chlorambucil has been researched along with Leukemia, Myeloid, Acute in 55 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Leukemia, Myeloid, Acute: Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chlorambucil is useful in patients with rheumatoid arthritis (RA) refractory to other agents but there is concern about the risk of haematological malignancy with this agent." | 7.67 | The oncogenicity of chlorambucil in rheumatoid arthritis. ( Browne, CD; Champion, GD; Cohen, ML; Day, RO; Graham, S; Patapanian, H; Sambrook, PN, 1988) |
| "A new case is reported here of acute myeloid leukemia after chlorambucil therapy for multiple sclerosis." | 7.67 | [Acute leukemia secondary to the treatment of multiple sclerosis with chlorambucil]. ( Aymard, JP; Barroche, G; Conroy, T; Humbert, JC; Lederlin, P; Streiff, F; Witz, F, 1985) |
| "Our clinical experience in 28 patients receiving chlorambucil for rheumatoid arthritis (RA) and the reports on chlorambucil therapy are reviewed." | 7.67 | Chlorambucil therapy in rheumatoid arthritis: clinical experience in 28 patients and literature review. ( Cannon, GW; Clegg, DO; Jackson, CG; Samuelson, CO; Ward, JR; Williams, HJ, 1985) |
| "Thirteen consecutive stage II breast cancer patients were treated with long-term adjuvant chemotherapy using chlorambucil." | 7.66 | Acute myelogenous leukemia in patients receiving chlorambucil as long-term adjuvant chemotherapy for stage II breast cancer. ( Lerner, HJ, 1978) |
| "Four patients who developed acute myeloblastic leukemia during the treatment of a non-Hodgkin's lymphoma are described." | 5.26 | Acute myeloid leukemia following non-Hodgkin's lymphoma: danger of prolonged use of chlorambucil as maintenance therapy. ( Dumont, J; Mazabraud, A; Natali, JC; Thiery, JP; Trapet, P; Vilcoq, JR, 1980) |
| "Chlorambucil is useful in patients with rheumatoid arthritis (RA) refractory to other agents but there is concern about the risk of haematological malignancy with this agent." | 3.67 | The oncogenicity of chlorambucil in rheumatoid arthritis. ( Browne, CD; Champion, GD; Cohen, ML; Day, RO; Graham, S; Patapanian, H; Sambrook, PN, 1988) |
| "A new case is reported here of acute myeloid leukemia after chlorambucil therapy for multiple sclerosis." | 3.67 | [Acute leukemia secondary to the treatment of multiple sclerosis with chlorambucil]. ( Aymard, JP; Barroche, G; Conroy, T; Humbert, JC; Lederlin, P; Streiff, F; Witz, F, 1985) |
| "Our clinical experience in 28 patients receiving chlorambucil for rheumatoid arthritis (RA) and the reports on chlorambucil therapy are reviewed." | 3.67 | Chlorambucil therapy in rheumatoid arthritis: clinical experience in 28 patients and literature review. ( Cannon, GW; Clegg, DO; Jackson, CG; Samuelson, CO; Ward, JR; Williams, HJ, 1985) |
