chlorambucil has been researched along with Glomerulonephritis, Membranous in 75 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Glomerulonephritis, Membranous: A type of glomerulonephritis that is characterized by the accumulation of immune deposits (COMPLEMENT MEMBRANE ATTACK COMPLEX) on the outer aspect of the GLOMERULAR BASEMENT MEMBRANE. It progresses from subepithelial dense deposits, to basement membrane reaction and eventual thickening of the basement membrane.
| Excerpt | Relevance | Reference |
|---|---|---|
| "There is now controlled evidence that a 6-month course with methylprednisolone and chlorambucil may favour remission of the nephrotic syndrome and may significantly improve the 10-year kidney survival in patients with idiopathic membranous nephropathy." | 7.73 | 20 years after methylprednisolone/chlorambucil treatment in idiopathic membranous nephropathy stage II-III with nephrotic syndrome. ( Dzikova, S; Grcevska, L; Polenakovic, M, 2006) |
| "We present the case of a 23-year-old woman with membranous nephropathy who developed acute hepatic failure after being administered chlorambucil for a month." | 7.70 | Chlorambucil-induced acute hepatic failure in a patient with membranous nephropathy. ( Adler, SG; Nast, CC; Patel, SP, 2000) |
| " To explore this uncertainty, a meta-analysis of controlled trials of treatment with cyclophosphamide or chlorambucil was performed in patients with idiopathic membranous nephropathy and nephrotic-range proteinuria." | 6.17 | Are cytotoxic agents beneficial in idiopathic membranous nephropathy? A meta-analysis of the controlled trials. ( Berns, JS; Goldfarb, S; Imperiale, TF, 1995) |
| "This observational study aimed to evaluate the results of treatment with low-dose chlorambucil in combination with corticosteroids in patients with idiopathic membranous nephropathy (iMGN) and nephrotic syndrome." | 5.14 | Efficacy and safety of low-dose chlorambucil in nephrotic patients with idiopathic membranous nephropathy. ( Idasiak-Piechocka, I; Oko, A; Skrobańska, B; Łochyńska-Bielecka, K, 2009) |
| "To validate the hypothesis that the 2 treatments were equivalent, patients with biopsy-proven membranous nephropathy and nephrotic syndrome were randomly assigned to methylprednisolone alternated with a cytotoxic drug every other month for 6 months (group A) or to intramuscular synthetic adrenocorticotropic hormone administered twice a week for 1 year (group B)." | 5.12 | A randomized pilot trial comparing methylprednisolone plus a cytotoxic agent versus synthetic adrenocorticotropic hormone in idiopathic membranous nephropathy. ( Mandolfo, S; Manno, C; Messa, P; Pasquali, S; Passerini, P; Ponticelli, C; Salvadori, M; Viola, BF, 2006) |
| "Two Italian controlled trials demonstrated that the difference in remission rates obtained with six months of methylprednisolone and chlorambucil (MP+Ch) compared to MP was smaller than MP+Ch versus symptomatic therapy in the treatment of idiopathic membranous nephropathy nephrotic syndrome (NS)." | 5.07 | Therapy for idiopathic membranous nephropathy: tailoring the choice by decision analysis. ( Passerini, P; Piccoli, A; Pillon, L; Ponticelli, C, 1994) |
| "Treatment with methylprednisolone and chlorambucil may protect renal function and increase the chance of remission of the nephrotic syndrome in patients with idiopathic membranous nephropathy." | 5.07 | Methylprednisolone plus chlorambucil as compared with methylprednisolone alone for the treatment of idiopathic membranous nephropathy. The Italian Idiopathic Membranous Nephropathy Treatment Study Group. ( Cesana, B; Passerini, P; Ponticelli, C; Zucchelli, P, 1992) |
| " It was found that RTX did not significantly improve serum albumin levels and e-GFR when compared with the control group (including cyclosporine and cyclophosphamide, chlorambucil, prednisone, non-immunosuppressive anti-proteinuria treatment), serum albumin levels (OR = 0." | 5.05 | Efficacy and safety of rituximab in the treatment of membranous nephropathy: A systematic review and meta-analysis. ( Gong, S; Li, J; Lu, W; Luo, H; Wang, Y, 2020) |
| "There is now controlled evidence that a 6-month course with methylprednisolone and chlorambucil may favour remission of the nephrotic syndrome and may significantly improve the 10-year kidney survival in patients with idiopathic membranous nephropathy." | 3.73 | 20 years after methylprednisolone/chlorambucil treatment in idiopathic membranous nephropathy stage II-III with nephrotic syndrome. ( Dzikova, S; Grcevska, L; Polenakovic, M, 2006) |
