |
| Beaugendre, F | 1 |
| de Giacomoni, P | 1 |
| Kahn, MF | 1 |
| Rambouts, C | 1 |
| de Sèze, S | 1 |
| Méry, JP | 1 |
| Girard, JF | 1 |
| Zech, P | 1 |
| Richard, P | 1 |
| Blanc-Brunat, N | 1 |
| Labeeuw, M | 1 |
| Colon, S | 1 |
| Pozet, N | 1 |
| Dupont, E | 1 |
| Fries, D | 1 |
| Traeger, J | 1 |
| Sauvezie, B | 1 |
| Sabolovic, D | 1 |
| Dumont, F | 1 |
| Guérin, D | 1 |
| Bussière, JL | 1 |
| Rampon, S | 1 |
| Skinner, MD | 1 |
| Schwartz, RS | 1 |
| Clarkson, AR | 1 |
| Robson, JS | 1 |
| Steinberg, AD | 1 |
| Gandzha, IM | 1 |
| Shub, NI | 1 |
| Lagrue, G | 2 |
| Bariety, J | 2 |
| Druet, P | 1 |
| Hirbec, G | 1 |
| Snaith, ML | 3 |
| Holt, JM | 3 |
| Oliver, DO | 2 |
| Dunnill, MS | 1 |
| Halley, W | 1 |
| Stephenson, AC | 1 |
| Stephenson, A | 1 |
| Marmont, A | 1 |
| Rossi, F | 1 |
| Bordo, D | 1 |
| Deicher, H | 2 |
| Fricke, R | 2 |
| Krull, P | 1 |
| Kruli, P | 1 |
| Clément, F | 1 |
| Amor, B | 1 |
| Kahan, A | 1 |
| Pompidou, A | 1 |
| Delbarre, F | 1 |
| Vandersarl, JV | 1 |
| Davis, CM | 1 |
| Fenton, RM | 1 |
| Panettiere, F | 1 |
| Petrányi, G | 1 |
| Leövey, A | 1 |
| Szegedi, G | 1 |
| Kakuk, G | 1 |
| Bobory, J | 1 |
| Kostanecki, W | 1 |
| Mazurkiewicz, W | 1 |
| Górkiewicz, A | 1 |
| Zborzil, J | 1 |
| Zosin, C | 1 |
| Mănescu, N | 1 |
| Iacob, G | 1 |
| Schwarzkopf, A | 1 |
| Sabo, I | 1 |
| Gluhovschi, G | 1 |
| Cruchaud, A | 1 |
| Milliez, P | 1 |
14 reviews available for chlorambucil and Libman-Sacks Disease
| Article | Year |
|---|---|
[Membranous nephropathy].
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Basement Membrane; Child; Child, Preschool; Chlorambuci | 2003 |
[Lupus erythematosus, modern aspects (author's transl)].
Topics: Antacids; Antibodies, Antinuclear; Antigen-Antibody Complex; Azathioprine; Chlorambucil; Cyclophosph | 1977 |
Immunosuppressive agents in the treatment of the nephrotic syndrome and glomerulonephritis in children.
Topics: Azathioprine; Child; Chlorambucil; Cyclophosphamide; Glomerulonephritis; Humans; Immunosuppressive A | 1979 |
Azathioprine, cyclophosphamide and chlorambucil.
Topics: Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Connective Tissue Diseases; Cyclophosphamide; Hum | 1990 |
Cytotoxic drugs: their clinical application to the rheumatic diseases.
Topics: Arthritis; Arthritis, Rheumatoid; Azathioprine; Behcet Syndrome; Bone Marrow; Cell Division; Chemica | 1986 |
Mechanisms of action and clinical applications of cytotoxic drugs in rheumatic disorders.
Topics: Arthritis, Reactive; Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Collagen Diseases; Cyclophos | 1985 |
[Therapy of lupus-nephritis using corticosteroids and immunosuppressive agents].
