chlorambucil has been researched along with Leukemia, Myeloid in 56 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Leukemia, Myeloid: Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Randomized studies have shown that the risk of thrombosis was significantly reduced in ET with the use of hydroxyurea (HU) and in PV with the use of chlorambucil or 32P." | 4.80 | Treatment of polycythaemia vera and essential thrombocythaemia. ( Silverstein, MN; Tefferi, A, 1998) |
| " Although multi-drug therapy is known to produce myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) in patients with CTD, treatment with single-agent therapy, particularly methotrexate, has rarely been associated with secondary MDS or AML." | 3.69 | Myelodysplastic syndromes and acute myeloid leukemia in connective tissue disease after single-agent chemotherapy. ( Farhi, DC; Rosenthal, NS, 1996) |
| "Two cases of advanced ovarian carcinoma treated with chlorambucil and terminating in acute leukemia are presented and the literature reviewed." | 3.65 | Acute leukemia in advanced ovarian carcinoma after treatment with alkylating agents. ( Jafari, K; Lash, AF; Sotrel, G; Stepto, RC, 1976) |
| "Patients with chronic lymphocytic leukemia (CLL) may have disease transformation to non-Hodgkin's lymphoma or prolymphocytic leukemia; however, development of therapy-related acute myeloid leukemia (t-AML) is unusual." | 2.70 | Therapy-related myeloid leukemias are observed in patients with chronic lymphocytic leukemia after treatment with fludarabine and chlorambucil: results of an intergroup study, cancer and leukemia group B 9011. ( Appelbaum, FR; Elias, L; Hines, JD; Kolitz, JE; Larson, RA; Morrison, VA; Peterson, BL; Rai, KR; Schiffer, CA; Shepherd, L, 2002) |
| "These included 4 cases of chronic lymphocytic leukemia (CLL), 5 cases of chronic myelogenous leukemia (CML), 5 cases of malignant lymphoma (ML) and 7 cases of multiple myeloma (MM)." | 2.66 | [Clinical trial of bestrabucil (KM 2210) on hematopoietic malignancies]. ( Katayama, N; Kita, K; Kobayashi, T; Matsuoka, N; Minami, N; Nishikawa, M; Ohno, T; Tanaka, H; Tomeoku, M; Uemura, Y, 1986) |
| "Hodgkin's disease is curable in the majority of patients, although a proportion of patients are resistant to or relapse after initial therapy." | 1.30 | High-dose BEAM chemotherapy with autologous haemopoietic stem cell transplantation for Hodgkin's disease is unlikely to be associated with a major increased risk of secondary MDS/AML. ( Devereux, S; Goldstone, AH; Gregory, W; Hancock, B; Harrison, CN; Hoskin, P; Hudson, GV; Linch, DC; MacMillan, AK; Milligan, D; Newland, AC; Winfield, D, 1999) |
| "The grounds for treating or not treating chronic lymphocytic leukemias (CLL) and chronic myelocytic leukemias (CML) are discussed in the light of results in recent years." | 1.26 | [When do we have to treat chronic leukemia?]. ( Maurice, PA, 1978) |
| "Chronic lymphocytic leukemia and chronic granulocytic leukemia vary considerably in their clinical features, laboratory findings, and therapy, but both generally have an ominous prognosis." | 1.26 | Managing chronic leukemias. ( Silverstein, MN, 1977) |
| "Thirteen cases of acute nonlymphocytic leukemia occurred among 5455 patients, as compared to 0." | 1.26 | Acute leukemia after alkylating-agent therapy of ovarian cancer. ( Fraumeni, JF; Hoover, R; Reimer, RR; Young, RC, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 46 (82.14) | 18.7374 |
