chlorambucil has been researched along with Hairy Cell Leukemia in 28 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Two patients with progressive hairy cell leukemia following splenectomy were treated with low-dose daily chlorambucil." | 7.66 | Chlorambucil therapy in hairy cell leukemia: effects on lipid composition and lymphocyte subpopulations. ( Krigel, R; Liebes, LF; Pelle, E; Silber, R, 1982) |
| "Of eight patients with progressive hairy cell leukemia who were treated with daily doses of an alkylating agent (chlorambucil, 4 mg) for at least 6 mo, seven have had an objective response, as measured by improved blood counts." | 7.66 | Progress report on chlorambucil therapy in postsplenectomy patients with progressive hairy cell leukemia. ( Golomb, HM, 1981) |
| "Four postsplenectomy patients with progressive hairy cell leukemia were treated with daily low doses of an alkylating agent (chlorambucil, 4 mg)." | 7.66 | Treatment of hairy cell leukemia (leukemic reticuloendotheliosis) II. Chlorambucil therapy in postsplenectomy patients with progressive disease. ( Golomb, HM; Mintz, U, 1979) |
| "A splenectomized patient with hairy cell leukemia (HCL) who had received chemotherapy with a low-dose alkylating agent for 2 years developed dysmyelopoietic syndrome (DMPS), the first such case to be described." | 5.27 | Development of dysmyelopoietic syndrome in a hairy cell leukemia patient treated with chlorambucil: cytogenetic and morphologic evaluation. ( Albain, KS; Golomb, HM; Le Beau, MM; Rowley, JD; Vardiman, JW, 1983) |
| "Hairy cell leukemia (HCL) is characterized by leukemic cells with abundant "hairy" cytoplasm, strong cytoplasmic positivity for tartrate-resistant acid phosphatase (TRAP), characteristic immunophenotype and sensitivity to treatment with purine nucleoside analogs." | 4.87 | Hairy cell leukemia and variant in Taiwan: report of a variant case and literature review. ( Chang, ST; Chuang, SS; Hsieh, YC; Li, CY; Lin, CN; Lu, CL; Tsao, CJ, 2011) |
| "Two patients with progressive hairy cell leukemia following splenectomy were treated with low-dose daily chlorambucil." | 3.66 | Chlorambucil therapy in hairy cell leukemia: effects on lipid composition and lymphocyte subpopulations. ( Krigel, R; Liebes, LF; Pelle, E; Silber, R, 1982) |
| "Of eight patients with progressive hairy cell leukemia who were treated with daily doses of an alkylating agent (chlorambucil, 4 mg) for at least 6 mo, seven have had an objective response, as measured by improved blood counts." | 3.66 | Progress report on chlorambucil therapy in postsplenectomy patients with progressive hairy cell leukemia. ( Golomb, HM, 1981) |
| "Four postsplenectomy patients with progressive hairy cell leukemia were treated with daily low doses of an alkylating agent (chlorambucil, 4 mg)." | 3.66 | Treatment of hairy cell leukemia (leukemic reticuloendotheliosis) II. Chlorambucil therapy in postsplenectomy patients with progressive disease. ( Golomb, HM; Mintz, U, 1979) |
| "Initial studies using interferon in the treatment of hairy cell leukemia look encouraging, but more investigation is necessary before the role of interferon in treatment of hairy cell leukemia is determined." | 1.27 | Hairy cell leukemia. ( Golomb, HM; Offermann, MK, 1984) |
| "Patients with hairy cell leukemia have a significant susceptibility to infections that can affect morbidity and mortality." | 1.27 | Infectious complications in 127 patients with hairy cell leukemia. ( Golomb, HM; Hadad, LJ, 1984) |