Topics: Adrenal Cortex Hormones; Antibodies, Antinuclear; Azathioprine; Beta-Globulins; Chlorambucil; Cyclop | 1974 |
[Auto-immune diseases and immunodepressive therapy. II. Current clinical indications].
Topics: Adrenal Cortex Hormones; Anemia, Hemolytic, Autoimmune; Antineoplastic Agents; Arteritis; Autoimmune | 1974 |
Cytotoxic drugs in treatment of nonmalignant diseases.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Arthritis, Rheumatoid; Azathioprine; Chlor | 1972 |
Immunosuppressive therapy. 2.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Adult; Azathioprine; Child; Chlorambucil; Clin | 1972 |
The effect of drugs on immunological renal disease.
Topics: Adrenal Cortex Hormones; Antilymphocyte Serum; Azathioprine; Chlorambucil; Cyclophosphamide; Glomeru | 1972 |
An approach to the use of immunosuppressive drugs in nonmalignant diseases.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Chlorambucil; Cyclophosphamide; G | 1973 |
Immunosuppressant agents in the treatment of glomerulonephritis. 2. Cytotoxic drugs.
Topics: Adult; Anti-Glomerular Basement Membrane Disease; Antilymphocyte Serum; Antineoplastic Agents; Azath | 1971 |
[Treatment of chronic diseases of connective tissue by cytostatic drugs].
Topics: Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Collagen Diseases; Cyclophosphamide; Female; Huma | 1970 |
4 trials available for chlorambucil and Libman-Sacks Disease
| Article | Year |
|---|---|
Comparison of chlorambucil, azathioprine or cyclophosphamide combined with corticosteroids in the treatment of lupus nephritis.
Topics: Adolescent; Adult; Azathioprine; Child; Chlorambucil; Clinical Trials as Topic; Cyclophosphamide; Dr | 1979 |
[Drug treatment of chronic glomerulonephritis: contra].
Topics: Azathioprine; Chlorambucil; Chronic Disease; Clinical Trials as Topic; Cyclophosphamide; Drug Therap | 1985 |
Immunosuppressive therapy. 2.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Adult; Azathioprine; Child; Chlorambucil; Clin | 1972 |
[Effectiveness of immunosuppressive agents in systemic lupus erythematosus. Comparative study of a series of 13 cases and of a control series of 12 cases].
Topics: Adrenal Cortex Hormones; Azathioprine; Chlorambucil; Drug Combinations; Drug Interactions; Humans; I | 1972 |
38 other studies available for chlorambucil and Libman-Sacks Disease
| Article | Year |
|---|---|
SOME OBSERVATIONS ON L. E. PHENOMENON.
Topics: Adsorption; Anticoagulants; Chlorambucil; Citrates; Dexamethasone; Edetic Acid; Erythrocytes; Humans | 1963 |
[THOUGHTS ON LUPUS ERYTHEMATOSUS].
Topics: Adrenal Cortex Hormones; Allergy and Immunology; Antimalarials; Autoimmune Diseases; Chlorambucil; D | 1964 |
ALTERATION OF BLOOD GROUP ANTIGENS IN LEUKEMIC LYMPHOCYTES.
Topics: ABO Blood-Group System; Anemia; Anemia, Aplastic; Antigens; Blood Group Antigens; Child; Chlorambuci | 1965 |
Azathioprine treatment of immunological renal disease.
Topics: Adolescent; Adult; Azathioprine; Chlorambucil; Cortisone; Female; Glomerulonephritis; Humans; Lupus | 1967 |
Prognostic significance of subepidermal immune deposits in uninvolved skin of patients with systemic lupus erythematosus: a 10-year longitudinal study.
Topics: Adolescent; Adult; Azathioprine; Biopsy; Child; Chlorambucil; Cyclophosphamide; Female; Fluorescent | 1984 |
Steroid-dependent nephrotic syndrome in lupus nephritis. Response to chlorambucil.
