chlorambucil has been researched along with Leucocythaemia in 140 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sixty-seven patients with acute nonlymphoblastic leukemia (ANLL) and above the age of 60 years were randomly allocated to treatment with either prednimustine + vincristine or cycles with cytosine arabinoside and thioguanine." | 9.05 | Prednimustine and vincristine compared with cytosine arabinoside and thioguanine for treatment of elderly patients with acute nonlymphoblastic leukemia. ( Andersson, B; Björkholm, M; Engstedt, L; Gahrton, G; Hast, R; Holm, G; Killander, A; Lantz, B; Lockner, D; Lönnqvist, B; Mellstedt, H; Oberg, G; Palmblad, J; Paul, C; Peterson, C; Simonsson, B; Stalfelt, AM; Udén, AM; Wadman, B, 1982) |
| "In polycythemia vera (PV), treatment with chlorambucil and radioactive phosphorus (p32) increases the risk of leukemic transformation from 1% to 13-14%." | 7.69 | Leukemogenic risk of hydroxyurea therapy in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. ( Fisher, SG; Godwin, J; Nand, S; Stock, W, 1996) |
| "Prednimustine, an ester of chlorambucil and prednisolone, was evaluated for efficacy and toxicity in a selected group of leukemia patients with a poor prognosis." | 7.66 | A phase II study of prednimustine in acute non-lymphocytic leukemia, smouldering leukemia, and refractory anemia with excess blasts. ( Carter, SK; Gandara, DR; George, CB; Koretz, MM; Lewis, JP; Ries, CA; Schiff, SA, 1982) |
| "A cell-surface localizing xenogeneic antibody against an AKR mouse lymphoma of spontaneous origin could be bound to chlorambucil without interference with either the alkylating activity of chlorambucil or the immunologic reactivity of the antibody." | 7.65 | Suppression of an AKR lymphoma by antibody and chlorambucil. ( Ghose, T; Guclu, A; Tai, J, 1975) |
| "In studies to determine the optimal treatment for polycythemia vera, 431 previously untreated patients whose disease met established diagnostic criteria were entered into a prospective, randomized controlled trial between 1967 and 1974." | 6.65 | Increased incidence of acute leukemia in polycythemia vera associated with chlorambucil therapy. ( Berk, PD; Donovan, PB; Ellis, JT; Goldberg, JD; Landaw, SA; Laszlo, J; Najean, Y; Pisciotta, AV; Silverstein, MN; Wasserman, LR; Weinfeld, A, 1981) |
| "Sixty-seven patients with acute nonlymphoblastic leukemia (ANLL) and above the age of 60 years were randomly allocated to treatment with either prednimustine + vincristine or cycles with cytosine arabinoside and thioguanine." | 5.05 | Prednimustine and vincristine compared with cytosine arabinoside and thioguanine for treatment of elderly patients with acute nonlymphoblastic leukemia. ( Andersson, B; Björkholm, M; Engstedt, L; Gahrton, G; Hast, R; Holm, G; Killander, A; Lantz, B; Lockner, D; Lönnqvist, B; Mellstedt, H; Oberg, G; Palmblad, J; Paul, C; Peterson, C; Simonsson, B; Stalfelt, AM; Udén, AM; Wadman, B, 1982) |
| " The present study investigated the synthesis and efficacy of carbazole-coumarin (CC)-fused heterocycles as a PTDDS platform for the photocontrolled release of a chemotherapeutic agent, chlorambucil, in an in vitro model of human breast and leukemia cancer cells." | 3.96 | Targeted photoresponsive carbazole-coumarin and drug conjugates for efficient combination therapy in leukemia cancer cells. ( Chang, WW; Chu, CC; Lai, YT; Lin, YC; Ou, JY; Wang, BY, 2020) |
| "In order to study the role of the steroidal moiety on the expression of anti-leukemic activity, we synthesized six derivatives of chlorambucil (CHL), and tested them on leukemias P388 and L1210 in vivo and in normal human lymphocytes in vitro." | 3.73 | Structure-anti-leukemic activity relationship study of B- and D-ring modified and non-modified steroidal esters of chlorambucil. ( Arsenou, ES; Fousteris, MA; Koutsourea, AI; Mourelatos, D; Nikolaropoulos, SS; Papageorgiou, A, 2006) |
| " In vitro studies of human chronic lymphocytic leukemia cells incubated with theophylline, a phosphodiesterase inhibitor, resulted in downregulation of bcl-2 concomitant with induction of apoptosis." | 3.70 | Theophylline, pentostatin (Nipent), and chlorambucil: a dose-escalation study targeting intrinsic biologic resistance mechanisms in patients with relapsed lymphoproliferative disorders. ( Byrd, JC; Flinn, IW; Goodrich, A; Grever, MR; Lucas, MA; Park, K; Shinn, C; Waselenko, JK; Willis, CR, 2000) |
| "In polycythemia vera (PV), treatment with chlorambucil and radioactive phosphorus (p32) increases the risk of leukemic transformation from 1% to 13-14%." | 3.69 | Leukemogenic risk of hydroxyurea therapy in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. ( Fisher, SG; Godwin, J; Nand, S; Stock, W, 1996) |
| " Human chronic myelogenous leukemia K-562 cells were efficiently transduced with the N2Yc retrovirus vector and showed a significant increase in the 50% inhibitory concentration of chlorambucil (3." | 3.69 | Retrovirus-mediated gene transfer of rat glutathione S-transferase Yc confers in vitro resistance to alkylating agents in human leukemia cells and in clonogenic mouse hematopoietic progenitor cells. ( Cournoyer, D; Greenbaum, M; Letourneau, S, 1996) |
