chlorambucil has been researched along with Glomerulonephritis, Minimal Change in 33 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mechlorethamine has been assessed in 28 patients with idiopathic nephrotic syndrome previously treated with prednisone only." | 7.67 | [Effect of mechlorethamine in idiopathic nephrotic syndrome in childhood]. ( Canals, MJ; Cervera, A; Gómez Campderá, FJ; Gómez Campderá, J; López Gómez, JM; Luque, A; Morales, JL, 1984) |
| " For instance, in patients with idiopathic membranous glomerulonephritis a six months treatment with chlorambucil (0." | 5.05 | [Drug treatment of chronic glomerulonephritis: pro]. ( Brodehl, J; Helmchen, U; Koch, KM; Kühn, K, 1985) |
| "Mechlorethamine has been assessed in 28 patients with idiopathic nephrotic syndrome previously treated with prednisone only." | 3.67 | [Effect of mechlorethamine in idiopathic nephrotic syndrome in childhood]. ( Canals, MJ; Cervera, A; Gómez Campderá, FJ; Gómez Campderá, J; López Gómez, JM; Luque, A; Morales, JL, 1984) |
| "Patients with nephrotic syndrome are in a constant state of flux with respect to fluid status, organ function, and critical protein balance." | 2.38 | Pharmacologic management of adult idiopathic nephrotic syndrome. ( Alaniz, C; Brosius, FC; Palmieri, J, 1993) |
| "There is no definite treatment for focal glomerulosclerosis." | 2.38 | Treatment of the nephrotic syndrome with cyclosporin A. ( Ponticelli, C, 1992) |
| " Therefore, intravenous high-dose steroid pulses, alternate-day prednisone, short courses with cytotoxic agents and long-term administration of azathioprine have been suggested as alternatives to the classical prolonged corticotherapy." | 2.38 | Conventional treatment of idiopathic nephrotic syndrome and membranous nephropathy in adults. ( Passerini, P; Ponticelli, C, 1991) |
| "Although nondiabetic nephropathies are common among type 2 diabetic patients, very few cases of minimal change nephrotic syndrome have been reported in diabetic patients." | 1.32 | [Relapsing nephrotic syndrome in a diabetic patient with minimal change]. ( Espejo, B; García Donaire, JA; Gutiérrez Martínez, E; Manzanera, MI; Praga, M; Valentín, MO, 2004) |
| " When the glucocorticoid dosage was reduced or the drug discontinued, the nephrotic syndrome recurred." | 1.29 | [T-cell lymphoma under immunosuppressive treatment in minimal change glomerulopathy with nephrotic syndrome]. ( Schollmeyer, P; Späth, M, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (57.58) | 18.7374 |
| 1990's | 12 (36.36) | 18.2507 |
| 2000's | 1 (3.03) | 29.6817 |
| 2010's | 1 (3.03) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wynsberghe, MV | 1 |
| Lenain, P | 1 |
| Drieux, F | 1 |
| Guerrot, D | 1 |
| Bertrand, D | 1 |
| García Donaire, JA | 1 |
| Manzanera, MI | 1 |
| Valentín, MO | 1 |
| Espejo, B | 1 |
| Gutiérrez Martínez, E | 1 |
| Praga, M | 1 |
| Bodaghi, E | 1 |
| Chamsa, AM | 1 |
| Ponticelli, C | 4 |
| Banfi, G | 1 |
| Imbasciati, E | 1 |
| Tarantino, A | 1 |
| Gómez Campderá, FJ | 1 |
| López Gómez, JM | 1 |
| Cervera, A | 1 |
| Gómez Campderá, J | 1 |
| Canals, MJ | 1 |
| Morales, JL | 1 |
| Luque, A | 1 |
