chlorambucil has been researched along with Focal Segmental Glomerulosclerosis in 24 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Prednisone-resistant nephrotic syndrome (NS) due to focal segmental glomerulosclerosis (FSGS), the most common acquired disease requiring chronic dialysis and transplantation in children, has a low likelihood of response to alkylating agent therapy." | 7.69 | Intravenous methylprednisolone and oral alkylating agent therapy of prednisone-resistant pediatric focal segmental glomerulosclerosis: a long-term follow-up. ( Griswold, WR; Kirpekar, R; Mendoza, SA; Reznik, VM; Sibley, RK; Tune, BM, 1995) |
| "Treatment with a combination of pulse methylprednisolone (MP) and an alkylating agent has been reported to induce long-term remission of proteinuria in patients with steroid-resistant nephrotic syndrome (SRNS)." | 7.68 | Methylprednisolone treatment of patients with steroid-resistant nephrotic syndrome. ( Benfield, MR; Kohaut, EC; Waldo, FB, 1992) |
| "Mechlorethamine has been assessed in 28 patients with idiopathic nephrotic syndrome previously treated with prednisone only." | 7.67 | [Effect of mechlorethamine in idiopathic nephrotic syndrome in childhood]. ( Canals, MJ; Cervera, A; Gómez Campderá, FJ; Gómez Campderá, J; López Gómez, JM; Luque, A; Morales, JL, 1984) |
| "Patients with prednisone-resistant nephrotic syndrome and biopsy-proven focal segmental glomerulosclerosis were treated with intravenous methylprednisone." | 7.67 | Treatment of childhood prednisone-resistant nephrotic syndrome and focal segmental glomerulosclerosis with intravenous methylprednisolone and oral alkylating agents. ( Brock, P; Griswold, WR; Mendoza, SA; Prime, DJ; Reznik, VM; Tune, BM; Vazquez, M, 1987) |
| "The therapy of nephrotic syndrome in focal segmental glomerulosclerosis (FSGS) is still a matter of controversy." | 6.71 | Cyclosporine A and chlorambucil in the treatment of idiopathic focal segmental glomerulosclerosis. ( Braun, N; Fünfstück, R; Grabensee, B; Heering, P; Ivens, K; Keller, F; Krämer, BK; Müllejans, R; Risler, T; Schollmeyer, P; Zäuner, I, 2004) |
| " For instance, in patients with idiopathic membranous glomerulonephritis a six months treatment with chlorambucil (0." | 5.05 | [Drug treatment of chronic glomerulonephritis: pro]. ( Brodehl, J; Helmchen, U; Koch, KM; Kühn, K, 1985) |
| "Prednisone-resistant nephrotic syndrome (NS) due to focal segmental glomerulosclerosis (FSGS), the most common acquired disease requiring chronic dialysis and transplantation in children, has a low likelihood of response to alkylating agent therapy." | 3.69 | Intravenous methylprednisolone and oral alkylating agent therapy of prednisone-resistant pediatric focal segmental glomerulosclerosis: a long-term follow-up. ( Griswold, WR; Kirpekar, R; Mendoza, SA; Reznik, VM; Sibley, RK; Tune, BM, 1995) |
| "A 4-year-old female with nephrotic syndrome secondary to focal segmental glomerulosclerosis (FSGS) was treated with pulse methylprednisolone and chlorambucil therapy." | 3.68 | Fatal Pneumocystis pneumonia in a child treated for focal segmental glomerulosclerosis. ( Chenaille, PJ; Kano, HL; Makker, SP; Murphy, JL, 1993) |
| "Treatment with a combination of pulse methylprednisolone (MP) and an alkylating agent has been reported to induce long-term remission of proteinuria in patients with steroid-resistant nephrotic syndrome (SRNS)." | 3.68 | Methylprednisolone treatment of patients with steroid-resistant nephrotic syndrome. ( Benfield, MR; Kohaut, EC; Waldo, FB, 1992) |