| "A rapid assay for chlorambucil, a drug used for the treatment of chronic lymphocytic leukemia, and its major metabolite is described." | 3.66 | Rapid assay for plasma chlorambucil and phenyl acetic mustard using reversed-phase liquid chromatography. ( Brown, PR; Zakaria, M, 1982) |
| "Prednimustine, an ester of chlorambucil and prednisolone, was evaluated for efficacy and toxicity in a selected group of leukemia patients with a poor prognosis." | 3.66 | A phase II study of prednimustine in acute non-lymphocytic leukemia, smouldering leukemia, and refractory anemia with excess blasts. ( Carter, SK; Gandara, DR; George, CB; Koretz, MM; Lewis, JP; Ries, CA; Schiff, SA, 1982) |
| "Two cases of advanced ovarian carcinoma treated with chlorambucil and terminating in acute leukemia are presented and the literature reviewed." | 3.65 | Acute leukemia in advanced ovarian carcinoma after treatment with alkylating agents. ( Jafari, K; Lash, AF; Sotrel, G; Stepto, RC, 1976) |
| "A cell-surface localizing xenogeneic antibody against an AKR mouse lymphoma of spontaneous origin could be bound to chlorambucil without interference with either the alkylating activity of chlorambucil or the immunologic reactivity of the antibody." | 3.65 | Suppression of an AKR lymphoma by antibody and chlorambucil. ( Ghose, T; Guclu, A; Tai, J, 1975) |
| "Chlorambucil and melphalan were the most leukemogenic drugs, followed by thiotepa; cyclophosphamide and treosulfan were the weakest leukemogens, and the effect per gram was substantially lower at high doses than at lower doses." | 2.67 | Leukemia following chemotherapy for ovarian cancer. ( Bell, J; Clarke, EA; Day, NE; Høst, H; Kaldor, JM; Karjalainen, S; Mehnert, W; Pedersen, D; Pettersson, F; Prior, P, 1990) |
| "We evaluated the occurrence of acute nonlymphocytic leukemia (ANL) among 1399 women with ovarian cancer who were treated in five randomized clinical trials." | 2.65 | Acute nonlymphocytic leukemia after therapy with alkylating agents for ovarian cancer: a study of five randomized clinical trials. ( Blessing, JA; Boice, JD; Dembo, AJ; Greene, MH; Greer, BE, 1982) |
| "In studies to determine the optimal treatment for polycythemia vera, 431 previously untreated patients whose disease met established diagnostic criteria were entered into a prospective, randomized controlled trial between 1967 and 1974." | 2.65 | Increased incidence of acute leukemia in polycythemia vera associated with chlorambucil therapy. ( Berk, PD; Donovan, PB; Ellis, JT; Goldberg, JD; Landaw, SA; Laszlo, J; Najean, Y; Pisciotta, AV; Silverstein, MN; Wasserman, LR; Weinfeld, A, 1981) |
| "Its use in the treatment of essential thrombocythemia began later in 1950." | 2.41 | Treatment of the myeloproliferative disorders with 32P. ( Berlin, NI, 2000) |
| "Data on the possible increased risk of malignancy in rheumatoid arthritis are still being collected, and until further information is available, the use of immunosuppressive drugs, particularly alkylating agents, in the treatment of rheumatoid arthritis should be reserved for patients with severe progressive disease or life-threatening complications." | 1.27 | Incidence of neoplasms in patients with rheumatoid arthritis exposed to different treatment regimens. ( Hazleman, B, 1985) |
| "Of 602 patients treated for non-Hodgkin's lymphomas, 9 developed overt acute nonlymphocytic leukemia or preleukemia with refractory cytopenia and cytogenetic abnormalities of the bone marrow." | 1.27 | Risk of acute nonlymphocytic leukemia and preleukemia in patients treated with cyclophosphamide for non-Hodgkin's lymphomas. Comparison with results obtained in patients treated for Hodgkin's disease and ovarian carcinoma with other alkylating agents. ( Ersbøll, J; Keiding, N; Larsen, MS; Larsen, SO; Nissen, NI; Pedersen-Bjergaard, J; Philip, P; Schultz, H; Sørensen, HM, 1985) |
| "Thirteen cases of acute nonlymphocytic leukemia occurred among 5455 patients, as compared to 0." | 1.26 | Acute leukemia after alkylating-agent therapy of ovarian cancer. ( Fraumeni, JF; Hoover, R; Reimer, RR; Young, RC, 1977) |
| "Azathioprine was best tolerated, but gave only medium results whereas procarbazine, as a very potent drug, had the highest rate of side effects (especially depression of bone marrow, infections, gastrointestinal manifestations etc." | 1.25 | [Side effects in immunosuppressive therapy]. ( Thumb, N, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 118 (84.29) | 18.7374 |
| 1990's | 9 (6.43) | 18.2507 |
| 2000's | 9 (6.43) | 29.6817 |
| 2010's | 3 (2.14) | 24.3611 |
| 2020's | 1 (0.71) | 2.80 |
| Authors | Studies |
|---|---|
| Ling, T | 1 |
| Maier, J | 1 |
| Das, S | 1 |
| Budhraja, A | 1 |
| Bassett, R | 1 |
| Potts, MB | 1 |
| Shelat, A | 1 |
| Rankovic, Z | 1 |
| Opferman, JT | 1 |
| Rivas, F | 1 |
| Wang, BY | 1 |
| Lin, YC | 1 |
| Lai, YT | 1 |
| Ou, JY | 1 |
| Chang, WW | 1 |
| Chu, CC | 1 |
| Goede, V | 1 |
| Mourtada, R | 1 |
| Fonseca, SB | 1 |
| Wisnovsky, SP | 1 |
| Pereira, MP | 1 |
| Wang, X | 1 |
| Hurren, R | 1 |
| Parfitt, J | 1 |
| Larsen, L | 1 |
| Smith, RA | 1 |
| Murphy, MP | 1 |
| Schimmer, AD | 1 |
| Kelley, SO | 1 |
| Lu, D | 1 |
| HANSEN, PB | 1 |
| LAMY, P | 1 |
| REMIGY, E | 1 |
| STEHLIN, H | 1 |
| KRAKOFF, IH | 1 |
| KARNOFSKY, DA | 1 |
| BURCHENAL, JH | 2 |
