Page last updated: 2024-10-24

chlorambucil and Fever

chlorambucil has been researched along with Fever in 10 studies

Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.

Fever: An abnormal elevation of body temperature, usually as a result of a pathologic process.

Research Excerpts

ExcerptRelevanceReference
"A patient with an unusual variant of Sweet's syndrome, in which the course of the disease was chronic and relapsing, was treated successfully with intravenous methylprednisolone (pulse therapy)."7.67The use of pulse methylprednisolone and chlorambucil in the treatment of Sweet's syndrome. ( Callen, JP; Case, JD; Smith, SZ, 1989)
"He developed recurrent skin rash, fever, hypereosinophilia, and acute renal failure after rechallenge with chlorambucil."5.35Drug rash with eosinophilia and systemic symptoms after chlorambucil treatment in chronic lymphocytic leukaemia. ( Damaj, G; Gruson, B; Makdassi, R; Roszkiewicz, F; Vaida, I, 2009)
"A patient with an unusual variant of Sweet's syndrome, in which the course of the disease was chronic and relapsing, was treated successfully with intravenous methylprednisolone (pulse therapy)."3.67The use of pulse methylprednisolone and chlorambucil in the treatment of Sweet's syndrome. ( Callen, JP; Case, JD; Smith, SZ, 1989)
"He developed recurrent skin rash, fever, hypereosinophilia, and acute renal failure after rechallenge with chlorambucil."1.35Drug rash with eosinophilia and systemic symptoms after chlorambucil treatment in chronic lymphocytic leukaemia. ( Damaj, G; Gruson, B; Makdassi, R; Roszkiewicz, F; Vaida, I, 2009)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19905 (50.00)18.7374
1990's0 (0.00)18.2507
2000's4 (40.00)29.6817
2010's0 (0.00)24.3611
2020's1 (10.00)2.80

Authors

AuthorsStudies
Wootton, F1
Glanemann, B1
Langley-Hobbs, S1
Breheny, C1
Fowlie, S1
Whitworth, F1
Silvestrini, P1
Threlfall, A1
Sorrell, S1
Black, V1
Vaida, I1
Roszkiewicz, F1
Gruson, B1
Makdassi, R1
Damaj, G1
Knauf, WU1
Lissichkov, T1
Aldaoud, A1
Liberati, A1
Loscertales, J1
Herbrecht, R1
Juliusson, G1
Postner, G1
Gercheva, L1
Goranov, S1
Becker, M1
Fricke, HJ1
Huguet, F1
Del Giudice, I1
Klein, P1
Tremmel, L1
Merkle, K1
Montillo, M1
Levin, M1
Libster, D1
Weber, E1
Berger, S1
Weber, S1
Case, JD1
Smith, SZ1
Callen, JP1
Mead, GM1
Williams, CJ1
Whitehouse, JM1
Ultmann, JE1
Nixon, DD1
Sawitsky, A1
Boklan, BF1
Benjamin, Z1
Smith, E1
Gáspár, IA1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Retrospective Multicenter Trial on Efficacy and Toxicity of Bendamustine Alone or Associated With Rituximab, As Salvage Therapy in Patients With Chronic Lymphoproliferative Disorders[NCT01832597]109 participants (Actual)Observational2010-11-30Completed
A Phase I/II Study of Bendamustine, Lenalidomide and Low-dose Dexamethasone, (BdL) for the Treatment of Patients With Relapsed Myeloma.[NCT01686386]Phase 1/Phase 260 participants (Anticipated)Interventional2010-02-28Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for chlorambucil and Fever

ArticleYear
The therapy of lymphoma.
    Seminars in hematology, 1969, Volume: 6, Issue:4

    Topics: Adrenal Cortex Hormones; Asparaginase; Bone Marrow Diseases; Chlorambucil; Cyclophosphamide; Cytarab

1969

Trials

1 trial available for chlorambucil and Fever

ArticleYear
Phase III randomized study of bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukemia.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Sep-10, Volume: 27, Issue:26

    Topics: Adult; Aged; Antineoplastic Agents; Bendamustine Hydrochloride; Chlorambucil; Disease-Free Survival;

2009
Phase III randomized study of bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukemia.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Sep-10, Volume: 27, Issue:26

    Topics: Adult; Aged; Antineoplastic Agents; Bendamustine Hydrochloride; Chlorambucil; Disease-Free Survival;

2009
Phase III randomized study of bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukemia.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Sep-10, Volume: 27, Issue:26

    Topics: Adult; Aged; Antineoplastic Agents; Bendamustine Hydrochloride; Chlorambucil; Disease-Free Survival;

2009
Phase III randomized study of bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukemia.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Sep-10, Volume: 27, Issue:26

    Topics: Adult; Aged; Antineoplastic Agents; Bendamustine Hydrochloride; Chlorambucil; Disease-Free Survival;

2009

Other Studies

8 other studies available for chlorambucil and Fever

ArticleYear
Feline non-erosive immune-mediated polyarthritis: a multicentre, retrospective study of 20 cases (2009-2020).
    Journal of feline medicine and surgery, 2022, Volume: 24, Issue:10

    Topics: Animals; Arthritis; Cat Diseases; Cats; Chlorambucil; Cyclosporine; Female; Fever; Immunosuppressive

2022
Drug rash with eosinophilia and systemic symptoms after chlorambucil treatment in chronic lymphocytic leukaemia.
    Pharmacology, 2009, Volume: 83, Issue:3

    Topics: Acute Kidney Injury; Adrenal Cortex Hormones; Aged; Chlorambucil; Drug Eruptions; Eosinophilia; Exan

2009
Allergic reaction to chlorambucil in chronic lymphocytic leukemia presenting with fever and lymphadenopathy.
    Leukemia & lymphoma, 2005, Volume: 46, Issue:8

    Topics: Aged; Chlorambucil; Disease Progression; Drug Hypersensitivity; Female; Fever; Humans; Leukemia, Lym

2005
Rapid desensitization for chlorambucil drug fever.
    Haematologica, 2007, Volume: 92, Issue:7

    Topics: Aged; Aged, 80 and over; Chlorambucil; Female; Fever; Humans; Male

2007
The use of pulse methylprednisolone and chlorambucil in the treatment of Sweet's syndrome.
    Cutis, 1989, Volume: 44, Issue:2

    Topics: Biopsy; Chlorambucil; Chronic Disease; Dermatitis; Female; Fever; Humans; Methylprednisolone; Middle

1989
Cisplatin, adriamycin and cyclophosphamide (PACe) combination chemotherapy in patients with ovarian carcinoma resistant to chlorambucil.
    Cancer chemotherapy and pharmacology, 1985, Volume: 15, Issue:2

    Topics: Alopecia; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Cisplatin; Cyclophosphamide;

1985
Drug fever produced by chlorambucil.
    New York state journal of medicine, 1971, Oct-15, Volume: 71, Issue:20

    Topics: Chlorambucil; Female; Fever; Humans; Leukemia, Lymphoid; Middle Aged

1971
Pentamidine treatment of Pneumocystis carinii pneumonitis in an adult with lymphatic leukemia.
    The American journal of medicine, 1968, Volume: 44, Issue:4

    Topics: Antiprotozoal Agents; Audiometry; Chlorambucil; Fever; Humans; Leukemia, Lymphoid; Lymph Nodes; Male

1968