chlorambucil has been researched along with Infection in 17 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Infections were seen more frequently in the 2-CdA+P-treated group (56%) than in the Chl+P-treated group (40%; P = ." | 2.69 | Cladribine with prednisone versus chlorambucil with prednisone as first-line therapy in chronic lymphocytic leukemia: report of a prospective, randomized, multicenter trial. ( Blasińska-Morawiec, M; Bloński, JZ; Ceglarek, B; Dmoszyńska, A; Dwilewicz-Trojaczek, J; Grieb, P; Hellmann, A; Kasznicki, M; Konopka, L; Kotlarek-Haus, S; Krykowski, E; Maj, S; Mrugala-Spiewak, H; Nowak, W; Potoczek, S; Robak, T; Skotnicki, AB; Urasiński, I; Zdziarska, B, 2000) |
| "Bleeding tendency was seen in 17%, infections in 17%, hyperviscosity syndrome in 12%, and cardiac failure in 25% of the patients." | 1.31 | Waldenström's macroglobulinemia: clinical course and prognostic factors in 60 patients. Experience from a single hematology unit. ( Angelopoulou, MK; Boussiotis, V; Dimopoulou, MN; Fessas, P; Gribabis, A; Kittas, C; Konstantopoulos, K; Kontopidou, FN; Kyrtsonis, MC; Pangalis, GA; Siakantaris, P; Vaiopoulos, GA; Vassilakopoulos, TP, 2001) |
| "Initial studies using interferon in the treatment of hairy cell leukemia look encouraging, but more investigation is necessary before the role of interferon in treatment of hairy cell leukemia is determined." | 1.27 | Hairy cell leukemia. ( Golomb, HM; Offermann, MK, 1984) |
| " Apart from infections, there were more adverse effects reported in the immunosuppressive therapy group." | 1.27 | Comparative toxicity of total lymphoid irradiation and immunosuppressive drug treated patients with intractable rheumatoid arthritis. ( Bloch, D; Fries, J; Sherrer, Y; Strober, S, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (76.47) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (23.53) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schmitt, B | 1 |
| Wendtner, CM | 1 |
| Bergmann, M | 1 |
| Busch, R | 1 |
| Franke, A | 1 |
| Pasold, R | 1 |
| Schlag, R | 1 |
| Hopfinger, G | 1 |
| Hiddemann, W | 1 |
| Emmerich, B | 1 |
| Hallek, M | 1 |
| Offermann, MK | 1 |
| Golomb, HM | 1 |
| Robak, T | 1 |
| Bloński, JZ | 1 |
| Kasznicki, M | 1 |
| Blasińska-Morawiec, M | 1 |
| Krykowski, E | 1 |
| Dmoszyńska, A | 1 |
| Mrugala-Spiewak, H | 1 |
| Skotnicki, AB | 1 |
| Nowak, W | 1 |
| Konopka, L | 1 |
| Ceglarek, B | 1 |
| Maj, S | 1 |
| Dwilewicz-Trojaczek, J | 1 |
| Hellmann, A | 1 |
| Urasiński, I | 1 |
| Zdziarska, B | 1 |
| Kotlarek-Haus, S | 1 |
| Potoczek, S | 1 |
| Grieb, P | 1 |
| Hall, RL | 1 |
| Leahy, MF | 1 |
| Kyrtsonis, MC | 1 |
| Vassilakopoulos, TP | 1 |
| Angelopoulou, MK | 1 |
| Siakantaris, P | 1 |
| Kontopidou, FN | 1 |
| Dimopoulou, MN | 1 |
| Boussiotis, V | 1 |
| Gribabis, A | 1 |
| Konstantopoulos, K | 1 |
| Vaiopoulos, GA | 1 |
| Fessas, P | 1 |
| Kittas, C | 1 |
| Pangalis, GA | 1 |
| Prieur, AM | 1 |
| Balafrej, M | 1 |
| Griscelli, C | 1 |
| Mozziconacci, P | 1 |
| Renier, JC | 1 |
| Bregeon, C | 1 |
| Bonnette, C | 1 |
| Sherrer, Y | 1 |
| Bloch, D | 1 |
| Strober, S | 1 |
| Fries, J | 1 |
| Konrad, H | 1 |
| Engelmann, C | 1 |
| Zubaidi, G | 1 |
| Obrecht, P | 1 |
| Heilmeyer, L | 1 |
| Cridland, MD | 1 |
| Brodehl, J | 1 |
| Forbes, IJ | 1 |
| Ultmann, JE | 1 |
| Nixon, DD | 1 |
| Saslaw, S | 1 |
| Carlisle, HN | 1 |
| Norcross, JW | 1 |
4 reviews available for chlorambucil and Infection
| Article | Year |
|---|---|
Fludarabine combination therapy for the treatment of chronic lymphocytic leukemia.
