chlorambucil has been researched along with Granulomatosis with Polyangiitis in 28 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Granulomatosis with Polyangiitis: A multisystemic disease of a complex genetic background. It is characterized by inflammation of the blood vessels (VASCULITIS) leading to damage in any number of organs. The common features include granulomatous inflammation of the RESPIRATORY TRACT and KIDNEYS. Most patients have measurable autoantibodies (ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES) against MYELOBLASTIN.
| Excerpt | Relevance | Reference |
|---|---|---|
| "If the vasculitis is secondary to an underlying disease, such as lymphoma, therapy should be directed at the primary disease." | 2.37 | Pulmonary vasculitis. ( Fauci, AS; Leavitt, RY, 1986) |
| "The classical type of Wegener's granulomatosis encompasses a necrotizing granulomatous vasculitis of the upper and lower respiratory tracts and a necrotizing glomerulonephritis." | 2.36 | [Wegener's granulomatosis and Wegener's Granuloma (author's transl)]. ( Chilla, R, 1980) |
| "Two patients with Wegener's granulomatosis have been treated with chlorambucil and prednisolone continuosly for 3 and 5 years, respectively." | 1.26 | Acute myeloid leukemia appearing in two patients after prolonged continuous chlorambucil treatment for Wegener's granulomatosis. ( Swolin, B; Westberg, NG, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hollander, D | 1 |
| Manning, RT | 1 |
| Chilla, R | 1 |
| Chanda, JJ | 1 |
| Callen, JP | 1 |
| Weiss, M | 1 |
| Militiano, Z | 1 |
| Lieberman, Y | 1 |
| Bank, H | 1 |
| Kuusisto, P | 1 |
| Westberg, NG | 2 |
| Swolin, B | 1 |
| Lindqvist, B | 1 |
| Söderbergh, H | 1 |
| Wentzel, T | 1 |
| Clements, PJ | 1 |
| Davis, J | 1 |
| Leavitt, RY | 1 |
| Fauci, AS | 1 |
| Nashel, DJ | 1 |
| Delespesse, G | 1 |
| Kennes, B | 1 |
| Duchateau, J | 1 |
| Rafii, MR | 1 |
| Betow, C | 1 |
| Méry, JP | 1 |
| Girard, JF | 1 |
| Skinner, MD | 1 |
| Schwartz, RS | 1 |
| Kaplan, SR | 1 |
| Calabresi, P | 1 |
| Steinberg, AD | 1 |
| Marmont, A | 1 |
| Rossi, F | 1 |
| Bordo, D | 1 |
| von Domarus, H | 1 |
| Cameron, JS | 1 |
| Duck, HJ | 1 |
| Rosenkranz, M | 1 |
| Rogos, R | 1 |
| Froud, PJ | 1 |
| Henderson, AH | 1 |
| Küstner, W | 1 |
| Lübbers, P | 1 |
| Uthgenannt, H | 1 |
| Wegener, F | 1 |
| Kisielewicz, J | 1 |
| Jablonowski, Z | 1 |
| Turczynowski, R | 1 |
| Ulatowska, J | 1 |
| Raitt, JW | 1 |
| Israel, HL | 1 |
| Patchefsky, AS | 1 |
| McIlvanie, SK | 1 |
10 reviews available for chlorambucil and Granulomatosis with Polyangiitis
| Article | Year |
|---|---|
[Wegener's granulomatosis and Wegener's Granuloma (author's transl)].
Topics: Chlorambucil; Cyclophosphamide; Glomerulonephritis; Glucocorticoids; Granuloma, Lethal Midline; Gran | 1980 |
Cytotoxic drugs: their clinical application to the rheumatic diseases.
Topics: Arthritis; Arthritis, Rheumatoid; Azathioprine; Behcet Syndrome; Bone Marrow; Cell Division; Chemica | 1986 |
Pulmonary vasculitis.
Topics: Adrenal Cortex Hormones; Azathioprine; Behcet Syndrome; Chlorambucil; Connective Tissue Diseases; Cy | 1986 |
Mechanisms of action and clinical applications of cytotoxic drugs in rheumatic disorders.
Topics: Arthritis, Reactive; Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Collagen Diseases; Cyclophos | 1985 |
[Auto-immune diseases and immunodepressive therapy. II. Current clinical indications].
Topics: Adrenal Cortex Hormones; Anemia, Hemolytic, Autoimmune; Antineoplastic Agents; Arteritis; Autoimmune | 1974 |
Cytotoxic drugs in treatment of nonmalignant diseases.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Arthritis, Rheumatoid; Azathioprine; Chlor | 1972 |
Immunosuppressive therapy. 2.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Adult; Azathioprine; Child; Chlorambucil; Clin | 1972 |
Drug therapy. Immunosuppressive agents. I.