| "We present the case of a 23-year-old woman with membranous nephropathy who developed acute hepatic failure after being administered chlorambucil for a month." | 3.70 | Chlorambucil-induced acute hepatic failure in a patient with membranous nephropathy. ( Adler, SG; Nast, CC; Patel, SP, 2000) |
| "Twenty-one patients with membranous nephropathy, heavy proteinuria and progressive renal failure were treated with alternating monthly cycles of corticosteroids and chlorambucil for six months." | 3.69 | Prednisolone and chlorambucil therapy for idiopathic membranous nephropathy with progressive renal failure. ( Boulton-Jones, JM; Geddes, CG; Warwick, GL, 1994) |
| " Forty of them, who presented a nephrotic syndrome, were treated by immunosuppressive drugs (prednisone, azathioprine, chlorambucil, cyclophosphamide) for 79 +/- 9." | 3.67 | Long-term immunosuppressive therapy of idiopathic membranoproliferative glomerulonephritis. ( Glyda, J; Gradowska, L; Juskowa, J; Klepacka, J; Lao, M; Morzycka-Michalik, M; Orlowski, T; Rancewicz, Z, 1988) |
| "For the subset of patients with idiopathic membranous nephropathy and deteriorating excretory renal function, 6 months' therapy with prednisolone and chlorambucil is the treatment approach best supported by our evidence." | 2.78 | Immunosuppression for progressive membranous nephropathy: a UK randomised controlled trial. ( Adu, D; Boulton-Jones, M; Chapman, TL; Feehally, J; Ferguson, C; Gaskin, GJ; Howman, A; Jayne, DR; Langdon, MM; Mathieson, PW; O'Donoghue, D, 2013) |
| "Patients with biopsy-proven membranous nephropathy and with a nephrotic syndrome were randomized to be given methylprednisolone (1 g intravenously for 3 consecutive days followed by oral methylprednisolone, 0." | 2.69 | A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy. ( Altieri, P; Antonucci, F; Bellazzi, R; Cesana, B; Dugo, M; Farina, M; Grassi, C; Lupo, A; Melis, P; Minari, M; Pasquali, S; Passerini, P; Pedrini, L; Piccoli, G; Pisano, G; Ponticelli, C; Pozzi, C; Roccatello, D; Sasdelli, M; Scalia, A; Scolari, F; Segagni, S; Valzorio, B, 1998) |
| "Four chlorambucil-treated patients developed ESRD, and five needed a second course of therapy, whereas only one cyclophosphamide-treated patient developed ESRD (p < 0." | 2.69 | Oral cyclophosphamide versus chlorambucil in the treatment of patients with membranous nephropathy and renal insufficiency. ( Branten, AJ; Koene, RA; Reichert, LJ; Wetzels, JF, 1998) |
| "The natural course of idiopathic membranous nephropathy is variable, with some patients slowly progressing to renal failure while others maintain normal renal function over the entire time." | 2.68 | A 10-year follow-up of a randomized study with methylprednisolone and chlorambucil in membranous nephropathy. ( Cesana, B; Grassi, C; Locatelli, F; Pasquali, S; Passerini, P; Ponticelli, C; Pozzi, C; Redaelli, B; Sasdelli, M; Zucchelli, P, 1995) |
| "Chlorambucil was given during months 2, 4, and 6 at a dose of 0." | 2.67 | Low-dose prednisolone/chlorambucil therapy in patients with severe membranous glomerulonephritis. ( Brunkhorst, R; Koch, KM; Wrenger, E, 1994) |
| "18 patients with membranous nephropathy, a nephrotic syndrome, and deteriorating renal function." | 2.67 | Preserving renal function in patients with membranous nephropathy: daily oral chlorambucil compared with intermittent monthly pulses of cyclophosphamide. ( Assmann, K; Huysmans, FT; Koene, RA; Reichert, LJ; Wetzels, JF, 1994) |
| "Idiopathic membranous nephropathy (IMN) is the most common pathological type for nephrotic syndrome in adults in western countries and China." | 2.48 | Immunosuppressive treatment for nephrotic idiopathic membranous nephropathy: a meta-analysis based on Chinese adults. ( Chen, D; Hu, X; Li, L; Ma, Y; Mao, Z; Mei, C; Sun, L; Xie, G; Xu, C; Xu, J; Yang, L; Ye, C; Zhao, X, 2012) |
| "Those with nephrotic syndrome are usually treated with steroids initially and often followed by alkylating agents (cyclophosphamide or chlorambucil)." | 2.46 | Membranous nephropathy in children: clinical presentation and therapeutic approach. ( Menon, S; Valentini, RP, 2010) |