Topics: Adolescent; Adult; Aged; Alemtuzumab; Antibiotics, Antineoplastic; Antibodies, Monoclonal; Antibodie | 2002 |
Cytotoxic drugs in treatment of nonmalignant diseases.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Arthritis, Rheumatoid; Azathioprine; Chlor | 1972 |
[Immunosuppressive therapy of the nephrotic syndrome in childhood].
Topics: Azathioprine; Child; Chlorambucil; Cyclophosphamide; Cystitis; Drug Resistance; Humans; Immunosuppre | 1972 |
The therapy of lymphoma.
Topics: Adrenal Cortex Hormones; Asparaginase; Bone Marrow Diseases; Chlorambucil; Cyclophosphamide; Cytarab | 1969 |
2 trials available for chlorambucil and Infection
| Article | Year |
|---|---|
Cladribine with prednisone versus chlorambucil with prednisone as first-line therapy in chronic lymphocytic leukemia: report of a prospective, randomized, multicenter trial.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Cladri | 2000 |
[Results of immunosuppressive therapy in 78 patients with rheumatoid polyarthritis, treated for at least 4 years].
Topics: Adrenal Cortex Hormones; Adult; Aged; Arthritis, Rheumatoid; Blood Sedimentation; Chlorambucil; Clin | 1975 |
11 other studies available for chlorambucil and Infection
| Article | Year |
|---|---|
Hairy cell leukemia.
Topics: Androgens; Bone Marrow; Chlorambucil; Female; Humans; Infections; Interferons; Leukapheresis; Leukem | 1984 |
Acquired Factor VIII autoantibody: four cases demonstrating the heterogenous nature of this condition and problems involved in diagnosis and treatment.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Autoantibodies; Autoimmune Diseases; Azathiop | 2001 |
Waldenström's macroglobulinemia: clinical course and prognostic factors in 60 patients. Experience from a single hematology unit.
Topics: Adult; Aged; Aged, 80 and over; Blood Viscosity; Cardiac Output, Low; Chlorambucil; Fatigue; Female; | 2001 |
[Results and long-term risks of immuno-suppressive treatment in chronic juvenile arthritis. Apropos of 40 cases].
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Arthritis, Juvenile; Child; Child, Preschool; Chlorambuc | 1979 |
Comparative toxicity of total lymphoid irradiation and immunosuppressive drug treated patients with intractable rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Cyclophosphamide; Female; Follow-Up Studies; Gast | 1987 |
[Cytostatic therapy of lymphogranulomatosis].
Topics: Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Chlorambucil; Cyclophosphamide; Cysti | 1972 |
[The treatment of chronic lymphatic leukemia].
Topics: Anabolic Agents; Anemia; Anti-Bacterial Agents; Antineoplastic Agents; Blood Transfusion; Chlorambuc | 1966 |
Chronic lymphocytic leukaemia.
Topics: Aged; B-Lymphocytes; Chlorambucil; Chronic Disease; Female; Humans; Infections; Leukemia, Lymphoid; | 1974 |
The clinical use of immunosuppressive drugs.
Topics: Adrenal Cortex Hormones; Aged; Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Cyclophosphamide; | 1973 |
Nonhuman primates in evaluation of hematotoxicity.
Topics: Animals; Busulfan; Chlorambucil; Cyclophosphamide; Dactinomycin; Drug-Related Side Effects and Adver | 1969 |
Chronic lymphatic leukemia in the older patient.
Topics: Aged; Anemia; Chlorambucil; Diagnosis, Differential; Humans; Infections; Leukemia, Lymphoid; Lymphat | 1968 |