| DOAN, CA | 1 |
| WISEMAN, BK | 1 |
| BOURONCLE, BA | 1 |
| LAWKOWICZ, W | 1 |
| BECALSKI, J | 1 |
| GALTON, DA | 1 |
| WILTSHAW, E | 2 |
| SZUR, L | 1 |
| DACIE, JV | 1 |
| SPRAGUE, CC | 1 |
| PITNEY, WR | 1 |
| NAKAMOTO, S | 1 |
| KOLFF, WJ | 1 |
| BIGLEY, RH | 1 |
| ELSON, LA | 1 |
| OSSIPOVSKI, B | 1 |
| EVANS, AM | 1 |
| RIEKHOF, P | 1 |
| ROSS, ED | 1 |
| SETTLE, JA | 1 |
| TELFER, AB | 1 |
| BERRY, CZ | 1 |
| SCHREIBER, MM | 1 |
| SHAPIRO, SI | 1 |
| ADAMS, JL | 1 |
| WILLIAMS, HM | 1 |
| NIZET, A | 1 |
| FEIWEL, M | 1 |
| MUNRO, DD | 1 |
| GRIZZLE, JE | 1 |
| BURNINGHAM, RA | 1 |
| RESTREPO, A | 1 |
| PUGH, RP | 1 |
| BROWN, EB | 1 |
| SCHLOSSMAN, SF | 1 |
| KHURI, PD | 1 |
| LESSNER, HE | 1 |
| HARRINGTON, WJ | 1 |
| DIAMANDOPOULOS, GT | 1 |
| SMITH, EB | 1 |
| BOOTSMA, BK | 1 |
| WOODLIFF, HJ | 1 |
| LOPESCARDOZO, E | 1 |
| MOLANDER, DW | 1 |
| LADUE, JS | 1 |
| COWLING, DC | 1 |
| QUAGLINO, D | 1 |
| HAYHOE, FG | 1 |
| HUTCHISON, JL | 1 |
| KAUNG, DT | 2 |
| WHITTINGTON, RM | 2 |
| PATNO, ME | 2 |
| INNES, J | 1 |
| DUMA, RJ | 1 |
| BOYETT, JD | 1 |
| BEETHAM, WP | 1 |
| EZDINLI, EZ | 2 |
| STUTZMAN, L | 1 |
| SMITH, JC | 1 |
| BOLANDE, RP | 1 |
| SBARRA, AJ | 1 |
| SHIRLEY, W | 1 |
| SELVARAJ, RJ | 1 |
| IOUCHI, E | 1 |
| ROSENBAUM, E | 1 |
| GREEN, RA | 1 |
| DIXON, H | 1 |
| HENNEMANN, HH | 1 |
| MOESCHLIN, S | 2 |
| BRODY, JI | 1 |
| BEIZER, LH | 1 |
| PALLESCHI, M | 1 |
| LIBANSKY, J | 1 |
| CHUDOMEL, V | 1 |
| BRABEC, V | 1 |
| SOCHMAN, J | 1 |
| SAMPEY, JR | 1 |
| RUNDLES, W | 1 |
| GRIZZLE, J | 1 |
| BONO, VH | 1 |
| JONSSON, U | 1 |
| HUGULEY, CM | 1 |
| CORLEY, CC | 1 |
| Kouloumenta, A | 1 |
| Stephanou, G | 1 |
| Demopoulos, NA | 1 |
| Nikolaropoulos, SS | 3 |
| Yen, CJ | 1 |
| Huang, WT | 1 |
| Huang, JJ | 1 |
| Chen, FF | 1 |
| Sung, JM | 1 |
| Papageorgiou, A | 2 |
| Koutsourea, AI | 2 |
| Arsenou, ES | 2 |
| Fousteris, MA | 2 |
| Mourelatos, D | 2 |
| Kryczka, T | 1 |
| Kazimierczuk, Z | 1 |
| Kozłowska, M | 1 |
| Chrapusta, SJ | 1 |
| Vilpo, L | 1 |
| Vilpo, J | 1 |
| Stachnik, K | 1 |
| Janisz, M | 1 |
| Grieb, P | 1 |
| Han, T | 1 |
| Sokal, JE | 1 |
| Raposa, T | 2 |
| Várkonyi, J | 1 |
| Gráf, F | 1 |
| Gaynon, PS | 1 |
| Baum, ES | 1 |
| Krivit, W | 1 |
| Hammond, D | 1 |
| Palmer, RG | 1 |
| Denman, AM | 1 |
| Ross, DW | 1 |
| Greene, MH | 1 |
| Boice, JD | 1 |
| Greer, BE | 1 |
| Blessing, JA | 1 |
| Dembo, AJ | 1 |
| Adamson, RH | 1 |
| Seiber, SM | 1 |
| Sølling, K | 1 |
| Nielsen, JL | 1 |
| Sølling, J | 1 |
| Ellegaard, J | 1 |
| Ayulo, MA | 1 |
| Preisler, HD | 1 |
| Balthazar, PA | 1 |
| Berk, PD | 3 |
| Goldberg, JD | 3 |
| Silverstein, MN | 2 |
| Weinfeld, A | 2 |
| Donovan, PB | 3 |
| Ellis, JT | 3 |
| Landaw, SA | 3 |
| Laszlo, J | 2 |
| Najean, Y | 2 |
| Pisciotta, AV | 2 |
| Wasserman, LR | 6 |
| Brodsky, I | 1 |
| Morrison, JC | 1 |
| Zakaria, M | 1 |
| Brown, PR | 1 |
| Gandara, DR | 1 |
| Ries, CA | 1 |
| Schiff, SA | 1 |
| George, CB | 1 |
| Lewis, JP | 1 |
| Koretz, MM | 1 |
| Carter, SK | 1 |
| Schmähl, D | 1 |
| Habs, M | 1 |
| Lorenz, M | 1 |
| Wagner, I | 1 |
| Lönnqvist, B | 1 |
| Andersson, B | 1 |
| Björkholm, M | 1 |
| Engstedt, L | 1 |
| Gahrton, G | 1 |
| Hast, R | 1 |
| Holm, G | 1 |
| Killander, A | 1 |
| Lantz, B | 1 |
| Lockner, D | 1 |
| Mellstedt, H | 1 |
| Palmblad, J | 1 |
| Paul, C | 1 |
| Peterson, C | 1 |
| Simonsson, B | 1 |
| Stalfelt, AM | 1 |
| Udén, AM | 1 |
| Wadman, B | 1 |
| Oberg, G | 1 |
| Balcerzak, SP | 1 |
| Berlin, NI | 3 |
| Dresch, C | 1 |
| McIntyre, OR | 1 |
| Tartaglia, AP | 1 |
| Tatarsky, I | 1 |
| Khalil, AM | 1 |
| Khatib, RA | 1 |
| Shamseddine, AI | 1 |
| Sharara, NH | 1 |
| Seoud, MA | 1 |
| Dousset, B | 1 |
| Boudet, MJ | 1 |
| Soubrane, O | 1 |
| Calmus, Y | 1 |
| Bernard, O | 1 |
| Houssin, D | 1 |
| Ho, WK | 1 |
| Robertson, MR | 1 |
| Macdonald, GJ | 1 |
| Charlesworth, JA | 1 |
| Pussell, BA | 1 |
| Nand, S | 1 |
| Stock, W | 1 |
| Godwin, J | 1 |
| Fisher, SG | 1 |
| Kauppi, MJ | 1 |
| Savolainen, HA | 1 |
| Anttila, VJ | 1 |
| Isomäki, HA | 1 |
| Letourneau, S | 1 |
| Greenbaum, M | 1 |
| Cournoyer, D | 1 |
| Grünwald, HW | 1 |
| Rosner, F | 1 |
| Byrd, JC | 1 |
| Grever, MR | 1 |
| Waselenko, JK | 1 |
| Willis, CR | 1 |
| Park, K | 1 |
| Goodrich, A | 1 |
| Lucas, MA | 1 |
| Shinn, C | 1 |
| Flinn, IW | 1 |
| Pearson, TC | 1 |
| Messinezy, M | 1 |
| Galbraith, RM | 1 |
| Eddleston, AL | 1 |
| Williams, R | 1 |
| Zuckerman, AJ | 1 |
| MacEwen, EG | 1 |
| Patnaik, AK | 1 |
| Wilkins, RJ | 1 |
| Hoffman, R | 1 |
| Reimer, RR | 1 |
| Hoover, R | 1 |
| Fraumeni, JF | 1 |
| Young, RC | 1 |
| Queisser, W | 1 |
| Kalb, M | 1 |
| Buriot, D | 1 |
| Prieur, AM | 1 |
| Lebranchu, Y | 1 |
| Messerschmitt, J | 1 |
| Griscelli, C | 1 |
| Morrison, J | 1 |
| Yon, JL | 1 |
| Cazalis, P | 1 |
| Caroit, M | 1 |
| Zittoun, R | 1 |
| Kahn, MF | 1 |
| Sèze, S | 1 |
| Cameron, S | 1 |
| Bauters, F | 1 |
| Latte, J | 1 |
| Jouet, JP | 1 |
| Goudemand, J | 1 |
| Goudemand, M | 1 |
| Sotrel, G | 1 |
| Jafari, K | 1 |
| Lash, AF | 1 |
| Stepto, RC | 1 |
| Gunz, FW | 1 |
| Clancy, RL | 1 |
| Gauldie, J | 1 |
| Vallieres, M | 1 |
| Bienenstock, J | 1 |
| Day, RP | 1 |
| Pineo, GF | 1 |
| Ghose, T | 1 |
| Guclu, A | 1 |
| Tai, J | 1 |
| Thumb, N | 1 |
| Avilés, A | 1 |
| Díaz-Maqueo, JC | 1 |