Topics: Adult; Chlorambucil; Female; Glomerulonephritis; Humans; Lupus Erythematosus, Systemic; Nephrotic Sy | 1984 |
[Malignant lymphoma in a case of disseminated lupus erythematosus treated with cytotoxic agents].
Topics: Adult; Chlorambucil; Female; Humans; Lupus Erythematosus, Systemic; Lymphoma; Melphalan | 1982 |
[Hemoperfusion through activated charcoal in the complex treatment of systemic lupus erythematosus].
Topics: Adolescent; Adult; Charcoal; Chlorambucil; Drug Therapy, Combination; Female; Humans; Lupus Erythema | 1981 |
[Effect of cytotoxic immunosuppressive agents on the level of urinary seromucoids and cathepsins in lupus nephritis].
Topics: Azathioprine; Cathepsins; Chlorambucil; Cyclophosphamide; Drug Therapy, Combination; Humans; Immunos | 1980 |
[Progressive multifocal leukoencephalopathy as a result of immunosuppressive therapy].
Topics: Brain; Chlorambucil; Diagnosis, Differential; Female; Humans; Immunocompromised Host; Immunosuppress | 1999 |
[Malignant lymphopathy in a patient suffering from acute disseminated lupus erythematosus (author's transl)].
Topics: Chlorambucil; Ganglia, Spinal; Humans; Lupus Erythematosus, Systemic; Lymphoma, Follicular; Male; Mi | 1977 |
Treatment of lupus nephritis.
Topics: Adrenal Cortex Hormones; Adult; Animals; Antibody Formation; Azathioprine; Chlorambucil; Cyclophosph | 1976 |
The treatment of the nephritis of lupus erythematosus.
Topics: Adult; Chlorambucil; Female; Glucocorticoids; Humans; Lupus Erythematosus, Systemic; Nephritis | 1977 |
Specificity of SLE serum antibody for single-stranded and double-stranded DNA configuration.
Topics: Adolescent; Ammonium Sulfate; Antibody Specificity; Arthritis, Rheumatoid; Chemical Precipitation; C | 1975 |
Irreversible bone marrow failure with chlorambucil.
Topics: Adolescent; Anemia, Aplastic; Arthritis, Rheumatoid; Bone Marrow; Chlorambucil; Female; Humans; Leuk | 1975 |
Sensitivity of lymphocytes from patients with systemic lupus erythematosus to the induction of sister chromatid exchanges by alkylating agents and bromodeoxyuridine.
Topics: Alkylating Agents; Bromodeoxyuridine; Chlorambucil; Humans; In Vitro Techniques; Lupus Erythematosus | 1987 |
Treatment of lupus nephritis with cyclophosphamide.
Topics: Adolescent; Adult; Age Factors; Azathioprine; Biopsy; Chlorambucil; Cortisone; Cyclophosphamide; Fem | 1970 |
Possible NZB syndrome in man.
Topics: Adult; Agglutinins; Anemia, Hemolytic; Antibodies, Antinuclear; Autoimmune Diseases; Blood Protein E | 1973 |
[Lupoid hepatitis].
Topics: Antibodies, Antinuclear; Chlorambucil; Female; Humans; Jaundice; Liver Diseases; Lupus Erythematosus | 1970 |
[Treatment of systemic lupus erythematosus with immunosupressive agents. Results of our experience and review of the literature].
Topics: Adult; Aged; Animals; Azathioprine; Chlorambucil; Female; Humans; Immunosuppressive Agents; Lupus Er | 1971 |
[Indications for immunosuppressive agents in glomerular nephropathies].
Topics: Adrenal Cortex Hormones; Anti-Glomerular Basement Membrane Disease; Azathioprine; Chlorambucil; Cycl | 1974 |
[Course of nephropathy in systemic lupus erythematosus . Influence of the treatment on clinical symptoms, renal function and histology].
