chlorambucil has been researched along with Leukemia P388 in 9 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Leukemia P388: An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (55.56) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gourdie, TA | 2 |
| Prakash, AS | 1 |
| Wakelin, LP | 2 |
| Woodgate, PD | 2 |
| Denny, WA | 3 |
| Gravatt, GL | 2 |
| Baguley, BC | 2 |
| Wilson, WR | 2 |
| Valu, KK | 1 |
| Boritzki, TJ | 1 |
| MacDiarmid, JE | 1 |
| Rose, WC | 1 |
| Biddle, WC | 1 |
| Perlman, ME | 1 |
| Breiner, RG | 1 |
| Ambrus, JL | 1 |
| Bardos, TJ | 1 |
| Garzon-Aburbeh, A | 1 |
| Poupaert, JH | 1 |
| Claesen, M | 1 |
| Dumont, P | 1 |
| Atassi, G | 1 |
| Koutsourea, AI | 1 |
| Fousteris, MA | 1 |
| Arsenou, ES | 1 |
| Papageorgiou, A | 1 |
| Pairas, GN | 1 |
| Nikolaropoulos, SS | 1 |
| Feinerman, B | 1 |
| Paul, RD | 1 |
| Feinerman, G | 1 |
| Brophy, GT | 1 |
| Sladek, NE | 1 |
| Roehrig, GR | 1 |
| Billman, JH | 1 |
| Marcec, J | 1 |
| Fritz, P | 1 |
| Shea, F | 1 |
9 other studies available for chlorambucil and Leukemia P388
| Article | Year |
|---|---|
Synthesis and evaluation of DNA-targeted spatially separated bis(aniline mustards) as potential alkylating agents with enhanced DNA cross-linking capability.
Topics: Alkylating Agents; Alkylation; Aniline Mustard; Animals; Antineoplastic Agents; Cell Line; Cell Surv | 1991 |
DNA-directed alkylating agents. 4. 4-anilinoquinoline-based minor groove directed aniline mustards.
Topics: Alkylating Agents; Aniline Mustard; Animals; Antineoplastic Agents; Cell Line; DNA; Leukemia P388; M | 1991 |
DNA-directed alkylating agents. 3. Structure-activity relationships for acridine-linked aniline mustards: consequences of varying the length of the linker chain.
Topics: Acridines; Alkylating Agents; Alkylation; Aniline Mustard; Animals; Chemical Phenomena; Chemistry; C | 1990 |
Synthesis and properties of bis(2,2-dimethylaziridinyl)phosphinic amides: a series of new antineoplastic agents.
Topics: Animals; Aziridines; Azirines; Chemical Phenomena; Chemistry; Chlorambucil; Cholinesterase Inhibitor | 1985 |
1,3-dipalmitoylglycerol ester of chlorambucil as a lymphotropic, orally administrable antineoplastic agent.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Cell Survival; Chlorambucil; Intestinal Mucosa | 1983 |
Rational design, synthesis, and in vivo evaluation of the antileukemic activity of six new alkylating steroidal esters.
Topics: Alkylation; Animals; Antineoplastic Agents; Disease Models, Animal; Dose-Response Relationship, Drug | 2008 |
Treatment of a murine leukemia with chlorambucil bound monoclonal antibodies.
Topics: Animals; Antibodies, Monoclonal; Cell Division; Chlorambucil; DNA, Neoplasm; Immunotherapy; Leukemia | 1983 |
Influence of pH on the cytotoxic activity of chlorambucil.
Topics: Animals; Antineoplastic Agents; Buffers; Cell Survival; Chlorambucil; Hydrogen-Ion Concentration; Le | 1983 |
Synthesis and antitumor activity of 4-[p-[bis(2-chloroethyl)amino]phenyl]butyrates.
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Chlorambucil; Leukemia L1210; Leukemi | 1980 |