| 1990's | 6 (10.71) | 18.2507 |
| 2000's | 4 (7.14) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Morrison, VA | 1 |
| Rai, KR | 1 |
| Peterson, BL | 1 |
| Kolitz, JE | 1 |
| Elias, L | 1 |
| Appelbaum, FR | 1 |
| Hines, JD | 1 |
| Shepherd, L | 1 |
| Larson, RA | 1 |
| Schiffer, CA | 1 |
| Metayer, C | 1 |
| Curtis, RE | 1 |
| Vose, J | 1 |
| Sobocinski, KA | 1 |
| Horowitz, MM | 1 |
| Bhatia, S | 1 |
| Fay, JW | 1 |
| Freytes, CO | 1 |
| Goldstein, SC | 1 |
| Herzig, RH | 1 |
| Keating, A | 1 |
| Miller, CB | 1 |
| Nevill, TJ | 1 |
| Pecora, AL | 1 |
| Rizzo, JD | 1 |
| Williams, SF | 1 |
| Li, CY | 1 |
| Travis, LB | 1 |
| Weisdorf, DJ | 1 |
| ROSS, ED | 1 |
| SETTLE, JA | 1 |
| TELFER, AB | 1 |
| NIZET, A | 1 |
| GRIZZLE, JE | 1 |
| MOLANDER, DW | 1 |
| LADUE, JS | 1 |
| COWLING, DC | 1 |
| QUAGLINO, D | 1 |
| HAYHOE, FG | 1 |
| INNES, J | 1 |
| SMITH, JC | 1 |
| BOLANDE, RP | 1 |
| MOESCHLIN, S | 1 |
| RUNDLES, W | 1 |
| GRIZZLE, J | 1 |
| BONO, VH | 1 |
| JONSSON, U | 1 |
| HUGULEY, CM | 2 |
| CORLEY, CC | 1 |
| Balakrishnan, C | 1 |
| Pathan, E | 1 |
| Khodaiji, S | 1 |
| Dasgupta, A | 1 |
| Mangat, G | 1 |
| Joshi, VR | 1 |
| Shanks, RH | 1 |
| Rizzieri, DA | 1 |
| Flowers, JL | 1 |
| Colvin, OM | 1 |
| Adams, DJ | 1 |
| Gaynon, PS | 1 |
| Baum, ES | 1 |
| Krivit, W | 1 |
| Hammond, D | 1 |
| Schreiber, ZA | 1 |
| Axelrod, MR | 1 |
| Abebe, LS | 1 |
| Sølling, K | 1 |
| Nielsen, JL | 1 |
| Sølling, J | 1 |
| Ellegaard, J | 1 |
| Varadi, S | 1 |
| Vijaykumar, S | 1 |
| Rosenthal, NS | 1 |
| Farhi, DC | 1 |
| Sánchez Fayos, J | 1 |
| Román Barbero, A | 1 |
| Nevado Reviriego, I | 1 |
| Harrison, CN | 1 |
| Gregory, W | 1 |
| Hudson, GV | 1 |
| Devereux, S | 1 |
| Goldstone, AH | 1 |
| Hancock, B | 1 |
| Winfield, D | 1 |
| MacMillan, AK | 1 |
| Hoskin, P | 1 |
| Newland, AC | 1 |
| Milligan, D | 1 |
| Linch, DC | 1 |
| Tefferi, A | 1 |
| Silverstein, MN | 2 |
| Galbraith, RM | 1 |
| Eddleston, AL | 1 |
| Williams, R | 1 |
| Zuckerman, AJ | 1 |
| MacEwen, EG | 1 |
| Patnaik, AK | 1 |
| Wilkins, RJ | 1 |
| Maurice, PA | 1 |
| Spanedda, R | 1 |
| Romanini, D | 1 |
| Cinotti, A | 1 |
| Reimer, RR | 1 |
| Hoover, R | 1 |
| Fraumeni, JF | 1 |
| Young, RC | 2 |
| Sotrel, G | 1 |
| Jafari, K | 1 |
| Lash, AF | 1 |
| Stepto, RC | 1 |
| Maurice, P | 1 |
| Gunz, FW | 1 |
| Migdalska, B | 1 |
| Leszko, B | 1 |
| Hartwig, W | 1 |
| Pawelski, S | 1 |
| Stutzman, L | 1 |
| Cavaliere, A | 1 |
| Pietropaoli, N | 1 |
| Alberti, PF | 1 |
| Vitali, R | 1 |
| Selby, P | 1 |
| Patel, P | 1 |
| Milan, S | 1 |
| Meldrum, M | 1 |
| Mansi, J | 1 |
| Mbidde, E | 1 |
| Brada, M | 1 |
| Perren, T | 1 |
| Forgeson, G | 1 |
| Gore, M | 1 |
| Nagura, E | 1 |
| Ohno, R | 1 |
| Yamada, K | 1 |
| Akao, Y | 1 |
| Naito, K | 1 |
| Nishikawa, M | 2 |
| Tanaka, H | 2 |
| Shirakawa, S | 1 |
| Ono, Y | 1 |
| Ezaki, K | 1 |
| Uemura, Y | 1 |
| Matsuoka, N | 1 |
| Ohno, T | 1 |
| Katayama, N | 1 |
| Tomeoku, M | 1 |
| Kobayashi, T | 1 |
| Kita, K | 1 |
| Minami, N | 1 |
| Steigbigel, RT | 1 |
| Kim, H | 1 |
| Potolsky, A | 1 |
| Schrier, SL | 1 |
| Patakfalvi, A | 1 |
| Spiers, AS | 1 |
| Liebman, SD | 1 |
| Crocker, AC | 1 |
| Geiser, CF | 1 |
| Ruffner, BW | 1 |
| Davis, HL | 1 |
| Prout, MN | 1 |
| McKenna, PJ | 1 |
| Cole, DR | 1 |
| Korbitz, BC | 1 |