| Ayala, JR | 1 |
| Cortés, HD | 1 |
| García, EL | 1 |
| Kaldor, JM | 1 |
| Day, NE | 1 |
| Pettersson, F | 1 |
| Clarke, EA | 1 |
| Pedersen, D | 1 |
| Mehnert, W | 1 |
| Bell, J | 1 |
| Høst, H | 1 |
| Prior, P | 1 |
| Karjalainen, S | 1 |
| Ignoffo, RJ | 1 |
| Forni, P | 1 |
| Horikoshi, N | 1 |
| Burger, T | 2 |
| Schmelczer, M | 2 |
| Molnár, L | 2 |
| Pajor, L | 2 |
| Koszorus, S | 2 |
| Fruchtman, SM | 1 |
| Peterson, P | 1 |
| Geller, SA | 1 |
| Rappaport, H | 1 |
| Hazleman, B | 1 |
| Pedersen-Bjergaard, J | 1 |
| Ersbøll, J | 1 |
| Sørensen, HM | 1 |
| Keiding, N | 1 |
| Larsen, SO | 1 |
| Philip, P | 1 |
| Larsen, MS | 1 |
| Schultz, H | 1 |
| Nissen, NI | 1 |
| Hill, BT | 1 |
| Lemmel, EM | 1 |
| Motycka, K | 1 |
| Soucek, J | 1 |
| Nouza, K | 1 |
| Patakfalvi, A | 1 |
| Duhamel, G | 1 |
| Lévy, VG | 1 |
| Ouahnich, M | 1 |
| Armstrong, JG | 1 |
| Le Goff, P | 1 |
| Le Menn, G | 1 |
| Klener, P | 1 |
| Faĭnshteĭn, FE | 1 |
| Prandota, J | 1 |
| Haak, HL | 1 |
| de Man, JC | 1 |
| Hijmans, W | 1 |
| Speck, B | 1 |
| Waldenström, JG | 1 |
| Obrecht, P | 1 |
| Bollag, W | 1 |
| Morrone, G | 1 |
| Marcolongo, R | 1 |
| Di Paolo, N | 1 |
| Bianco, G | 1 |
| Bravi, A | 1 |
| Clément, F | 1 |
| Hartwich, G | 1 |
| Butzler, W | 1 |
| Berceanu, S | 1 |
| Gociu, M | 1 |
| Geib, R | 1 |
| Sighetea, E | 1 |
| Dăncescu, I | 1 |
| Segal, E | 1 |
| Tănăsescu, C | 1 |
| Hardisty, RM | 1 |
| Till, MM | 1 |
| McPhedran, P | 1 |
| Heath, CW | 1 |
| White, LP | 1 |
| Bartelheimer, H | 1 |
| Frenzel, H | 1 |
| Bishop, RC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Multicenter Phase 2 Study of Efficacy and Safety of Pegylated Interferon-alfa 2a in Polycythemia Vera Patients[NCT00241241] | Phase 2 | 40 participants | Interventional | 2004-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
12 reviews available for chlorambucil and Leucocythaemia
| Article | Year |
|---|---|
Malignancies induced by chlorambucil.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Chlorambucil; Female; Humans; Leukemia; Male; Midd | 1984 |
Chemically induced leukemia in humans.
Topics: Benzene; Chlorambucil; Chloramphenicol; Cyclophosphamide; Humans; Leukemia; Melphalan; Phenylbutazon | 1981 |
Busulphan treatment of polycythaemia vera.
Topics: Busulfan; Chlorambucil; Clinical Trials as Topic; Humans; Leukemia; Polycythemia Vera | 1982 |
Treatment of the myeloproliferative disorders with 32P.
Topics: Adult; Aged; Alkylating Agents; Chlorambucil; Clinical Trials as Topic; Combined Modality Therapy; D | 2000 |
Idiopathic erythrocytosis, diagnosis and clinical management.
Topics: Aged; Arterial Occlusive Diseases; Bone Marrow; Chlorambucil; Diagnosis, Differential; Endocrine Sys | 2001 |
Natural history and management of polycythemia vera.
Topics: Acute Disease; Adult; Antineoplastic Agents; Bloodletting; Cell Transformation, Neoplastic; Chloramb | 1979 |
Chlorambucil.
Topics: Animals; Carcinogens; Chlorambucil; Drug Evaluation, Preclinical; Female; Fetus; Humans; Lethal Dose | 1975 |
[Clinical aspects of the problem of treating leukemias].
Topics: Acute Disease; Antineoplastic Agents; Chlorambucil; Chlorine; Chronic Disease; Daunorubicin; Dimetho | 1973 |
[Chemotherapy of chronic leukemias].
Topics: Antineoplastic Agents; Busulfan; Chlorambucil; Chronic Disease; Cyclophosphamide; Humans; Hydroxyure | 1974 |
[Therapy of chronic leukemia].
Topics: Antineoplastic Agents; Busulfan; Chlorambucil; Female; Glucocorticoids; Humans; Leukemia; Leukemia, | 1968 |
[Biochemistry of antileukemic drugs].
Topics: Adrenal Cortex Hormones; Alkylating Agents; Antineoplastic Agents; Asparaginase; Busulfan; Chlorambu | 1970 |
[Cytostatic chemotherapy of neoplasms in children].
Topics: Adrenal Cortex Hormones; Aminopterin; Antineoplastic Agents; Asparaginase; Child; Child, Preschool; | 1971 |
8 trials available for chlorambucil and Leucocythaemia
| Article | Year |
|---|---|
Acute nonlymphocytic leukemia after therapy with alkylating agents for ovarian cancer: a study of five randomized clinical trials.
Topics: Acute Disease; Adult; Aged; Alkylating Agents; Animals; Chlorambucil; Clinical Trials as Topic; Fema | 1982 |
Increased incidence of acute leukemia in polycythemia vera associated with chlorambucil therapy.
Topics: Acute Disease; Chlorambucil; Clinical Trials as Topic; Dose-Response Relationship, Drug; Humans; Leu | 1981 |
Busulphan treatment of polycythaemia vera.
Topics: Busulfan; Chlorambucil; Clinical Trials as Topic; Humans; Leukemia; Polycythemia Vera | 1982 |
Prednimustine and vincristine compared with cytosine arabinoside and thioguanine for treatment of elderly patients with acute nonlymphoblastic leukemia.
Topics: Acute Disease; Aged; Blood Cell Count; Chlorambucil; Cytarabine; Drug Therapy, Combination; Female; | 1982 |
Leukemia following chemotherapy for ovarian cancer.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Case-Control Studie | 1990 |
Therapeutic recommendations in polycythemia vera based on Polycythemia Vera Study Group protocols.
Topics: Acute Disease; Age Factors; Bloodletting; Chlorambucil; Combined Modality Therapy; False Positive Re | 1986 |
Studies of the bone marrow in polycythemia vera and the evolution of myelofibrosis and second hematologic malignancies.
