chlorambucil has been researched along with Granulomatosis, Wegener's in 28 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "If the vasculitis is secondary to an underlying disease, such as lymphoma, therapy should be directed at the primary disease." | 2.37 | Pulmonary vasculitis. ( Fauci, AS; Leavitt, RY, 1986) |
| "The classical type of Wegener's granulomatosis encompasses a necrotizing granulomatous vasculitis of the upper and lower respiratory tracts and a necrotizing glomerulonephritis." | 2.36 | [Wegener's granulomatosis and Wegener's Granuloma (author's transl)]. ( Chilla, R, 1980) |
| "Two patients with Wegener's granulomatosis have been treated with chlorambucil and prednisolone continuosly for 3 and 5 years, respectively." | 1.26 | Acute myeloid leukemia appearing in two patients after prolonged continuous chlorambucil treatment for Wegener's granulomatosis. ( Swolin, B; Westberg, NG, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hollander, D | 1 |
| Manning, RT | 1 |
| Chilla, R | 1 |
| Chanda, JJ | 1 |
| Callen, JP | 1 |
| Weiss, M | 1 |
| Militiano, Z | 1 |
| Lieberman, Y | 1 |
| Bank, H | 1 |
| Kuusisto, P | 1 |
| Westberg, NG | 2 |
| Swolin, B | 1 |
| Lindqvist, B | 1 |
| Söderbergh, H | 1 |
| Wentzel, T | 1 |
| Clements, PJ | 1 |
| Davis, J | 1 |
| Leavitt, RY | 1 |
| Fauci, AS | 1 |
| Nashel, DJ | 1 |
| Delespesse, G | 1 |
| Kennes, B | 1 |
| Duchateau, J | 1 |
| Rafii, MR | 1 |
| Betow, C | 1 |
| Méry, JP | 1 |
| Girard, JF | 1 |
| Skinner, MD | 1 |
| Schwartz, RS | 1 |
| Kaplan, SR | 1 |
| Calabresi, P | 1 |
| Steinberg, AD | 1 |
| Marmont, A | 1 |
| Rossi, F | 1 |
| Bordo, D | 1 |
| von Domarus, H | 1 |
| Cameron, JS | 1 |
| Duck, HJ | 1 |
| Rosenkranz, M | 1 |
| Rogos, R | 1 |
| Froud, PJ | 1 |
| Henderson, AH | 1 |
| Küstner, W | 1 |
| Lübbers, P | 1 |
| Uthgenannt, H | 1 |
| Wegener, F | 1 |
| Kisielewicz, J | 1 |
| Jablonowski, Z | 1 |
| Turczynowski, R | 1 |
| Ulatowska, J | 1 |
| Raitt, JW | 1 |
| Israel, HL | 1 |
| Patchefsky, AS | 1 |
| McIlvanie, SK | 1 |
10 reviews available for chlorambucil and Granulomatosis, Wegener's
| Article | Year |
|---|---|
[Wegener's granulomatosis and Wegener's Granuloma (author's transl)].
Topics: Chlorambucil; Cyclophosphamide; Glomerulonephritis; Glucocorticoids; Granuloma, Lethal Midline; Gran | 1980 |
Cytotoxic drugs: their clinical application to the rheumatic diseases.
Topics: Arthritis; Arthritis, Rheumatoid; Azathioprine; Behcet Syndrome; Bone Marrow; Cell Division; Chemica | 1986 |
Pulmonary vasculitis.
Topics: Adrenal Cortex Hormones; Azathioprine; Behcet Syndrome; Chlorambucil; Connective Tissue Diseases; Cy | 1986 |
Mechanisms of action and clinical applications of cytotoxic drugs in rheumatic disorders.
Topics: Arthritis, Reactive; Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Collagen Diseases; Cyclophos | 1985 |
[Auto-immune diseases and immunodepressive therapy. II. Current clinical indications].
Topics: Adrenal Cortex Hormones; Anemia, Hemolytic, Autoimmune; Antineoplastic Agents; Arteritis; Autoimmune | 1974 |
Cytotoxic drugs in treatment of nonmalignant diseases.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Arthritis, Rheumatoid; Azathioprine; Chlor | 1972 |
Immunosuppressive therapy. 2.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Adult; Azathioprine; Child; Chlorambucil; Clin | 1972 |
Drug therapy. Immunosuppressive agents. I.
Topics: Adrenal Cortex Hormones; Adult; Alkylating Agents; Antimetabolites; Arthritis, Rheumatoid; Autoimmun | 1973 |
An approach to the use of immunosuppressive drugs in nonmalignant diseases.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Chlorambucil; Cyclophosphamide; G | 1973 |
Immunosuppressant agents in the treatment of glomerulonephritis. 2. Cytotoxic drugs.
