chlorambucil has been researched along with Infections, Helicobacter in 9 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aetiological association between MALT lymphomas and Helicobacter pylori is well established." | 2.74 | Chlorambucil versus observation after anti-Helicobacter therapy in gastric MALT lymphomas: results of the international randomised LY03 trial. ( Ambrosetti, A; Burton, C; Capella, C; Cavalli, F; Copie-Bergman, C; Cortelazzo, S; Delchier, JC; Ferreri, AJ; Gisselbrecht, C; Hancock, BW; Jakupovic, I; Levy, M; Linch, D; Martinelli, G; Pinotti, G; Qian, W; Smith, P; Souhami, R; Traulle, C; Vitolo, U; Wotherspoon, A; Zucca, E, 2009) |
| "Less than half of the patients with MALT lymphoma can achieve sustained molecular remission after anti-Helicobacter therapy." | 2.70 | Molecular follow-up in gastric mucosa-associated lymphoid tissue lymphomas: early analysis of the LY03 cooperative trial. ( Bertoni, F; Biondi, A; Capella, C; Cavalli, F; Cazzaniga, G; Conconi, A; Cotter, FE; Giardini, R; Hancock, BW; Motta, T; Novero, D; Pedrinis, E; Ponzoni, M; Rinaldi, P; Smith, P; Souhami, R; Wotherspoon, A; Zucca, E, 2002) |
| "Localized MALT lymphomas have excellent prognosis following moderate-dose RT." | 1.31 | Stage I and II MALT lymphoma: results of treatment with radiotherapy. ( Bezjak, A; Crump, M; Gospodarowicz, MK; Hodgson, DC; Pintilie, M; Tsang, RW; Wells, W, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 5 (55.56) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hancock, BW | 2 |
| Qian, W | 1 |
| Linch, D | 1 |
| Delchier, JC | 3 |
| Smith, P | 2 |
| Jakupovic, I | 1 |
| Burton, C | 1 |
| Souhami, R | 2 |
| Wotherspoon, A | 2 |
| Copie-Bergman, C | 3 |
| Capella, C | 3 |
| Traulle, C | 2 |
| Levy, M | 3 |
| Cortelazzo, S | 1 |
| Ferreri, AJ | 1 |
| Ambrosetti, A | 1 |
| Pinotti, G | 2 |
| Martinelli, G | 1 |
| Vitolo, U | 1 |
| Cavalli, F | 3 |
| Gisselbrecht, C | 1 |
| Zucca, E | 3 |
| Molinier-Frenkel, V | 1 |
| Riou, A | 1 |
| Haioun, C | 1 |
| Gaulard, P | 2 |
| Delfau-Larue, MH | 1 |
| Sobhani, I | 1 |
| Leroy, K | 1 |
| Mirabile, A | 1 |
| Devizzi, L | 1 |
| Gianni, AM | 1 |
| Cabras, A | 1 |
| Carbone, A | 1 |
| Novik, AA | 1 |
| Denisov, NL | 1 |
| Gershanovich, ML | 1 |
| Pozharisskiĭ, KM | 1 |
| Gorodokin, I | 1 |
| Roggero, E | 1 |
| Pascarella, A | 1 |
| Bertoni, F | 2 |
| Savio, A | 1 |
| Savio, E | 1 |
| Pedrinis, E | 2 |
| Saletti, P | 1 |
| Morandi, E | 1 |
| Santandrea, G | 1 |
| Bornand-Rousselot, A | 1 |
| Saint-Jean, O | 1 |
| Leblond, V | 1 |
| Tsang, RW | 1 |
| Gospodarowicz, MK | 1 |
| Pintilie, M | 1 |
| Bezjak, A | 1 |
| Wells, W | 1 |
| Hodgson, DC | 1 |
| Crump, M | 1 |
| Lavergne-Slove, A | 1 |
| Brousse, N | 1 |
| Flejou, JF | 1 |
| de Mascarel, A | 1 |
| Hemery, F | 1 |
| Conconi, A | 1 |
| Motta, T | 1 |
| Giardini, R | 1 |
| Ponzoni, M | 1 |
| Novero, D | 1 |
| Rinaldi, P | 1 |
| Cazzaniga, G | 1 |
| Biondi, A | 1 |
| Cotter, FE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Protocol for a Randomised Trial of Observation Versus Chlorambucil After Anti-Helicobacter Therapy in Low Grade Gastric Lymphoma[NCT00003617] | Phase 3 | 200 participants (Anticipated) | Interventional | 1995-03-31 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for chlorambucil and Infections, Helicobacter
| Article | Year |
|---|---|
[Helicobacter pylori infection and gastric MALT lymphoma: present-day approaches to research and treatment].
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Chr | 2002 |
5 trials available for chlorambucil and Infections, Helicobacter
| Article | Year |
|---|---|
Chlorambucil versus observation after anti-Helicobacter therapy in gastric MALT lymphomas: results of the international randomised LY03 trial.
Topics: Aged; Anti-Bacterial Agents; Antineoplastic Agents, Alkylating; Chlorambucil; Disease-Free Survival; | 2009 |
Treatment of t(11;18)-positive gastric mucosa-associated lymphoid tissue lymphoma with rituximab and chlorambucil: clinical, histological, and molecular follow-up.
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined | 2010 |
Clinical features, treatment and outcome in a series of 93 patients with low-grade gastric MALT lymphoma.
Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Antineoplastic Agents, Alkylating; Antineopla | 1997 |
Conservative treatment of primary gastric low-grade B-cell lymphoma of mucosa-associated lymphoid tissue: predictive factors of response and outcome.
Topics: Adult; Aged; Amoxicillin; Antineoplastic Agents, Alkylating; Biopsy, Needle; Chlorambucil; Clarithro | 2002 |
Molecular follow-up in gastric mucosa-associated lymphoid tissue lymphomas: early analysis of the LY03 cooperative trial.
Topics: Antineoplastic Agents, Alkylating; Chlorambucil; Disease-Free Survival; False Negative Reactions; Fo | 2002 |
3 other studies available for chlorambucil and Infections, Helicobacter
| Article | Year |
|---|---|
MALT lymphoma and Kaposi sarcoma in an HIV-negative patient.
Topics: Aged; Amoxicillin; Anti-Bacterial Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, | 2010 |
Sequential chlorambucil and prednisone as second line therapy in gastric malt lymphoma resistant to Helicobacter pylori eradication. A case report in an octogenarian patient.
Topics: Aged; Aged, 80 and over; Chlorambucil; Drug Therapy, Combination; Female; Helicobacter Infections; H | 1998 |
Stage I and II MALT lymphoma: results of treatment with radiotherapy.
Topics: Adult; Aged; Anti-Bacterial Agents; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Co | 2001 |