Topics: Acute Disease; Aged; Bloodletting; Bone Marrow; Bone Marrow Cells; Chlorambucil; Combined Modality T | 1986 |
Vinca alkaloids. Experimental and clinical trials.
Topics: Animals; Cell Movement; Chlorambucil; Choriocarcinoma; Female; Hematopoiesis; Hematopoietic Stem Cel | 1974 |
121 other studies available for chlorambucil and Leucocythaemia
| Article | Year |
|---|---|
Identification of substituted 5-membered heterocyclic compounds as potential anti-leukemic agents.
Topics: Animals; Antineoplastic Agents; Apoptosis; Caspases; Cell Line, Tumor; Drug Evaluation, Preclinical; | 2019 |
Targeted photoresponsive carbazole-coumarin and drug conjugates for efficient combination therapy in leukemia cancer cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Carbazoles; Chlorambucil; Coumarins; Delayed-Action Prepara | 2020 |
Frontline treatment of chronic lymphocytic leukemia with obinutuzumab and chlorambucil: how does it work in "real‑life"?
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Chlorambucil; Humans; Leukemia; Leukemia, Lymphocyti | 2018 |
Re-directing an alkylating agent to mitochondria alters drug target and cell death mechanism.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Cell-Penetrating Peptides; Chlorambucil; Cros | 2013 |
[The way to cure leukemia].
Topics: Bone Marrow Transplantation; Chlorambucil; Combined Modality Therapy; Genetic Therapy; Humans; Leuke | 2001 |
Clinical experience with CB 1348 (NN-di(2-chloroethyl, -P-aminophenylbutyric acid) in the treatment of chronic lymphatic leukaemia.
Topics: Chlorambucil; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Mechlorethamine; | 1957 |
[Severe terminal purpura during CB 1348 therapy of chronic lymphoid leukemia].
Topics: Chlorambucil; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Mechlorethamine; | 1957 |
Remissions induced by chlorambucil in chronic granulocytic leukemia.
Topics: Chlorambucil; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mechlorethamine; Neoplasms | 1958 |
[Lymphoid leukemia treated by the combination of cortisone, CB 1348 & transfusions].
Topics: Blood Transfusion; Chlorambucil; Cortisone; Leukemia; Leukemia, Lymphoid; Mechlorethamine; Nitrogen | 1958 |
Clinical evaluation of CB 1348 in leukemias and lymphomas.
Topics: Chlorambucil; Leukemia; Lymphoma; Mechlorethamine; Nitrogen Mustard Compounds | 1958 |
[Observations on the application of CB-1348 in lymphatic leukemias].
Topics: Chlorambucil; Humans; Leukemia; Leukemia, Lymphoid; Mechlorethamine; Nitrogen Mustard Compounds | 1959 |
The use of chlorambucil and steroids in the treatment of chronic lymphocytic leukaemia.
Topics: Adrenal Cortex Hormones; Chlorambucil; Humans; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leu | 1961 |
Evaluation of the effectiveness of radioactive phosphorus and chlorambucil in patients with chronic lymphocytic leukemia.
Topics: Chlorambucil; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Lymphocytes; Mec | 1962 |
Chemotherapy of malignant disease. II. Diseases of lymphoid tissue and bone marrow.
Topics: Adrenal Cortex Hormones; Aged; Bone Marrow; Busulfan; Chlorambucil; Cyclophosphamide; Hodgkin Diseas | 1962 |
THE URIC ACID ANURIA OF LEUKEMIA TREATED BY DIALYSIS.
Topics: Adolescent; Anuria; Chlorambucil; Fluid Therapy; Humans; Kidney; Kidneys, Artificial; Leukemia; Mech | 1963 |
TREATMENT OF CHRONIC LEUKEMIC LYMPHOCYTIC LEUKEMIA WITH TRIETHYLENE MELAMINE (TEM) AND CHLORAMBUCIL (CB-1348).
Topics: Chlorambucil; Leukemia; Leukemia, Lymphoid; Lymphocytes; Triethylenemelamine | 1963 |
EXPERIMENTAL APPROACHES TO THE CHEMOTHERAPY OF LEUKAEMIA.
Topics: Busulfan; Chlorambucil; Leukemia; Leukemia, Experimental; Neoplasms; Rats; Research | 1963 |
[THERAPY OF HEMATODERMIAS].
Topics: Busulfan; Chlorambucil; Cortisone; Cyclophosphamide; Dermatology; Hydrocortisone; Leukemia; Lymphoma | 1963 |
LEUKEMIA. AN ANALYSIS OF 209 CASES FROM THE ELLIS FISCHEL STATE CANCER HOSPITAL.
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Antineoplastic Agents; Busulfan; Cancer Care Facilit | 1963 |
DRUGS IN THE TREATMENT OF LEUKAEMIA.
Topics: Busulfan; Chlorambucil; Cyclophosphamide; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; M | 1963 |
CUTANEOUS GRANULOMA WITH EOSINOPHILS.
Topics: Chlorambucil; Classification; Dermatology; Diagnosis, Differential; Eosinophilic Granuloma; Eosinoph | 1963 |
CHRONIC LYMPHATIC LEUKAEMIA AND ITS MANAGEMENT.
Topics: Adrenal Cortex Hormones; Chlorambucil; Geriatrics; Humans; Leukemia; Leukemia, Lymphoid; Mechloretha | 1963 |
CLINICAL EVALUATION OF URACIL MUSTARD.
Topics: Anemia; Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Female; Hodgkin Disease; Humans; Kidn | 1963 |
THE TREATMENT OF LEUKEMIA.
Topics: Antineoplastic Agents; Busulfan; Chlorambucil; Cyclophosphamide; Leukemia; Mercaptopurine; Methotrex | 1964 |
[HOW TO TREAT LEUKEMIA IN 1963].
Topics: Busulfan; Child; Chlorambucil; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Mercaptopuri | 1963 |
THE RETICULOSES.
Topics: Adrenal Cortex Hormones; Chlorambucil; Cyclophosphamide; Dermatitis, Exfoliative; Genetic Diseases, | 1964 |
MULTIVARIATE COMPARISON OF RESULTS OF TREATMENT IN CHRONIC LYMPHOCYTIC AND CHRONIC GRANULOCYTIC LEUKEMIA.
Topics: Antineoplastic Agents; Blood Platelets; Busulfan; Chlorambucil; Factor Analysis, Statistical; Hemogl | 1964 |
WEEKLY HIGH-DOSAGE GLUCOCORTICOSTEROID TREATMENT OF LYMPHOCYTIC LEUKEMIAS AND LYMPHOMAS.
Topics: Anemia; Anemia, Hemolytic; Betamethasone; Chlorambucil; Dexamethasone; Geriatrics; Humans; Leukemia; | 1964 |
PHAGOCYTOSIS IN RETICULUM CELL SARCOMA.
Topics: Adolescent; Black People; Child; Chlorambucil; Cyclophosphamide; Dactinomycin; Geriatrics; Leukemia; | 1964 |
[EXPERIENCE IN THE TREATMENT OF MALIGNANT DISEASES OF THE RETICULOENDOTHELIAL SYSTEM AND LEUKEMIAS. II].