| "A case of acute myeloblastic leukaemia is reported in a patient treated with chlorambucil during 72 months for multiple sclerosis." | 3.66 | Acute leukaemia after prolonged chlorambucil treatment for non-malignant disease: report of a new case and literature survey. ( Aymard, JP; Colomb, JN; Frustin, J; Herbeuval, R; Lederlin, P; Witz, F, 1980) |
| "A 55-year-old man was treated during 22 months with chlorambucil (total dose : 4 218 g) for glomerulonephritis." | 3.66 | [Acute leukaemia during immunosuppressive treatment. One case (author's transl)]. ( Blanc, AP; Carcassonne, Y; Dalivoust, P; Gastaut, JA; Murisasco, A; Sébahoun, G, 1981) |
| "Thirteen consecutive stage II breast cancer patients were treated with long-term adjuvant chemotherapy using chlorambucil." | 3.66 | Acute myelogenous leukemia in patients receiving chlorambucil as long-term adjuvant chemotherapy for stage II breast cancer. ( Lerner, HJ, 1978) |
| "The authors report the case of a man suffering from rheumatoid arthritis treated for almost 5 years with chlorambucil." | 3.65 | [Acute leukemia with megakaryoblasts. Incidence following immunosuppressive treatment of rheumatoid polyarthritis]. ( Delbarre, F; Delrieu, F; Lévy, JP; Mathiot, C; Menkès, CJ; Weill, B, 1975) |
| "Two cases of advanced ovarian carcinoma treated with chlorambucil and terminating in acute leukemia are presented and the literature reviewed." | 3.65 | Acute leukemia in advanced ovarian carcinoma after treatment with alkylating agents. ( Jafari, K; Lash, AF; Sotrel, G; Stepto, RC, 1976) |
| "We evaluated the occurrence of acute nonlymphocytic leukemia (ANL) among 1399 women with ovarian cancer who were treated in five randomized clinical trials." | 2.65 | Acute nonlymphocytic leukemia after therapy with alkylating agents for ovarian cancer: a study of five randomized clinical trials. ( Blessing, JA; Boice, JD; Dembo, AJ; Greene, MH; Greer, BE, 1982) |
| "Waldenstrom's macroglobulinemia (WM) is a rare condition, accounting for approximately 2% of haematologic malignancies." | 1.33 | Waldenstrom's macroglobulinemia terminating in acute myeloid leukemia. ( Adil, SN; Khalid, S; Khurshid, M, 2006) |
| "Four patients who developed acute myeloblastic leukemia during the treatment of a non-Hodgkin's lymphoma are described." | 1.26 | Acute myeloid leukemia following non-Hodgkin's lymphoma: danger of prolonged use of chlorambucil as maintenance therapy. ( Dumont, J; Mazabraud, A; Natali, JC; Thiery, JP; Trapet, P; Vilcoq, JR, 1980) |
| "Thirteen cases of acute nonlymphocytic leukemia occurred among 5455 patients, as compared to 0." | 1.26 | Acute leukemia after alkylating-agent therapy of ovarian cancer. ( Fraumeni, JF; Hoover, R; Reimer, RR; Young, RC, 1977) |
| "Two patients with Wegener's granulomatosis have been treated with chlorambucil and prednisolone continuosly for 3 and 5 years, respectively." | 1.26 | Acute myeloid leukemia appearing in two patients after prolonged continuous chlorambucil treatment for Wegener's granulomatosis. ( Swolin, B; Westberg, NG, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 50 (90.91) | 18.7374 |
