chlorambucil has been researched along with Glomerulosclerosis, Focal Segmental in 24 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Glomerulosclerosis, Focal Segmental: A clinicopathological syndrome or diagnostic term for a type of glomerular injury that has multiple causes, primary or secondary. Clinical features include PROTEINURIA, reduced GLOMERULAR FILTRATION RATE, and EDEMA. Kidney biopsy initially indicates focal segmental glomerular consolidation (hyalinosis) or scarring which can progress to globally sclerotic glomeruli leading to eventual KIDNEY FAILURE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Prednisone-resistant nephrotic syndrome (NS) due to focal segmental glomerulosclerosis (FSGS), the most common acquired disease requiring chronic dialysis and transplantation in children, has a low likelihood of response to alkylating agent therapy." | 7.69 | Intravenous methylprednisolone and oral alkylating agent therapy of prednisone-resistant pediatric focal segmental glomerulosclerosis: a long-term follow-up. ( Griswold, WR; Kirpekar, R; Mendoza, SA; Reznik, VM; Sibley, RK; Tune, BM, 1995) |
| "Treatment with a combination of pulse methylprednisolone (MP) and an alkylating agent has been reported to induce long-term remission of proteinuria in patients with steroid-resistant nephrotic syndrome (SRNS)." | 7.68 | Methylprednisolone treatment of patients with steroid-resistant nephrotic syndrome. ( Benfield, MR; Kohaut, EC; Waldo, FB, 1992) |
| "Mechlorethamine has been assessed in 28 patients with idiopathic nephrotic syndrome previously treated with prednisone only." | 7.67 | [Effect of mechlorethamine in idiopathic nephrotic syndrome in childhood]. ( Canals, MJ; Cervera, A; Gómez Campderá, FJ; Gómez Campderá, J; López Gómez, JM; Luque, A; Morales, JL, 1984) |
| "Patients with prednisone-resistant nephrotic syndrome and biopsy-proven focal segmental glomerulosclerosis were treated with intravenous methylprednisone." | 7.67 | Treatment of childhood prednisone-resistant nephrotic syndrome and focal segmental glomerulosclerosis with intravenous methylprednisolone and oral alkylating agents. ( Brock, P; Griswold, WR; Mendoza, SA; Prime, DJ; Reznik, VM; Tune, BM; Vazquez, M, 1987) |
| "The therapy of nephrotic syndrome in focal segmental glomerulosclerosis (FSGS) is still a matter of controversy." | 6.71 | Cyclosporine A and chlorambucil in the treatment of idiopathic focal segmental glomerulosclerosis. ( Braun, N; Fünfstück, R; Grabensee, B; Heering, P; Ivens, K; Keller, F; Krämer, BK; Müllejans, R; Risler, T; Schollmeyer, P; Zäuner, I, 2004) |
| " For instance, in patients with idiopathic membranous glomerulonephritis a six months treatment with chlorambucil (0." | 5.05 | [Drug treatment of chronic glomerulonephritis: pro]. ( Brodehl, J; Helmchen, U; Koch, KM; Kühn, K, 1985) |
| "Prednisone-resistant nephrotic syndrome (NS) due to focal segmental glomerulosclerosis (FSGS), the most common acquired disease requiring chronic dialysis and transplantation in children, has a low likelihood of response to alkylating agent therapy." | 3.69 | Intravenous methylprednisolone and oral alkylating agent therapy of prednisone-resistant pediatric focal segmental glomerulosclerosis: a long-term follow-up. ( Griswold, WR; Kirpekar, R; Mendoza, SA; Reznik, VM; Sibley, RK; Tune, BM, 1995) |
| "A 4-year-old female with nephrotic syndrome secondary to focal segmental glomerulosclerosis (FSGS) was treated with pulse methylprednisolone and chlorambucil therapy." | 3.68 | Fatal Pneumocystis pneumonia in a child treated for focal segmental glomerulosclerosis. ( Chenaille, PJ; Kano, HL; Makker, SP; Murphy, JL, 1993) |