Topics: Betamethasone; Busulfan; Chlorambucil; Copper; Cyclophosphamide; Dexamethasone; Genetic Diseases, X- | 1964 |
IN-VITRO SENSITIVITY TESTS OF LEUKAEMIC CELLS TO CHEMOTHERAPEUTIC AGENTS.
Topics: Aminopterin; Animals; Antineoplastic Agents; Busulfan; Chlorambucil; Cyclophosphamide; Geriatrics; H | 1964 |
[CYTOSTATIC THERAPY].
Topics: Antineoplastic Agents; Breast Neoplasms; Busulfan; Chlorambucil; Colchicine; Cyclophosphamide; Femal | 1964 |
III. IMPROVEMENT OF CANCER CHEMOTHERAPY IN MAN.
Topics: Animals; Antineoplastic Agents; Chlorambucil; Fluorouracil; Leukemia; Leukemia, Experimental; Mercap | 1964 |
CHRONIC LEUKEMIA.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Alkylating Agents; Anemia; Anemia, Hemolytic, | 1964 |
PLASMA FACTORS IN LEUKAEMIA. IMMUNOLOGICAL AND "IN VITRO" CULTURAL STUDIES.
Topics: Blood Group Antigens; Busulfan; Chlorambucil; Complement Fixation Tests; Coombs Test; Humans; In Vit | 1964 |
THE MANAGEMENT OF LEUKEMIA AND LYMPHOMA.
Topics: Adrenal Cortex Hormones; Busulfan; Chlorambucil; Cortisone; Cyclophosphamide; Hodgkin Disease; Human | 1964 |
CHEMOTHERAPY OF CHRONIC LYMPHOCYTIC LEUKEMIA.
Topics: Blood Platelets; Chlorambucil; Cyclophosphamide; Drug Therapy; Hematocrit; Hemoglobinometry; Humans; | 1964 |
ANTI-LEUKAEMIC DRUGS.
Topics: Busulfan; Chlorambucil; Cyclophosphamide; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; M | 1964 |
TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA WITH CHLORAMBUCIL (NSC-3088) AND CYCLOPHOSPHAMIDE (NSC-26271).
Topics: Chlorambucil; Cyclophosphamide; Humans; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, | 1964 |
MEDICAL GRAND ROUNDS FROM THE UNIVERSITY OF ALABAMA MEDICAL CENTER.
Topics: Beta-Globulins; Blood Protein Disorders; Bone Marrow Examination; Bone Resorption; Chlorambucil; Dia | 1964 |
CHLORAMBUCIL THERAPY FOR LYMPHOMAS AND CHRONIC LYMPHOCYTIC LEUKEMIA.
Topics: Adrenal Cortex Hormones; Chlorambucil; Drug Synergism; Hodgkin Disease; Leukemia; Leukemia, Lymphocy | 1965 |
RADIATION AND DRUG INDUCED HYALINIZATION OF THE STOMACH.
Topics: Antineoplastic Agents; Child; Chlorambucil; Cyclophosphamide; Drug Therapy; Ganglioneuroma; Gastroin | 1965 |
THE ROLE OF THE PHAGOCYTE IN HOST-PARASITE INTERACTIONS. I. THE PHAGOCYTIC CAPABILITIES OF LEUKOCYTES FROM LYMPHOPROLIFERATIVE DISORDERS.
Topics: Chlorambucil; Drug Therapy; Escherichia coli Infections; Geriatrics; Host-Parasite Interactions; Hum | 1964 |
EXPECTANCY FOR LIFE IN CHRONIC LYMPHATIC LEUKEMIA.
Topics: Adrenal Cortex Hormones; Alkylating Agents; Antineoplastic Agents; Child; Chlorambucil; Cyclophospha | 1965 |
[TREATMENT OF CHRONIC LYMPHADENOSIS].
Topics: Adrenal Cortex Hormones; Chlorambucil; Drug Therapy; Humans; Leukemia; Leukemia, Lymphoid; Triethyle | 1965 |
[MODERN TREATMENT OF LEUKEMIA].
Topics: Agranulocytosis; Busulfan; Chlorambucil; Cyclophosphamide; Drug Therapy; Genetic Diseases, X-Linked; | 1965 |
ALTERATION OF BLOOD GROUP ANTIGENS IN LEUKEMIC LYMPHOCYTES.
Topics: ABO Blood-Group System; Anemia; Anemia, Aplastic; Antigens; Blood Group Antigens; Child; Chlorambuci | 1965 |
[FINDINGS ON A CASE OF CHRONIC LYMPHATIC LEUKOSIS WITH ASCITES AND ITS THERAPY].
Topics: Ascites; Chlorambucil; Humans; Leukemia; Leukemia, Lymphoid | 1965 |
Treatment of malignant lymphomas and lymphadenoses with leukeran.
Topics: Chlorambucil; Hodgkin Disease; Leukemia; Leukemia, Lymphoid; Lymphoma; Mechlorethamine; Nitrogen Mus | 1959 |
CB 1348 therapy in leukemia and allied diseases.
Topics: Arylsulfonates; Chlorambucil; Leukemia; Mechlorethamine; Nitrogen Mustard Compounds | 1959 |
Comparison of CB-1348 (chlorambucil, leukeran) and CB-1364.
Topics: Antineoplastic Agents; Chlorambucil; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Mechlo | 1962 |
Genetic effects caused by potent antileukemic steroidal esters of chlorambucil's active metabolite.
Topics: Adult; Alkylation; Antineoplastic Agents, Alkylating; Cells, Cultured; Chlorambucil; DNA; Esters; Fe | 2005 |
Prolonged chlorambucil therapy for idiopathic membranous nephropathy may induce myelodysplastic syndrome and acute leukemia: report of a case.
Topics: Acute Disease; Adult; Antineoplastic Agents, Alkylating; Chlorambucil; Chromosomes, Human, Pair 7; F | 2004 |
Structure-anti-leukemic activity relationship study of B- and D-ring modified and non-modified steroidal esters of chlorambucil's active metabolite.
Topics: Animals; Antineoplastic Agents, Alkylating; Cell Proliferation; Chlorambucil; Esters; Female; Leukem | 2005 |
Structure-anti-leukemic activity relationship study of B- and D-ring modified and non-modified steroidal esters of chlorambucil.
Topics: Animals; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Chlorambucil; Female; Humans; Leukemia | 2006 |
Two novel nucleoside ester derivatives of chlorambucil as potential antileukemic prodrugs: a preliminary study.
Topics: Animals; Antineoplastic Agents, Alkylating; Binding, Competitive; Cell Line, Tumor; Cell Membrane; C | 2007 |
Complete remission in chronic lymphocytic leukemia and leukolymphosarcoma.
Topics: Aged; Chlorambucil; Female; Humans; Leukemia; Leukemia, Lymphoid; Lymphoma, Non-Hodgkin; Male; Middl | 1967 |
Characteristics of secondary acute nonlymphocytic leukemias. Cytological aspects (a review).
Topics: Alkylating Agents; Cell Differentiation; Chlorambucil; Combined Modality Therapy; Cyclophosphamide; | 1984 |
Phase II trial of prednimustine in children with recurrent cancer: a Children's Cancer Study Group report.