| Theml, H | 1 |
| Kaboth, W | 1 |
| Canellos, GP | 1 |
| De Vita, VT | 1 |
| Schein, P | 1 |
| Chabner, B | 1 |
| Sokal, JE | 1 |
| Aungst, CW | 1 |
| Han, T | 1 |
| Thornes, RD | 1 |
| Obrecht, P | 1 |
| Marie, J | 1 |
| Hennequet, A | 1 |
| Lévêque, B | 1 |
| Debauchez, C | 1 |
| Desbois, C | 1 |
| Watchi, JM | 1 |
| Israëls, MC | 1 |
| Morgano, G | 1 |
| Patrone, E | 1 |
| Muratore, A | 1 |
| Shaw, S | 1 |
| White, LP | 1 |
| Stacher, A | 1 |
| McNutt, DR | 1 |
| Fudenberg, HH | 1 |
4 reviews available for chlorambucil and Leukemia, Myeloid
| Article | Year |
|---|---|
[Efficacious treatment of a fatal blood disease: polycythemia vera].
Topics: Acute Disease; Alkylating Agents; Busulfan; Chlorambucil; Humans; Hydroxyurea; Leukemia, Myeloid; Le | 1997 |
Treatment of polycythaemia vera and essential thrombocythaemia.
Topics: Adult; Aged; Aspirin; Chlorambucil; Disease Progression; Female; Hemorrhage; Humans; Hydroxyurea; In | 1998 |
Current status of treatment of lymphomas.
Topics: Adrenal Cortex Hormones; Antineoplastic Agents; Chlorambucil; Cyclophosphamide; Drug Therapy, Combin | 1975 |
[Therapy of chronic leukemia].
Topics: Antineoplastic Agents; Busulfan; Chlorambucil; Female; Glucocorticoids; Humans; Leukemia; Leukemia, | 1968 |
3 trials available for chlorambucil and Leukemia, Myeloid
| Article | Year |
|---|---|
Therapy-related myeloid leukemias are observed in patients with chronic lymphocytic leukemia after treatment with fludarabine and chlorambucil: results of an intergroup study, cancer and leukemia group B 9011.
Topics: Acute Disease; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Chlorambuci | 2002 |
[Clinical trial of bestrabucil (KM 2210) on hematopoietic malignancies].
Topics: Aged; Chlorambucil; Clinical Trials as Topic; Drug Administration Schedule; Estradiol; Female; Human | 1986 |
Oral anticoagulant therapy of human cancer.
Topics: Administration, Oral; Anticoagulants; Antineoplastic Agents; Breast Neoplasms; Busulfan; Chlorambuci | 1974 |
49 other studies available for chlorambucil and Leukemia, Myeloid
| Article | Year |
|---|---|
Myelodysplastic syndrome and acute myeloid leukemia after autotransplantation for lymphoma: a multicenter case-control study.
Topics: Acute Disease; Adolescent; Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemoth | 2003 |
DRUGS IN THE TREATMENT OF LEUKAEMIA.
Topics: Busulfan; Chlorambucil; Cyclophosphamide; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; M | 1963 |
[HOW TO TREAT LEUKEMIA IN 1963].
Topics: Busulfan; Child; Chlorambucil; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Mercaptopuri | 1963 |
MULTIVARIATE COMPARISON OF RESULTS OF TREATMENT IN CHRONIC LYMPHOCYTIC AND CHRONIC GRANULOCYTIC LEUKEMIA.
Topics: Antineoplastic Agents; Blood Platelets; Busulfan; Chlorambucil; Factor Analysis, Statistical; Hemogl | 1964 |
CHRONIC LEUKEMIA.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Alkylating Agents; Anemia; Anemia, Hemolytic, | 1964 |
PLASMA FACTORS IN LEUKAEMIA. IMMUNOLOGICAL AND "IN VITRO" CULTURAL STUDIES.
Topics: Blood Group Antigens; Busulfan; Chlorambucil; Complement Fixation Tests; Coombs Test; Humans; In Vit | 1964 |
ANTI-LEUKAEMIC DRUGS.
Topics: Busulfan; Chlorambucil; Cyclophosphamide; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; M | 1964 |
RADIATION AND DRUG INDUCED HYALINIZATION OF THE STOMACH.