| McEnery, PT | 1 |
| Strife, CF | 1 |
| Donadio, JV | 1 |
| Späth, M | 1 |
| Schollmeyer, P | 1 |
| Passerini, P | 2 |
| Como, G | 1 |
| Melis, P | 1 |
| Viganò, E | 1 |
| Pozzi, C | 1 |
| Altieri, P | 1 |
| Almeida, AF | 1 |
| Chafekar, DS | 1 |
| Alaniz, C | 1 |
| Brosius, FC | 1 |
| Palmieri, J | 1 |
| Abu-Farsakh, H | 1 |
| Berry, PL | 1 |
| Hill, LL | 1 |
| Powell, D | 1 |
| Hawkins, EP | 1 |
| Di Toro, R | 1 |
| Parlier, G | 1 |
| Bensman, A | 1 |
| Leverger, G | 1 |
| Boccon-Gibod, L | 1 |
| Gruner, M | 1 |
| Sten'shinskaia, EV | 1 |
| Ilamanov, M | 1 |
| Naumova, VI | 1 |
| Brodehl, J | 3 |
| Tejani, A | 1 |
| Jones, DP | 1 |
| Stapleton, FB | 1 |
| Roy, S | 1 |
| Wyatt, RJ | 1 |
| Schulman, SL | 1 |
| Kaiser, BA | 1 |
| Polinsky, MS | 1 |
| Srinivasan, R | 1 |
| Baluarte, HJ | 1 |
| Kalinicheva, EO | 1 |
| Papaian, AV | 1 |
| Kashtan, C | 1 |
| Melvin, T | 1 |
| Kim, Y | 1 |
| Trompeter, RS | 1 |
| Kühn, K | 1 |
| Koch, KM | 1 |
| Helmchen, U | 1 |
| Shapiro, CM | 1 |
| Vander Laan, BF | 1 |
| Jao, W | 1 |
| Sloan, DE | 1 |
| Hooft, C | 1 |
| van Acker, KJ | 1 |
| Méry, JP | 1 |
| Girard, JF | 1 |
| Boda, D | 1 |
| Koltay, M | 1 |
| Virág, I | 1 |
| Oechslen, D | 1 |
| Kluthe, R | 1 |
| Sarre, H | 1 |
| Wyszyńska, T | 1 |
| Wojnarowski, M | 1 |
| Rowecka-Trzebicka, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Ofatumumab in Children With Steroid- and Calcineurin-inhibitor-resistant Nephrotic Syndrome: a Double-blind Randomized, Controlled, Superiority Trial[NCT02394106] | Phase 2 | 13 participants (Actual) | Interventional | 2015-07-31 | Terminated | ||
| Ofatumumab Versus Rituximab in Children With Steroid and Calcineurin Inhibitor-dependent Idiopathic Nephrotic Syndrome: an Open-label, Randomized, Controlled, Superiority Trial.[NCT02394119] | Phase 2 | 140 participants (Actual) | Interventional | 2015-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
10 reviews available for chlorambucil and Glomerulonephritis, Minimal Change
| Article | Year |
|---|---|
Immunosuppressive therapy in primary glomerulonephritis (pros).
Topics: Adrenocorticotropic Hormone; Azathioprine; Chlorambucil; Cyclophosphamide; Dipyridamole; Glomerulone | 1982 |
Nephrotic syndrome in childhood. Management and treatment in patients with minimal change disease, mesangial proliferation, or focal glomerulosclerosis.
Topics: Adolescent; Child; Child, Preschool; Chlorambucil; Cyclophosphamide; Diuretics; Female; Glomerulonep | 1982 |
Nephrotic syndrome in childhood. Management and treatment in patients with minimal change disease, mesangial proliferation, or focal glomerulosclerosis.
Topics: Adolescent; Child; Child, Preschool; Chlorambucil; Cyclophosphamide; Diuretics; Female; Glomerulonep | 1982 |
Nephrotic syndrome in childhood. Management and treatment in patients with minimal change disease, mesangial proliferation, or focal glomerulosclerosis.
Topics: Adolescent; Child; Child, Preschool; Chlorambucil; Cyclophosphamide; Diuretics; Female; Glomerulonep | 1982 |
Nephrotic syndrome in childhood. Management and treatment in patients with minimal change disease, mesangial proliferation, or focal glomerulosclerosis.