| "Membranous nephropathy is the most common histologic phenotype associated with the primary nephrotic syndrome in adults and the second most common etiological diagnosis in over sixteen hundred renal biopsies on native kidneys processed at our institution over a 30 year period." | 2.42 | [Membranous kidney diseases in adults]. ( Sobarzo Toro, M; Vilches, A, 2004) |
| "Membranous nephropathy is the most common cause of idiopathic nephrotic syndrome in adults." | 2.42 | [Membranous nephropathy]. ( Godin, M; Legallicier, B; Passos, EM, 2003) |
| "The best treatment of idiopathic membranous nephropathy remains an area of clinical controversy." | 2.41 | Treatment of idiopathic membranous nephropathy (IMN). ( Alexopoulos, E; Papagianni, A, 2000) |
| "Patients with nephrotic syndrome are in a constant state of flux with respect to fluid status, organ function, and critical protein balance." | 2.38 | Pharmacologic management of adult idiopathic nephrotic syndrome. ( Alaniz, C; Brosius, FC; Palmieri, J, 1993) |
| "There is no definite treatment for focal glomerulosclerosis." | 2.38 | Treatment of the nephrotic syndrome with cyclosporin A. ( Ponticelli, C, 1992) |
| " Therefore, intravenous high-dose steroid pulses, alternate-day prednisone, short courses with cytotoxic agents and long-term administration of azathioprine have been suggested as alternatives to the classical prolonged corticotherapy." | 2.38 | Conventional treatment of idiopathic nephrotic syndrome and membranous nephropathy in adults. ( Passerini, P; Ponticelli, C, 1991) |
| "Idiopathic Idiopathic membranous nephropathy (iMN) is an immune-complex mediated renal disease which is usually associated with the nephrotic syndrome (NS)." | 1.56 | Idiopathic Membranous Nephropathy and Treatment Related Complications. ( Dzemidzic, J; Haskovic, D; Muslimovic, A; Serdarevic, N; Uncanin, S, 2020) |
| "Membranous nephropathy is among the most common causes of nephrotic syndrome worldwide, with a high healthcare burden." | 1.48 | Rituximab versus the modified Ponticelli regimen in the treatment of primary membranous nephropathy: a Health Economic Model. ( Brenchley, P; Hamilton, P; Kanigicherla, D; Meads, D; Venning, M, 2018) |
| "Chlorambucil is an alkylating agent used in combination with prednisolone for the treatment of idiopathic membranous nephropathy." | 1.40 | Chlorambucil-induced cytomegalovirus infection: a case report. ( Arambarri-Segura, M; de la Nieta-García, MD; López-Lluva, MT; Martínez-Calero, A; Piqueras-Flores, J; Rivera-Hernández, F, 2014) |
| "Idiopathic membranous nephropathy (IMN) is one of the most frequent causes of the nephrotic syndrome in adults and one of the most common cause of chronic renal failure among primary glomerular diseases." | 1.36 | Application of artificial neural networks in estimating predictive factors and therapeutic efficacy in idiopathic membranous nephropathy. ( Basta-Jovanovic, G; Furuncic, D; Jovanovic, D; Lezaic, V; Naumovic, R; Stosovic, M, 2010) |
| " No untoward effect from drugs sufficient to alter the dosage used was recorded." | 1.30 | Clinical features and treatment outcome of idiopathic membranous nephropathy in Chinese patients. ( Chan, TM; Cheng, IK; Lai, KN; Tang, S, 1999) |
| "Nephrotic syndrome was observed in nine patients." | 1.28 | Glomerulonephritis in chronic lymphocytic leukemia and related B-cell lymphomas. ( Fillastre, JP; Francois, A; Mignon, F; Mougenot, B; Moulin, B; Ronco, PM, 1992) |
| "Eight patients with idiopathic membranous nephropathy whose renal function was deteriorating were given a 6-month course of alternating monthly cycles of prednisolone and chlorambucil." | 1.27 | Prednisolone and chlorambucil treatment in idiopathic membranous nephropathy with deteriorating renal function. ( Evans, DJ; Maidment, CG; Mathieson, PW; Rees, AJ; Turner, AN, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (10.67) | 18.7374 |
| 1990's | 31 (41.33) | 18.2507 |
| 2000's | 15 (20.00) | 29.6817 |
| 2010's | 19 (25.33) | 24.3611 |
| 2020's | 2 (2.67) | 2.80 |
| Authors | Studies |
|---|---|
| Lu, W | 1 |
| Gong, S | 1 |
| Li, J | 1 |
| Luo, H | 1 |
| Wang, Y | 2 |
| Uncanin, S | 1 |
| Dzemidzic, J | 1 |
| Serdarevic, N | 1 |
| Muslimovic, A | 1 |
| Haskovic, D | 1 |
| Angioi, A | 1 |
| Lepori, N | 1 |
| López, AC | 1 |
| Sethi, S | 1 |
| Fervenza, FC | 1 |
| Pani, A | 1 |
| Ren, S | 1 |
| Xian, L | 1 |
| Toyama, T | 1 |
| Jardine, M | 1 |
| Li, G | 1 |
| Perkovic, V | 1 |