| 1990's | 1 (1.82) | 18.2507 |
| 2000's | 2 (3.64) | 29.6817 |
| 2010's | 2 (3.64) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bell-Horwath, TR | 1 |
| Vadukoot, AK | 1 |
| Thowfeik, FS | 1 |
| Li, G | 1 |
| Wunderlich, M | 1 |
| Mulloy, JC | 1 |
| Merino, EJ | 1 |
| Zhao, XL | 1 |
| Wei, SN | 1 |
| Liu, KQ | 1 |
| Lin, D | 1 |
| Wei, H | 1 |
| Wang, Y | 1 |
| Zhou, CL | 1 |
| Liu, BC | 1 |
| Li, W | 1 |
| Cao, Z | 1 |
| Gong, BF | 1 |
| Liu, YT | 1 |
| Gong, XY | 1 |
| Li, Y | 1 |
| Gu, RX | 1 |
| Zhang, GJ | 1 |
| Wang, JX | 1 |
| Mi, YC | 1 |
| Leleu, X | 1 |
| Soumerai, J | 1 |
| Roccaro, A | 1 |
| Hatjiharissi, E | 1 |
| Hunter, ZR | 1 |
| Manning, R | 1 |
| Ciccarelli, BT | 1 |
| Sacco, A | 1 |
| Ioakimidis, L | 1 |
| Adamia, S | 1 |
| Moreau, AS | 1 |
| Patterson, CJ | 1 |
| Ghobrial, IM | 1 |
| Treon, SP | 1 |
| Khalid, S | 1 |
| Adil, SN | 1 |
| Khurshid, M | 1 |
| Palmer, RG | 1 |
| Doré, CJ | 1 |
| Denman, AM | 1 |
| Ludwig, C | 1 |
| Ifrah, N | 1 |
| Marie, JP | 1 |
| Zittoun, R | 2 |
| Gaynon, PS | 1 |
| Baum, ES | 1 |
| Krivit, W | 1 |
| Hammond, D | 1 |
| Horsman, DE | 1 |
| Card, RT | 1 |
| Skinnider, LF | 1 |
| Aymard, JP | 3 |
| Lederlin, P | 3 |
| Witz, F | 3 |
| Rumilly, F | 1 |
| Eisemann, JC | 1 |
| Buisine, J | 1 |
| Gregoire, MJ | 1 |
| Guerci, O | 1 |
| Streiff, F | 2 |
| Greene, MH | 2 |
| Boice, JD | 2 |
| Greer, BE | 1 |
| Blessing, JA | 1 |
| Dembo, AJ | 1 |
| Frustin, J | 1 |
| Colomb, JN | 1 |
| Herbeuval, R | 1 |
| Sølling, K | 1 |
| Nielsen, JL | 1 |
| Sølling, J | 1 |
| Ellegaard, J | 1 |
| Latif, ZA | 1 |
| Lozzio, BB | 1 |
| Wust, CJ | 1 |
| Krauss, S | 1 |
| Aggio, MC | 1 |
| Lozzio, CB | 1 |
| Asbjørnsen, G | 1 |
| Godal, HC | 1 |
| Myhre, K | 1 |
| Blanc, AP | 2 |
| Gastaut, JA | 2 |
| Sébahoun, G | 1 |
| Dalivoust, P | 1 |
| Murisasco, A | 1 |
| Carcassonne, Y | 2 |
| Dumont, J | 1 |
| Thiery, JP | 1 |
| Mazabraud, A | 1 |
| Natali, JC | 1 |
| Trapet, P | 1 |
| Vilcoq, JR | 1 |
| Fiere, D | 1 |
| Felman, P | 1 |
| Vu Van, H | 1 |
| Coiffier, B | 1 |
| Lerner, HJ | 1 |
| Zimonyi, I | 1 |
| Czirbesz, Z | 1 |
| Dózsa, M | 1 |
| Brandt, L | 2 |
| Könyves, I | 2 |
| Juul, K | 1 |
| Sørensen, P | 1 |
| Pedersen-Bjergaard, J | 1 |
| Jensen, MK | 1 |
| Reimer, RR | 1 |
| Hoover, R | 1 |
| Fraumeni, JF | 1 |
| Young, RC | 1 |
| Cazalis, P | 1 |
| Caroit, M | 1 |
| Kahn, MF | 1 |
| Sèze, S | 1 |
| Menkès, CJ | 1 |
| Lévy, JP | 1 |
| Weill, B | 1 |
| Delrieu, F | 1 |
| Mathiot, C | 1 |
| Delbarre, F | 1 |
| Sotrel, G | 1 |
| Jafari, K | 1 |
| Lash, AF | 1 |
| Stepto, RC | 1 |
| Westberg, NG | 2 |
| Swolin, B | 1 |
| Tchernia, G | 1 |
| Mielot, F | 1 |
| Subtil, E | 1 |
| Parmentier, C | 1 |
| Migdalska, B | 1 |
| Leszko, B | 1 |
| Hartwig, W | 1 |
| Pawelski, S | 1 |
| Haq, AU | 1 |
| Mahoney, DH | 1 |
| McClain, KL | 1 |
| Hanson, IC | 1 |