Topics: Adolescent; Adult; Carcinoma, Hepatocellular; Child; Child, Preschool; Chlorambucil; Drug Administra | 1982 |
Unbalanced cell growth and increased protein synthesis induced by chemotherapeutic agents.
Topics: Animals; Antineoplastic Agents; Cell Count; Cell Transformation, Neoplastic; Cells, Cultured; Chlora | 1983 |
Free light chains of immunoglobulins in serum from patients with leukaemias and multiple myeloma.
Topics: Adolescent; Adult; Aged; Child; Chlorambucil; Humans; Immunoglobulin kappa-Chains; Immunoglobulin la | 1982 |
Prednimustine in acute nonlymphocytic leukemia.
Topics: Acute Disease; Adolescent; Adult; Aged; Chlorambucil; Drug Evaluation; Female; Humans; Leukemia; Mal | 1983 |
[Leukemia and other neoplasms possibly induced by immunosuppressors in non-malignant diseases (author's transl)].
Topics: Animals; Azathioprine; Chlorambucil; Cyclophosphamide; Humans; Immunosuppressive Agents; Leukemia; N | 1980 |
Polycythemia vera and alkylating agents.
Topics: Alkylating Agents; Chlorambucil; Humans; Leukemia; Polycythemia Vera | 1982 |
Rapid assay for plasma chlorambucil and phenyl acetic mustard using reversed-phase liquid chromatography.
Topics: Chlorambucil; Chromatography, Liquid; Humans; Kinetics; Leukemia; Reference Values | 1982 |
A phase II study of prednimustine in acute non-lymphocytic leukemia, smouldering leukemia, and refractory anemia with excess blasts.
Topics: Acute Disease; Adult; Aged; Anemia, Aplastic; Chlorambucil; Drug Evaluation; Female; Humans; Leukemi | 1982 |
Occurrence of second tumors in man after anticancer drug treatment.
Topics: Adolescent; Adult; Aged; Alkylating Agents; Antineoplastic Agents; Arthritis, Rheumatoid; Azathiopri | 1982 |
Influence of therapy on causes of death in polycythemia vera.
Topics: Chlorambucil; Hematocrit; Humans; Leukemia; Platelet Count; Polycythemia Vera; Risk; Thrombosis; Vei | 1981 |
Prolonged intake of chlorambucil for ovarian cancer.
Topics: Chlorambucil; Cystadenocarcinoma; Female; Humans; Leukemia; Middle Aged; Ovarian Neoplasms | 1995 |
Liver transplantation in patients with preexisting malignancy.
Topics: Adenocarcinoma; Adolescent; Adult; Carcinoma, Renal Cell; Child; Child, Preschool; Chlorambucil; Col | 1995 |
Association of acute leukaemia with chlorambucil after renal transplantation.
Topics: Acute Disease; Chlorambucil; Humans; Kidney Transplantation; Leukemia; Postoperative Complications | 1994 |
Leukemogenic risk of hydroxyurea therapy in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis.
Topics: Acute Disease; Anemia, Refractory, with Excess of Blasts; Busulfan; Cell Transformation, Neoplastic; | 1996 |
Increased risk of leukaemia in patients with juvenile chronic arthritis treated with chlorambucil.
Topics: Antineoplastic Agents, Alkylating; Arthritis, Juvenile; Child, Preschool; Chlorambucil; Female; Huma | 1996 |
Retrovirus-mediated gene transfer of rat glutathione S-transferase Yc confers in vitro resistance to alkylating agents in human leukemia cells and in clonogenic mouse hematopoietic progenitor cells.
Topics: Alkylating Agents; Animals; Blotting, Southern; Blotting, Western; Bone Marrow Transplantation; Chlo | 1996 |
Secondary acute leukemia in chronic lymphocytic leukemia.
Topics: Antineoplastic Agents, Alkylating; Chlorambucil; Humans; Leukemia; Leukemia, Lymphocytic, Chronic, B | 1998 |
Theophylline, pentostatin (Nipent), and chlorambucil: a dose-escalation study targeting intrinsic biologic resistance mechanisms in patients with relapsed lymphoproliferative disorders.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy | 2000 |
Fulminant hepatic failure in leukaemia and choriocarcinoma related to withdrawal of cytotoxic drug therapy.
Topics: Adult; Antineoplastic Agents; Chlorambucil; Choriocarcinoma; Cyclophosphamide; Dactinomycin; Female; | 1975 |
Sister chromatid exchange studies for monitoring DNA damage and repair capacity after cytostatics in vitro and in lymphocytes of leukaemic patients under cytostatic therapy.
Topics: Antineoplastic Agents; Busulfan; Cells, Cultured; Chlorambucil; Chromatids; Crossing Over, Genetic; | 1978 |
Diagnosis and treatment of canine hematopoietic neoplasms.
Topics: Animals; Chlorambucil; Dog Diseases; Dogs; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Lymphoma | 1977 |
Acute leukemia after alkylating-agent therapy of ovarian cancer.
Topics: Acute Disease; Alkylating Agents; Altretamine; Chlorambucil; Cyclophosphamide; Female; Fluorouracil; | 1977 |
[Secondary carcinoma: a complication of cytostatic therapy?].
Topics: Antineoplastic Agents; Breast Neoplasms; Carcinogens; Chlorambucil; Female; Humans; Immunosuppressio | 1979 |
[Acute leukemia in 3 children with chronic juvenile arthritis treated with chlorambucil].
Topics: Acute Disease; Alkylating Agents; Arthritis, Juvenile; Child; Child, Preschool; Chlorambucil; Chromo | 1979 |
Acute leukemia following chlorambucil therapy of advanced ovarian and fallopian tube carcinoma.
Topics: Acute Disease; Carcinoma; Chlorambucil; Fallopian Tube Neoplasms; Female; Humans; Leukemia; Middle A | 1978 |
[A particular risk of prolonged immunosuppressive treatment: a case of acute myelomonocytic leukemia after chlorambucil treatment of severe rheumatoid arhtritis].
Topics: Adult; Antineoplastic Agents; Arthritis, Rheumatoid; Autoimmune Diseases; Carcinogens; Chlorambucil; | 1976 |
Chlorambucil and leukemia.
Topics: Arthritis, Rheumatoid; Chlorambucil; Humans; Leukemia | 1977 |
[Leukemia with tricholeukocytes: clinical, hematological and evolutive study (apropos of 10 cases)].
Topics: Adrenal Cortex Hormones; Adult; Aged; Chlorambucil; Female; Humans; Leukemia; Lymphatic Diseases; Ma | 1977 |
Acute leukemia in advanced ovarian carcinoma after treatment with alkylating agents.
Topics: Acute Disease; Adenocarcinoma, Papillary; Adult; Alkylating Agents; Chlorambucil; Cystadenoma; Femal | 1976 |
Diagnostic and therapeutic approach to chronic leukaemia.
Topics: Busulfan; Chlorambucil; Chronic Disease; Diagnosis, Differential; Glucocorticoids; Leukemia; Leukemi | 1975 |
An approach to immunotherapy using antibody to IgE in mast cell leukemia.
Topics: Animals; Antibodies, Anti-Idiotypic; Binding Sites, Antibody; Chlorambucil; Humans; Immune Sera; Imm | 1976 |
Suppression of an AKR lymphoma by antibody and chlorambucil.