| Hong, D | 1 |
| Hamilton, P | 1 |
| Kanigicherla, D | 1 |
| Venning, M | 1 |
| Brenchley, P | 1 |
| Meads, D | 1 |
| Remuzzi, G | 3 |
| Ruggenenti, P | 2 |
| Gödel, M | 1 |
| Huber, TB | 1 |
| Cirillo, M | 1 |
| Dhaun, N | 1 |
| Kluth, DC | 1 |
| Chen, Z | 1 |
| Du, X | 1 |
| Hofstra, J | 1 |
| Wetzels, J | 1 |
| Mathieson, PW | 3 |
| López-Lluva, MT | 1 |
| de la Nieta-García, MD | 1 |
| Piqueras-Flores, J | 1 |
| Arambarri-Segura, M | 1 |
| Martínez-Calero, A | 1 |
| Rivera-Hernández, F | 1 |
| Schmidt, S | 1 |
| Sears, M | 1 |
| Crawford, S | 1 |
| Cicci, C | 1 |
| Diskin, CJ | 1 |
| Idasiak-Piechocka, I | 1 |
| Oko, A | 1 |
| Łochyńska-Bielecka, K | 1 |
| Skrobańska, B | 1 |
| Menon, S | 1 |
| Valentini, RP | 1 |
| Hofstra, JM | 1 |
| Wetzels, JF | 5 |
| Naumovic, R | 1 |
| Furuncic, D | 1 |
| Jovanovic, D | 1 |
| Stosovic, M | 1 |
| Basta-Jovanovic, G | 1 |
| Lezaic, V | 1 |
| Xie, G | 1 |
| Xu, J | 1 |
| Ye, C | 1 |
| Chen, D | 1 |
| Xu, C | 1 |
| Yang, L | 1 |
| Ma, Y | 1 |
| Hu, X | 1 |
| Li, L | 1 |
| Sun, L | 1 |
| Zhao, X | 1 |
| Mao, Z | 1 |
| Mei, C | 1 |
| Howman, A | 1 |
| Chapman, TL | 1 |
| Langdon, MM | 1 |
| Ferguson, C | 1 |
| Adu, D | 1 |
| Feehally, J | 1 |
| Gaskin, GJ | 1 |
| Jayne, DR | 1 |
| O'Donoghue, D | 1 |
| Boulton-Jones, M | 1 |
| Sakai, H | 1 |
| Kurokawa, K | 1 |
| Saito, T | 1 |
| Shiiki, H | 1 |
| Nishi, S | 1 |
| Mitarai, T | 1 |
| Yokoyama, H | 1 |
| Yoshimura, A | 1 |
| Yorioka, N | 1 |
| Passerini, P | 11 |
| Ponticelli, C | 13 |
| Passos, EM | 1 |
| Legallicier, B | 1 |
| Godin, M | 1 |
| Sobarzo Toro, M | 1 |
| Vilches, A | 1 |
| du Buf-Vereijken, PW | 1 |
| Feith, GW | 1 |
| Hollander, D | 1 |
| Gerlag, PG | 1 |
| Wirtz, JJ | 1 |
| Noordzij, TC | 1 |
| Yen, CJ | 1 |
| Huang, WT | 1 |
| Huang, JJ | 1 |
| Chen, FF | 1 |
| Sung, JM | 1 |
| Hebert, LA | 2 |
| Rovin, BH | 1 |
| Agarwal, AK | 1 |
| Spetie, DN | 1 |
| Imai, H | 1 |
| Salvadori, M | 1 |
| Manno, C | 1 |
| Viola, BF | 1 |
| Pasquali, S | 4 |
| Mandolfo, S | 1 |
| Messa, P | 1 |
| Polenakovic, M | 2 |
| Grcevska, L | 3 |
| Dzikova, S | 1 |
| Imperiale, TF | 1 |
| Goldfarb, S | 1 |
| Berns, JS | 1 |
| Piccoli, A | 2 |
| Pillon, L | 2 |
| Reichert, LJ | 3 |
| Huysmans, FT | 1 |
| Assmann, K | 1 |
| Koene, RA | 2 |
| Brunkhorst, R | 1 |
| Wrenger, E | 1 |
| Koch, KM | 1 |
| Como, G | 2 |
| Viganò, E | 2 |
| Melis, P | 3 |
| Pozzi, C | 5 |
| Altieri, P | 3 |
| Winearls, CG | 1 |
| Sanderson, F | 1 |
| Warwick, GL | 1 |
| Geddes, CG | 1 |
| Boulton-Jones, JM | 1 |
| Rollino, C | 2 |
| Basolo, B | 2 |
| Roccatello, D | 3 |
| Vallero, A | 1 |
| Funaro, L | 1 |
| Piccoli, G | 3 |
| Alaniz, C | 1 |
| Brosius, FC | 1 |
| Palmieri, J | 1 |
| Zucchelli, P | 3 |
| Cesana, B | 4 |
| Locatelli, F | 1 |
| Sasdelli, M | 2 |
| Redaelli, B | 2 |
| Grassi, C | 3 |
| Ardiles, LG | 1 |
| Mezzano, SA | 1 |
| Cattran, DC | 1 |
| McGregor, DO | 1 |
| Bailey, RR | 1 |
| Scolari, F | 1 |
| Valzorio, B | 1 |
| Lupo, A | 1 |
| Segagni, S | 1 |
| Antonucci, F | 1 |
| Dugo, M | 1 |
| Minari, M | 1 |
| Scalia, A | 1 |
| Pedrini, L | 1 |
| Pisano, G | 1 |
| Farina, M | 1 |
| Bellazzi, R | 1 |
| Branten, AJ | 1 |
| Moroni, G | 1 |
| Faricciotti, A | 1 |
| Farricciotti, A | 1 |
| Cappelletti, M | 1 |
| Apaydin, S | 1 |
| Ozaras, R | 1 |
| Erek, E | 1 |
| Tahan, V | 1 |
| Altiparmak, MR | 1 |
| Celik, Y | 1 |
| Cetinkaya, A | 1 |
| Polenakovik, MH | 1 |
| Tang, S | 1 |
| Chan, TM | 1 |
| Cheng, IK | 1 |
| Lai, KN | 1 |
| Patel, SP | 1 |
| Nast, CC | 1 |
| Adler, SG | 1 |
| Alexopoulos, E | 1 |
| Papagianni, A | 1 |
| Torres, A | 1 |
| Domínguez-Gil, B | 1 |
| Carreño, A | 1 |
| Hernández, E | 1 |
| Morales, E | 1 |
| Segura, J | 1 |
| González, E | 1 |
| Praga, M | 1 |
| Moulin, B | 1 |
| Ronco, PM | 1 |
| Mougenot, B | 1 |
| Francois, A | 1 |
| Fillastre, JP | 1 |
| Mignon, F | 1 |
| Cameron, JS | 1 |
| Giachino, O | 1 |
| Tietjen, DP | 1 |
| Mavromatidis, C | 1 |
| Spaia, S | 1 |
| Christidou, F | 1 |
| Vayonas, G | 1 |
| Cagnoli, L | 1 |
| Imbasciati, E | 1 |
| Klinger, M | 1 |
| Szewczyk, Z | 1 |
| Turner, AN | 1 |
| Maidment, CG | 1 |
| Evans, DJ | 1 |
| Rees, AJ | 1 |
| Garattini, S | 1 |
| Bertani, T | 1 |
| Orlowski, T | 1 |
| Rancewicz, Z | 1 |
| Lao, M | 1 |
| Juskowa, J | 1 |
| Klepacka, J | 1 |
| Gradowska, L | 1 |
| Morzycka-Michalik, M | 1 |