| Taylor, LD | 1 |
| Steuber, CP | 1 |
| Devilliers, E | 1 |
| Carli, PM | 1 |
| Lorenzini, JL | 1 |
| Mugneret, F | 1 |
| Turc-Carel, C | 1 |
| Bonhomme, J | 1 |
| Guy, H | 1 |
| Patapanian, H | 1 |
| Graham, S | 1 |
| Sambrook, PN | 1 |
| Browne, CD | 1 |
| Champion, GD | 1 |
| Cohen, ML | 1 |
| Day, RO | 1 |
| Tisdale, MJ | 1 |
| Bennett, JM | 1 |
| Moloney, WC | 1 |
| Michels, SD | 1 |
| McKenna, RW | 1 |
| Arthur, DC | 1 |
| Brunning, RD | 1 |
| Conroy, T | 1 |
| Humbert, JC | 1 |
| Barroche, G | 1 |
| Cannon, GW | 1 |
| Jackson, CG | 1 |
| Samuelson, CO | 1 |
| Ward, JR | 1 |
| Williams, HJ | 1 |
| Clegg, DO | 1 |
| Sahakian, GJ | 1 |
| al-Mondhiry, H | 1 |
| Lacher, MJ | 1 |
| Connolly, CE | 1 |
| Danieli, G | 1 |
| Steigbigel, RT | 1 |
| Kim, H | 1 |
| Potolsky, A | 1 |
| Schrier, SL | 1 |
| Ruffner, BW | 1 |
| Forbes, IJ | 1 |
| Schaefer, UW | 1 |
| Kanzler, G | 1 |
| Davis, HL | 1 |
| Prout, MN | 1 |
| McKenna, PJ | 1 |
| Cole, DR | 1 |
| Korbitz, BC | 1 |
| Gunz, FW | 1 |
| Levi, JA | 1 |
| Lind, DE | 1 |
| Vincent, PC | 1 |
| Tulliez, M | 1 |
| Ricard, MF | 1 |
| Jan, F | 1 |
| Sultan, C | 1 |
| Faĭnshteĭn, FE | 1 |
| McPhedran, P | 1 |
| Heath, CW | 1 |
| Gosselin, G | 1 |
| Neemeh, J | 1 |
| Long, LA | 1 |
| Pretty, H | 1 |
| Lefebvre, R | 1 |
| White, LP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| US Post-Marketing Retrospective Observational Safety Study of Moxetumomab Pasudotox-tdfk (LUMOXITI)(TM)[NCT04125290] | 2 participants (Actual) | Observational | 2019-12-09 | Terminated (stopped due to Study stopped due to lack of recruitment.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for chlorambucil and Leukemia, Myeloid, Acute
| Article | Year |
|---|---|
Acute leukaemia following prolonged chlorambucil treatment for non-neoplastic disease - a study of two cases and literature review.
Topics: Adult; Aged; Chlorambucil; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Leukemia | 1983 |
[Clinical aspects of the problem of treating leukemias].
Topics: Acute Disease; Antineoplastic Agents; Chlorambucil; Chlorine; Chronic Disease; Daunorubicin; Dimetho | 1973 |
4 trials available for chlorambucil and Leukemia, Myeloid, Acute
| Article | Year |
|---|---|
Acute nonlymphocytic leukemia after therapy with alkylating agents for ovarian cancer: a study of five randomized clinical trials.
Topics: Acute Disease; Adult; Aged; Alkylating Agents; Animals; Chlorambucil; Clinical Trials as Topic; Fema | 1982 |
[Prednimustine in treatment of acute leukemia in elderly patients].
Topics: Age Factors; Aged; Antineoplastic Agents; Chlorambucil; Clinical Trials as Topic; Drug Evaluation; F | 1977 |
Prednimustine in adult acute myeloid leukaemia.
Topics: Adult; Aged; Blood Cell Count; Chlorambucil; Clinical Trials as Topic; Drug Therapy, Combination; Fe | 1979 |
Phase II trial of Prednimustine. Leo-1031 (NSC-134087) in acute non-lymphocytic leukemia.