Topics: Adolescent; Child; Child, Preschool; Chlorambucil; Cyclophosphamide; Diuretics; Female; Glomerulonep | 1982 |
Primary nephrotic syndrome in the elderly.
Topics: Actuarial Analysis; Acute Kidney Injury; Adrenal Cortex Hormones; Adult; Aged; Chlorambucil; Female; | 1993 |
Pharmacologic management of adult idiopathic nephrotic syndrome.
Topics: Adrenal Cortex Hormones; Chlorambucil; Cyclosporine; Drug Therapy, Combination; Edema; Glomeruloneph | 1993 |
Treatment of the nephrotic syndrome with cyclosporin A.
Topics: Chlorambucil; Cyclophosphamide; Cyclosporine; Glomerulonephritis, Membranous; Glomerulosclerosis, Fo | 1992 |
Conventional treatment of idiopathic nephrotic syndrome and membranous nephropathy in adults.
Topics: Adult; Chlorambucil; Cyclophosphamide; Glomerulonephritis, Membranous; Glomerulosclerosis, Focal Seg | 1991 |
Conventional therapy for idiopathic nephrotic syndrome in children.
Topics: Child; Chlorambucil; Cyclophosphamide; Humans; Nephrosis, Lipoid; Prednisone; Recurrence | 1991 |
The treatment of minimal change nephrotic syndrome: lessons learned from multicentre co-operative studies.
Topics: Alkylating Agents; Child; Chlorambucil; Cyclophosphamide; Cyclosporins; Humans; Immunosuppressive Ag | 1991 |
[Effect of cytostatic preparations used in the treatment of glomerulonephritis in children on the functional activity of the gonads].
Topics: Amenorrhea; Chlorambucil; Cyclophosphamide; Female; Humans; Male; Nephrosis, Lipoid; Oligospermia | 1987 |
[Prognosis of the idiopathic nephrotic syndrome in children].
Topics: Adrenocorticotropic Hormone; Biopsy; Blood Proteins; Chlorambucil; Cyclophosphamide; Female; Humans; | 1974 |
3 trials available for chlorambucil and Glomerulonephritis, Minimal Change
| Article | Year |
|---|---|
[Evaluation of the effectiveness of various programs of active therapy of primary glomerulonephritis with nephrotic syndrome in children].
Topics: Adolescent; Child; Child, Preschool; Chlorambucil; Drug Administration Schedule; Drug Therapy, Combi | 1991 |
The treatment of minimal change nephrotic syndrome: lessons learned from multicentre co-operative studies.
Topics: Alkylating Agents; Child; Chlorambucil; Cyclophosphamide; Cyclosporins; Humans; Immunosuppressive Ag | 1991 |
[Drug treatment of chronic glomerulonephritis: pro].
Topics: Chlorambucil; Chronic Disease; Clinical Trials as Topic; Cyclophosphamide; Cyclosporins; Glomerulone | 1985 |
21 other studies available for chlorambucil and Glomerulonephritis, Minimal Change
| Article | Year |
|---|---|
Monoclonal B lymphocytosis and minimal change disease: a new monoclonal B-cell disorder of renal significance?
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; B-Lymphocytes; Chlorambucil; Female; Humans; L | 2018 |
[Relapsing nephrotic syndrome in a diabetic patient with minimal change].
Topics: Chlorambucil; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diagnosis, Differential; Drug Thera | 2004 |
[Primary nephrotic syndromes in children in Iran].
Topics: Adolescent; Anti-Inflammatory Agents; Biopsy; Child; Child, Preschool; Chlorambucil; Cyclophosphamid | 1978 |
[Effect of mechlorethamine in idiopathic nephrotic syndrome in childhood].
Topics: Child; Child, Preschool; Chlorambucil; Cyclophosphamide; Drug Tolerance; Female; Glomerulosclerosis, | 1984 |
Primary glomerular disease: to treat or not to treat.
