chlorambucil has been researched along with Extravascular Hemolysis in 8 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Chlorambucil may hold advantages over the immunosuppressive drugs normally recommended in this condition, azathioprine and cyclophosphamide, as it appears less liable to cause important marrow suppression and, unlike cyclophosphamide is not associated with alopecia and haemorrhagic cystitis." | 7.65 | Treatment of patients with systemic lupus erythematosus including nephritis with chlorambucil. ( Dunnill, MS; Halley, W; Holt, JM; Oliver, DO; Snaith, ML; Stephenson, AC, 1973) |
| " Chlorambucil may hold advantages over the immunosuppressive drugs normally recommended in this condition, azathioprine and cyclophosphamide, as it appears less liable to cause important marrow suppression and, unlike cyclophosphamide is not associated with alopecia and haemorrhagic cystitis." | 3.65 | Treatment of patients with systemic lupus erythematosus including nephritis with chlorambucil. ( Dunnill, MS; Halley, W; Holt, JM; Oliver, DO; Snaith, ML; Stephenson, AC, 1973) |
| "Chlorambucil (CHL) is a water-insoluble antineoplastic drug having a short elimination half-life." | 1.42 | Long-circulating lipoprotein-mimic nanoparticles for smart intravenous delivery of a practically-insoluble antineoplastic drug: Development, preliminary safety evaluations and preclinical pharmacokinetic studies. ( Al-Mahallawi, AM; Tadros, MI, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (75.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, X | 1 |
| Li, J | 1 |
| Xu, C | 1 |
| Li, Y | 1 |
| Gong, T | 1 |
| Sun, X | 1 |
| Fu, Y | 1 |
| He, Q | 1 |
| Zhang, Z | 1 |
| Tadros, MI | 1 |
| Al-Mahallawi, AM | 1 |
| Budmiger, H | 1 |
| Rhyner, K | 1 |
| Siegenthaler-Zuber, G | 1 |
| Bollinger, A | 1 |
| Pronk, EA | 1 |
| Elkerbout, F | 1 |
| Klein, F | 1 |
| Radema, H | 1 |
| Cleton, FJ | 1 |
| Spiers, AS | 1 |
| Snaith, ML | 1 |
| Holt, JM | 1 |
| Oliver, DO | 1 |
| Dunnill, MS | 1 |
| Halley, W | 1 |
| Stephenson, AC | 1 |
| Schumacher, K | 1 |
| Gross, R | 1 |
| Linford, JH | 1 |
| Hryniuk, W | 1 |
| Israels, LG | 1 |
1 trial available for chlorambucil and Extravascular Hemolysis
| Article | Year |
|---|---|
Therapy of macroglobulinaemia. Comparison of the effect of therapy on the level of monoclonal immunoglobulins and on clinical symptoms in four cases of waldenström's macroglobulinaemia and one case of IgA myeloma.
Topics: Agar; Aged; Alkylating Agents; Anemia, Hemolytic; Blood Coagulation Disorders; Blood Protein Disorde | 1969 |
7 other studies available for chlorambucil and Extravascular Hemolysis
| Article | Year |
|---|---|
Scopine as a novel brain-targeting moiety enhances the brain uptake of chlorambucil.
Topics: Amines; Animals; Apoptosis; Biological Transport; Blood-Brain Barrier; Brain; Cell Cycle; Cell Line, | 2014 |
Long-circulating lipoprotein-mimic nanoparticles for smart intravenous delivery of a practically-insoluble antineoplastic drug: Development, preliminary safety evaluations and preclinical pharmacokinetic studies.
Topics: Administration, Intravenous; Animals; Antineoplastic Agents; Chlorambucil; Drug Carriers; Ear; Hemol | 2015 |
[Idiopathic cold agglutinin disease. Clinical aspects, therapy and course in 6 patients].
Topics: Aged; Anemia, Hemolytic, Autoimmune; Chlorambucil; Cyclophosphamide; Drug Therapy, Combination; Eryt | 1988 |
Chronic granulocytic leukaemia and chronic lymphocytic leukaemia.
Topics: Allopurinol; Amenorrhea; Busulfan; Chlorambucil; Chronic Disease; Drug Eruptions; Female; Hemolysis; | 1974 |
Treatment of patients with systemic lupus erythematosus including nephritis with chlorambucil.
Topics: Adult; Alopecia; Amenorrhea; Azathioprine; Biopsy; Bone Marrow; Chlorambucil; Cyclophosphamide; Cyst | 1973 |
[Immunosuppressive treatment of autoantibody anemia and idiopathic thrombocytopenic purpura].
Topics: Adrenal Cortex Hormones; Alkylating Agents; Anemia, Hemolytic, Autoimmune; Antibodies; Autoantibodie | 1972 |
Adsorption to human red blood cells of chlorambucil and other biological alkylating agents.
Topics: Alkylation; Azo Compounds; Binding Sites; Biological Transport; Buffers; Cell Membrane Permeability; | 1969 |