Topics: Adult; Aged; Chlorambucil; Clinical Trials as Topic; Female; Humans; Leukemia, Erythroblastic, Acute | 1979 |
49 other studies available for chlorambucil and Leukemia, Myeloid, Acute
| Article | Year |
|---|---|
Novel ROS-activated agents utilize a tethered amine to selectively target acute myeloid leukemia.
Topics: Amines; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; DNA; Dose-Response Relationship | 2013 |
[Efficacy Analysis of MAC Regimen as Salvage Treatment Protocol for Acute Myeloid Leukemia Patients Older Than 55 Years].
Topics: Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Cytarabine; Dactinomycin; Humans; Leuk | 2015 |
Increased incidence of transformation and myelodysplasia/acute leukemia in patients with Waldenström macroglobulinemia treated with nucleoside analogs.
Topics: Adult; Aged; Aged, 80 and over; Cell Transformation, Neoplastic; Chlorambucil; Cladribine; Female; F | 2009 |
Waldenstrom's macroglobulinemia terminating in acute myeloid leukemia.
Topics: Adult; Chlorambucil; Cyclophosphamide; Humans; Leukemia, Myeloid, Acute; Male; Waldenstrom Macroglob | 2006 |
Chlorambucil-induced chromosome damage to human lymphocytes is dose-dependent and cumulative.
Topics: Adult; Behcet Syndrome; Chlorambucil; Chromosomes, Human; Dose-Response Relationship, Drug; Female; | 1984 |
[The meaning of maintenance therapy in oncology].
Topics: Breast Neoplasms; Chlorambucil; Hodgkin Disease; Leukemia, Myeloid, Acute; Lymphoma; Methotrexate; N | 1980 |
[Acute myeloid leukemia secondary to chronic lymphoid leukemia].
Topics: Chlorambucil; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Middle Aged; Time Factors | 1984 |
Phase II trial of prednimustine in children with recurrent cancer: a Children's Cancer Study Group report.
Topics: Adolescent; Adult; Carcinoma, Hepatocellular; Child; Child, Preschool; Chlorambucil; Drug Administra | 1982 |
Waldenström macroglobulinemia terminating in acute leukemia: a report of three cases.
Topics: Aged; Chlorambucil; Cyclophosphamide; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; | 1983 |
Acute leukaemia after prolonged chlorambucil treatment for non-malignant disease: report of a new case and literature survey.
Topics: Adult; Chlorambucil; Female; Humans; Immunosuppression Therapy; Leukemia, Myeloid, Acute; Multiple S | 1980 |
Free light chains of immunoglobulins in serum from patients with leukaemias and multiple myeloma.
Topics: Adolescent; Adult; Aged; Child; Chlorambucil; Humans; Immunoglobulin kappa-Chains; Immunoglobulin la | 1982 |
Evaluation of drug-antibody conjugates in the treatment of human myelosarcomas transplanted in nude mice.
Topics: Animals; Antibodies, Neoplasm; Antibody Specificity; Antineoplastic Agents; Chlorambucil; Daunorubic | 1980 |
[Acute myelogenous leukemia after cytostatic therapy of breast cancer].
Topics: Aged; Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Female; Humans; Leukemia, Myeloid, Acut | 1981 |
[Acute leukaemia during immunosuppressive treatment. One case (author's transl)].
Topics: Blood Cell Count; Chlorambucil; Glomerulonephritis; Humans; Leukemia, Myeloid, Acute; Male; Middle A | 1981 |
Acute myeloid leukemia following non-Hodgkin's lymphoma: danger of prolonged use of chlorambucil as maintenance therapy.
Topics: Adult; Aged; Chlorambucil; Female; Humans; Leukemia, Myeloid, Acute; Lymphoma; Middle Aged; Time Fac | 1980 |
[Acute myeloid leukemia following chlorambucil administration. 2 observations].