Topics: Animals; Antibodies, Neoplasm; Chlorambucil; Female; Fluorescent Antibody Technique; Immunization, P | 1975 |
[Side effects in immunosuppressive therapy].
Topics: Alopecia; Amenorrhea; Anemia; Azathioprine; Bacterial Infections; Chlorambucil; Female; Humans; Immu | 1975 |
The treatment of polycythemia vera.
Topics: Blood Transfusion; Bloodletting; Bone Marrow; Bone Marrow Cells; Chlorambucil; Chronic Disease; Eryt | 1976 |
Hodgkin's disease and acute leukemia. Is it a true association?
Topics: Acute Disease; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil | 1992 |
Correction: Cancer Chemotherapy Protocols and dose of chlorambucil.
Topics: Chlorambucil; Chronic Disease; Humans; Leukemia; Reference Books | 1989 |
[Second malignancies and cancer chemotherapy].
Topics: Antineoplastic Agents; Chlorambucil; Hodgkin Disease; Humans; Leukemia; Melphalan; Neoplasms; Risk F | 1989 |
Course and transformation of polycythaemia vera in relation to therapy.
Topics: Adult; Aged; Aged, 80 and over; Chlorambucil; Female; Humans; Leukemia; Leukemia, Radiation-Induced; | 1988 |
[Clinical course and transformation of polycythemia vera and its relation to applied therapy].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Busulfan; Chlorambucil; Combined Modali | 1987 |
Acute leukemia in polycythemia vera.
Topics: Acute Disease; Antigens, Neoplasm; Bloodletting; Chlorambucil; Chromosome Aberrations; Chromosome Di | 1986 |
A cooperative study of polycythemia vera.
Topics: Aspirin; Chlorambucil; Dipyridamole; Humans; Leukemia; Polycythemia Vera; Prognosis | 1985 |
Incidence of neoplasms in patients with rheumatoid arthritis exposed to different treatment regimens.
Topics: Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Cyclophosphamide; Cystitis; Humans; Immunosuppres | 1985 |
Risk of acute nonlymphocytic leukemia and preleukemia in patients treated with cyclophosphamide for non-Hodgkin's lymphomas. Comparison with results obtained in patients treated for Hodgkin's disease and ovarian carcinoma with other alkylating agents.
Topics: Acute Disease; Adolescent; Adult; Aged; Alkylating Agents; Antineoplastic Combined Chemotherapy Prot | 1985 |
Stimulation of D.N.A. synthesis in lymphocytes by chlorambucil.
Topics: Chlorambucil; DNA; Humans; Leukemia; Leukemia, Lymphoid; Lymphocytes | 1972 |
[The influence of age and experimentally-induced disease on the tolerance of cytostatically-active materials in mice].
Topics: Age Factors; Aminopterin; Animals; Antineoplastic Agents; Busulfan; Chlorambucil; Cyclophosphamide; | 1967 |
Secondary antibody deficiency syndrome in haemoblastosis.
Topics: Agammaglobulinemia; Antibodies; Antigens, Bacterial; Blood Protein Disorders; Blood Proteins; Busulf | 1972 |
[A case of lymphoid myelofibrosis. Anatomo-clinical and critical study].
Topics: Adult; Chlorambucil; Diagnosis, Differential; Humans; Leukemia; Male; Prednisone; Primary Myelofibro | 1967 |
Current problems in the use of the oncolytic drugs.
Topics: Antineoplastic Agents; Busulfan; Carcinoma, Squamous Cell; Child; Chlorambucil; Choriocarcinoma; Dac | 1968 |
[Cancer and immunosuppressive treatment. Apropos of 2 cases].
Topics: Arthritis, Rheumatoid; Autoimmune Diseases; Brain Neoplasms; Carcinoma, Squamous Cell; Chlorambucil; | 1974 |
Further evidence for the lymphocytic nature of leukaemic reticuloendotheliosis (hairy-cell leukaemia).
Topics: Acid Phosphatase; Blood Cell Count; Chlorambucil; Fluorescent Antibody Technique; Histocytochemistry | 1974 |
From bad to worse? Treatment and leukemogenesis.
Topics: Antibiotics, Antineoplastic; Busulfan; Chlorambucil; Chromosome Aberrations; Chromosome Disorders; H | 1973 |
Macroglobulinemia Waldenström with miliary lunginfiltrations and terminal plasmacell-leukemia. (Chlorambuci induced clinical remission despite autoradiographically persistant DNA- and RNA-synthesis).
Topics: Aged; Autoradiography; Biopsy; Bone Marrow Examination; Chlorambucil; DNA; Female; Humans; Immunoele | 1966 |
[Clinical usefulness of eticholanolone in the evaluation of bone marrow reserves in patients treated with myelosuppressive drugs and with radiotherapy].
Topics: Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Bone Marrow Diseases; Bone Marrow Examination | 1969 |
[Modern hematology. Sidero-achrestic anemias, polyglobulias, chemotherapy].
Topics: Adenoma; Adolescent; Adult; Aged; Anemia, Hypochromic; Anemia, Macrocytic; Anemia, Sideroblastic; Bl | 1971 |
[Secondary tumors in hemoblastoses during cytostatic treatment].
Topics: Adrenal Gland Neoplasms; Aged; Antineoplastic Agents; Bronchial Neoplasms; Busulfan; Carcinoma; Chlo | 1971 |
[Results and current biological bases of therapy of malignant hemoreticulopathies].
Topics: Antineoplastic Agents; Chlorambucil; Cortisone; Cyclophosphamide; Humans; Hydrazines; Leukemia; Lymp | 1971 |
Acute leukaemia 1959-64: factors affecting prognosis.
Topics: Blood Cell Count; Child; Child, Preschool; Chlorambucil; Cyclophosphamide; Female; Humans; Leukemia; | 1968 |
Drugs in the treatment of leukemia.
Topics: Asparaginase; Busulfan; Chlorambucil; Cyclophosphamide; Cytarabine; Humans; Hydroxyurea; Leukemia; L | 1968 |
Acute leukemia occurring during chronic lymphocytic leukemia.
Topics: Adult; Aged; Bone Marrow Examination; Chlorambucil; Female; Hemoglobinometry; Humans; Leukemia; Leuk | 1970 |
Leukemia and lymphoma.
Topics: Antineoplastic Agents; BCG Vaccine; Burkitt Lymphoma; Busulfan; Chlorambucil; Cyclophosphamide; Cyta | 1970 |
Pipobroman (Vercyte) - a new antineoplastic drug.
Topics: Anemia, Hemolytic; Antineoplastic Agents; Bone Marrow; Busulfan; Chlorambucil; Gastrointestinal Hemo | 1967 |
[Desired and undesirable effects of cytostatic therapy].
Topics: Androgens; Anti-Bacterial Agents; Antineoplastic Agents; Busulfan; Chlorambucil; Cyclophosphamide; E | 1967 |
Chemotherapy of Hodgkin's disease, lymphoma, and leukemia.
Topics: Adult; Antineoplastic Agents; Busulfan; Chlorambucil; Hodgkin Disease; Humans; Leukemia; Lymphoma; M | 1968 |