| "Treatment with a combination of pulse methylprednisolone (MP) and an alkylating agent has been reported to induce long-term remission of proteinuria in patients with steroid-resistant nephrotic syndrome (SRNS)." | 3.68 | Methylprednisolone treatment of patients with steroid-resistant nephrotic syndrome. ( Benfield, MR; Kohaut, EC; Waldo, FB, 1992) |
| "Mechlorethamine has been assessed in 28 patients with idiopathic nephrotic syndrome previously treated with prednisone only." | 3.67 | [Effect of mechlorethamine in idiopathic nephrotic syndrome in childhood]. ( Canals, MJ; Cervera, A; Gómez Campderá, FJ; Gómez Campderá, J; López Gómez, JM; Luque, A; Morales, JL, 1984) |
| "Patients with prednisone-resistant nephrotic syndrome and biopsy-proven focal segmental glomerulosclerosis were treated with intravenous methylprednisone." | 3.67 | Treatment of childhood prednisone-resistant nephrotic syndrome and focal segmental glomerulosclerosis with intravenous methylprednisolone and oral alkylating agents. ( Brock, P; Griswold, WR; Mendoza, SA; Prime, DJ; Reznik, VM; Tune, BM; Vazquez, M, 1987) |
| "The therapy of nephrotic syndrome in focal segmental glomerulosclerosis (FSGS) is still a matter of controversy." | 2.71 | Cyclosporine A and chlorambucil in the treatment of idiopathic focal segmental glomerulosclerosis. ( Braun, N; Fünfstück, R; Grabensee, B; Heering, P; Ivens, K; Keller, F; Krämer, BK; Müllejans, R; Risler, T; Schollmeyer, P; Zäuner, I, 2004) |
| "Patients with nephrotic syndrome are in a constant state of flux with respect to fluid status, organ function, and critical protein balance." | 2.38 | Pharmacologic management of adult idiopathic nephrotic syndrome. ( Alaniz, C; Brosius, FC; Palmieri, J, 1993) |
| "There is no definite treatment for focal glomerulosclerosis." | 2.38 | Treatment of the nephrotic syndrome with cyclosporin A. ( Ponticelli, C, 1992) |
| " Therefore, intravenous high-dose steroid pulses, alternate-day prednisone, short courses with cytotoxic agents and long-term administration of azathioprine have been suggested as alternatives to the classical prolonged corticotherapy." | 2.38 | Conventional treatment of idiopathic nephrotic syndrome and membranous nephropathy in adults. ( Passerini, P; Ponticelli, C, 1991) |
| "Approximately 30% of children with focal segmental glomerulosclerosis enter remission following treatment with corticosteroids." | 2.38 | Immunosuppressive therapy in the nephrotic syndrome in children. ( Trompeter, RS, 1989) |
| "When focal segmental glomerulosclerosis (FSGS) has reached the stage of chronic renal insufficiency, further progression is usually considered inevitable." | 1.30 | Aggressive treatment of severe idiopathic focal segmental glomerulosclerosis. ( Aviles, DH; Dublin, LS; Irwin, KC; Vehaskari, VM, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (54.17) | 18.7374 |
| 1990's | 8 (33.33) | 18.2507 |
| 2000's | 3 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Braun, N | 2 |
| Schmutzler, F | 1 |
| Lange, C | 1 |
| Perna, A | 1 |
| Remuzzi, G | 1 |
| Risler, T | 2 |
| Willis, NS | 1 |
| Sakai, H | 1 |
| Kurokawa, K | 1 |
| Saito, T | 1 |
| Shiiki, H | 1 |
| Nishi, S | 1 |
| Mitarai, T | 1 |
| Yokoyama, H | 1 |
| Yoshimura, A | 1 |
| Yorioka, N | 1 |
| Heering, P | 1 |
| Müllejans, R | 1 |
| Ivens, K | 1 |
| Zäuner, I | 1 |
| Fünfstück, R | 1 |
| Keller, F | 1 |
| Krämer, BK | 1 |
| Schollmeyer, P | 1 |
| Grabensee, B | 1 |
| Bodaghi, E | 1 |
| Chamsa, AM | 1 |
| Ponticelli, C | 3 |
| Banfi, G | 1 |
| Imbasciati, E | 1 |
| Tarantino, A | 1 |
| Gómez Campderá, FJ | 1 |
| López Gómez, JM | 1 |
| Cervera, A | 1 |
| Gómez Campderá, J | 1 |
| Canals, MJ | 1 |
| Morales, JL | 1 |
| Luque, A | 1 |
| McEnery, PT | 1 |
| Strife, CF | 1 |
| Donadio, JV | 1 |
| Tune, BM | 3 |
| Kirpekar, R | 1 |
| Sibley, RK | 1 |
| Reznik, VM | 2 |
| Griswold, WR | 2 |
| Mendoza, SA | 3 |