Topics: Adolescent; Adult; Aged; Antibodies, Antinuclear; Antimalarials; Azathioprine; Biopsy; Chlorambucil; | 1972 |
[The action of chloraminophene on lymphocyte populations. Value of cell electrophoresis].
Topics: Arthritis, Rheumatoid; Cell Movement; Cell Separation; Chlorambucil; Electrophoresis; Humans; Immuni | 1974 |
Immunologic events preceding clinical exacerbation of systemic lupus erythematosus.
Topics: Adolescent; Antibodies; Chlorambucil; Complement System Proteins; Glomerulonephritis; Humans; Immuno | 1973 |
[Immunodepressants in the treatment of the major collagenoses].
Topics: Adolescent; Adult; Arthritis, Rheumatoid; Chlorambucil; Chloroquine; Female; Humans; Immunosuppressi | 1972 |
[2 cases of apparently primary glomerulopathies with deposits. Recovery with immunodepressive agents. Secondary onset of an acute S.L.E. without renal involvement].
Topics: Acute Disease; Biopsy; Chlorambucil; Glomerulonephritis; Humans; Inclusion Bodies, Viral; Kidney Glo | 1972 |
Treatment of patients with systemic lupus erythematosus including nephritis with chlorambucil.
Topics: Adult; Alopecia; Amenorrhea; Azathioprine; Biopsy; Bone Marrow; Chlorambucil; Cyclophosphamide; Cyst | 1973 |
Successful treatment of patients with systemic lupus erythematosus, including nephritis, using chlorambucil.
Topics: Chlorambucil; Female; Humans; Lupus Erythematosus, Systemic; Nephritis; Proteinuria | 1973 |
[Current aspects of immunosuppressive therapy of collagen diseases].
Topics: Arthritis, Rheumatoid; Asparaginase; Chlorambucil; Collagen Diseases; Cyclophosphamide; Dermatomyosi | 1973 |
Chlorambucil in the treatment of systemic lupus erythematosus.
Topics: Adult; Chlorambucil; Evaluation Studies as Topic; Female; Gonads; Hematopoietic System; Humans; Lupu | 1974 |
[Treatment of chronic connective tissue diseases with cytostatics].
Topics: Antineoplastic Agents; Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Chronic Disease; Collagen | 1970 |
[Modern hematology. Sidero-achrestic anemias, polyglobulias, chemotherapy].
Topics: Adenoma; Adolescent; Adult; Aged; Anemia, Hypochromic; Anemia, Macrocytic; Anemia, Sideroblastic; Bl | 1971 |
Cytosine arabinoside therapy for Herpes Zoster in a patient with systemic lupus erythematosus.
Topics: Adolescent; Chlorambucil; Cytarabine; Female; Herpes Zoster; Humans; Immunosuppressive Agents; Lupus | 1972 |
Therapy of autoimmune nephropathy with steroids and cytostatics. A follow-up study of 80 patients and of 16 years.
Topics: Adolescent; Adult; Aged; Antimalarials; Autoimmune Diseases; Azathioprine; Chlorambucil; Cyclophosph | 1971 |
[Hair changes in immunosuppressive therapy].
Topics: Antineoplastic Agents; Azathioprine; Chlorambucil; Cyclophosphamide; Hair; Humans; Immunosuppression | 1971 |
[Immunodepressive therapy in nephropathies].
Topics: Azathioprine; Chlorambucil; Collagen Diseases; Diabetic Nephropathies; Glomerulonephritis; Humans; I | 1969 |
[Immunosuppressive treatment of collagen diseases].
Topics: Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Collagen Diseases; Cyclophosphamide; Dermatomyosi | 1969 |
[Lupus nephropathies and their treatment].
Topics: Chlorambucil; Glomerulonephritis; Humans; Kidney Diseases; Lupus Erythematosus, Systemic; Prednisolo | 1968 |