Topics: Adult; Anti-Glomerular Basement Membrane Disease; Antilymphocyte Serum; Antineoplastic Agents; Azath | 1971 |
1 trial available for chlorambucil and Granulomatosis, Wegener's
| Article | Year |
|---|---|
Immunosuppressive therapy. 2.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Adult; Azathioprine; Child; Chlorambucil; Clin | 1972 |
18 other studies available for chlorambucil and Granulomatosis, Wegener's
| Article | Year |
|---|---|
The use of alkylating agents in the treatment of Wegener's granulomatosis.
Topics: Adrenal Cortex Hormones; Adult; Blood Protein Electrophoresis; Blood Urea Nitrogen; Chlorambucil; Cr | 1967 |
Necrotizing vasculitis (angiitis) with granulomatosis.
Topics: Azathioprine; Chlorambucil; Cyclophosphamide; Diagnosis, Differential; Granuloma, Lethal Midline; Gr | 1984 |
[Wegener's granulomatosis].
Topics: Chlorambucil; Granulomatosis with Polyangiitis; Humans; Middle Aged | 1980 |
[Wegener's granulomatosis].
Topics: Antineoplastic Agents; Chlorambucil; Glucocorticoids; Granulomatosis with Polyangiitis; Humans; Male | 1978 |
Acute myeloid leukemia appearing in two patients after prolonged continuous chlorambucil treatment for Wegener's granulomatosis.
Topics: Bone Marrow; Bone Marrow Cells; Chlorambucil; Granulomatosis with Polyangiitis; Humans; Leukemia, My | 1976 |
[Wegener's granulomatosis--therapy, treatment complications and follow-up study].
Topics: Adrenal Cortex Hormones; Adult; Chlorambucil; Female; Follow-Up Studies; Granulomatosis with Polyang | 1976 |
[Wegener's granulomatosis].
Topics: Adrenal Cortex Hormones; Adult; Antibiotics, Antineoplastic; Blood; Chlorambucil; Extracorporeal Cir | 1976 |
[Wegener's granulomatosis. Contribution to the diagnosis, therapy and course].
Topics: Aged; Chlorambucil; Cyclophosphamide; Female; Glomerulonephritis; Granulomatosis with Polyangiitis; | 1974 |
[Indications for immunosuppressive agents in glomerular nephropathies].
Topics: Adrenal Cortex Hormones; Anti-Glomerular Basement Membrane Disease; Azathioprine; Chlorambucil; Cycl | 1974 |
[Current aspects of immunosuppressive therapy of collagen diseases].
Topics: Arthritis, Rheumatoid; Asparaginase; Chlorambucil; Collagen Diseases; Cyclophosphamide; Dermatomyosi | 1973 |
[Pains in the face and jaws, due to Wegener's granuloma (author's transl)].
Topics: Adult; Bone Resorption; Chlorambucil; Facial Neuralgia; Female; Glomerulonephritis; Granulomatosis w | 1973 |
[Immunosuppressive therapy of Wegener's granulomatosis].
Topics: Azathioprine; Biopsy; Chlorambucil; Female; Granulomatosis with Polyangiitis; Humans; Immunosuppress | 1971 |
The treatment of Wegener's granulomatosis with immunosuppressive-cytotoxic drugs.
Topics: Adult; Azathioprine; Chlorambucil; Female; Granulomatosis with Polyangiitis; Humans; Male; Methylpre | 1971 |
[Wegener's granulomatosis. Diagnostic problems and clinical course under immunosuppressive therapy].
Topics: Adrenal Cortex Hormones; Adult; Azathioprine; Chlorambucil; Female; Granulomatosis with Polyangiitis | 1971 |
[Successful treatment of Wegener's granuloma with leukeran].
Topics: Adult; Chlorambucil; Female; Granulomatosis with Polyangiitis; Humans | 1969 |
Wegener's granulomatosis: treatment with cytotoxic agents and adrenocorticoids.
Topics: Adult; Antineoplastic Agents; Azathioprine; Biopsy; Chlorambucil; Creatinine; Cyclophosphamide; Fema | 1971 |
Wegener's granulomatosis of lung: diagnosis and treatment. Experience with 12 cases.
Topics: Adult; Aged; Antineoplastic Agents; Azathioprine; Chlorambucil; Female; Granulomatosis with Polyangi | 1971 |
Wegener's granulomatosis. Successful treatment with chlorambucil.
Topics: Aged; Blood Protein Electrophoresis; Chlorambucil; Female; Granulomatosis with Polyangiitis; Humans; | 1966 |