| Murphy, JL | 1 |
| Kano, HL | 1 |
| Chenaille, PJ | 1 |
| Makker, SP | 1 |
| Alaniz, C | 1 |
| Brosius, FC | 1 |
| Palmieri, J | 1 |
| Aviles, DH | 1 |
| Irwin, KC | 1 |
| Dublin, LS | 1 |
| Vehaskari, VM | 1 |
| Simon, NM | 1 |
| Rosenberg, MJ | 1 |
| Vázquez Tadei, G | 1 |
| Fernández, J | 1 |
| Martin Malo, A | 1 |
| Campdera, FG | 1 |
| Sanz Guajardo, D | 1 |
| Traver, JA | 1 |
| Botella, J | 1 |
| Waldo, FB | 1 |
| Benfield, MR | 1 |
| Kohaut, EC | 1 |
| Passerini, P | 1 |
| Trompeter, RS | 1 |
| Schulman, SL | 1 |
| Kaiser, BA | 1 |
| Polinsky, MS | 1 |
| Srinivasan, R | 1 |
| Baluarte, HJ | 1 |
| Sinn, W | 1 |
| Ratner, M | 1 |
| Tomilina, N | 1 |
| Klinkmann, H | 1 |
| Nizze, H | 1 |
| Vazquez, M | 1 |
| Prime, DJ | 1 |
| Brock, P | 1 |
| Kühn, K | 1 |
| Brodehl, J | 1 |
| Koch, KM | 1 |
| Helmchen, U | 1 |
| Cameron, JS | 1 |
| Ogg, CS | 1 |
| Turner, DR | 1 |
| Weller, RO | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Ofatumumab in Children With Steroid- and Calcineurin-inhibitor-resistant Nephrotic Syndrome: a Double-blind Randomized, Controlled, Superiority Trial[NCT02394106] | Phase 2 | 13 participants (Actual) | Interventional | 2015-07-31 | Terminated | ||
| Ofatumumab Versus Rituximab in Children With Steroid and Calcineurin Inhibitor-dependent Idiopathic Nephrotic Syndrome: an Open-label, Randomized, Controlled, Superiority Trial.[NCT02394119] | Phase 2 | 140 participants (Actual) | Interventional | 2015-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for chlorambucil and Glomerulosclerosis, Focal Segmental
| Article | Year |
|---|---|
Immunosuppressive treatment for focal segmental glomerulosclerosis in adults.
Topics: Adult; Chlorambucil; Cyclosporine; Glomerulosclerosis, Focal Segmental; Humans; Immunosuppressive Ag | 2008 |
[Guidelines for the management of refractory nephrotic syndrome--from investigations between 1997 and 2001--research project team for progressive renal lesions in the Ministry of Health, Labor and Welfare, Japan].
Topics: Blood Component Removal; Cause of Death; Chlorambucil; Clinical Trials as Topic; Cyclophosphamide; D | 2002 |
Immunosuppressive therapy in primary glomerulonephritis (pros).
Topics: Adrenocorticotropic Hormone; Azathioprine; Chlorambucil; Cyclophosphamide; Dipyridamole; Glomerulone | 1982 |
Nephrotic syndrome in childhood. Management and treatment in patients with minimal change disease, mesangial proliferation, or focal glomerulosclerosis.
Topics: Adolescent; Child; Child, Preschool; Chlorambucil; Cyclophosphamide; Diuretics; Female; Glomerulonep | 1982 |
Nephrotic syndrome in childhood. Management and treatment in patients with minimal change disease, mesangial proliferation, or focal glomerulosclerosis.
Topics: Adolescent; Child; Child, Preschool; Chlorambucil; Cyclophosphamide; Diuretics; Female; Glomerulonep | 1982 |
Nephrotic syndrome in childhood. Management and treatment in patients with minimal change disease, mesangial proliferation, or focal glomerulosclerosis.
Topics: Adolescent; Child; Child, Preschool; Chlorambucil; Cyclophosphamide; Diuretics; Female; Glomerulonep | 1982 |
Nephrotic syndrome in childhood. Management and treatment in patients with minimal change disease, mesangial proliferation, or focal glomerulosclerosis.
Topics: Adolescent; Child; Child, Preschool; Chlorambucil; Cyclophosphamide; Diuretics; Female; Glomerulonep | 1982 |
Pharmacologic management of adult idiopathic nephrotic syndrome.
Topics: Adrenal Cortex Hormones; Chlorambucil; Cyclosporine; Drug Therapy, Combination; Edema; Glomeruloneph | 1993 |
Medical treatment of glomerular diseases.
Topics: Adult; Anti-Glomerular Basement Membrane Disease; Azathioprine; Child; Chlorambucil; Cyclophosphamid | 1978 |
Treatment of the nephrotic syndrome with cyclosporin A.
