chlorambucil has been researched along with Helicobacter Infections in 9 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Helicobacter Infections: Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aetiological association between MALT lymphomas and Helicobacter pylori is well established." | 2.74 | Chlorambucil versus observation after anti-Helicobacter therapy in gastric MALT lymphomas: results of the international randomised LY03 trial. ( Ambrosetti, A; Burton, C; Capella, C; Cavalli, F; Copie-Bergman, C; Cortelazzo, S; Delchier, JC; Ferreri, AJ; Gisselbrecht, C; Hancock, BW; Jakupovic, I; Levy, M; Linch, D; Martinelli, G; Pinotti, G; Qian, W; Smith, P; Souhami, R; Traulle, C; Vitolo, U; Wotherspoon, A; Zucca, E, 2009) |
| "Less than half of the patients with MALT lymphoma can achieve sustained molecular remission after anti-Helicobacter therapy." | 2.70 | Molecular follow-up in gastric mucosa-associated lymphoid tissue lymphomas: early analysis of the LY03 cooperative trial. ( Bertoni, F; Biondi, A; Capella, C; Cavalli, F; Cazzaniga, G; Conconi, A; Cotter, FE; Giardini, R; Hancock, BW; Motta, T; Novero, D; Pedrinis, E; Ponzoni, M; Rinaldi, P; Smith, P; Souhami, R; Wotherspoon, A; Zucca, E, 2002) |
| "Localized MALT lymphomas have excellent prognosis following moderate-dose RT." | 1.31 | Stage I and II MALT lymphoma: results of treatment with radiotherapy. ( Bezjak, A; Crump, M; Gospodarowicz, MK; Hodgson, DC; Pintilie, M; Tsang, RW; Wells, W, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 5 (55.56) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hancock, BW | 2 |
| Qian, W | 1 |
| Linch, D | 1 |
| Delchier, JC | 3 |
| Smith, P | 2 |
| Jakupovic, I | 1 |
| Burton, C | 1 |
| Souhami, R | 2 |
| Wotherspoon, A | 2 |
| Copie-Bergman, C | 3 |
| Capella, C | 3 |
| Traulle, C | 2 |
| Levy, M | 3 |
| Cortelazzo, S | 1 |
| Ferreri, AJ | 1 |
| Ambrosetti, A | 1 |
| Pinotti, G | 2 |
| Martinelli, G | 1 |
| Vitolo, U | 1 |
| Cavalli, F | 3 |
| Gisselbrecht, C | 1 |
| Zucca, E | 3 |
| Molinier-Frenkel, V | 1 |
| Riou, A | 1 |
| Haioun, C | 1 |
| Gaulard, P | 2 |
| Delfau-Larue, MH | 1 |
| Sobhani, I | 1 |
| Leroy, K | 1 |
| Mirabile, A | 1 |
| Devizzi, L | 1 |
| Gianni, AM | 1 |
| Cabras, A | 1 |
| Carbone, A | 1 |
| Novik, AA | 1 |
| Denisov, NL | 1 |
| Gershanovich, ML | 1 |
| Pozharisskiĭ, KM | 1 |
| Gorodokin, I | 1 |
| Roggero, E | 1 |
| Pascarella, A | 1 |
| Bertoni, F | 2 |
| Savio, A | 1 |
| Savio, E | 1 |
| Pedrinis, E | 2 |
| Saletti, P | 1 |
| Morandi, E | 1 |
| Santandrea, G | 1 |
| Bornand-Rousselot, A | 1 |
| Saint-Jean, O | 1 |
| Leblond, V | 1 |
| Tsang, RW | 1 |
| Gospodarowicz, MK | 1 |
| Pintilie, M | 1 |
| Bezjak, A | 1 |
| Wells, W | 1 |
| Hodgson, DC | 1 |
| Crump, M | 1 |
| Lavergne-Slove, A | 1 |
| Brousse, N | 1 |
| Flejou, JF | 1 |
| de Mascarel, A | 1 |
| Hemery, F | 1 |
| Conconi, A | 1 |
| Motta, T | 1 |
| Giardini, R | 1 |
| Ponzoni, M | 1 |
| Novero, D | 1 |
| Rinaldi, P | 1 |
| Cazzaniga, G | 1 |
| Biondi, A | 1 |
| Cotter, FE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Protocol for a Randomised Trial of Observation Versus Chlorambucil After Anti-Helicobacter Therapy in Low Grade Gastric Lymphoma[NCT00003617] | Phase 3 | 200 participants (Anticipated) | Interventional | 1995-03-31 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for chlorambucil and Helicobacter Infections
| Article | Year |
|---|---|
[Helicobacter pylori infection and gastric MALT lymphoma: present-day approaches to research and treatment].
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Chr | 2002 |
5 trials available for chlorambucil and Helicobacter Infections
| Article | Year |
|---|---|
Chlorambucil versus observation after anti-Helicobacter therapy in gastric MALT lymphomas: results of the international randomised LY03 trial.
Topics: Aged; Anti-Bacterial Agents; Antineoplastic Agents, Alkylating; Chlorambucil; Disease-Free Survival; | 2009 |
Treatment of t(11;18)-positive gastric mucosa-associated lymphoid tissue lymphoma with rituximab and chlorambucil: clinical, histological, and molecular follow-up.
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined | 2010 |
Clinical features, treatment and outcome in a series of 93 patients with low-grade gastric MALT lymphoma.
Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Antineoplastic Agents, Alkylating; Antineopla | 1997 |
Conservative treatment of primary gastric low-grade B-cell lymphoma of mucosa-associated lymphoid tissue: predictive factors of response and outcome.
Topics: Adult; Aged; Amoxicillin; Antineoplastic Agents, Alkylating; Biopsy, Needle; Chlorambucil; Clarithro | 2002 |
Molecular follow-up in gastric mucosa-associated lymphoid tissue lymphomas: early analysis of the LY03 cooperative trial.
Topics: Antineoplastic Agents, Alkylating; Chlorambucil; Disease-Free Survival; False Negative Reactions; Fo | 2002 |
3 other studies available for chlorambucil and Helicobacter Infections
| Article | Year |
|---|---|
MALT lymphoma and Kaposi sarcoma in an HIV-negative patient.
Topics: Aged; Amoxicillin; Anti-Bacterial Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, | 2010 |
Sequential chlorambucil and prednisone as second line therapy in gastric malt lymphoma resistant to Helicobacter pylori eradication. A case report in an octogenarian patient.
Topics: Aged; Aged, 80 and over; Chlorambucil; Drug Therapy, Combination; Female; Helicobacter Infections; H | 1998 |
Stage I and II MALT lymphoma: results of treatment with radiotherapy.
Topics: Adult; Aged; Anti-Bacterial Agents; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Co | 2001 |