| Glyda, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| ADRENL - ACTHAR Gel for Drug REsistant Nephrotic Syndrome in Children, Pilot Study[NCT03408405] | Phase 4 | 0 participants (Actual) | Interventional | 2018-06-30 | Withdrawn (stopped due to Withdrawal of funding from primary sponsor) | ||
| A Randomized Controlled Trial of Rituximab Versus Steroids and Cyclophosphamide in the Treatment of Idiopathic Membranous Nephropathy[NCT03018535] | Phase 3 | 76 participants (Actual) | Interventional | 2012-01-31 | Active, not recruiting | ||
| Random, Open, Control and Monocentric Clinical Research on Tacrolimus Monotherapy for Idiopathic Membranous Nephropathy (IMN)[NCT03549663] | 108 participants (Anticipated) | Interventional | 2018-07-04 | Recruiting | |||
| Clinical Study of Rituximab or Cyclophosphamide Combined With Steroids in the Treatment of Idiopathic Membranous Nephropathy[NCT05514015] | Phase 4 | 72 participants (Anticipated) | Interventional | 2022-08-25 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
20 reviews available for chlorambucil and Glomerulonephritis, Membranous
| Article | Year |
|---|---|
Efficacy and safety of rituximab in the treatment of membranous nephropathy: A systematic review and meta-analysis.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Antineoplastic Agen | 2020 |
Treatment of primary membranous nephropathy: where are we now?
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Antineoplastic Agents, Alkylating; Antineoplas | 2018 |
Comparative effectiveness and tolerance of immunosuppressive treatments for idiopathic membranous nephropathy: A network meta-analysis.
Topics: Chlorambucil; Cyclophosphamide; Cyclosporine; Drug Tolerance; Female; Glomerulonephritis, Membranous | 2017 |
Membranous nephropathy in children: clinical presentation and therapeutic approach.
Topics: Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Biopsy; Child; Chlorambucil; Cycl | 2010 |
Alkylating agents in membranous nephropathy: efficacy proven beyond doubt.
Topics: Alkylating Agents; Chlorambucil; Cyclophosphamide; Glomerulonephritis, Membranous; Humans; Immunosup | 2010 |
Immunosuppressive treatment for nephrotic idiopathic membranous nephropathy: a meta-analysis based on Chinese adults.
Topics: Adult; Alkylating Agents; Calcineurin Inhibitors; China; Chlorambucil; Clinical Trials as Topic; Cyc | 2012 |
[Guidelines for the management of refractory nephrotic syndrome--from investigations between 1997 and 2001--research project team for progressive renal lesions in the Ministry of Health, Labor and Welfare, Japan].
Topics: Blood Component Removal; Cause of Death; Chlorambucil; Clinical Trials as Topic; Cyclophosphamide; D | 2002 |
Corticosteroids, cyclophosphamide, and chlorambucil therapy of membranous nephropathy.
Topics: Antineoplastic Agents, Alkylating; Chlorambucil; Cyclophosphamide; Drug Therapy, Combination; Glomer | 2003 |
[Membranous nephropathy].
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Basement Membrane; Child; Child, Preschool; Chlorambuci | 2003 |
[Membranous kidney diseases in adults].
Topics: Adrenal Cortex Hormones; Adult; Chlorambucil; Cyclophosphamide; Cyclosporine; Glomerulonephritis, Me | 2004 |
Medical decision-making in membranous nephropathy: how to use limited clinical research evidence in patient management.
Topics: Adult; Aged; Chlorambucil; Cyclophosphamide; Decision Trees; Evidence-Based Medicine; Glomerulonephr | 2005 |
Are cytotoxic agents beneficial in idiopathic membranous nephropathy? A meta-analysis of the controlled trials.
Topics: Chlorambucil; Cyclophosphamide; Glomerulonephritis, Membranous; Humans; Kidney; Nephrotic Syndrome; | 1995 |
Primary nephrotic syndrome in the elderly.
Topics: Actuarial Analysis; Acute Kidney Injury; Adrenal Cortex Hormones; Adult; Aged; Chlorambucil; Female; | 1993 |
Pharmacologic management of adult idiopathic nephrotic syndrome.
Topics: Adrenal Cortex Hormones; Chlorambucil; Cyclosporine; Drug Therapy, Combination; Edema; Glomeruloneph | 1993 |
Cytotoxics, cyclosporine and membranous nephropathy.
Topics: Adrenal Cortex Hormones; Chlorambucil; Clinical Trials as Topic; Cyclosporine; Drug Therapy, Combina | 1996 |
Efficacy of immunosuppressive treatment in patients with membranous nephropathy and renal insufficiency.
Topics: Adult; Aged; Chlorambucil; Follow-Up Studies; Glomerulonephritis, Membranous; Humans; Immunosuppress | 1997 |
Treatment of idiopathic membranous nephropathy (IMN).
