chlorambucil has been researched along with Granulocytic Leukemia, Chronic in 10 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "One of the MPDs, chronic myeloid leukemia (CML), has the distinct cytogenetic abnormality of the Philadelphia chromosome." | 2.42 | Treatment paradigms in the management of myeloproliferative disorders. ( Fruchtman, SM, 2004) |
| "Its use in the treatment of essential thrombocythemia began later in 1950." | 2.41 | Treatment of the myeloproliferative disorders with 32P. ( Berlin, NI, 2000) |
| "Chlorambucil has been used for treatment of B cell chronic lymphocytic leukemia, non-Hodgkin's and Hodgkin's disease." | 1.35 | Growth arrest of BCR-ABL positive cells with a sequence-specific polyamide-chlorambucil conjugate. ( Alvarez, D; Chou, CJ; Druker, BJ; Eide, CA; Gottesfeld, JM; Lefebvre, S; O'Hare, T; Tyner, JW, 2008) |
| " Unlike conventional and distamycin-based alkylators, little or no cytotoxicities and animal toxicities were observed in mg/kg dosage ranges." | 1.35 | Small molecules targeting histone H4 as potential therapeutics for chronic myelogenous leukemia. ( Alvarez, D; Chou, CJ; Dervan, PB; Farkas, ME; Gottesfeld, JM; Tsai, SM, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (20.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 5 (50.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mendoza-Cardozo, S | 1 |
| Pedro-Hernández, LD | 1 |
| Organista-Mateos, U | 1 |
| Allende-Alarcón, LI | 1 |
| Martínez-Klimova, E | 1 |
| Ramírez-Ápan, T | 1 |
| Martínez-García, M | 1 |
| Barrientos, JC | 1 |
| Chou, CJ | 2 |
| O'Hare, T | 1 |
| Lefebvre, S | 1 |
| Alvarez, D | 2 |
| Tyner, JW | 1 |
| Eide, CA | 1 |
| Druker, BJ | 1 |
| Gottesfeld, JM | 2 |
| Amrein, L | 1 |
| Hernandez, TA | 1 |
| Ferrario, C | 1 |
| Johnston, J | 1 |
| Gibson, SB | 1 |
| Panasci, L | 1 |
| Aloyz, R | 1 |
| KRAKOFF, IH | 1 |
| KARNOFSKY, DA | 1 |
| BURCHENAL, JH | 1 |
| GRIZZLE, JE | 1 |
| Fruchtman, SM | 1 |
| Farkas, ME | 1 |
| Tsai, SM | 1 |
| Dervan, PB | 1 |
| Berlin, NI | 1 |
| Majado, MJ | 1 |
| González García, C | 1 |
| Marín-Blazquez, MD | 1 |
| Morales Lázaro, A | 1 |
| Moreno Moreno, M | 1 |
3 reviews available for chlorambucil and Granulocytic Leukemia, Chronic
| Article | Year |
|---|---|
Sequencing of chronic lymphocytic leukemia therapies.
Topics: Alanine; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemothe | 2016 |
Treatment paradigms in the management of myeloproliferative disorders.
Topics: Antineoplastic Agents, Alkylating; Busulfan; Chlorambucil; Hydroxyurea; Interferon-alpha; Leukemia, | 2004 |
Treatment of the myeloproliferative disorders with 32P.
Topics: Adult; Aged; Alkylating Agents; Chlorambucil; Clinical Trials as Topic; Combined Modality Therapy; D | 2000 |
7 other studies available for chlorambucil and Granulocytic Leukemia, Chronic
| Article | Year |
|---|---|
In vitro activity of resorcinarene-chlorambucil conjugates for therapy in human chronic myelogenous leukemia cells.
Topics: Antineoplastic Agents; Calixarenes; Chlorambucil; Dendrimers; Drug Carriers; Drug Screening Assays, | 2019 |
Growth arrest of BCR-ABL positive cells with a sequence-specific polyamide-chlorambucil conjugate.
Topics: Animals; Antineoplastic Agents, Alkylating; Base Sequence; Benzamides; Blood Cells; Bone Marrow Cell | 2008 |
Dasatinib sensitizes primary chronic lymphocytic leukaemia lymphocytes to chlorambucil and fludarabine in vitro.
Topics: Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Cell Survival; Chlorambucil; Cyto | 2008 |
Remissions induced by chlorambucil in chronic granulocytic leukemia.
Topics: Chlorambucil; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mechlorethamine; Neoplasms | 1958 |
MULTIVARIATE COMPARISON OF RESULTS OF TREATMENT IN CHRONIC LYMPHOCYTIC AND CHRONIC GRANULOCYTIC LEUKEMIA.
Topics: Antineoplastic Agents; Blood Platelets; Busulfan; Chlorambucil; Factor Analysis, Statistical; Hemogl | 1964 |
Small molecules targeting histone H4 as potential therapeutics for chronic myelogenous leukemia.
Topics: Alkylation; Animals; Base Sequence; Blotting, Western; Cell Cycle; Cell Proliferation; Cell Survival | 2008 |
[Appearance of a chronic myeloid leukemia in Waldenström's macroglobulinemia].
Topics: Busulfan; Chlorambucil; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; | 1992 |