chlorambucil has been researched along with Histiocytosis, Langerhans-Cell in 13 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Histiocytosis, Langerhans-Cell: A group of disorders resulting from the abnormal proliferation of and tissue infiltration by LANGERHANS CELLS which can be detected by their characteristic Birbeck granules (X bodies), or by monoclonal antibody staining for their surface CD1 ANTIGENS. Langerhans-cell granulomatosis can involve a single organ, or can be a systemic disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A prospective study for histiocytosis X was designed to determine whether "good risk" patients, ie, those without evidence of dysfunction of liver, lung, or hemopoietic system, would respond to single agent therapy; in this case chlorambucil (CMB) used in a dose of 5 mgm/m2/day." | 2.65 | Histiocytosis X: clinical trial of chlorambucil: a report from Childrens Cancer Study Group. ( Hammond, D; Heyn, RM; Lahey, ME; Leikin, S; Newton, WA; Shore, N; Smith, WB, 1979) |
| "We describe two cases of Hodgkin's disease after heart and heart/lung transplants respectively." | 1.29 | Hodgkin's disease after cardiac transplant: a report of two cases. ( Hood, IM; Mahendra, P; Marcus, RE; McNeil, K, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (92.31) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pastor Durán, X | 1 |
| Palomeque Rico, A | 1 |
| Cruz Hernández, M | 1 |
| Nagata, Y | 1 |
| Miwa, A | 1 |
| Murai, Y | 1 |
| Mori, M | 1 |
| Yamamoto, T | 1 |
| Karbe, S | 1 |
| Koike, N | 1 |
| Starling, KA | 1 |
| Iyer, R | 1 |
| Silva-Sosa, M | 1 |
| Komp, D | 1 |
| Herson, J | 1 |
| Trueworthy, RC | 1 |
| Hood, IM | 1 |
| Mahendra, P | 1 |
| McNeil, K | 1 |
| Marcus, RE | 1 |
| Lahey, ME | 1 |
| Heyn, RM | 1 |
| Newton, WA | 1 |
| Shore, N | 1 |
| Smith, WB | 1 |
| Leikin, S | 1 |
| Hammond, D | 1 |
| Mahoney, DH | 1 |
| McClain, KL | 1 |
| Hanson, IC | 1 |
| Taylor, LD | 1 |
| Steuber, CP | 1 |
| Donat, J | 1 |
| Fernández-Delgado, R | 1 |
| Fernández, L | 1 |
| Jubert, A | 1 |
| Kritharides, L | 1 |
| Lawrie, K | 1 |
| Varigos, GA | 1 |
| Rossier, A | 1 |
| De Kraker, J | 1 |
| Voûte, PA | 1 |
| Van Putten, WJ | 1 |
| Delemarre, JF | 1 |
| Marie, J | 1 |
| Hennequet, A | 1 |
| Lévêque, B | 1 |
| Debauchez, C | 1 |
| Desbois, C | 1 |
| Watchi, JM | 1 |
| Appalanarasayya, K | 1 |
| Devi, OB | 1 |
| Drescher, J | 1 |
1 trial available for chlorambucil and Histiocytosis, Langerhans-Cell
| Article | Year |
|---|---|
Histiocytosis X: clinical trial of chlorambucil: a report from Childrens Cancer Study Group.
Topics: Adolescent; Child; Child, Preschool; Chlorambucil; Clinical Trials as Topic; Female; Histiocytosis, | 1979 |
12 other studies available for chlorambucil and Histiocytosis, Langerhans-Cell
| Article | Year |
|---|---|
[Histiocytosis X with thyroid involvement].
Topics: Child, Preschool; Chlorambucil; Combined Modality Therapy; Ear Diseases; Histiocytosis, Langerhans-C | 1984 |
[A case of Hand-Schüller-Christian disease with foam cells in the pericardial effusion treated effectively by KM 2210].
Topics: Adult; Chlorambucil; Estradiol; Female; Foam Cells; Histiocytosis, Langerhans-Cell; Humans; Macropha | 1982 |
Chlorambucil in histiocytosis X: a Southwest Oncology Group study.
Topics: Adolescent; Child; Child, Preschool; Chlorambucil; Drug Evaluation; Drug Therapy, Combination; Histi | 1980 |
Hodgkin's disease after cardiac transplant: a report of two cases.
Topics: Adult; Antibodies, Viral; Antineoplastic Combined Chemotherapy Protocols; Aspergillosis; Chlorambuci | 1996 |
Acquired immune deficiency, myelodysplasia, and acute nonlymphocytic leukemia associated with monosomy 7 and t(3;3) (q21;q26) in a child with Langerhans cell histiocytosis.
Topics: Chlorambucil; Chromosome Deletion; Chromosomes, Human, Pair 3; Chromosomes, Human, Pair 7; Female; H | 1989 |
[Histiocytosis X: localized and disseminated forms. Apropos of 13 cases].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child, Preschool; Chlorambucil; Comb | 1986 |
Cyclophosphamide hypersensitivity and cross-reactivity with chlorambucil.
Topics: Adult; Chlorambucil; Cross Reactions; Cyclophosphamide; Drug Hypersensitivity; Female; Histiocytosis | 1987 |
[Trial therapy of reticulosis X].
Topics: Adrenocorticotropic Hormone; Aminopterin; Chlorambucil; Cortisone; Eosinophilic Granuloma; Glucocort | 1969 |
[Eosinophilic granuloma].
Topics: Adolescent; Child; Child, Preschool; Chlorambucil; Eosinophilic Granuloma; Histiocytes; Histiocytosi | 1974 |
[Histiocytic reticulosis in infants or Letterer-Siwe disease. (Clinical and therapeutical study)].
Topics: Acrodermatitis; Betamethasone; Biopsy; Blood Cell Count; Bone Diseases; Child, Preschool; Chlorambuc | 1968 |
Hand-Schueller-Christian disease. Report of a case and review of the literature.
Topics: Biopsy; Child, Preschool; Chlorambucil; Cyclophosphamide; Granuloma; Histiocytes; Histiocytosis, Lan | 1970 |
[Hand-Schüller-Christian disease].
Topics: Child, Preschool; Chlorambucil; Cyclophosphamide; Histiocytosis, Langerhans-Cell; Humans; Mercaptopu | 1971 |