Topics: Antineoplastic Agents, Alkylating; Chlorambucil; Cyclosporine; Glomerulonephritis, Membranous; Gluco | 2000 |
Treatment of membranous nephropathy.
Topics: Adrenal Cortex Hormones; Chlorambucil; Cyclophosphamide; Cyclosporine; Drug Therapy, Combination; Gl | 2001 |
Treatment of the nephrotic syndrome with cyclosporin A.
Topics: Chlorambucil; Cyclophosphamide; Cyclosporine; Glomerulonephritis, Membranous; Glomerulosclerosis, Fo | 1992 |
Conventional treatment of idiopathic nephrotic syndrome and membranous nephropathy in adults.
Topics: Adult; Chlorambucil; Cyclophosphamide; Glomerulonephritis, Membranous; Glomerulosclerosis, Focal Seg | 1991 |
17 trials available for chlorambucil and Glomerulonephritis, Membranous
| Article | Year |
|---|---|
Efficacy and safety of low-dose chlorambucil in nephrotic patients with idiopathic membranous nephropathy.
Topics: Adult; Anti-Inflammatory Agents; Antineoplastic Agents, Alkylating; Chlorambucil; Female; Follow-Up | 2009 |
Immunosuppression for progressive membranous nephropathy: a UK randomised controlled trial.
Topics: Chlorambucil; Cyclosporine; Drug Administration Schedule; Drug Therapy, Combination; Glomerular Filt | 2013 |
A randomized pilot trial comparing methylprednisolone plus a cytotoxic agent versus synthetic adrenocorticotropic hormone in idiopathic membranous nephropathy.
Topics: Adrenocorticotropic Hormone; Adult; Aged; Antineoplastic Agents, Alkylating; Chlorambucil; Cyclophos | 2006 |
Are cytotoxic agents beneficial in idiopathic membranous nephropathy? A meta-analysis of the controlled trials.
Topics: Chlorambucil; Cyclophosphamide; Glomerulonephritis, Membranous; Humans; Kidney; Nephrotic Syndrome; | 1995 |
Therapy for idiopathic membranous nephropathy: tailoring the choice by decision analysis.
Topics: Adolescent; Adult; Aged; Chlorambucil; Decision Support Techniques; Drug Therapy, Combination; Femal | 1994 |
Preserving renal function in patients with membranous nephropathy: daily oral chlorambucil compared with intermittent monthly pulses of cyclophosphamide.
Topics: Administration, Oral; Adult; Aged; Chlorambucil; Cyclophosphamide; Drug Administration Schedule; Dru | 1994 |
Low-dose prednisolone/chlorambucil therapy in patients with severe membranous glomerulonephritis.
Topics: Adult; Aged; Chlorambucil; Drug Therapy, Combination; Female; Glomerulonephritis, Membranous; Humans | 1994 |
Idiopathic membranous nephropathy in the elderly.
Topics: Adolescent; Adult; Aged; Chlorambucil; Creatinine; Drug Therapy, Combination; Female; Glomerulonephr | 1993 |
A 10-year follow-up of a randomized study with methylprednisolone and chlorambucil in membranous nephropathy.
Topics: Adult; Aged; Chlorambucil; Creatinine; Female; Follow-Up Studies; Glomerulonephritis, Membranous; Hu | 1995 |
A 10-year follow-up of a randomized study with methylprednisolone and chlorambucil in membranous nephropathy.
Topics: Adult; Aged; Chlorambucil; Creatinine; Female; Follow-Up Studies; Glomerulonephritis, Membranous; Hu | 1995 |
A 10-year follow-up of a randomized study with methylprednisolone and chlorambucil in membranous nephropathy.
Topics: Adult; Aged; Chlorambucil; Creatinine; Female; Follow-Up Studies; Glomerulonephritis, Membranous; Hu | 1995 |
A 10-year follow-up of a randomized study with methylprednisolone and chlorambucil in membranous nephropathy.
Topics: Adult; Aged; Chlorambucil; Creatinine; Female; Follow-Up Studies; Glomerulonephritis, Membranous; Hu | 1995 |
Efficacy of immunosuppressive treatment in patients with membranous nephropathy and renal insufficiency.
Topics: Adult; Aged; Chlorambucil; Follow-Up Studies; Glomerulonephritis, Membranous; Humans; Immunosuppress | 1997 |
A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy.
Topics: Adolescent; Adult; Aged; Amenorrhea; Anemia; Antineoplastic Agents, Alkylating; Carcinoma; Chlorambu | 1998 |
A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy.
Topics: Adolescent; Adult; Aged; Amenorrhea; Anemia; Antineoplastic Agents, Alkylating; Carcinoma; Chlorambu | 1998 |
A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy.
Topics: Adolescent; Adult; Aged; Amenorrhea; Anemia; Antineoplastic Agents, Alkylating; Carcinoma; Chlorambu | 1998 |
A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy.
Topics: Adolescent; Adult; Aged; Amenorrhea; Anemia; Antineoplastic Agents, Alkylating; Carcinoma; Chlorambu | 1998 |
Oral cyclophosphamide versus chlorambucil in the treatment of patients with membranous nephropathy and renal insufficiency.