Topics: Adrenal Cortex Hormones; Adult; Alkylating Agents; Antimetabolites; Arthritis, Rheumatoid; Autoimmun | 1973 |
An approach to the use of immunosuppressive drugs in nonmalignant diseases.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Chlorambucil; Cyclophosphamide; G | 1973 |
Immunosuppressant agents in the treatment of glomerulonephritis. 2. Cytotoxic drugs.
Topics: Adult; Anti-Glomerular Basement Membrane Disease; Antilymphocyte Serum; Antineoplastic Agents; Azath | 1971 |
1 trial available for chlorambucil and Granulomatosis with Polyangiitis
| Article | Year |
|---|---|
Immunosuppressive therapy. 2.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Adult; Azathioprine; Child; Chlorambucil; Clin | 1972 |
18 other studies available for chlorambucil and Granulomatosis with Polyangiitis
| Article | Year |
|---|---|
The use of alkylating agents in the treatment of Wegener's granulomatosis.
Topics: Adrenal Cortex Hormones; Adult; Blood Protein Electrophoresis; Blood Urea Nitrogen; Chlorambucil; Cr | 1967 |
Necrotizing vasculitis (angiitis) with granulomatosis.
Topics: Azathioprine; Chlorambucil; Cyclophosphamide; Diagnosis, Differential; Granuloma, Lethal Midline; Gr | 1984 |
[Wegener's granulomatosis].
Topics: Chlorambucil; Granulomatosis with Polyangiitis; Humans; Middle Aged | 1980 |
[Wegener's granulomatosis].
Topics: Antineoplastic Agents; Chlorambucil; Glucocorticoids; Granulomatosis with Polyangiitis; Humans; Male | 1978 |
Acute myeloid leukemia appearing in two patients after prolonged continuous chlorambucil treatment for Wegener's granulomatosis.
Topics: Bone Marrow; Bone Marrow Cells; Chlorambucil; Granulomatosis with Polyangiitis; Humans; Leukemia, My | 1976 |
[Wegener's granulomatosis--therapy, treatment complications and follow-up study].
Topics: Adrenal Cortex Hormones; Adult; Chlorambucil; Female; Follow-Up Studies; Granulomatosis with Polyang | 1976 |
[Wegener's granulomatosis].
Topics: Adrenal Cortex Hormones; Adult; Antibiotics, Antineoplastic; Blood; Chlorambucil; Extracorporeal Cir | 1976 |
[Wegener's granulomatosis. Contribution to the diagnosis, therapy and course].
Topics: Aged; Chlorambucil; Cyclophosphamide; Female; Glomerulonephritis; Granulomatosis with Polyangiitis; | 1974 |
[Indications for immunosuppressive agents in glomerular nephropathies].
Topics: Adrenal Cortex Hormones; Anti-Glomerular Basement Membrane Disease; Azathioprine; Chlorambucil; Cycl | 1974 |
[Current aspects of immunosuppressive therapy of collagen diseases].
Topics: Arthritis, Rheumatoid; Asparaginase; Chlorambucil; Collagen Diseases; Cyclophosphamide; Dermatomyosi | 1973 |
[Pains in the face and jaws, due to Wegener's granuloma (author's transl)].
Topics: Adult; Bone Resorption; Chlorambucil; Facial Neuralgia; Female; Glomerulonephritis; Granulomatosis w | 1973 |
[Immunosuppressive therapy of Wegener's granulomatosis].
Topics: Azathioprine; Biopsy; Chlorambucil; Female; Granulomatosis with Polyangiitis; Humans; Immunosuppress | 1971 |
The treatment of Wegener's granulomatosis with immunosuppressive-cytotoxic drugs.
Topics: Adult; Azathioprine; Chlorambucil; Female; Granulomatosis with Polyangiitis; Humans; Male; Methylpre | 1971 |
[Wegener's granulomatosis. Diagnostic problems and clinical course under immunosuppressive therapy].
Topics: Adrenal Cortex Hormones; Adult; Azathioprine; Chlorambucil; Female; Granulomatosis with Polyangiitis | 1971 |
[Successful treatment of Wegener's granuloma with leukeran].
Topics: Adult; Chlorambucil; Female; Granulomatosis with Polyangiitis; Humans | 1969 |
Wegener's granulomatosis: treatment with cytotoxic agents and adrenocorticoids.
Topics: Adult; Antineoplastic Agents; Azathioprine; Biopsy; Chlorambucil; Creatinine; Cyclophosphamide; Fema | 1971 |
Wegener's granulomatosis of lung: diagnosis and treatment. Experience with 12 cases.
Topics: Adult; Aged; Antineoplastic Agents; Azathioprine; Chlorambucil; Female; Granulomatosis with Polyangi | 1971 |
Wegener's granulomatosis. Successful treatment with chlorambucil.
Topics: Aged; Blood Protein Electrophoresis; Chlorambucil; Female; Granulomatosis with Polyangiitis; Humans; | 1966 |