| "A splenectomized patient with hairy cell leukemia (HCL) who had received chemotherapy with a low-dose alkylating agent for 2 years developed dysmyelopoietic syndrome (DMPS), the first such case to be described." | 1.27 | Development of dysmyelopoietic syndrome in a hairy cell leukemia patient treated with chlorambucil: cytogenetic and morphologic evaluation. ( Albain, KS; Golomb, HM; Le Beau, MM; Rowley, JD; Vardiman, JW, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (82.14) | 18.7374 |
| 1990's | 3 (10.71) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (3.57) | 24.3611 |
| 2020's | 1 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, Y | 1 |
| Wang, T | 1 |
| Yu, Y | 1 |
| Wang, Q | 1 |
| Yan, Y | 1 |
| Li, R | 1 |
| Sun, Q | 1 |
| Xiong, W | 1 |
| Lyu, R | 1 |
| Yu, Z | 1 |
| Liu, W | 1 |
| Sui, W | 1 |
| Huang, W | 1 |
| Wang, H | 1 |
| Li, C | 1 |
| Wang, J | 2 |
| Zou, D | 1 |
| An, G | 1 |
| Qiu, L | 1 |
| Yi, S | 1 |
| Hsieh, YC | 1 |
| Chang, ST | 1 |
| Chuang, SS | 1 |
| Lu, CL | 1 |
| Tsao, CJ | 1 |
| Lin, CN | 1 |
| Li, CY | 1 |
| FEIWEL, M | 1 |
| MUNRO, DD | 1 |
| BOOTSMA, BK | 1 |
| LOPESCARDOZO, E | 1 |
| MOESCHLIN, S | 1 |
| Offermann, MK | 1 |
| Golomb, HM | 10 |
| Silber, R | 2 |
| Silingardi, V | 1 |
| Federico, M | 1 |
| Bonaccorsi, G | 1 |
| Barbieri, F | 1 |
| De Pasquale, A | 1 |
| Piccinini, L | 1 |
| Curci, G | 1 |
| Dini, D | 1 |
| Mussini, C | 1 |
| Sacchi, S | 1 |
| Schmidt, K | 1 |
| Vardiman, JW | 2 |
| Jansen, J | 1 |
| den Ottolander, GJ | 1 |
| Holdrinet, RS | 1 |
| Tricot, GJ | 1 |
| Hermans, J | 1 |
| Catovsky, D | 1 |
| Golde, DW | 1 |
| Gaynor, E | 1 |
| McClellan, J | 1 |
| Hadad, LJ | 1 |
| Bolognesi, G | 1 |
| Sølling, K | 1 |
| Nielsen, JL | 1 |
| Sølling, J | 1 |
| Ellegaard, J | 1 |
| Albain, KS | 1 |
| Le Beau, MM | 1 |
| Rowley, JD | 1 |
| Krigel, R | 1 |
| Liebes, LF | 1 |
| Pelle, E | 1 |
| Brittinger, G | 2 |
| Hellriegel, KP | 2 |
| Hiddemann, W | 2 |
| Mintz, U | 1 |
| Cheson, BD | 1 |
| Shpilberg, O | 1 |
| Ehrenfeld, M | 1 |
| Berkovitz, M | 1 |
| Maier, MK | 1 |
| Samra, Y | 1 |
| Debusscher, L | 1 |
| Stryckmans, P | 1 |
| Lembersky, BC | 1 |
| Ratain, MJ | 1 |
6 reviews available for chlorambucil and Hairy Cell Leukemia
| Article | Year |
|---|---|
Hairy cell leukemia and variant in Taiwan: report of a variant case and literature review.
Topics: Acid Phosphatase; Aged; Antigens, CD; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Bone Mar | 2011 |
Hairy cell leukemia: the importance of accurate diagnosis and sequential management.
Topics: Adult; Aged; Blood Cell Count; Bone Marrow Transplantation; Chlorambucil; Combined Modality Therapy; | 1984 |
Chronic lymphocytic leukemia and hairy-cell leukemia--diagnosis and treatment: results of a consensus meeting of the German CLL Cooperative Group.
Topics: Antineoplastic Agents, Alkylating; Chlorambucil; Humans; Immunophenotyping; Leukemia, Hairy Cell; Le | 1997 |
[Chronic lymphatic leukemia and hairy cell leukemia. Diagnosis and therapy].
Topics: Chlorambucil; Combined Modality Therapy; Humans; Interferon-alpha; Leukemia, Hairy Cell; Leukemia, L | 1997 |
Chronic lymphocytic leukemia and hairy-cell leukemia.
Topics: Adult; Antineoplastic Agents; B-Lymphocytes; Chlorambucil; Humans; Immunologic Factors; Interferon T | 1991 |
Perspectives in the treatment of hairy cell leukemia.
Topics: Adult; Chlorambucil; Coformycin; Humans; Interferon Type I; Leukemia, Hairy Cell; Male; Middle Aged; | 1987 |
22 other studies available for chlorambucil and Hairy Cell Leukemia
| Article | Year |
|---|---|
Purine nucleoside analogs plus rituximab are an effective treatment choice for hairy cell leukemia-variant.
Topics: Adult; Aged; Chlorambucil; Female; Humans; Leukemia, Hairy Cell; Male; Middle Aged; Nucleosides; Pur | 2022 |
CHEMOTHERAPY IN RETICULOSES.
Topics: Chlorambucil; Cyclophosphamide; Genetic Diseases, X-Linked; Hodgkin Disease; Humans; Leukemia, Hairy | 1963 |
THE RETICULOSES.