Topics: Adult; Aged; Anti-Inflammatory Agents; Chlorambucil; Cyclophosphamide; Drug Therapy, Combination; Fe | 1998 |
Methylprednisolone plus chlorambucil as compared with methylprednisolone alone for the treatment of idiopathic membranous nephropathy. The Italian Idiopathic Membranous Nephropathy Treatment Study Group.
Topics: Adolescent; Adult; Aged; Chlorambucil; Drug Administration Schedule; Drug Therapy, Combination; Fema | 1992 |
A randomized trial of methylprednisolone and chlorambucil in idiopathic membranous nephropathy.
Topics: Administration, Oral; Adolescent; Adult; Aged; Chlorambucil; Clinical Trials as Topic; Creatinine; D | 1989 |
[Programs of immunosuppressive and anti-inflammatory therapy of primary idiopathic glomerulonephritis. II. Membranous, membrano- proliferative and mesangial glomerulonephritis].
Topics: Chlorambucil; Clinical Trials as Topic; Cyclophosphamide; Drug Administration Schedule; Drug Therapy | 1989 |
Immunosuppression for membranous nephropathy.
Topics: Adult; Chlorambucil; Clinical Trials as Topic; Drug Administration Schedule; Follow-Up Studies; Glom | 1988 |
Steroids and cytotoxic drugs in the treatment of membranous glomerulopathy.
Topics: Chlorambucil; Clinical Trials as Topic; Glomerulonephritis, Membranous; Humans; Steroids | 1988 |
40 other studies available for chlorambucil and Glomerulonephritis, Membranous
| Article | Year |
|---|---|
Idiopathic Membranous Nephropathy and Treatment Related Complications.
Topics: Anti-Inflammatory Agents; Anticoagulants; Antineoplastic Agents, Alkylating; Chlorambucil; Drug Ther | 2020 |
Rituximab versus the modified Ponticelli regimen in the treatment of primary membranous nephropathy: a Health Economic Model.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Cost-Benefit Analysis; Cyclopho | 2018 |
ACP Journal Club. Prednisolone plus chlorambucil preserved renal function in membranous nephropathy.
Topics: Chlorambucil; Cyclosporine; Glomerulonephritis, Membranous; Humans; Immunosuppressive Agents; Predni | 2013 |
Immunosuppression for membranous nephropathy.
Topics: Chlorambucil; Cyclosporine; Glomerulonephritis, Membranous; Humans; Immunosuppressive Agents; Predni | 2013 |
Immunosuppression for membranous nephropathy.
Topics: Chlorambucil; Cyclosporine; Glomerulonephritis, Membranous; Humans; Immunosuppressive Agents; Predni | 2013 |
Immunosuppression for membranous nephropathy.
Topics: Chlorambucil; Cyclosporine; Glomerulonephritis, Membranous; Humans; Immunosuppressive Agents; Predni | 2013 |
Immunosuppression for membranous nephropathy.
Topics: Chlorambucil; Cyclosporine; Glomerulonephritis, Membranous; Humans; Immunosuppressive Agents; Predni | 2013 |
Immunosuppression for membranous nephropathy.
Topics: Chlorambucil; Cyclosporine; Glomerulonephritis, Membranous; Humans; Immunosuppressive Agents; Predni | 2013 |
Immunosuppression for membranous nephropathy - Authors' reply.
Topics: Chlorambucil; Cyclosporine; Glomerulonephritis, Membranous; Humans; Immunosuppressive Agents; Predni | 2013 |
Chlorambucil-induced cytomegalovirus infection: a case report.
Topics: Aged, 80 and over; Alkylating Agents; Chlorambucil; Cytomegalovirus Infections; Glomerulonephritis, | 2014 |
Membranous Glomerulopathy in Hypogammaglobulinemia.
Topics: Agammaglobulinemia; Chlorambucil; gamma-Globulins; Glomerulonephritis, Membranous; Humans; Infusions | 2017 |
Application of artificial neural networks in estimating predictive factors and therapeutic efficacy in idiopathic membranous nephropathy.
Topics: Adult; Anti-Inflammatory Agents; Chlorambucil; Cyclophosphamide; Drug Therapy, Combination; Female; | 2010 |
Idiopathic membranous nephropathy: back to the future?
Topics: Chlorambucil; Cyclosporine; Glomerulonephritis, Membranous; Humans; Immunosuppressive Agents; Predni | 2013 |
A difficult trade off for adults with membranous nephropathy.
Topics: Adult; Chlorambucil; Drug Therapy, Combination; Glomerulonephritis, Membranous; Humans; Immunosuppre | 2013 |
Restrictive use of immunosuppressive treatment in patients with idiopathic membranous nephropathy: high renal survival in a large patient cohort.
Topics: Adult; Aged; Chlorambucil; Cyclophosphamide; Female; Glomerulonephritis, Membranous; Humans; Immunos | 2004 |
Prolonged chlorambucil therapy for idiopathic membranous nephropathy may induce myelodysplastic syndrome and acute leukemia: report of a case.
Topics: Acute Disease; Adult; Antineoplastic Agents, Alkylating; Chlorambucil; Chromosomes, Human, Pair 7; F | 2004 |
Cyclophosphamide or chlorambucil therapy is indicated in idiopathic membranous nephropathy with strong risk factors for progression.
Topics: Chlorambucil; Creatinine; Cyclophosphamide; Disease Progression; Drug Therapy, Combination; Glomerul | 2005 |
20 years after methylprednisolone/chlorambucil treatment in idiopathic membranous nephropathy stage II-III with nephrotic syndrome.
