chlorambucil has been researched along with Kidney Failure, Chronic in 18 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Kidney Failure, Chronic: The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This observational study aimed to evaluate the results of treatment with low-dose chlorambucil in combination with corticosteroids in patients with idiopathic membranous nephropathy (iMGN) and nephrotic syndrome." | 5.14 | Efficacy and safety of low-dose chlorambucil in nephrotic patients with idiopathic membranous nephropathy. ( Idasiak-Piechocka, I; Oko, A; Skrobańska, B; Łochyńska-Bielecka, K, 2009) |
| "Twenty-one patients with membranous nephropathy, heavy proteinuria and progressive renal failure were treated with alternating monthly cycles of corticosteroids and chlorambucil for six months." | 3.69 | Prednisolone and chlorambucil therapy for idiopathic membranous nephropathy with progressive renal failure. ( Boulton-Jones, JM; Geddes, CG; Warwick, GL, 1994) |
| " Forty of them, who presented a nephrotic syndrome, were treated by immunosuppressive drugs (prednisone, azathioprine, chlorambucil, cyclophosphamide) for 79 +/- 9." | 3.67 | Long-term immunosuppressive therapy of idiopathic membranoproliferative glomerulonephritis. ( Glyda, J; Gradowska, L; Juskowa, J; Klepacka, J; Lao, M; Morzycka-Michalik, M; Orlowski, T; Rancewicz, Z, 1988) |
| "Four chlorambucil-treated patients developed ESRD, and five needed a second course of therapy, whereas only one cyclophosphamide-treated patient developed ESRD (p < 0." | 2.69 | Oral cyclophosphamide versus chlorambucil in the treatment of patients with membranous nephropathy and renal insufficiency. ( Branten, AJ; Koene, RA; Reichert, LJ; Wetzels, JF, 1998) |
| "18 patients with membranous nephropathy, a nephrotic syndrome, and deteriorating renal function." | 2.67 | Preserving renal function in patients with membranous nephropathy: daily oral chlorambucil compared with intermittent monthly pulses of cyclophosphamide. ( Assmann, K; Huysmans, FT; Koene, RA; Reichert, LJ; Wetzels, JF, 1994) |
| "Levamisole was given to 56 children (13%) and cyclosporin to 53 (12%)." | 1.29 | Alternative treatment to corticosteroids in steroid sensitive idiopathic nephrotic syndrome. ( Barratt, TM; Dillon, MJ; Fay, J; Neuhaus, TJ; Trompeter, RS, 1994) |
| "Treatment with chlorambucil, prednisolone, and renal bed irradiation resulted in a substantial improvement in renal function which persisted until the the patient's death from marrow failure some eight years later." | 1.29 | Renal failure caused by leukaemic infiltration in chronic lymphocytic leukaemia. ( Bass, PS; Davies, DR; Jones, NF; Majumdar, G; Pearson, TC; Phillips, JK, 1993) |
| "Risk of ESRD by WHO class at 5 years was as follows: class III, 0%; IV, 9%; V, 16% (P = ." | 1.29 | Lupus in the 1980s: III. Influence of clinical variables, biopsy, and treatment on the outcome in 150 patients with lupus nephritis seen at a single center. ( Azen, C; Fichman, M; Klinenberg, JR; Metzger, AL; Nessim, S; Neumann, K; Wallace, DJ, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (44.44) | 18.7374 |
| 1990's | 8 (44.44) | 18.2507 |
| 2000's | 2 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Idasiak-Piechocka, I | 1 |
| Oko, A | 1 |
| Łochyńska-Bielecka, K | 1 |
| Skrobańska, B | 1 |
| Hebert, LA | 1 |
| Rovin, BH | 1 |
| Agarwal, AK | 1 |
| Spetie, DN | 1 |
| Kleinknecht, C | 1 |
| Broyer, M | 1 |
| Gubler, MC | 1 |
| Palcoux, JB | 1 |
| Neuhaus, TJ | 1 |
| Fay, J | 1 |
| Dillon, MJ | 1 |
| Trompeter, RS | 1 |
| Barratt, TM | 1 |
| Reichert, LJ | 3 |
| Huysmans, FT | 1 |
| Assmann, K | 1 |
| Koene, RA | 2 |
| Wetzels, JF | 3 |
| Winearls, CG | 1 |
| Sanderson, F | 1 |
| Warwick, GL | 1 |
| Geddes, CG | 1 |
| Boulton-Jones, JM | 1 |
| Phillips, JK | 1 |
| Bass, PS | 1 |
| Majumdar, G | 1 |
| Davies, DR | 1 |
| Jones, NF | 1 |
| Pearson, TC | 1 |
| Neumann, K | 1 |
| Wallace, DJ | 1 |
| Azen, C | 1 |
| Nessim, S | 1 |
| Fichman, M | 1 |
| Metzger, AL | 1 |
| Klinenberg, JR | 1 |
| Branten, AJ | 1 |
| Donadio, JV | 1 |
| Slack, TK | 1 |
| Holley, KE | 1 |
| Ilstrup, DM | 1 |
| Mohácsi, G | 1 |
| Benkó, G | 1 |
| Mágori, A | 1 |
| György, A | 1 |
| Sonkodi, S | 1 |
| Orlowski, T | 1 |
| Rancewicz, Z | 1 |
| Lao, M | 1 |
| Juskowa, J | 1 |
| Klepacka, J | 1 |
| Gradowska, L | 1 |
| Morzycka-Michalik, M | 1 |
| Glyda, J | 1 |
| Ahlmen, M | 1 |
| Ahlmen, J | 1 |
| Svalander, C | 1 |
| Bucht, H | 1 |
| Ben Ammar, M | 1 |
| Ben Dridi, MF | 1 |
| Ben Moussa, K | 1 |
| Ben Maïz, H | 1 |
| Ben Osman, R | 1 |
| Ultmann, JE | 1 |
| Nixon, DD | 1 |
| Seaton, A | 1 |
| Meland, JM | 1 |
| Lapp, NL | 1 |
2 reviews available for chlorambucil and Kidney Failure, Chronic
| Article | Year |
|---|---|
Efficacy of immunosuppressive treatment in patients with membranous nephropathy and renal insufficiency.
