chlorambucil has been researched along with Leukemia L 1210 in 17 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chlorambucil (CLB) is a bifunctional nitrogen mustard whose therapeutic and major side-effects are thought to be caused by binding to DNA." | 1.28 | Studies of chlorambucil-DNA adducts. ( Bank, BB, 1992) |
| "Chlorambucil is an exception." | 1.26 | Structure-activity relationships in antitumor aniline mustards. ( Hansch, C; Leo, A; Panthananickal, A, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (58.82) | 18.7374 |
| 1990's | 4 (23.53) | 18.2507 |
| 2000's | 3 (17.65) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Panthananickal, A | 1 |
| Hansch, C | 2 |
| Leo, A | 1 |
| Selassie, CD | 1 |
| Khwaja, TA | 1 |
| MacDiarmid, JE | 1 |
| Rose, WC | 1 |
| Biddle, WC | 1 |
| Perlman, ME | 1 |
| Breiner, RG | 1 |
| Ambrus, JL | 1 |
| Bardos, TJ | 1 |
| Perjési, P | 1 |
| Das, U | 1 |
| De Clercq, E | 1 |
| Balzarini, J | 1 |
| Kawase, M | 1 |
| Sakagami, H | 1 |
| Stables, JP | 1 |
| Lorand, T | 1 |
| Rozmer, Z | 1 |
| Dimmock, JR | 1 |
| Koutsourea, AI | 1 |
| Fousteris, MA | 1 |
| Arsenou, ES | 1 |
| Papageorgiou, A | 1 |
| Pairas, GN | 1 |
| Nikolaropoulos, SS | 1 |
| Roehrig, GR | 1 |
| Billman, JH | 1 |
| Marcec, J | 1 |
| Fritz, P | 1 |
| Shea, F | 1 |
| Cullis, PM | 1 |
| Green, RE | 1 |
| Malone, ME | 1 |
| Merson-Davies, L | 1 |
| Weaver, R | 1 |
| Kuin, A | 1 |
| Aalders, M | 1 |
| Lamfers, M | 1 |
| van Zuidam, DJ | 1 |
| Essers, M | 1 |
| Beijnen, JH | 1 |
| Smets, LA | 1 |
| Jin, GZ | 1 |
| You, YJ | 1 |
| Kim, Y | 1 |
| Nam, NH | 1 |
| Ahn, BZ | 1 |
| Schiffman, FJ | 2 |
| Fisher, JM | 2 |
| Rabinovitz, M | 2 |
| Uehara, Y | 1 |
| Bank, BB | 1 |
| Rubens, RD | 1 |
| Goodman, MT | 2 |
| Folk, RM | 1 |
| Ackerman, GA | 2 |
| Vermel', EM | 1 |
| DeVita, VT | 1 |
| Carbone, PP | 1 |
1 review available for chlorambucil and Leukemia L 1210
| Article | Year |
|---|---|
[Current views on drug therapy of tumors].
Topics: Animals; Antineoplastic Agents; Carcinoma, Brown-Pearce; Carcinoma, Ehrlich Tumor; Chlorambucil; Cyc | 1970 |
1 trial available for chlorambucil and Leukemia L 1210
| Article | Year |
|---|---|
Chemotherapeutic implications of staging in Hodgkin's disease.
Topics: Animals; Chlorambucil; Clinical Trials as Topic; Cyclophosphamide; Drug Combinations; Follow-Up Stud | 1971 |
15 other studies available for chlorambucil and Leukemia L 1210
| Article | Year |
|---|---|
Structure-activity relationships in antitumor aniline mustards.
Topics: Aniline Mustard; Animals; Antineoplastic Agents; Carcinoma 256, Walker; Hydrolysis; Lethal Dose 50; | 1978 |
Structure-activity relationships of antineoplastic agents in multidrug resistance.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Cricetinae; Dactinomycin; Drug Resistance; | 1990 |
Synthesis and properties of bis(2,2-dimethylaziridinyl)phosphinic amides: a series of new antineoplastic agents.
Topics: Animals; Aziridines; Azirines; Chemical Phenomena; Chemistry; Chlorambucil; Cholinesterase Inhibitor | 1985 |
Design, synthesis and antiproliferative activity of some 3-benzylidene-2,3-dihydro-1-benzopyran-4-ones which display selective toxicity for malignant cells.
Topics: Animals; Antineoplastic Agents; Benzopyrans; Cell Survival; Drug Design; Drug Screening Assays, Anti | 2008 |
Rational design, synthesis, and in vivo evaluation of the antileukemic activity of six new alkylating steroidal esters.
Topics: Alkylation; Animals; Antineoplastic Agents; Disease Models, Animal; Dose-Response Relationship, Drug | 2008 |
Synthesis and antitumor activity of 4-[p-[bis(2-chloroethyl)amino]phenyl]butyrates.
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Chlorambucil; Leukemia L1210; Leukemi | 1980 |
Targeting of tumour cells with polyamine-drug conjugates.
Topics: Animals; Biological Transport; Cell Line; Cell Survival; Chlorambucil; Cross-Linking Reagents; Leuke | 1994 |
Potentiation of anti-cancer drug activity at low intratumoral pH induced by the mitochondrial inhibitor m-iodobenzylguanidine (MIBG) and its analogue benzylguanidine (BG).
Topics: 3-Iodobenzylguanidine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amiloride; Animals; Antineo | 1999 |
Esters of chlorambucil with 2-substituted 1,4-dihydroxy-9,10-anthraquinones as multifunctional anticancer agents.
Topics: Animals; Anthraquinones; Antineoplastic Agents; Chlorambucil; Drug Screening Assays, Antitumor; Leuk | 2001 |
Serum displacing agents in cancer chemotherapy.
Topics: Animals; Cattle; Cells, Cultured; Chemical Phenomena; Chemistry; Chlorambucil; Clofibrate; Culture M | 1977 |
Potentiation of chlorambucil activity by phenylbutazone.
Topics: Animals; Cell Survival; Cells, Cultured; Chlorambucil; Drug Synergism; Drug Therapy, Combination; Le | 1978 |
Studies of chlorambucil-DNA adducts.
Topics: Animals; Carbon Radioisotopes; Cell-Free System; Chlorambucil; Deoxyglucose; DNA, Neoplasm; Leukemia | 1992 |
Antibodies as carriers of anticancer agents.
Topics: Animals; Antibodies, Neoplasm; Antigen-Antibody Reactions; Antigens, Neoplasm; Antineoplastic Agents | 1974 |
Effects of antileukemic agents on the respiratory activity of murine lymphocytic Leukemia L1210.
Topics: Animals; Buffers; Busulfan; Cell Adhesion; Cell Survival; Chlorambucil; Cyclophosphamide; Cytoplasm; | 1973 |
The effects of antineoplastic agents on the respiratory activity of murine lymphocytic leukemia L1210.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Chlorambucil; Dactinomycin; Dose-Response Relations | 1973 |