Page last updated: 2024-10-24

chlorambucil and Leukemic Infiltration

chlorambucil has been researched along with Leukemic Infiltration in 8 studies

Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.

Leukemic Infiltration: A pathologic change in leukemia in which leukemic cells permeate various organs at any stage of the disease. All types of leukemia show various degrees of infiltration, depending upon the type of leukemia. The degree of infiltration may vary from site to site. The liver and spleen are common sites of infiltration, the greatest appearing in myelocytic leukemia, but infiltration is seen also in the granulocytic and lymphocytic types. The kidney is also a common site and of the gastrointestinal system, the stomach and ileum are commonly involved. In lymphocytic leukemia the skin is often infiltrated. The central nervous system too is a common site.

Research Excerpts

ExcerptRelevanceReference
"Treatment with chlorambucil, prednisolone, and renal bed irradiation resulted in a substantial improvement in renal function which persisted until the the patient's death from marrow failure some eight years later."1.29Renal failure caused by leukaemic infiltration in chronic lymphocytic leukaemia. ( Bass, PS; Davies, DR; Jones, NF; Majumdar, G; Pearson, TC; Phillips, JK, 1993)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (12.50)18.2507
2000's4 (50.00)29.6817
2010's3 (37.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kacem, K1
Zriba, S1
Saadi, M1
Doghri, R1
Streu, E1
Hapgood, G1
Mooney, E1
Dinh, HV1
Gin, D1
McLean, C1
Ting, SB1
Aktan, M1
Akkaya, A1
Doğan, O1
Dincol, G1
Kalac, M1
Suvic-Krizanic, V1
Ostojic, S1
Kardum-Skelin, I1
Barsic, B1
Jaksica, B1
Sureda, NC1
Bosch, MP1
Kurpis, M1
Ruiz Lascano, A1
Phillips, JK1
Bass, PS1
Majumdar, G1
Davies, DR1
Jones, NF1
Pearson, TC1
Várkonyi, J1
Zalatnai, A1
Timár, J1
Matolcsi, A1
Falus, A1
Bencsáth, M1
László, V1
Pócsik, E1
Kotlán, B1
Császár, A1

Other Studies

8 other studies available for chlorambucil and Leukemic Infiltration

ArticleYear
Gingival Leukemic Infiltration in Chronic Lymphocytic Leukemia
    Turkish journal of haematology : official journal of Turkish Society of Haematology, 2019, Nov-18, Volume: 36, Issue:4

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Female; Humans; Leukemia, Lympho

2019
Second malignancies in chronic lymphocytic leukemia.
    Oncology nursing forum, 2014, Jan-01, Volume: 41, Issue:1

    Topics: Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Carcin

2014
Leukaemia cutis in chronic lymphocytic leukaemia following varicella zoster virus reactivation.
    Internal medicine journal, 2012, Volume: 42, Issue:12

    Topics: Aged; Antineoplastic Agents, Alkylating; Chlorambucil; Disease Progression; Herpes Zoster; Humans; L

2012
Chronic lymphocytic leukemia and multiple myeloma in the same patient: case report.
    Leukemia & lymphoma, 2003, Volume: 44, Issue:8

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; B-Lymphocytes; Bone Neoplasms; Chlorambucil; C

2003
Central nervous system involvement of previously undiagnosed chronic lymphocytic leukemia in a patient with neuroborreliosis.
    International journal of hematology, 2007, Volume: 85, Issue:4

    Topics: Anti-Infective Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Blood-Bra

2007
[Leukaemia cutis: clinical manifestation of chronic lymphocytic leukaemia relapse].
    Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina), 2007, Volume: 64, Issue:1

    Topics: Aged; Antineoplastic Agents, Alkylating; Biopsy; Chlorambucil; Humans; Leukemia, Lymphocytic, Chroni

2007
Renal failure caused by leukaemic infiltration in chronic lymphocytic leukaemia.
    Journal of clinical pathology, 1993, Volume: 46, Issue:12

    Topics: Chlorambucil; Combined Modality Therapy; Humans; Kidney; Kidney Failure, Chronic; Leukemia, Lymphocy

1993
Secondary cutaneous infiltration in B cell chronic lymphocytic leukemia.
    Acta haematologica, 2000, Volume: 103, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Cyclophosphamide; Doxorubicin; Histidi

2000