Topics: Adrenal Cortex Hormones; Chlorambucil; Cyclophosphamide; Dermatitis, Exfoliative; Genetic Diseases, | 1964 |
[EXPERIENCE IN THE TREATMENT OF MALIGNANT DISEASES OF THE RETICULOENDOTHELIAL SYSTEM AND LEUKEMIAS. II].
Topics: Betamethasone; Busulfan; Chlorambucil; Copper; Cyclophosphamide; Dexamethasone; Genetic Diseases, X- | 1964 |
[CYTOSTATIC THERAPY].
Topics: Antineoplastic Agents; Breast Neoplasms; Busulfan; Chlorambucil; Colchicine; Cyclophosphamide; Femal | 1964 |
[MODERN TREATMENT OF LEUKEMIA].
Topics: Agranulocytosis; Busulfan; Chlorambucil; Cyclophosphamide; Drug Therapy; Genetic Diseases, X-Linked; | 1965 |
Hairy cell leukemia.
Topics: Androgens; Bone Marrow; Chlorambucil; Female; Humans; Infections; Interferons; Leukapheresis; Leukem | 1984 |
Chronic lymphocytic leukemia in the elderly.
Topics: Aged; B-Lymphocytes; Chlorambucil; Diagnosis, Differential; Glucosephosphate Dehydrogenase; Humans; | 1982 |
[Hairy cell leukemia. Clinico-pathological study of 30 cases observed 1966 to 1979].
Topics: Adrenal Cortex Hormones; Adult; Aged; Chlorambucil; Cyclophosphamide; Female; Follow-Up Studies; Hum | 1984 |
Chlorambucil therapy of twenty-four postsplenectomy patients with progressive hairy cell leukemia.
Topics: Chlorambucil; Follow-Up Studies; Humans; Leukemia, Hairy Cell; Leukopenia; Splenectomy | 1984 |
Prognosis and therapy in hairy cell leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Cyclophosphamide; Doxorubicin; Follow- | 1984 |
Hairy cell leukemia: a five-year update on seventy-one patients.
Topics: Chlorambucil; Follow-Up Studies; Humans; Leukemia, Hairy Cell; Organ Size; Prognosis; Spleen; Splene | 1983 |
Initial alkylating agent chemotherapy in a leukemic hairy cell patient.
Topics: Chlorambucil; Female; Follow-Up Studies; Humans; Leukemia, Hairy Cell; Middle Aged; Time Factors | 1984 |
Infectious complications in 127 patients with hairy cell leukemia.
Topics: Bacterial Infections; Blood Cell Count; Chlorambucil; Humans; Leukemia, Hairy Cell; Splenectomy | 1984 |
[Hairy cell leukemia].
Topics: Chlorambucil; Diagnosis, Differential; Heavy Chain Disease; Humans; Leukemia, Hairy Cell; Leukemia, | 1982 |
Free light chains of immunoglobulins in serum from patients with leukaemias and multiple myeloma.
Topics: Adolescent; Adult; Aged; Child; Chlorambucil; Humans; Immunoglobulin kappa-Chains; Immunoglobulin la | 1982 |
Development of dysmyelopoietic syndrome in a hairy cell leukemia patient treated with chlorambucil: cytogenetic and morphologic evaluation.
Topics: Bone Marrow; Chlorambucil; Chromosome Aberrations; Humans; Karyotyping; Leukemia, Hairy Cell; Male; | 1983 |
Chlorambucil therapy in hairy cell leukemia: effects on lipid composition and lymphocyte subpopulations.
Topics: Aged; B-Lymphocytes; Chlorambucil; Cholesterol; Humans; Leukemia, Hairy Cell; Leukocyte Count; Lipid | 1982 |
Progress report on chlorambucil therapy in postsplenectomy patients with progressive hairy cell leukemia.
Topics: Allopurinol; Blood Platelets; Bone Marrow Examination; Chlorambucil; Humans; Leukemia, Hairy Cell; L | 1981 |
Treatment of hairy cell leukemia (leukemic reticuloendotheliosis) II. Chlorambucil therapy in postsplenectomy patients with progressive disease.
Topics: Chlorambucil; Humans; Leukemia, Hairy Cell; Pancytopenia; Splenectomy | 1979 |
Hairy cell leukemia with an autoimmune syndrome, paraproteinemia, and cryoglobulinemia.
Topics: Aged; Aged, 80 and over; Autoimmune Diseases; Chlorambucil; Cryoglobulinemia; Humans; Immunoglobulin | 1989 |
Skeletal complications in hairy cell leukemia: diagnosis and therapy.
Topics: Adult; Bone Marrow; Chlorambucil; Humans; Interferon Type I; Leukemia, Hairy Cell; Male; Medical Rec | 1988 |