| "Mechlorethamine has been assessed in 28 patients with idiopathic nephrotic syndrome previously treated with prednisone only." | 3.67 | [Effect of mechlorethamine in idiopathic nephrotic syndrome in childhood]. ( Canals, MJ; Cervera, A; Gómez Campderá, FJ; Gómez Campderá, J; López Gómez, JM; Luque, A; Morales, JL, 1984) |
| "Patients with prednisone-resistant nephrotic syndrome and biopsy-proven focal segmental glomerulosclerosis were treated with intravenous methylprednisone." | 3.67 | Treatment of childhood prednisone-resistant nephrotic syndrome and focal segmental glomerulosclerosis with intravenous methylprednisolone and oral alkylating agents. ( Brock, P; Griswold, WR; Mendoza, SA; Prime, DJ; Reznik, VM; Tune, BM; Vazquez, M, 1987) |
| "The therapy of nephrotic syndrome in focal segmental glomerulosclerosis (FSGS) is still a matter of controversy." | 2.71 | Cyclosporine A and chlorambucil in the treatment of idiopathic focal segmental glomerulosclerosis. ( Braun, N; Fünfstück, R; Grabensee, B; Heering, P; Ivens, K; Keller, F; Krämer, BK; Müllejans, R; Risler, T; Schollmeyer, P; Zäuner, I, 2004) |
| "Patients with nephrotic syndrome are in a constant state of flux with respect to fluid status, organ function, and critical protein balance." | 2.38 | Pharmacologic management of adult idiopathic nephrotic syndrome. ( Alaniz, C; Brosius, FC; Palmieri, J, 1993) |
| "There is no definite treatment for focal glomerulosclerosis." | 2.38 | Treatment of the nephrotic syndrome with cyclosporin A. ( Ponticelli, C, 1992) |
| " Therefore, intravenous high-dose steroid pulses, alternate-day prednisone, short courses with cytotoxic agents and long-term administration of azathioprine have been suggested as alternatives to the classical prolonged corticotherapy." | 2.38 | Conventional treatment of idiopathic nephrotic syndrome and membranous nephropathy in adults. ( Passerini, P; Ponticelli, C, 1991) |
| "Approximately 30% of children with focal segmental glomerulosclerosis enter remission following treatment with corticosteroids." | 2.38 | Immunosuppressive therapy in the nephrotic syndrome in children. ( Trompeter, RS, 1989) |
| "When focal segmental glomerulosclerosis (FSGS) has reached the stage of chronic renal insufficiency, further progression is usually considered inevitable." | 1.30 | Aggressive treatment of severe idiopathic focal segmental glomerulosclerosis. ( Aviles, DH; Dublin, LS; Irwin, KC; Vehaskari, VM, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (54.17) | 18.7374 |
| 1990's | 8 (33.33) | 18.2507 |
| 2000's | 3 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Braun, N | 2 |
| Schmutzler, F | 1 |
| Lange, C | 1 |
| Perna, A | 1 |
| Remuzzi, G | 1 |
| Risler, T | 2 |
| Willis, NS | 1 |
| Sakai, H | 1 |
| Kurokawa, K | 1 |
| Saito, T | 1 |
| Shiiki, H | 1 |
| Nishi, S | 1 |
| Mitarai, T | 1 |
| Yokoyama, H | 1 |
| Yoshimura, A | 1 |
| Yorioka, N | 1 |
| Heering, P | 1 |
| Müllejans, R | 1 |
| Ivens, K | 1 |
| Zäuner, I | 1 |
| Fünfstück, R | 1 |
| Keller, F | 1 |
| Krämer, BK | 1 |
| Schollmeyer, P | 1 |
| Grabensee, B | 1 |
| Bodaghi, E | 1 |
| Chamsa, AM | 1 |
| Ponticelli, C | 3 |
| Banfi, G | 1 |
| Imbasciati, E | 1 |
| Tarantino, A | 1 |
| Gómez Campderá, FJ | 1 |
| López Gómez, JM | 1 |
| Cervera, A | 1 |
| Gómez Campderá, J | 1 |
| Canals, MJ | 1 |
| Morales, JL | 1 |
| Luque, A | 1 |
| McEnery, PT | 1 |
| Strife, CF | 1 |
| Donadio, JV | 1 |
| Tune, BM | 3 |
| Kirpekar, R | 1 |
| Sibley, RK | 1 |
| Reznik, VM | 2 |
| Griswold, WR | 2 |
| Mendoza, SA | 3 |
| Murphy, JL | 1 |
| Kano, HL | 1 |
| Chenaille, PJ | 1 |
| Makker, SP | 1 |
| Alaniz, C | 1 |
| Brosius, FC | 1 |
| Palmieri, J | 1 |
| Aviles, DH | 1 |
| Irwin, KC | 1 |
| Dublin, LS | 1 |
| Vehaskari, VM | 1 |
| Simon, NM | 1 |
| Rosenberg, MJ | 1 |
| Vázquez Tadei, G | 1 |
| Fernández, J | 1 |