Topics: Arthritis, Rheumatoid; Chlorambucil; Female; Humans; Leukemia, Myeloid, Acute; Middle Aged; Nephroti | 1978 |
Acute leukemia after prolonged immunosuppressive therapy for glomerulonephritis.
Topics: Adolescent; Alkylating Agents; Chlorambucil; Dipyridamole; Glomerulonephritis; Humans; Indomethacin; | 1978 |
Acute myelogenous leukemia in patients receiving chlorambucil as long-term adjuvant chemotherapy for stage II breast cancer.
Topics: Adult; Aged; Breast Neoplasms; Chlorambucil; Female; Humans; Leukemia, Myeloid, Acute; Middle Aged; | 1978 |
[Acute myeloid leukemia occurring after nephrotic syndrome treated with leukeran].
Topics: Child; Chlorambucil; Female; Humans; Leukemia, Myeloid, Acute; Nephrotic Syndrome | 1979 |
Acute leukemia after alkylating-agent therapy of ovarian cancer.
Topics: Acute Disease; Alkylating Agents; Altretamine; Chlorambucil; Cyclophosphamide; Female; Fluorouracil; | 1977 |
[A particular risk of prolonged immunosuppressive treatment: a case of acute myelomonocytic leukemia after chlorambucil treatment of severe rheumatoid arhtritis].
Topics: Adult; Antineoplastic Agents; Arthritis, Rheumatoid; Autoimmune Diseases; Carcinogens; Chlorambucil; | 1976 |
[Acute leukemia with megakaryoblasts. Incidence following immunosuppressive treatment of rheumatoid polyarthritis].
Topics: Arthritis, Rheumatoid; Blood Cell Count; Bone Marrow Cells; Chlorambucil; Humans; Immunosuppressive | 1975 |
Acute leukemia in advanced ovarian carcinoma after treatment with alkylating agents.
Topics: Acute Disease; Adenocarcinoma, Papillary; Adult; Alkylating Agents; Chlorambucil; Cystadenoma; Femal | 1976 |
Acute myeloid leukemia appearing in two patients after prolonged continuous chlorambucil treatment for Wegener's granulomatosis.
Topics: Bone Marrow; Bone Marrow Cells; Chlorambucil; Granulomatosis with Polyangiitis; Humans; Leukemia, My | 1976 |
[Wegener's granulomatosis--therapy, treatment complications and follow-up study].
Topics: Adrenal Cortex Hormones; Adult; Chlorambucil; Female; Follow-Up Studies; Granulomatosis with Polyang | 1976 |
Acute myeloblastic leukemia after immunodepressive therapy for primary nonmalignant disease.
Topics: Arthritis, Rheumatoid; Bone Marrow; Bone Marrow Cells; Chlorambucil; Cyclophosphamide; Diagnosis, Di | 1976 |
Evaluation of the hypothalamic-pituitary-adrenocortical axis in chronic leukaemia.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Adult; Aged; Busulfan; Chloramb | 1976 |
Transformation of polycythemia vera to Ph-positive chronic myelogenous leukemia.
Topics: Bloodletting; Cell Transformation, Neoplastic; Chlorambucil; Humans; Leukemia, Myeloid, Acute; Leuko | 1990 |
Acquired immune deficiency, myelodysplasia, and acute nonlymphocytic leukemia associated with monosomy 7 and t(3;3) (q21;q26) in a child with Langerhans cell histiocytosis.
Topics: Chlorambucil; Chromosome Deletion; Chromosomes, Human, Pair 3; Chromosomes, Human, Pair 7; Female; H | 1989 |
[Acute myeloid leukemia in chronic lymphoid leukemia treated with chlorambucil].
Topics: Chlorambucil; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Middle Aged | 1986 |
The oncogenicity of chlorambucil in rheumatoid arthritis.