Topics: Antineoplastic Agents; Child; Chlorambucil; Cyclophosphamide; Drug Therapy; Ganglioneuroma; Gastroin | 1965 |
[MODERN TREATMENT OF LEUKEMIA].
Topics: Agranulocytosis; Busulfan; Chlorambucil; Cyclophosphamide; Drug Therapy; Genetic Diseases, X-Linked; | 1965 |
Comparison of CB-1348 (chlorambucil, leukeran) and CB-1364.
Topics: Antineoplastic Agents; Chlorambucil; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Mechlo | 1962 |
Myelodysplasia and acute myeloid leukaemia in a case of rheumatoid arthritis with secondary amyloidosis treated with chlorambucil.
Topics: Acute Disease; Amyloidosis; Antirheumatic Agents; Arthritis, Rheumatoid; Chlorambucil; Fatal Outcome | 2004 |
Preclinical evaluation of gemcitabine combination regimens for application in acute myeloid leukemia.
Topics: Acute Disease; Antineoplastic Agents; Apoptosis; Camptothecin; Caspase 3; Caspase 7; Caspases; Cell | 2005 |
Phase II trial of prednimustine in children with recurrent cancer: a Children's Cancer Study Group report.
Topics: Adolescent; Adult; Carcinoma, Hepatocellular; Child; Child, Preschool; Chlorambucil; Drug Administra | 1982 |
Coexistence of chronic myelogenous leukemia and chronic lymphocytic leukemia.
Topics: Aged; Chlorambucil; Chromosomes, Human, 21-22 and Y; Female; Humans; Leukemia, Lymphoid; Leukemia, M | 1984 |
Free light chains of immunoglobulins in serum from patients with leukaemias and multiple myeloma.
Topics: Adolescent; Adult; Aged; Child; Chlorambucil; Humans; Immunoglobulin kappa-Chains; Immunoglobulin la | 1982 |
Myeloproliferative disease developing in chronic lymphocytic leukaemia.
Topics: Aged; Chlorambucil; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Male | 1982 |
Myelodysplastic syndromes and acute myeloid leukemia in connective tissue disease after single-agent chemotherapy.
Topics: Acute Disease; Adult; Aged; Antigens, CD; Antirheumatic Agents; Chlorambucil; Connective Tissue Dise | 1996 |
High-dose BEAM chemotherapy with autologous haemopoietic stem cell transplantation for Hodgkin's disease is unlikely to be associated with a major increased risk of secondary MDS/AML.
Topics: Acute Disease; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; | 1999 |
Fulminant hepatic failure in leukaemia and choriocarcinoma related to withdrawal of cytotoxic drug therapy.
Topics: Adult; Antineoplastic Agents; Chlorambucil; Choriocarcinoma; Cyclophosphamide; Dactinomycin; Female; | 1975 |
Diagnosis and treatment of canine hematopoietic neoplasms.
Topics: Animals; Chlorambucil; Dog Diseases; Dogs; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Lymphoma | 1977 |
[When do we have to treat chronic leukemia?].
Topics: Busulfan; Chlorambucil; Chromosome Aberrations; Cyclophosphamide; Drug Therapy, Combination; Female; | 1978 |
[Evolutionary aspects of the picture of pulmonary pathology in the course of chronic blood diseases (a correlation with cytostatic treatment)].
Topics: Adult; Aged; Antineoplastic Agents; Busulfan; Chlorambucil; Female; Humans; Leukemia, Lymphoid; Leuk | 1979 |
Managing chronic leukemias.
Topics: Adult; B-Lymphocytes; Chlorambucil; Female; Granulocytes; Humans; Leukemia, Lymphoid; Leukemia, Myel | 1977 |
Acute leukemia after alkylating-agent therapy of ovarian cancer.
Topics: Acute Disease; Alkylating Agents; Altretamine; Chlorambucil; Cyclophosphamide; Female; Fluorouracil; | 1977 |
Acute leukemia in advanced ovarian carcinoma after treatment with alkylating agents.
Topics: Acute Disease; Adenocarcinoma, Papillary; Adult; Alkylating Agents; Chlorambucil; Cystadenoma; Femal | 1976 |
[The treatment of myeloproliferative syndromes].
Topics: Aged; Bloodletting; Busulfan; Chlorambucil; Female; Humans; Leukemia, Myeloid; Male; Myeloproliferat | 1975 |
Diagnostic and therapeutic approach to chronic leukaemia.