| Martin Malo, A | 1 |
| Campdera, FG | 1 |
| Sanz Guajardo, D | 1 |
| Traver, JA | 1 |
| Botella, J | 1 |
| Waldo, FB | 1 |
| Benfield, MR | 1 |
| Kohaut, EC | 1 |
| Passerini, P | 1 |
| Trompeter, RS | 1 |
| Schulman, SL | 1 |
| Kaiser, BA | 1 |
| Polinsky, MS | 1 |
| Srinivasan, R | 1 |
| Baluarte, HJ | 1 |
| Sinn, W | 1 |
| Ratner, M | 1 |
| Tomilina, N | 1 |
| Klinkmann, H | 1 |
| Nizze, H | 1 |
| Vazquez, M | 1 |
| Prime, DJ | 1 |
| Brock, P | 1 |
| Kühn, K | 1 |
| Brodehl, J | 1 |
| Koch, KM | 1 |
| Helmchen, U | 1 |
| Cameron, JS | 1 |
| Ogg, CS | 1 |
| Turner, DR | 1 |
| Weller, RO | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Ofatumumab in Children With Steroid- and Calcineurin-inhibitor-resistant Nephrotic Syndrome: a Double-blind Randomized, Controlled, Superiority Trial[NCT02394106] | Phase 2 | 13 participants (Actual) | Interventional | 2015-07-31 | Terminated | ||
| Ofatumumab Versus Rituximab in Children With Steroid and Calcineurin Inhibitor-dependent Idiopathic Nephrotic Syndrome: an Open-label, Randomized, Controlled, Superiority Trial.[NCT02394119] | Phase 2 | 140 participants (Actual) | Interventional | 2015-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for chlorambucil and Focal Segmental Glomerulosclerosis
| Article | Year |
|---|---|
Immunosuppressive treatment for focal segmental glomerulosclerosis in adults.
Topics: Adult; Chlorambucil; Cyclosporine; Glomerulosclerosis, Focal Segmental; Humans; Immunosuppressive Ag | 2008 |
[Guidelines for the management of refractory nephrotic syndrome--from investigations between 1997 and 2001--research project team for progressive renal lesions in the Ministry of Health, Labor and Welfare, Japan].
Topics: Blood Component Removal; Cause of Death; Chlorambucil; Clinical Trials as Topic; Cyclophosphamide; D | 2002 |
Immunosuppressive therapy in primary glomerulonephritis (pros).
Topics: Adrenocorticotropic Hormone; Azathioprine; Chlorambucil; Cyclophosphamide; Dipyridamole; Glomerulone | 1982 |
Nephrotic syndrome in childhood. Management and treatment in patients with minimal change disease, mesangial proliferation, or focal glomerulosclerosis.
Topics: Adolescent; Child; Child, Preschool; Chlorambucil; Cyclophosphamide; Diuretics; Female; Glomerulonep | 1982 |
Nephrotic syndrome in childhood. Management and treatment in patients with minimal change disease, mesangial proliferation, or focal glomerulosclerosis.
Topics: Adolescent; Child; Child, Preschool; Chlorambucil; Cyclophosphamide; Diuretics; Female; Glomerulonep | 1982 |
Nephrotic syndrome in childhood. Management and treatment in patients with minimal change disease, mesangial proliferation, or focal glomerulosclerosis.
Topics: Adolescent; Child; Child, Preschool; Chlorambucil; Cyclophosphamide; Diuretics; Female; Glomerulonep | 1982 |
Nephrotic syndrome in childhood. Management and treatment in patients with minimal change disease, mesangial proliferation, or focal glomerulosclerosis.
Topics: Adolescent; Child; Child, Preschool; Chlorambucil; Cyclophosphamide; Diuretics; Female; Glomerulonep | 1982 |
Pharmacologic management of adult idiopathic nephrotic syndrome.
Topics: Adrenal Cortex Hormones; Chlorambucil; Cyclosporine; Drug Therapy, Combination; Edema; Glomeruloneph | 1993 |
Medical treatment of glomerular diseases.
Topics: Adult; Anti-Glomerular Basement Membrane Disease; Azathioprine; Child; Chlorambucil; Cyclophosphamid | 1978 |
Treatment of the nephrotic syndrome with cyclosporin A.
Topics: Chlorambucil; Cyclophosphamide; Cyclosporine; Glomerulonephritis, Membranous; Glomerulosclerosis, Fo | 1992 |
Conventional treatment of idiopathic nephrotic syndrome and membranous nephropathy in adults.
