chlorambucil has been researched along with Glial Cell Tumors in 5 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metronomic (daily low-dose) chlorambucil requires further study before use in human patients with glioma." | 7.88 | Canine (Pet Dog) Tumor Microsurgery and Intratumoral Concentration and Safety of Metronomic Chlorambucil for Spontaneous Glioma: A Phase I Clinical Trial. ( Bentley, RT; Cohen-Gadol, AA; Knapp, DW; Miller, MA; Thomovsky, SA, 2018) |
| "The objective of this study was to investigate a possible mechanism of action of metronomic chlorambucil on glioma by studying the in vitro cytotoxicity and anti-angiogenic effects on glioma and endothelial cells, respectively." | 7.88 | In vitro effect of chlorambucil on human glioma cell lines (SF767 and U87-MG), and human microvascular endothelial cell (HMVEC) and endothelial progenitor cells (ECFCs), in the context of plasma chlorambucil concentrations in tumor-bearing dogs. ( Anderson, KM; Case, J; Jones, DR; Knapp, DW; Mund, JA; Packer, RA; Reese, MJ, 2018) |
| "Metronomic (daily low-dose) chlorambucil requires further study before use in human patients with glioma." | 3.88 | Canine (Pet Dog) Tumor Microsurgery and Intratumoral Concentration and Safety of Metronomic Chlorambucil for Spontaneous Glioma: A Phase I Clinical Trial. ( Bentley, RT; Cohen-Gadol, AA; Knapp, DW; Miller, MA; Thomovsky, SA, 2018) |
| "The objective of this study was to investigate a possible mechanism of action of metronomic chlorambucil on glioma by studying the in vitro cytotoxicity and anti-angiogenic effects on glioma and endothelial cells, respectively." | 3.88 | In vitro effect of chlorambucil on human glioma cell lines (SF767 and U87-MG), and human microvascular endothelial cell (HMVEC) and endothelial progenitor cells (ECFCs), in the context of plasma chlorambucil concentrations in tumor-bearing dogs. ( Anderson, KM; Case, J; Jones, DR; Knapp, DW; Mund, JA; Packer, RA; Reese, MJ, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bentley, RT | 1 |
| Thomovsky, SA | 1 |
| Miller, MA | 1 |
| Knapp, DW | 2 |
| Cohen-Gadol, AA | 1 |
| Reese, MJ | 1 |
| Anderson, KM | 1 |
| Mund, JA | 1 |
| Case, J | 1 |
| Jones, DR | 1 |
| Packer, RA | 1 |
| Wang, X | 1 |
| Li, J | 1 |
| Xu, C | 1 |
| Li, Y | 1 |
| Gong, T | 1 |
| Sun, X | 1 |
| Fu, Y | 1 |
| He, Q | 1 |
| Zhang, Z | 1 |
| Belenkov, AI | 1 |
| Paiement, JP | 1 |
| Panasci, LC | 1 |
| Monia, BP | 1 |
| Chow, TY | 1 |
| Nogales, FF | 1 |
| Oliva, HA | 1 |
5 other studies available for chlorambucil and Glial Cell Tumors
| Article | Year |
|---|---|
Canine (Pet Dog) Tumor Microsurgery and Intratumoral Concentration and Safety of Metronomic Chlorambucil for Spontaneous Glioma: A Phase I Clinical Trial.
Topics: Administration, Metronomic; Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chlorambuci | 2018 |
In vitro effect of chlorambucil on human glioma cell lines (SF767 and U87-MG), and human microvascular endothelial cell (HMVEC) and endothelial progenitor cells (ECFCs), in the context of plasma chlorambucil concentrations in tumor-bearing dogs.
Topics: Animals; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cel | 2018 |
Scopine as a novel brain-targeting moiety enhances the brain uptake of chlorambucil.
Topics: Amines; Animals; Apoptosis; Biological Transport; Blood-Brain Barrier; Brain; Cell Cycle; Cell Line, | 2014 |
An antisense oligonucleotide targeted to human Ku86 messenger RNA sensitizes M059K malignant glioma cells to ionizing radiation, bleomycin, and etoposide but not DNA cross-linking agents.
Topics: Antigens, Nuclear; Antineoplastic Agents; Bleomycin; Chlorambucil; Cisplatin; DNA Helicases; DNA-Act | 2002 |
Peritoneal gliomatosis produced by ovarian teratomas.
Topics: Adult; Chlorambucil; Dactinomycin; Fallopian Tubes; Female; Glioma; Humans; Hysterectomy; Methotrexa | 1974 |