chlorambucil has been researched along with Glioma in 5 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metronomic (daily low-dose) chlorambucil requires further study before use in human patients with glioma." | 7.88 | Canine (Pet Dog) Tumor Microsurgery and Intratumoral Concentration and Safety of Metronomic Chlorambucil for Spontaneous Glioma: A Phase I Clinical Trial. ( Bentley, RT; Cohen-Gadol, AA; Knapp, DW; Miller, MA; Thomovsky, SA, 2018) |
| "The objective of this study was to investigate a possible mechanism of action of metronomic chlorambucil on glioma by studying the in vitro cytotoxicity and anti-angiogenic effects on glioma and endothelial cells, respectively." | 7.88 | In vitro effect of chlorambucil on human glioma cell lines (SF767 and U87-MG), and human microvascular endothelial cell (HMVEC) and endothelial progenitor cells (ECFCs), in the context of plasma chlorambucil concentrations in tumor-bearing dogs. ( Anderson, KM; Case, J; Jones, DR; Knapp, DW; Mund, JA; Packer, RA; Reese, MJ, 2018) |
| "Metronomic (daily low-dose) chlorambucil requires further study before use in human patients with glioma." | 3.88 | Canine (Pet Dog) Tumor Microsurgery and Intratumoral Concentration and Safety of Metronomic Chlorambucil for Spontaneous Glioma: A Phase I Clinical Trial. ( Bentley, RT; Cohen-Gadol, AA; Knapp, DW; Miller, MA; Thomovsky, SA, 2018) |
| "The objective of this study was to investigate a possible mechanism of action of metronomic chlorambucil on glioma by studying the in vitro cytotoxicity and anti-angiogenic effects on glioma and endothelial cells, respectively." | 3.88 | In vitro effect of chlorambucil on human glioma cell lines (SF767 and U87-MG), and human microvascular endothelial cell (HMVEC) and endothelial progenitor cells (ECFCs), in the context of plasma chlorambucil concentrations in tumor-bearing dogs. ( Anderson, KM; Case, J; Jones, DR; Knapp, DW; Mund, JA; Packer, RA; Reese, MJ, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bentley, RT | 1 |
| Thomovsky, SA | 1 |
| Miller, MA | 1 |
| Knapp, DW | 2 |
| Cohen-Gadol, AA | 1 |
| Reese, MJ | 1 |
| Anderson, KM | 1 |
| Mund, JA | 1 |
| Case, J | 1 |
| Jones, DR | 1 |
| Packer, RA | 1 |
| Wang, X | 1 |
| Li, J | 1 |
| Xu, C | 1 |
| Li, Y | 1 |
| Gong, T | 1 |
| Sun, X | 1 |
| Fu, Y | 1 |
| He, Q | 1 |
| Zhang, Z | 1 |
| Belenkov, AI | 1 |
| Paiement, JP | 1 |
| Panasci, LC | 1 |
| Monia, BP | 1 |
| Chow, TY | 1 |
| Nogales, FF | 1 |
| Oliva, HA | 1 |
5 other studies available for chlorambucil and Glioma
| Article | Year |
|---|---|
Canine (Pet Dog) Tumor Microsurgery and Intratumoral Concentration and Safety of Metronomic Chlorambucil for Spontaneous Glioma: A Phase I Clinical Trial.
Topics: Administration, Metronomic; Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chlorambuci | 2018 |
In vitro effect of chlorambucil on human glioma cell lines (SF767 and U87-MG), and human microvascular endothelial cell (HMVEC) and endothelial progenitor cells (ECFCs), in the context of plasma chlorambucil concentrations in tumor-bearing dogs.
Topics: Animals; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cel | 2018 |
Scopine as a novel brain-targeting moiety enhances the brain uptake of chlorambucil.
Topics: Amines; Animals; Apoptosis; Biological Transport; Blood-Brain Barrier; Brain; Cell Cycle; Cell Line, | 2014 |
An antisense oligonucleotide targeted to human Ku86 messenger RNA sensitizes M059K malignant glioma cells to ionizing radiation, bleomycin, and etoposide but not DNA cross-linking agents.
Topics: Antigens, Nuclear; Antineoplastic Agents; Bleomycin; Chlorambucil; Cisplatin; DNA Helicases; DNA-Act | 2002 |
Peritoneal gliomatosis produced by ovarian teratomas.
Topics: Adult; Chlorambucil; Dactinomycin; Fallopian Tubes; Female; Glioma; Humans; Hysterectomy; Methotrexa | 1974 |