Topics: Adult; Aged; Chlorambucil; Follow-Up Studies; Glomerulonephritis, Membranous; Humans; Immunosuppress | 1997 |
The therapy of lymphoma.
Topics: Adrenal Cortex Hormones; Asparaginase; Bone Marrow Diseases; Chlorambucil; Cyclophosphamide; Cytarab | 1969 |
6 trials available for chlorambucil and Kidney Failure, Chronic
| Article | Year |
|---|---|
Efficacy and safety of low-dose chlorambucil in nephrotic patients with idiopathic membranous nephropathy.
Topics: Adult; Anti-Inflammatory Agents; Antineoplastic Agents, Alkylating; Chlorambucil; Female; Follow-Up | 2009 |
Irreversible renal failure after indomethacin in steroid-resistant nephrosis.
Topics: Child; Chlorambucil; Clinical Trials as Topic; Female; Glomerular Filtration Rate; Humans; Indometha | 1980 |
Preserving renal function in patients with membranous nephropathy: daily oral chlorambucil compared with intermittent monthly pulses of cyclophosphamide.
Topics: Administration, Oral; Adult; Aged; Chlorambucil; Cyclophosphamide; Drug Administration Schedule; Dru | 1994 |
Efficacy of immunosuppressive treatment in patients with membranous nephropathy and renal insufficiency.
Topics: Adult; Aged; Chlorambucil; Follow-Up Studies; Glomerulonephritis, Membranous; Humans; Immunosuppress | 1997 |
Oral cyclophosphamide versus chlorambucil in the treatment of patients with membranous nephropathy and renal insufficiency.
Topics: Adult; Aged; Anti-Inflammatory Agents; Chlorambucil; Cyclophosphamide; Drug Therapy, Combination; Fe | 1998 |
Cytotoxic drug treatment of reactive amyloidosis in rheumatoid arthritis with special reference to renal insufficiency.
Topics: Adult; Aged; Amyloidosis; Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Cyclophosphamide; Femal | 1987 |
11 other studies available for chlorambucil and Kidney Failure, Chronic
| Article | Year |
|---|---|
Cyclophosphamide or chlorambucil therapy is indicated in idiopathic membranous nephropathy with strong risk factors for progression.
Topics: Chlorambucil; Creatinine; Cyclophosphamide; Disease Progression; Drug Therapy, Combination; Glomerul | 2005 |
Alternative treatment to corticosteroids in steroid sensitive idiopathic nephrotic syndrome.
Topics: Adrenal Cortex Hormones; Child; Child, Preschool; Chlorambucil; Chloramphenicol; Cyclophosphamide; C | 1994 |
Treatment of aggressive idiopathic membranous glomerulonephritis.
Topics: Chlorambucil; Glomerulonephritis, Membranous; Humans; Kidney Failure, Chronic; Prognosis; Proteinuri | 1994 |
Prednisolone and chlorambucil therapy for idiopathic membranous nephropathy with progressive renal failure.
Topics: Adult; Aged; Chlorambucil; Cohort Studies; Female; Glomerulonephritis, Membranous; Humans; Kidney; K | 1994 |
Renal failure caused by leukaemic infiltration in chronic lymphocytic leukaemia.
Topics: Chlorambucil; Combined Modality Therapy; Humans; Kidney; Kidney Failure, Chronic; Leukemia, Lymphocy | 1993 |
Lupus in the 1980s: III. Influence of clinical variables, biopsy, and treatment on the outcome in 150 patients with lupus nephritis seen at a single center.
Topics: Adult; Anti-Inflammatory Agents; Azathioprine; Biopsy; Blood Component Removal; Chlorambucil; Cyclop | 1995 |
Idiopathic membranoproliferative (mesangiocapillary) glomerulonephritis: a clinicopathologic study.
Topics: Adolescent; Adult; Aged; Azathioprine; Child; Chlorambucil; Complement C3; Cyclophosphamide; Drug Th | 1979 |
[Polyarteritis nodosa based on a case report].
Topics: Adult; Appendectomy; Appendicitis; Appendix; Chlorambucil; Colitis, Ulcerative; Crohn Disease; Diagn | 1987 |
Long-term immunosuppressive therapy of idiopathic membranoproliferative glomerulonephritis.
Topics: Adult; Azathioprine; Chlorambucil; Cyclophosphamide; Drug Therapy, Combination; Female; Follow-Up St | 1988 |
[Juvenile nephrotic syndrome with diffuse mesangial sclerosis. Apropos of a case report].
Topics: Child, Preschool; Chlorambucil; Female; Glomerular Mesangium; Humans; Kidney Failure, Chronic; Nephr | 1986 |
Remission in Goodpasture's syndrome: report of two patients treated by immunosuppression and review of the literature.
Topics: Anti-Glomerular Basement Membrane Disease; Azathioprine; Chlorambucil; Humans; Immunosuppression The | 1971 |