Topics: Adult; Chlorambucil; Drug Therapy, Combination; Female; Follow-Up Studies; Glomerulonephritis, Membr | 2006 |
Development of bronchial adenocarcinoma 11 years after the onset of membranous nephropathy associated with chlorambucil therapy.
Topics: Adenocarcinoma; Adult; Bronchial Neoplasms; Chlorambucil; Glomerulonephritis, Membranous; Humans; Ma | 1995 |
Therapy of membranous nephropathy: what to do after the after (meta) analyses.
Topics: Chlorambucil; Cyclophosphamide; Glomerulonephritis, Membranous; Humans; Immunosuppression Therapy; M | 1995 |
Treatment of idiopathic membranous nephropathy.
Topics: Chlorambucil; Clinical Trials as Topic; Drug Therapy, Combination; Follow-Up Studies; Glomerulonephr | 1994 |
Treatment of aggressive idiopathic membranous glomerulonephritis.
Topics: Chlorambucil; Glomerulonephritis, Membranous; Humans; Kidney Failure, Chronic; Prognosis; Proteinuri | 1994 |
Prednisolone and chlorambucil therapy for idiopathic membranous nephropathy with progressive renal failure.
Topics: Adult; Aged; Chlorambucil; Cohort Studies; Female; Glomerulonephritis, Membranous; Humans; Kidney; K | 1994 |
Outcome of membranous glomerulonephritis in the elderly.
Topics: Adrenal Cortex Hormones; Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Chlorambucil; D | 1993 |
Complete remission of nephrotic syndrome after steroid-chlorambucil in a previous failed short-term steroidal treatment of a primary membranous nephropathy.
Topics: Adult; Antineoplastic Agents, Alkylating; Chlorambucil; Follow-Up Studies; Glomerulonephritis, Membr | 1996 |
Mesenteric arterial thrombosis complicating the nephrotic syndrome.
Topics: Adult; Anti-Inflammatory Agents; Antineoplastic Agents, Alkylating; Chlorambucil; Glomerulonephritis | 1997 |
Retroperitoneal fibrosis and membranous nephropathy. Improvement of both diseases after treatment with steroids and immunosuppressive agents.
Topics: Anti-Inflammatory Agents; Chlorambucil; Drug Therapy, Combination; Glomerulonephritis, Membranous; H | 1999 |
Chlorambucil-induced seizure in a patient with nephrotic syndrome.
Topics: Adult; Chlorambucil; Glomerulonephritis, Membranous; Humans; Male; Nephrotic Syndrome; Seizures | 1999 |
Treatment and long-term follow-up of patients with stage II to III idiopathic membranous nephropathy.
Topics: Adult; Chlorambucil; Cyclosporine; Drug Administration Schedule; Drug Therapy, Combination; Female; | 1999 |
Clinical features and treatment outcome of idiopathic membranous nephropathy in Chinese patients.
Topics: Aged; Antihypertensive Agents; Chlorambucil; Creatinine; Cyclophosphamide; Drug Therapy, Combination | 1999 |
Chlorambucil-induced acute hepatic failure in a patient with membranous nephropathy.
Topics: Adult; Alkylating Agents; Chlorambucil; Female; Glomerulonephritis, Membranous; Humans; Kidney; Live | 2000 |
Conservative versus immunosuppressive treatment of patients with idiopathic membranous nephropathy.
Topics: Adult; Aged; Anti-Inflammatory Agents; Antineoplastic Agents, Alkylating; Chlorambucil; Creatinine; | 2002 |
Glomerulonephritis in chronic lymphocytic leukemia and related B-cell lymphomas.
Topics: Adult; Aged; Aged, 80 and over; B-Lymphocytes; Chlorambucil; Female; Glomerulonephritis; Glomerulone | 1992 |
Membranous nephropathy--still a treatment dilemma.
Topics: Adult; Chlorambucil; Drug Therapy, Combination; Glomerulonephritis, Membranous; Humans; Methylpredni | 1992 |
Hepatitis C virus infection and membranous glomerulonephritis.
Topics: Chlorambucil; Female; Glomerulonephritis, Membranous; Hepatitis Antibodies; Hepatitis C; Humans; Mal | 1991 |
Retreatment of membranous nephropathy with steroids and chlorambucil after initial unresponsiveness to alternate-day prednisone.
Topics: Chlorambucil; Drug Therapy, Combination; Glomerulonephritis, Membranous; Humans; Male; Middle Aged; | 1990 |
Immunosuppression for membranous nephropathy.
Topics: Adolescent; Adult; Chlorambucil; Drug Administration Schedule; Drug Therapy, Combination; Follow-Up | 1989 |
Treatment of membranous nephropathy with prednisolone and chlorambucil.
Topics: Adrenal Insufficiency; Chlorambucil; Drug Therapy, Combination; Glomerulonephritis, Membranous; Huma | 1989 |
Prednisolone and chlorambucil treatment in idiopathic membranous nephropathy with deteriorating renal function.
Topics: Adult; Chlorambucil; Drug Administration Schedule; Drug Evaluation; Female; Follow-Up Studies; Glome | 1988 |
Long-term immunosuppressive therapy of idiopathic membranoproliferative glomerulonephritis.
Topics: Adult; Azathioprine; Chlorambucil; Cyclophosphamide; Drug Therapy, Combination; Female; Follow-Up St | 1988 |