Topics: Chlorambucil; Cyclophosphamide; Cyclosporine; Glomerulonephritis, Membranous; Glomerulosclerosis, Fo | 1992 |
Conventional treatment of idiopathic nephrotic syndrome and membranous nephropathy in adults.
Topics: Adult; Chlorambucil; Cyclophosphamide; Glomerulonephritis, Membranous; Glomerulosclerosis, Focal Seg | 1991 |
Immunosuppressive therapy in the nephrotic syndrome in children.
Topics: Adrenal Cortex Hormones; Child; Child, Preschool; Chlorambucil; Cyclophosphamide; Cyclosporins; Glom | 1989 |
3 trials available for chlorambucil and Glomerulosclerosis, Focal Segmental
| Article | Year |
|---|---|
Cyclosporine A and chlorambucil in the treatment of idiopathic focal segmental glomerulosclerosis.
Topics: Adult; Aged; Alkylating Agents; Biopsy; Chlorambucil; Cyclosporine; Drug Therapy, Combination; Femal | 2004 |
[New results concerning the effectiveness of therapy of chronic glomerulonephritis. Results of cytostatics-anticoagulants-aggregation inhibitors, cystostatics-anticoagulants-aggregation inhibitors-prednisone and cystostatics-prednisone therapy, derived fr
Topics: Anticoagulants; Chlorambucil; Chronic Disease; Clinical Trials as Topic; Drug Evaluation; Drug Thera | 1986 |
[Drug treatment of chronic glomerulonephritis: pro].
Topics: Chlorambucil; Chronic Disease; Clinical Trials as Topic; Cyclophosphamide; Cyclosporins; Glomerulone | 1985 |
12 other studies available for chlorambucil and Glomerulosclerosis, Focal Segmental
| Article | Year |
|---|---|
[Primary nephrotic syndromes in children in Iran].
Topics: Adolescent; Anti-Inflammatory Agents; Biopsy; Child; Child, Preschool; Chlorambucil; Cyclophosphamid | 1978 |
[Effect of mechlorethamine in idiopathic nephrotic syndrome in childhood].
Topics: Child; Child, Preschool; Chlorambucil; Cyclophosphamide; Drug Tolerance; Female; Glomerulosclerosis, | 1984 |
Primary glomerular disease: to treat or not to treat.
Topics: Azathioprine; Chlorambucil; Cyclophosphamide; Dipyridamole; Glomerulonephritis; Glomerulosclerosis, | 1982 |
Intravenous methylprednisolone and oral alkylating agent therapy of prednisone-resistant pediatric focal segmental glomerulosclerosis: a long-term follow-up.
Topics: Child, Preschool; Chlorambucil; Cyclophosphamide; Drug Administration Schedule; Drug Resistance; Dru | 1995 |
Fatal Pneumocystis pneumonia in a child treated for focal segmental glomerulosclerosis.
Topics: Child, Preschool; Chlorambucil; Fatal Outcome; Female; Glomerulosclerosis, Focal Segmental; Humans; | 1993 |
Aggressive treatment of severe idiopathic focal segmental glomerulosclerosis.
Topics: Adolescent; Anti-Inflammatory Agents; Antineoplastic Agents, Alkylating; Black People; Child; Child, | 1999 |
[Clinical course and recurrences of the nephrotic syndrome due to minimal histologic lesions. Review of 73 cases (author's transl)].
Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Chlorambucil; Drug Therapy, Combination; Fe | 1979 |
Methylprednisolone treatment of patients with steroid-resistant nephrotic syndrome.
Topics: Administration, Oral; Adolescent; Child; Child, Preschool; Chlorambucil; Drug Administration Schedul | 1992 |
Controlled, multi-center trials are needed in pediatric nephrology.
Topics: Chlorambucil; Glomerulosclerosis, Focal Segmental; Humans; Methylprednisolone; Multicenter Studies a | 1992 |
Predicting the response to cytotoxic therapy for childhood nephrotic syndrome: superiority of response to corticosteroid therapy over histopathologic patterns.
Topics: Adolescent; Biopsy; Child; Child, Preschool; Chlorambucil; Cyclophosphamide; Glomerulonephritis; Glo | 1988 |
Treatment of childhood prednisone-resistant nephrotic syndrome and focal segmental glomerulosclerosis with intravenous methylprednisolone and oral alkylating agents.
Topics: Administration, Oral; Adolescent; Child; Child, Preschool; Chlorambucil; Cyclophosphamide; Drug Resi | 1987 |
Focal glomerulosclerosis.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Azathioprine; Child; Child, Preschool; Chlorambucil; Cyc | 1973 |