Topics: Acute Disease; Arthritis, Rheumatoid; Azathioprine; Carcinogens; Chlorambucil; Humans; Leukemia, Mye | 1988 |
Antitumor imidazotetrazines--XV. Role of guanine O6 alkylation in the mechanism of cytotoxicity of imidazotetrazinones.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Line; Chlorambucil; Colonic Neoplasms; Dacarbaz | 1987 |
Acute myeloid leukemia and other myelopathic disorders following treatment with alkylating agents.
Topics: Adolescent; Adult; Aged; Alkylating Agents; Anemia, Aplastic; Child; Child, Preschool; Chlorambucil; | 1987 |
Therapy-related acute myeloid leukemia and myelodysplastic syndrome: a clinical and morphologic study of 65 cases.
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Behcet Syndrome; Bone Marrow; Carcinoma; Child; Chil | 1985 |
[Acute leukemia secondary to the treatment of multiple sclerosis with chlorambucil].
Topics: Adult; Alkylating Agents; Chlorambucil; Female; Humans; Immunosuppressive Agents; Leukemia, Myeloid, | 1985 |
Chlorambucil therapy in rheumatoid arthritis: clinical experience in 28 patients and literature review.
Topics: Adult; Arthritis, Rheumatoid; Chlorambucil; Drug Evaluation; Female; Humans; Leukemia, Myeloid, Acut | 1985 |
Acute leukemia in Hodgkin's disease.
Topics: Adult; Bleomycin; Carmustine; Chlorambucil; Drug Therapy, Combination; Female; Hodgkin Disease; Huma | 1974 |
[1973 treatment of acute leukemias].
Topics: Chlorambucil; Colchicine; Cyclophosphamide; Cytarabine; Dactinomycin; Daunorubicin; Doxorubicin; Dru | 1974 |
Acute myeloproliferative disorder following long-term chlorambucil therapy.
Topics: Biopsy; Bone Marrow; Chlorambucil; Female; Humans; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Long | 1974 |
Letter: Androgen role in erythroleukemia after treatment with alkylating agents.
Topics: Adult; Alkylating Agents; Androgens; Carcinoma, Intraductal, Noninfiltrating; Chlorambucil; Cytarabi | 1974 |
Development of acute leukaemia in Waldenstrom's macroglobulinaemia after prolonged treatment with chlorambucil.
Topics: Aged; Chlorambucil; Female; Humans; Leukemia, Myeloid, Acute; Purpura, Hyperglobulinemic; Time Facto | 1972 |
[Leukemia in Hodgkin's disease due to cancerostatic therapy?].
Topics: Adult; Chlorambucil; Cyclophosphamide; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Po | 1972 |
Acute leukemia complicating metastatic breast cancer.
Topics: Adult; Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Cyclophosphamide; Female; Fluorouracil | 1973 |
Development of acute leukaemia in a patient with lymphosarcoma.
Topics: Autopsy; Bone Marrow; Bone Marrow Cells; Chlorambucil; Humans; Immunoglobulins; Karyotyping; Leukemi | 1973 |
Preleukaemic abnormal myelopoiesis induced by chlorambucil: a case study.
Topics: Anemia, Sideroblastic; Blood Platelets; Bone Marrow; Chlorambucil; Female; Humans; Leukemia, Myeloid | 1974 |
Drugs in the treatment of leukemia.
Topics: Asparaginase; Busulfan; Chlorambucil; Cyclophosphamide; Cytarabine; Humans; Hydroxyurea; Leukemia; L | 1968 |
Acute leukemia occurring during chronic lymphocytic leukemia.
Topics: Adult; Aged; Bone Marrow Examination; Chlorambucil; Female; Hemoglobinometry; Humans; Leukemia; Leuk | 1970 |
[Appearance of acute myeloid leukemia during the development of lymphosarcoma].
Topics: Chlorambucil; Female; Humans; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Middle Aged | 1970 |
Leukemia and lymphoma.
Topics: Antineoplastic Agents; BCG Vaccine; Burkitt Lymphoma; Busulfan; Chlorambucil; Cyclophosphamide; Cyta | 1970 |