Topics: Azathioprine; Chlorambucil; Cyclophosphamide; Dipyridamole; Glomerulonephritis; Glomerulosclerosis, | 1982 |
[T-cell lymphoma under immunosuppressive treatment in minimal change glomerulopathy with nephrotic syndrome].
Topics: Adult; Chlorambucil; Cyclosporins; Female; Humans; Immunosuppressive Agents; Lymphoma, T-Cell; Nephr | 1995 |
Minimal change nephrotic syndrome.
Topics: Adult; Child; Chlorambucil; Cyclophosphamide; Humans; Nephrosis, Lipoid; Prednisolone; Remission Ind | 1993 |
Mesangial IgG in childhood minimal change disease: clinical relevance.
Topics: Biopsy; Child, Preschool; Chlorambucil; Cyclophosphamide; Cyclosporine; Fluorescent Antibody Techniq | 1993 |
[Therapy of lipoid nephrosis].
Topics: Calcium; Child; Child, Preschool; Chlorambucil; Diuretics; Glucocorticoids; Humans; Immunosuppressiv | 1977 |
[Neurectodermal malignant tumor of the soft tissues after treatment with immunosuppressive agents of lipoid nephrosis].
Topics: Adrenal Cortex Hormones; Antineoplastic Combined Chemotherapy Protocols; Child; Chlorambucil; Cyclop | 1992 |
[Results of the treatment of glomerulonephritis in children with hepatitis B].
Topics: Adolescent; Age Factors; Child; Child, Preschool; Chlorambucil; Cyclophosphamide; Drug Resistance; D | 1991 |
Relapsing nephrotic syndrome.
Topics: Captopril; Chlorambucil; Cyclophosphamide; Cyclosporins; Glomerular Mesangium; Humans; Immune Comple | 1987 |
Beneficial effect of second courses of cytotoxic therapy in children with minimal change nephrotic syndrome.
Topics: Adolescent; Child; Child, Preschool; Chlorambucil; Cyclophosphamide; Drug Resistance; Female; Humans | 1988 |
Predicting the response to cytotoxic therapy for childhood nephrotic syndrome: superiority of response to corticosteroid therapy over histopathologic patterns.
Topics: Adolescent; Biopsy; Child; Child, Preschool; Chlorambucil; Cyclophosphamide; Glomerulonephritis; Glo | 1988 |
Long-term follow-up of patients with steroid-dependent, minimal change nephrotic syndrome.
Topics: Adolescent; Adult; Chlorambucil; Cyclophosphamide; Follow-Up Studies; Growth; Humans; Nephrosis, Lip | 1988 |
Minimal change nephrotic syndrome and cyclophosphamide.
Topics: Child; Chlorambucil; Cyclophosphamide; Humans; Mechlorethamine; Nephrosis, Lipoid | 1986 |
Nephrotic syndrome in two patients with cured Hodgkin's disease.
Topics: Adult; Chlorambucil; Gallium Radioisotopes; Hodgkin Disease; Humans; Male; Nephrosis, Lipoid; Nephro | 1985 |
[Indications for immunosuppressive agents in glomerular nephropathies].
Topics: Adrenal Cortex Hormones; Anti-Glomerular Basement Membrane Disease; Azathioprine; Chlorambucil; Cycl | 1974 |
[Immunosuppressive treatment of corticoid resistant nephrotic syndrome in childhood].
Topics: Azathioprine; Child; Child, Preschool; Chlorambucil; Dexamethasone; Female; Humans; Male; Nephrosis, | 1969 |
[Cytostatic treatment of the steroid-resistant nephrotic syndrome. (Long term study on 24 patients)].
Topics: Adult; Azathioprine; Biopsy; Chlorambucil; Female; Glomerulonephritis; Humans; Kidney Function Tests | 1968 |
[Results of immunosuppressive treatment of diseases of renal glomerulus in children].
Topics: Azathioprine; Child; Child, Preschool; Chlorambucil; Chronic Disease; Female; Glomerulonephritis; Hu | 1969 |