Topics: Adult; Chlorambucil; Cyclophosphamide; Glomerulonephritis, Membranous; Glomerulosclerosis, Focal Seg | 1991 |
Immunosuppressive therapy in the nephrotic syndrome in children.
Topics: Adrenal Cortex Hormones; Child; Child, Preschool; Chlorambucil; Cyclophosphamide; Cyclosporins; Glom | 1989 |
3 trials available for chlorambucil and Focal Segmental Glomerulosclerosis
| Article | Year |
|---|---|
Cyclosporine A and chlorambucil in the treatment of idiopathic focal segmental glomerulosclerosis.
Topics: Adult; Aged; Alkylating Agents; Biopsy; Chlorambucil; Cyclosporine; Drug Therapy, Combination; Femal | 2004 |
[New results concerning the effectiveness of therapy of chronic glomerulonephritis. Results of cytostatics-anticoagulants-aggregation inhibitors, cystostatics-anticoagulants-aggregation inhibitors-prednisone and cystostatics-prednisone therapy, derived fr
Topics: Anticoagulants; Chlorambucil; Chronic Disease; Clinical Trials as Topic; Drug Evaluation; Drug Thera | 1986 |
[Drug treatment of chronic glomerulonephritis: pro].
Topics: Chlorambucil; Chronic Disease; Clinical Trials as Topic; Cyclophosphamide; Cyclosporins; Glomerulone | 1985 |
12 other studies available for chlorambucil and Focal Segmental Glomerulosclerosis
| Article | Year |
|---|---|
[Primary nephrotic syndromes in children in Iran].
Topics: Adolescent; Anti-Inflammatory Agents; Biopsy; Child; Child, Preschool; Chlorambucil; Cyclophosphamid | 1978 |
[Effect of mechlorethamine in idiopathic nephrotic syndrome in childhood].
Topics: Child; Child, Preschool; Chlorambucil; Cyclophosphamide; Drug Tolerance; Female; Glomerulosclerosis, | 1984 |
Primary glomerular disease: to treat or not to treat.
Topics: Azathioprine; Chlorambucil; Cyclophosphamide; Dipyridamole; Glomerulonephritis; Glomerulosclerosis, | 1982 |
Intravenous methylprednisolone and oral alkylating agent therapy of prednisone-resistant pediatric focal segmental glomerulosclerosis: a long-term follow-up.
Topics: Child, Preschool; Chlorambucil; Cyclophosphamide; Drug Administration Schedule; Drug Resistance; Dru | 1995 |
Fatal Pneumocystis pneumonia in a child treated for focal segmental glomerulosclerosis.
Topics: Child, Preschool; Chlorambucil; Fatal Outcome; Female; Glomerulosclerosis, Focal Segmental; Humans; | 1993 |
Aggressive treatment of severe idiopathic focal segmental glomerulosclerosis.
Topics: Adolescent; Anti-Inflammatory Agents; Antineoplastic Agents, Alkylating; Black People; Child; Child, | 1999 |
[Clinical course and recurrences of the nephrotic syndrome due to minimal histologic lesions. Review of 73 cases (author's transl)].
Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Chlorambucil; Drug Therapy, Combination; Fe | 1979 |
Methylprednisolone treatment of patients with steroid-resistant nephrotic syndrome.
Topics: Administration, Oral; Adolescent; Child; Child, Preschool; Chlorambucil; Drug Administration Schedul | 1992 |
Controlled, multi-center trials are needed in pediatric nephrology.
Topics: Chlorambucil; Glomerulosclerosis, Focal Segmental; Humans; Methylprednisolone; Multicenter Studies a | 1992 |
Predicting the response to cytotoxic therapy for childhood nephrotic syndrome: superiority of response to corticosteroid therapy over histopathologic patterns.
Topics: Adolescent; Biopsy; Child; Child, Preschool; Chlorambucil; Cyclophosphamide; Glomerulonephritis; Glo | 1988 |
Treatment of childhood prednisone-resistant nephrotic syndrome and focal segmental glomerulosclerosis with intravenous methylprednisolone and oral alkylating agents.
Topics: Administration, Oral; Adolescent; Child; Child, Preschool; Chlorambucil; Cyclophosphamide; Drug Resi | 1987 |
Focal glomerulosclerosis.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Azathioprine; Child; Child, Preschool; Chlorambucil; Cyc | 1973 |