Topics: Busulfan; Chlorambucil; Chronic Disease; Diagnosis, Differential; Glucocorticoids; Leukemia; Leukemi | 1975 |
Evaluation of the hypothalamic-pituitary-adrenocortical axis in chronic leukaemia.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Adult; Aged; Busulfan; Chloramb | 1976 |
Chlorambucil carcinogenesis in BALB/c mice.
Topics: Adenocarcinoma; Administration, Oral; Animals; Chlorambucil; Female; Incidence; Leukemia, Myeloid; L | 1990 |
ChlVPP combination chemotherapy for Hodgkin's disease: long-term results.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bone Mar | 1990 |
[Early phase II trial of bestrabucil in hematological malignancies].
Topics: Adult; Aged; Chlorambucil; Drug Administration Schedule; Drug Evaluation; Estradiol; Female; Humans; | 1986 |
Acute myeloproliferative disorder following long-term chlorambucil therapy.
Topics: Biopsy; Bone Marrow; Chlorambucil; Female; Humans; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Long | 1974 |
Secondary antibody deficiency syndrome in haemoblastosis.
Topics: Agammaglobulinemia; Antibodies; Antigens, Bacterial; Blood Protein Disorders; Blood Proteins; Busulf | 1972 |
Chronic granulocytic leukaemia and chronic lymphocytic leukaemia.
Topics: Allopurinol; Amenorrhea; Busulfan; Chlorambucil; Chronic Disease; Drug Eruptions; Female; Hemolysis; | 1974 |
Corneal xanthomas in childhood.
Topics: Adolescent; Adrenocorticotropic Hormone; Child, Preschool; Chlorambucil; Corneal Opacity; Female; Hu | 1966 |
Letter: Androgen role in erythroleukemia after treatment with alkylating agents.
Topics: Adult; Alkylating Agents; Androgens; Carcinoma, Intraductal, Noninfiltrating; Chlorambucil; Cytarabi | 1974 |
Chronic myelocytic and chronic lymphocytic leukemia.
Topics: Age Factors; Antilymphocyte Serum; Antineoplastic Agents; Blood Cell Count; Busulfan; Chlorambucil; | 1972 |
Acute leukemia complicating metastatic breast cancer.
Topics: Adult; Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Cyclophosphamide; Female; Fluorouracil | 1973 |
[Treatment of chronic leukemias].
Topics: Antineoplastic Agents; Asparaginase; Busulfan; Chlorambucil; Extracorporeal Circulation; Humans; Imm | 1973 |
Proceedings: The chronic leukemias: current therapeutic concepts.
Topics: Bromine; Busulfan; Cell Division; Chlorambucil; Chromosome Aberrations; Cyclophosphamide; Humans; Hy | 1972 |
Effect of BCG on delayed hypersensitivity responses of patients with neoplastic disease.
Topics: Animals; Antigen-Antibody Reactions; BCG Vaccine; Cattle; Chlorambucil; Cyclophosphamide; Hodgkin Di | 1973 |
[Histiocytic reticulosis in infants or Letterer-Siwe disease. (Clinical and therapeutical study)].
Topics: Acrodermatitis; Betamethasone; Biopsy; Blood Cell Count; Bone Diseases; Child, Preschool; Chlorambuc | 1968 |
The treatment of chronic leukaemia.
Topics: Aged; Betamethasone; Busulfan; Chlorambucil; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Middle A | 1966 |
Drugs in the treatment of leukemia.
Topics: Asparaginase; Busulfan; Chlorambucil; Cyclophosphamide; Cytarabine; Humans; Hydroxyurea; Leukemia; L | 1968 |
[Atypical aspects of leukoses. Venous thrombosis; jaundice].
Topics: Aged; Chlorambucil; Female; Femoral Vein; Humans; Jaundice; Leukemia, Myeloid; Liver Diseases; Male; | 1969 |
The treatment of chronic leukaemia.
Topics: Antibiotics, Antineoplastic; Busulfan; Chlorambucil; Cyclophosphamide; Female; Humans; Hydroxyurea; | 1970 |
Leukemia and lymphoma.
Topics: Antineoplastic Agents; BCG Vaccine; Burkitt Lymphoma; Busulfan; Chlorambucil; Cyclophosphamide; Cyta | 1970 |
[Progress in the therapy of leukoses].
Topics: Antineoplastic Agents; Azathioprine; Busulfan; Chlorambucil; Cyclophosphamide; Daunorubicin; Humans; | 1970 |
Disseminated scotochromogen infection and unusual myeloproliferative disorder. Report of a case and review of the literature.
Topics: Adolescent; Adult; Aged; Autopsy; Busulfan; Child; Child, Preschool; Chlorambucil; Female; Humans; L | 1971 |